Abstract:
:The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the authors also compared the clinical features of patients with HPV-positive and HPV-negative results to determine the clinical significance of HPV. HPV 16 and 18 were detected in 7 of the 49 cases (14%) of SCC. In the other histologic types of carcinoma (n = 11), neither HPV 16 nor HPV 18 was detected. No significant differences in the clinical features were observed between patients with SCC with HPV-positive and HPV-negative results. The results suggest that HPV 16 and 18 are implicated in the pathogenesis of SCC arising from the NC and PS. However, the presence of HPV is not related to local progression, occurrence of metastases, or the prognosis of the patients.
journal_name
Cancerjournal_title
Cancerauthors
Furuta Y,Takasu T,Asai T,Shinohara T,Sawa H,Nagashima K,Inuyama Ydoi
10.1002/1097-0142(19920115)69:2<353::aid-cncr28206subject
Has Abstractpub_date
1992-01-15 00:00:00pages
353-7issue
2eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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