Skeletal muscle wasting and protein-energy malnutrition in children with a newly diagnosed acute leukemia.

Abstract:

:The changes in skeletal muscle mass of 14 children with newly diagnosed acute leukemia were studied during the first 24 weeks of antileukemia therapy. A muscle index was calculated from the femoral quadriceps muscle thickness, measured by using an ultrasound method, and from the body surface area. Serum albumin concentration was used as a biochemical indicator of protein status. Some children had muscle wasting before diagnosis. The highest degree of muscle wasting developed by 4 to 6 weeks with an average of 27% decrease of the muscle index. Because of simultaneous increase of adipose tissue (average, 33% at 6 weeks and 37% at 12 weeks), the relative body weight or the limb circumferences did not decrease. Muscle mass recovery occurred within the next 6 months. Our data emphasize that changes in the relative body weight or limb circumferences do not reveal nutritional protein depletion and muscle wasting that occurs in children with newly diagnosed acute leukemia.

journal_name

Cancer

journal_title

Cancer

authors

Koskelo EK,Saarinen UM,Siimes MA

doi

10.1002/1097-0142(19900715)66:2<373::aid-cncr28206

subject

Has Abstract

pub_date

1990-07-15 00:00:00

pages

373-6

issue

2

eissn

0008-543X

issn

1097-0142

journal_volume

66

pub_type

杂志文章

相关文献

CANCER文献大全
  • Spinal cord sparing reirradiation with helical tomotherapy.

    abstract:BACKGROUND:The purpose of this study was to present planning, feasibility, toxicity, and outcome of helical tomotherapy for spinal cord-sparing reirradiation of spinal metastases and tumors. METHODS:Thirty-six patients with spinal metastases and tumors who had undergone previous radiotherapy were reirradiated with hel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25187

    authors: Sterzing F,Hauswald H,Uhl M,Herm H,Wiener A,Herfarth K,Debus J,Krempien R

    更新日期:2010-08-15 00:00:00

  • Multifocal occurrence of gastric carcinoma in patients with a family history of gastric carcinoma.

    abstract:BACKGROUND:Smoking and alcoholic beverage drinking habits as well as a family history of cancer are well known risk factors for the multifocal occurrence of squamous cell carcinoma of the esophagus and the head and neck region. However, the role of these risk factors in multiple gastric carcinoma remains to be clarifie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Morita M,Kuwano H,Baba H,Taketomi A,Kohnoe S,Tomoda H,Araki K,Saeki H,Kitamura K,Sugimachi K

    更新日期:1998-10-01 00:00:00

  • The emerging role of retinoids and retinoic acid metabolism blocking agents in the treatment of cancer.

    abstract:BACKGROUND:Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic tumors remains poor. Differentiating agents redirect cells toward their normal phenotype and therefore may reverse or suppress evolving malignant lesions or prevent cancer invasion. I...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19981015)83:8<1471::aid-cn

    authors: Miller WH Jr

    更新日期:1998-10-15 00:00:00

  • The National Cancer Institute's intervention trials.

    abstract::The National Cancer Institute (NCI) has increased its emphasis in cancer prevention by undertaking a number of human intervention trials. Special emphasis is placed on chemoprevention, diet, and smoking and tobacco use. Some 24 clinical trials are ongoing in chemoprevention to assess the role of specific chemicals (na...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19881015)62:1+<1851::aid-cncr282

    authors: Cullen JW

    更新日期:1988-10-15 00:00:00

  • Histology and DNA contents of a secondary malignancy arising in a mature residual lesion six years after chemotherapy for a disseminated nonseminomatous testicular tumor.

    abstract::The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860715)58:2<264::aid-cncr28205

    authors: Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

    更新日期:1986-07-15 00:00:00

  • The metabolic syndrome and risk of incident colorectal cancer.

    abstract:BACKGROUND:The authors tested the hypothesis that the metabolic syndrome (> or =3 of the following components: high blood pressure, increased waist circumference, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, or diabetes/hyperglycemia) is a risk factor for colorectal cancer. METHODS:Data fr...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.21950

    authors: Ahmed RL,Schmitz KH,Anderson KE,Rosamond WD,Folsom AR

    更新日期:2006-07-01 00:00:00

  • Prognostic value of bone marrow biopsy in breast cancer.

    abstract::Bone marrow biopsies (BMB) were performed on 622 women with a history of primary or metastatic breast cancer. In 332 of the patients bone scintigraphy (BSC) was also carried out at the time of initial diagnosis or during follow-up. The BMB revealed metastases in 22/88 patients (25%) in Stage I--III with positive BSC a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820201)49:3<513::aid-cncr28204

    authors: Landys K

    更新日期:1982-02-01 00:00:00

  • Progesterone therapy for endometrial carcinoma reduces cell proliferation but does not alter apoptosis.

    abstract:BACKGROUND:Although the anticancer effects of progesterone therapy for patients with endometrial carcinoma are widely acknowledged, a detailed assessment of the resultant morphologic alterations in tumor tissue kinetics has hitherto been lacking. METHODS:Biopsy and hysterectomy specimens of 14 endometrial carcinomas (...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980701)83:1<111::aid-cnc

    authors: Saegusa M,Okayasu I

    更新日期:1998-07-01 00:00:00

  • Characterization of cancer cell dissociation factor in a highly invasive pancreatic cancer cell line.

    abstract:BACKGROUND:Two pancreatic cancer cell lines, the highly invasive and metastatic cell line PC-1.0 and the weakly invasive and rarely metastatic cell line PC-1, were established from a pancreatic ductal carcinoma induced by N-nitrosobis (2-oxopropyl) amine in a Syrian golden hamster. METHODS:The cancer cell dissociation...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6+<1554::aid-cncr282

    authors: Kurizaki T,Egami H,Hirota M,Akagi J,Ohmachi H,Yamamoto S,Ogawa M

    更新日期:1995-03-15 00:00:00

  • The prevalence of unsuspected thyroid pathology in 300 sequential autopsies, with special reference to the incidental carcinoma.

    abstract::Three-hundred whole thyroid glands were collected at autopsy from patients who had no known clinical history of thyroid disease, and who varied from 13 to 82 years of age; 200 were male and 100 female. Thyroid glands were weighed, measured, and examined after previous formalin fixation. Histologic examination was done...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19891101)64:9<1888::aid-cncr2820

    authors: Bisi H,Fernandes VS,de Camargo RY,Koch L,Abdo AH,de Brito T

    更新日期:1989-11-01 00:00:00

  • A morphometric study of neovascularization in colorectal carcinoma.

    abstract:BACKGROUND:Neovascularization reportedly is correlated with metastasis, recurrence, and prognosis in some types of tumors. Microvessel quantification in so-called "hot spots" has been studied extensively as the only factor reflecting angiogenesis in various malignant tumors. The objective of this report was to evaluate...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Pavlopoulos PM,Konstantinidou AE,Agapitos E,Kavantzas N,Nikolopoulou P,Davaris P

    更新日期:1998-11-15 00:00:00

  • Cervical adenocarcinoma and squamous cell carcinoma incidence trends among white women and black women in the United States for 1976-2000.

    abstract:BACKGROUND:Although cervical carcinoma incidence and mortality rates have declined in the U.S. greatly since the introduction of the Papanicolaou smear, this decline has not been uniform for all histologic subtypes. Therefore, the authors assessed the differential incidence rates of squamous cell carcinoma (SCC) and ad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20064

    authors: Wang SS,Sherman ME,Hildesheim A,Lacey JV Jr,Devesa S

    更新日期:2004-03-01 00:00:00

  • Primitive neuroectodermal tumors after prophylactic central nervous system irradiation in children. Association with an activated K-ras gene.

    abstract::Three patients had supratentorial malignant brain tumors 7 to 9 years after prophylactic central nervous system (CNS) treatment for acute lymphocytic leukemia or malignant T-cell lymphoma. Therapy was administered at the age of 3 to 8 years and included cranial irradiation (total dose, 1800 to 2400 cGy) and intratheca...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920501)69:9<2385::aid-cncr2820

    authors: Brüstle O,Ohgaki H,Schmitt HP,Walter GF,Ostertag H,Kleihues P

    更新日期:1992-05-01 00:00:00

  • Radiation therapy at the end of life in patients with incurable nonsmall cell lung cancer.

    abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27401

    authors: Kapadia NS,Mamet R,Zornosa C,Niland JC,D'Amico TA,Hayman JA

    更新日期:2012-09-01 00:00:00

  • Gynecologic cancer treatment: risk factors for therapeutically induced neoplasia.

    abstract::Therapeutic intervention in a course of illness, while producing the desired result, also may have some adverse long-term effects on the patient. Second malignancies are one of the known complications of therapy. The treatments of gynecologic cancers by surgery, irradiation and chemotherapy have been associated with s...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19810715)48:1+<442::aid-cncr2820

    authors: Messerschmidt GL,Hoover R,Young RC

    更新日期:1981-07-15 00:00:00

  • A prospective evaluation of a triple-drug regimen containing cisplatin, vinblastine, and dacarbazine (CVD) for metastatic melanoma.

    abstract::Based on the independent activity of cisplatin, vinblastine, and dimethyl-triazeno-imidazole-carboxamide (DTIC) (CVD), a combination of these agents was used in the treatment of patients with advanced melanoma. Vinblastine was used in a dose of 1.6 mg/m2/d for 5 days, DTIC was used in a dose of 800 mg/m2 intravenously...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19891115)64:10<2024::aid-cncr282

    authors: Legha SS,Ring S,Papadopoulos N,Plager C,Chawla S,Benjamin R

    更新日期:1989-11-15 00:00:00

  • Differences in the diagnostic criteria used by Japanese and Western pathologists to diagnose colorectal carcinoma.

    abstract:BACKGROUND:In view of the many studies of early stage colorectal carcinoma from Japan, it is essential to know whether the criteria for the histologic diagnosis of colorectal carcinoma are similar in Japan and Western countries. METHODS:Eight expert pathologists from Japan (4), North America (2), and Europe (2) indivi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19980101)82:1<60::aid-cncr

    authors: Schlemper RJ,Itabashi M,Kato Y,Lewin KJ,Riddell RH,Shimoda T,Sipponen P,Stolte M,Watanabe H

    更新日期:1998-01-01 00:00:00

  • ESR1 mutations in breast cancer.

    abstract::The acquisition of ligand-independent ESR1 mutations during aromatase inhibitor therapy in metastatic estrogen receptor (ER)-positive breast cancer is a common mechanism of hormonal therapy resistance. Preclinical and clinical studies have demonstrated that ESR1 mutations can preexist in primary tumors and can be enri...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.32345

    authors: Dustin D,Gu G,Fuqua SAW

    更新日期:2019-11-01 00:00:00

  • Carcinocythemia (carcinoma cell leukemia) due to metastatic carcinoma of the breast: report of a case.

    abstract::A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197712)40:6<3107::aid-cncr282040

    authors: Myerowitz RL,Edwards PA,Sartiano GP

    更新日期:1977-12-01 00:00:00

  • Medical treatment and long-term survival in a prospective study of 84 patients with endocrine pancreatic tumors.

    abstract::A prospective study was performed on 84 patients with neuroendocrine pancreatic tumors. Fifty-nine (70%) had malignant tumors and received causal medical treatment. Streptozotocin in combination with 5-fluorouracil or doxorubicin was used as first-line treatment and produced overall objective responses in 20 of 44 (45...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820

    authors: Eriksson B,Skogseid B,Lundqvist G,Wide L,Wilander E,Oberg K

    更新日期:1990-05-01 00:00:00

  • Mammography in the symptomatic woman.

    abstract::This is a statistical analysis of the use of mammography in the symptomatic patient. Eighty-eight percent of women older than 50 years who had a palpable cancer of the breast had a positive mammogram; only 57% of women younger than 51 years of age had a positive mammogram. When the cancer presented as nipple discharge...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890401)63:7<1412::aid-cncr2820

    authors: Edeiken S

    更新日期:1989-04-01 00:00:00

  • Cognitive functioning after cancer treatment: a 3-year longitudinal comparison of breast cancer survivors treated with chemotherapy or radiation and noncancer controls.

    abstract:BACKGROUND:This study examined the influence of prior treatment on the course of cognitive functioning in breast cancer survivors. Changes in cognitive functioning over time were compared in breast cancer survivors treated with chemotherapy plus radiotherapy, breast cancer survivors treated with radiotherapy only, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26432

    authors: Phillips KM,Jim HS,Small BJ,Laronga C,Andrykowski MA,Jacobsen PB

    更新日期:2012-04-01 00:00:00

  • Predicted prostate specific antigen results using transrectal ultrasound gland volume. Differentiation of benign prostatic hyperplasia and prostate cancer.

    abstract:METHODS:The diagnostic performance of transrectal ultrasound (TRUS) gland volume and prostate specific antigen (PSA) results were evaluated in 204 men consecutively scheduled to undergo transurethral prostatic resection (TUR). RESULTS:Nonpalpable prostate cancer was detected by TRUS alone in 18% (29 of 161) and by TUR...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920701)70:1+<211::aid-cncr2820

    authors: Lee F,Littrup PJ,Loft-Christensen L,Kelly BS Jr,McHugh TA,Siders DB,Mitchell AE,Newby JE

    更新日期:1992-07-01 00:00:00

  • Synchronous neoplasms in patients with diminutive colorectal adenomas.

    abstract::The distribution of synchronous neoplasms was retrospectively analyzed in 220 patients undergoing initial colonoscopic evaluation for colorectal neoplasms. In 159 of the 220 patients, an index neoplasm was present in the rectosigmoid region. Of these 159 patients, 32 had an index rectosigmoid adenoma less than 5 mm in...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19871001)60:7<1599::aid-cncr2820

    authors: Tripp MR,Morgan TR,Sampliner RE,Kogan FJ,Protell RL,Earnest DL

    更新日期:1987-10-01 00:00:00

  • Obesity and screening for breast, cervical, and colorectal cancer in women: a review.

    abstract::The literature examining obesity as a barrier to screening for breast, cervical, and colorectal cancer has not been evaluated systematically. With the increasing prevalence of obesity and its impact on cancer incidence and mortality, it is important to determine whether obesity is a barrier to screening so that cancer...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.23408

    authors: Cohen SS,Palmieri RT,Nyante SJ,Koralek DO,Kim S,Bradshaw P,Olshan AF

    更新日期:2008-05-01 00:00:00

  • Elimination of dose limiting toxicities of cisplatin, 5-fluorouracil, and leucovorin using a weekly 24-hour infusion schedule for the treatment of patients with nasopharyngeal carcinoma.

    abstract:BACKGROUND:Cisplatin, 5-flourouracil (5-FU), and leucovorin (PFL) chemotherapy has been reported to be effective in the treatment of cancers but severe mucositis or neutropenia are dose limiting toxicities. This Phase II study evaluated the anticancer effect and the toxicities of a new weekly 24-hour infusional PFL che...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19951201)76:11<2186::aid-cncr282

    authors: Chi KH,Chan WK,Shu CH,Law CK,Chen SY,Yen SH,Chen KY

    更新日期:1995-12-01 00:00:00

  • Rate of incidence of hepatocellular carcinoma in patients with compensated viral cirrhosis.

    abstract:BACKGROUND:Cirrhosis of viral etiology due to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for hepatocellular carcinoma (HCC). The current study evaluated the rate of incidence of HCC in patients with compensated cirrhosis of viral etiology. METHODS:Two hundred fifty-nine cirrhotic pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Chiaramonte M,Stroffolini T,Vian A,Stazi MA,Floreani A,Lorenzoni U,Lobello S,Farinati F,Naccarato R

    更新日期:1999-05-15 00:00:00

  • Esophageal dilation in malignant dysphagia.

    abstract::Esophageal dilation by means of guided Neoplex (Medoc) tubes in 38 patients with malignant obstruction of the esophagus was analyzed. Peroral dilation proved to be a simple, well-tolerated primary procedure in the management of malignant strictures. Most patients have a temporary improvement of dysphagic symptoms, but...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2713::aid-cncr282

    authors: Aste H,Munizzi F,Martines H,Pugliese V

    更新日期:1985-12-01 00:00:00

  • Sequential identification of factors predicting distant relapse in breast cancer patients treated by conservative surgery.

    abstract:BACKGROUND AND METHODS:Predictors of distant relapse following conservative surgery for breast cancer were studied in a review of 425 women. Five steps of breast cancer patient management were defined in which increasing amounts of information, potentially relevant to prognosis for metastasis-free survival (MFS), were ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930815)72:4<1261::aid-cncr2820

    authors: Tubiana-Hulin M,Le Doussal V,Hacene K,Rouëssé J,Brunet M

    更新日期:1993-08-15 00:00:00

  • Activity of temozolomide and bevacizumab in the treatment of locally advanced, recurrent, and metastatic hemangiopericytoma and malignant solitary fibrous tumor.

    abstract:BACKGROUND:Hemangiopericytomas and malignant solitary fibrous tumors (HPC/SFT) are rare, closely related sarcomas with unpredictable behavior that respond infrequently to chemotherapy. An optimal systemic treatment strategy for advanced HPC/SFT has not yet been identified. METHODS:We retrospectively analyzed the recor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26098

    authors: Park MS,Patel SR,Ludwig JA,Trent JC,Conrad CA,Lazar AJ,Wang WL,Boonsirikamchai P,Choi H,Wang X,Benjamin RS,Araujo DM

    更新日期:2011-11-01 00:00:00