A prospective evaluation of a triple-drug regimen containing cisplatin, vinblastine, and dacarbazine (CVD) for metastatic melanoma.

abstract：:The molecular genetic alterations in colorectal carcinoma are among the best understood of any common human cancer. Identified abnormalities include both dominant-acting oncogenes (ras, myc, src) and suppressor genes which undergo inactivation or deletion (deleted in colorectal carcinoma gene [DCC], p53, adenomatous p...

journal_title：Cancer

authors： Hamilton SR

更新日期：1992-03-15 00:00:00

abstract：:Twenty-four patients with various solid tumors including metastatic liver cancer and cancer of the lung, gallbladder, and pancreas were treated with a lipophilic macromolecular drug, copoly(styrene-maleic acid) conjugated neocarzinostatin (SMANCS). The drug was dissolved in a lipid contrast medium Lipiodol and adminis...

journal_title：Cancer

authors： Konno T,Maeda H,Iwai K,Maki S,Tashiro S,Uchida M,Miyauchi Y

更新日期：1984-12-01 00:00:00

abstract：:Although cancer often is referred to as "a disease of the genes," it is indisputable that the (epi)genetic properties of individual cancer cells are highly variable, even within the same tumor. Hence, preexisting resistant clones will emerge and proliferate after therapeutic selection that targets sensitive clones. He...

journal_title：Cancer

authors： Napel S,Mu W,Jardim-Perassi BV,Aerts HJWL,Gillies RJ

更新日期：2018-12-15 00:00:00

abstract：:Merkel cell carcinoma (MCC) is a relatively rare cutaneous malignancy that occurs predominantly in the older white population. The incidence of MCC appears to have tripled during the past 20 years; an increase that is likely to continue because of the growing number of older Americans. The pathogenesis of MCC remains ...

journal_title：Cancer

authors： Bichakjian CK,Lowe L,Lao CD,Sandler HM,Bradford CR,Johnson TM,Wong SL

更新日期：2007-07-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) determinations performed in the milk of a nursing mother with an inoperable breast cancer revealed a 10-15-fold higher level compared with CEA levels in the milk of healthy nursing women. CEA was highly elevated in the milk of the tumor-bearing breast (1100 +/- 100 ng/ml) and moderately ...

journal_title：Cancer

authors： Bartal AH,Kahana L,Yarom J

更新日期：1980-11-01 00:00:00

abstract：:Cancer tissues from 30 patients with squamous cell carcinoma of the oral cavity were examined immunohistopathologically as to the responsiveness of the host against its own cancer cells in both biopsy and surgically resected specimens from the same patients. Subpopulations of the infiltrating lymphocytes in cancer tis...

journal_title：Cancer

authors： Hiratsuka H,Imamura M,Ishii Y,Kohama G,Kikuchi K

更新日期：1984-06-01 00:00:00

abstract：:Estrogen and progesterone receptors (ER/PR) were measured in primary tumors and metastases of 397 breast cancer patients. Survival following mastectomy was significantly longer in patients with ER and PR positive tumors, as was survival after first recurrence. The prognostic value of ER and PR was compared with such c...

journal_title：Cancer

authors： Alanko A,Heinonen E,Scheinin T,Tolppanen EM,Vihko R

更新日期：1985-10-01 00:00:00

abstract：:To investigate the utility of thallium 201 (Tl-201) thyroid scintigraphy for the detection of thyroid malignancies, early and delayed Tl-201 scintigraphy was done in 70 consecutive patients with a clinically solitary cold (Iodine 123 [I-123]) nodule. Early Tl-201 scintigraphy had a sensitivity of 100% and a specificit...

journal_title：Cancer

authors： Bleichrodt RP,Vermey A,Piers DA,de Langen ZJ

更新日期：1987-12-01 00:00:00

abstract：:The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...

journal_title：Cancer

authors： Furuta Y,Takasu T,Asai T,Shinohara T,Sawa H,Nagashima K,Inuyama Y

更新日期：1992-01-15 00:00:00

abstract：:Despite the fact that expression of Fas ligand (FasL) in cytotoxic T lymphocytes (CTLs) and in natural killer (NK) cells plays an important role in Fas-mediated tumor killing, During tumor progression FasL-expressing tumor cells are involved in counterattacking to kill tumor-infiltrating lymphocytes (TILs). Soluble Fa...

journal_title：Cancer

authors： Kim R,Emi M,Tanabe K,Uchida Y,Toge T

更新日期：2004-06-01 00:00:00

abstract：BACKGROUND:The current study evaluated whether the risk of developing thyroid cancer in Asian women was associated with infertility and the use of fertility drugs. METHODS:The authors conducted a large, retrospective cohort study using Taiwan's National Health Insurance Research Database. From the insurance claims dat...

journal_title：Cancer

authors： Ding DC,Chen W,Wang JH,Lin SZ,Sung FC

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...

journal_title：Cancer

authors： Allal AS,Maire D,Becker M,Dulguerov P

更新日期：2000-02-01 00:00:00

abstract：BACKGROUND:The current study examines 1) the sensitivity of detection and 2) sampling and screening/diagnostic error in the cytologic diagnosis of adenocarcinoma in situ (AIS) of the cervix. The data were taken from public and private sector screening laboratories reporting 25,000 and 80,000 smears, respectively, each ...

journal_title：Cancer

authors： Schoolland M,Segal A,Allpress S,Miranda A,Frost FA,Sterrett GF

更新日期：2002-12-25 00:00:00

abstract：BACKGROUND:Humoral hypercalcemia rarely is associated with colorectal carcinoma; to the authors' knowledge only nine cases have been reported to date. METHODS:Two cases of advanced colorectal carcinoma with humoral hypercalcemia of malignancy (HHM) are presented. RESULTS:The two patients had severe hypercalcemia with...

journal_title：Cancer

authors： Lortholary AH,Cadeau SD,Bertrand GM,Guerin-Meyer VI,Gamelin EC,Audran MJ

更新日期：1999-12-01 00:00:00

abstract：:In order to determine if there are morphologically identifiable characteristics between malignant cells obtained from a primary cancer and its metastasis the nuclear diameter was used as an indicator of the degree of malignancy, since there is good correlation between nuclear size, DNA content, and chromosome numbers....

journal_title：Cancer

authors： Zajdela A,Asselain B,Ghossein NA

更新日期：1985-10-01 00:00:00

abstract：:From the standpoint of chemotherapy, the first progress in the treatment of Hodgkin's disease was the identification of the activity of nitrogen mustard in the 1940's. The initial antitumor effect of the drug created a great excitement. However, when all patients later relapsed, there was subsequent dejection and skep...

journal_title：Cancer

authors： DeVita VT Jr,Lewis BJ,Rozencweig M,Muggia FM

更新日期：1978-08-01 00:00:00

abstract：BACKGROUND:Some growth factors may promote tumor growth by affecting tumor angiogenesis. The angiogenic growth factor, pleiotrophin, was demonstrated previously in human breast carcinoma tissues; however, the pattern of pleiotrophin expression in normal breast tissues has not been established. METHODS:The expression o...

journal_title：Cancer

authors： Garver RI Jr,Radford DM,Donis-Keller H,Wick MR,Milner PG

更新日期：1994-09-01 00:00:00

abstract：:The National Wilms' Tumor Study (NWTS) was initiated in 1969. One of its objectives was to modulate treatments according to risk factors to minimize the number and severity of treatment-related short-term and long-term iatrogenic complications. The NWTS has therefore incorporated a Long Term Follow-up Study (LTFS) wit...

journal_title：Cancer

authors： Evans AE,Norkool P,Evans I,Breslow N,D'Angio GJ

更新日期：1991-01-15 00:00:00

abstract：:Currently attention is focused on the testicle as a site of leukemic relapse. Leukemic involvement of the ovary has been described in several autopsy series with an incidence of 11-50% in patients with bone marrow relapse, but has rarely been reported during the clinical course of leukemia. In this report, four girls ...

journal_title：Cancer

authors： Cecalupo AJ,Frankel LS,Sullivan MP

更新日期：1982-08-01 00:00:00

abstract：BACKGROUND:This study aimed to determine the potential diagnostic value of migration-inhibitory factor (MIF) for gastric cancer in patients presenting with dyspepsia and its prognostic value for gastric cancer. METHODS:A cohort of 97 patients with histologically confirmed gastric adenocarcinoma and 222 patients with d...

journal_title：Cancer

authors： Xia HH,Yang Y,Chu KM,Gu Q,Zhang YY,He H,Wong WM,Leung SY,Yuen ST,Yuen MF,Chan AO,Wong BC

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND:Patients scheduled to receive chemotherapy frequently undergo pretherapy dental treatment to eliminate potential sources of odontogenic infection. A prospective study was conducted to assess a new protocol emphasizing minimal pretherapy dental treatment. METHODS:Forty-eight consecutive patients diagnosed wi...

journal_title：Cancer

authors： Toljanic JA,Bedard JF,Larson RA,Fox JP

更新日期：1999-04-15 00:00:00

abstract：BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...

journal_title：Cancer

authors： Adelstein DJ,Rice TW,Becker M,Larto MA,Kirby TJ,Koka A,Tefft M,Zuccaro G

更新日期：1997-09-15 00:00:00

abstract：BACKGROUND:The authors assessed the prognostic significance of abnormal cyclin dependent kinase inhibitor (CDKI) expression in adenocarcinomas of the uterine cervix. METHODS:Population-based, archival material from patients with International Federation of Gynecology and Obstetrics (FIGO) Stage I and II cervical adeno...

journal_title：Cancer

authors： Alfsen GC,Reed W,Sandstad B,Kristensen GB,Abeler VM

更新日期：2003-11-01 00:00:00

abstract：:Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

journal_title：Cancer

authors： Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

更新日期：1981-10-15 00:00:00

abstract：:Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation ...

journal_title：Cancer

authors： Nagasue N,Inokuchi K,Kobayashi M,Ogawa Y,Iwaki A

更新日期：1976-12-01 00:00:00

abstract：BACKGROUND:The reported frequency of gastrointestinal (GI) tract involvement in patients with mantle cell lymphoma (MCL) is 15-30%. However, this figure most likely is an underestimate because most patients with MCL involving the GI tract previously reported were examined endoscopically only if they had GI tract sympto...

journal_title：Cancer

authors： Romaguera JE,Medeiros LJ,Hagemeister FB,Fayad LE,Rodriguez MA,Pro B,Younes A,McLaughlin P,Goy A,Sarris AH,Dang NH,Samaniego F,Brown HM,Gagneja HK,Cabanillas F

更新日期：2003-02-01 00:00:00

abstract：:Malignant sweat gland neoplasms are rare tumors. Historically, the principal mode of treatment has been local surgical excision. Eight published studies show that greater than 50% of patients develop either local tumor recurrence after surgery or regional lymph node metastases. Most patients have evidence of locoregio...

journal_title：Cancer

authors： Harari PM,Shimm DS,Bangert JL,Cassady JR

更新日期：1990-04-15 00:00:00

abstract：:The greatest decrease in breast cancer mortality is likely to derive from applying globally existing therapies at an earlier stage. A high priority of the World Health Organization (WHO) cancer control program is the outreach approach that promotes worldwide access to cancer therapies of proven values. Therefore, the ...

journal_title：Cancer

authors： Koroltchouk V,Stanley K,Stjernswärd J

更新日期：1990-06-15 00:00:00

abstract：:This study sought to replicate and expand findings reported by the National Surgical Adjuvant Breast and Bowel Project (NSABP) on prognostic factors in resectable colon cancer. Mantel-Haenszel tests and the Cox model were used to analyze prognostic significance and effect of primary disease symptoms and tumor location...

journal_title：Cancer

authors： Steinberg SM,Barkin JS,Kaplan RS,Stablein DM

更新日期：1986-05-01 00:00:00

abstract：:The role of palliative radiation treatment of prostate cancer is well recognized. Appreciation of the value of definitive radiation therapy in management of locally advanced prostate cancer is increasing. Optimal management requires careful patient selection with multidiscipline evaluation to provide accurate grading ...

journal_title：Cancer

authors： Taylor WJ

更新日期：1977-02-01 00:00:00