A reliable method for evaluating drug compliance in children with cancer.

Abstract:

:Poor drug compliance may cause a decreased survival of children with malignancies. Children who fail to take their medications are not receiving optimum amounts of chemotherapy and suboptimal therapy causes a shortened survival in children with cancer. This is a study of prednisone compliance in 52 children with cancer during three distinct phases of therapy. The patients were either known to be taking prednisone (on-therapy group), off prednisone (off-therapy group), or their compliance was unknown (unknown group). Evaluation of prednisone compliance was attempted by measuring hemoglobin level changes, weight changes, and random urinary 17-ketogenic steroids. The results obtained show that while hemoglobin and weight changes are not helpful, a random urine 17-ketogenic steroid assay is able to differentiate clearly those patients who are taking their prednisone. By the use of this assay it was found that 33% of patients who by protocol and instruction were supposed to be receiving prednisone were not complying. Separate analysis of adolescents revealed an even more alarming 59% noncompliance rate. This striking level of noncompliance strongly suggests that the survival of patients may be threatened by noncompliance.

journal_name

Cancer

journal_title

Cancer

authors

Smith SD,Rosen D,Trueworthy RC,Lowman JT

doi

10.1002/1097-0142(197901)43:1<169::aid-cncr2820430

subject

Has Abstract

pub_date

1979-01-01 00:00:00

pages

169-73

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

43

pub_type

杂志文章

相关文献

CANCER文献大全
  • Prognostic factors for survival after stereotactic radiosurgery vary with the number of cerebral metastases.

    abstract:BACKGROUND:Little is understood about the factors that influence survival in patients who undergo gamma-knife stereotactic radiosurgery (SRS) for brain metastases. METHODS:Demographic, disease, treatment, and survival data on 334 patients with intracranial metastases who underwent initial SRS from 1998 to 2004 were ab...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22367

    authors: DiLuna ML,King JT Jr,Knisely JP,Chiang VL

    更新日期:2007-01-01 00:00:00

  • The two types of correction of absorbed dose estimates for internal emitters.

    abstract:BACKGROUND:Two types of correction for absorbed dose (D) estimates are described for clinical applications of internal emitters. The first is appropriate for legal and scientific reasons involving phantom-based estimates; the second is patient-specific and primarily intended for radioimmunotherapy (RIT). METHODS:The M...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10290

    authors: Williams LE,Liu A,Yamauchi DM,Lopatin G,Raubitschek AA,Wong JY

    更新日期:2002-02-15 00:00:00

  • Evaluation of cervical cancer by computed tomography: current status.

    abstract::In the evaluation of cervical cancer, computed tomography (CT) is used primarily to stage advanced tumors and evaluate for recurrence. Because of reports that CT imaging lacks sensitivity and specificity in the detection of primary tumors and metastatic lesions, its use in these applications has been limited, but rece...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.11684

    authors: Pannu HK,Fishman EK

    更新日期:2003-11-01 00:00:00

  • Long-term results of a phase 2 trial of nilotinib 400 mg twice daily in newly diagnosed patients with chronic-phase chronic myeloid leukemia.

    abstract:BACKGROUND:Nilotinib is a potent, second-generation inhibitor of BCR-ABL1 tyrosine kinase and has been approved as frontline and salvage therapy for patients with chronic-phase chronic myeloid leukemia (CP-CML). METHODS:In this single-institution, phase 2 study, 122 patients with newly diagnosed CP-CML received niloti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32623

    authors: Masarova L,Cortes JE,Patel KP,O'Brien S,Nogueras-Gonzalez GM,Konopleva M,Verstovsek S,Garcia-Manero G,Ferrajoli A,Kadia TM,Ravandi-Kashani F,Borthakur G,DellaSala S,Estrov Z,Jabbour EJ,Kantarjian HM

    更新日期:2020-04-01 00:00:00

  • A multivariate analysis of the survival of patients with aggressive lymphoma: variations in the predictive value of prognostic factors during the course of the disease. Groupe d'Etudes des Lymphomes de l'Adulte.

    abstract:BACKGROUND:Aggressive non-Hodgkin's lymphoma is now often curable with chemotherapy. The International Prognostic Index (IPI) was recently developed to predict patient survival on the basis of pretreatment clinical features. However, classical multivariate regression models such as the IPI fail to detect time-dependent...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Mounier N,Morel P,Haioun C,Coiffier B,Tilly H,Chatelain C,Lederlin P,Thyss A,Herbrecht R,Gisselbrecht C,Lepage E

    更新日期:1998-05-15 00:00:00

  • The risk for cancer among children of women who underwent in vitro fertilization.

    abstract:BACKGROUND:The possible association between ovarian carcinoma and ovulation-inducing drugs has led to renewed interest in the potential carcinogenic risks of these drugs. In vitro fertilization (IVF) has been linked to multiple pregnancies and possibly congenital malformations. However, to the authors' knowledge the as...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20000615)88:12<2845::aid-cncr26>

    authors: Lerner-Geva L,Toren A,Chetrit A,Modan B,Mandel M,Rechavi G,Dor J

    更新日期:2000-06-15 00:00:00

  • Salivary duct carcinoma: cytologic characteristics and application of androgen receptor immunostaining for diagnosis.

    abstract:BACKGROUND:Although there have been several reports of cytologic features for salivary duct carcinoma (SDC), it still can be difficult to diagnose patients with these tumor accurately at the time of fine-needle aspiration (FNA). Review of the literature indicates that, immunohistochemically, SDC expresses androgen rece...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.9050

    authors: Moriki T,Ueta S,Takahashi T,Mitani M,Ichien M

    更新日期:2001-10-25 00:00:00

  • Predictors of invasion in patients with core-needle biopsy-diagnosed ductal carcinoma in situ and recommendations for a selective approach to sentinel lymph node biopsy in ductal carcinoma in situ.

    abstract:BACKGROUND:Among patients with core-needle biopsy (CNB)-diagnosed ductal carcinoma in situ (DCIS), the guidelines for the selection of patients to undergo sentinel lymph node (SLN) biopsy are not well defined, and many patients with no invasion undergo an unnecessary SLN biopsy. The objective of this study was to ident...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22216

    authors: Huo L,Sneige N,Hunt KK,Albarracin CT,Lopez A,Resetkova E

    更新日期:2006-10-15 00:00:00

  • Combined BCG and irradiation treatment of skin metastases originating from malignant melanoma.

    abstract::Treatment with BCG (Bacillus Calmette-Guérin) followed by irradiation was attempted to improve response to therapy by cutaneous metastases from malignant skin melanomas. Both agents were applied in low doses, known to cause minimal side effects. Nineteen patients, divided into three groups, entered the clinical trial....

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820915)50:6<1100::aid-cncr2820

    authors: Plesnicar S,Rudolf Z

    更新日期:1982-09-15 00:00:00

  • Improved accuracy in differentiating malignant from benign mammographic abnormalities: a simple, improved magnetic resonance imaging method.

    abstract:BACKGROUND:Although several refinements have been reported for breast magnetic resonance imaging (MRI), there has been no uniform agreement by researchers on the optimal method. The authors report a simple and effective MRI method that incorporated the best qualities of other breast MRI methods yet eliminated the compl...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20010801)92:3<471::aid-cncr1345>

    authors: Khatri VP,Stuppino JJ,Espinosa MH,Pollack MS

    更新日期:2001-08-01 00:00:00

  • Radical nephrectomy surgical outcomes in the University HealthSystem Consortium Data Base: Impact of hospital case volume, hospital size, and geographic location on 40,000 patients.

    abstract:BACKGROUND:We sought to determine the impact of radical nephrectomy case volume, hospital size, and geographic region on immediate surgical outcomes for patients undergoing radical nephrectomy in academic centers across the country. METHODS:The University HealthSystem Consortium (UHC) Clinical Data Base was queried fo...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24292

    authors: Mitchell RE,Lee BT,Cookson MS,Barocas DA,Duke Herrell S,Clark PE,Smith JA,Chang SS

    更新日期:2009-06-01 00:00:00

  • Obesity at diagnosis is associated with inferior outcomes in hormone receptor-positive operable breast cancer.

    abstract:BACKGROUND:Obesity has been associated with inferior outcomes in operable breast cancer, but the relation between body mass index (BMI) and outcomes by breast cancer subtype has not been previously evaluated. METHODS:The authors evaluated the relation between BMI and outcomes in 3 adjuvant trials coordinated by the Ea...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27527

    authors: Sparano JA,Wang M,Zhao F,Stearns V,Martino S,Ligibel JA,Perez EA,Saphner T,Wolff AC,Sledge GW Jr,Wood WC,Fetting J,Davidson NE

    更新日期:2012-12-01 00:00:00

  • Relationship of inherent resistance to doxorubicin, proliferative activity and expression of P-glycoprotein 170, and glutathione S-transferase-pi in human lung tumors.

    abstract:BACKGROUND:This study analyzed whether proliferative activity and expression of P-glycoprotein 170 (P-170) or glutathione S-transferase-pi (GST-pi) in human non-small cell lung carcinomas (NSCLC) represent independent factors in resistance to doxorubicin or whether an association exists between these factors. METHODS:...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920815)70:4<764::aid-cncr28207

    authors: Volm M,Mattern J,Samsel B

    更新日期:1992-08-15 00:00:00

  • Malignant mesenchymoma of the bladder.

    abstract::A case of malignant mesenchymoma of the bladder, containing fibroleiomyomatous, myxomatous, osteoid, and cartilaginous components is presented. The primary pedunculated tumor measuring 18 X 10 X 9 cm and weighing 934 g, arose from the anterior wall of the bladder and was treated by partial cystectomy. Six months after...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19870815)60:4<858::aid-cncr28206

    authors: Terada Y,Saito I,Morohoshi T,Niijima T

    更新日期:1987-08-15 00:00:00

  • Preoperative chemotherapy for giant cell carcinoma of the thyroid.

    abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821201)50:11<2252::aid-cncr282

    authors: Spanos GA,WolK D,Desner MR,Khan A,Platt N,Khafif RA,Cortes EP

    更新日期:1982-12-01 00:00:00

  • Neurosarcomatous transformation in malignant melanoma: an ultrastructural study.

    abstract::Six cases of desmoplastic melanoma were studied by light and electron microscopy. The tumors fulfilled one or more of the following criteria: (1) having the presence of atypical intraepidermal melanocytic proliferation bordering the primary lesions; (2) an antecedent history of melanoma at the site of recurrence; (3) ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821201)50:11<2345::aid-cncr282

    authors: DiMaio SM,Mackay B,Smith JL Jr,Dickersin GR

    更新日期:1982-12-01 00:00:00

  • Telomerase activity in bladder carcinoma and its implication for noninvasive diagnosis by detection of exfoliated cancer cells in urine.

    abstract:BACKGROUND:Telomerase is an enzyme that can reconstitute the ends (telomeres) of chromosomes after cell division and thus circumvent the cumulative damage that occurs in normal adult somatic cells during successive mitotic cycles. Recently, it has been proposed that this enzyme should, therefore, be detectable in immor...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970115)79:2<362::aid-cnc

    authors: Yoshida K,Sugino T,Tahara H,Woodman A,Bolodeoku J,Nargund V,Fellows G,Goodison S,Tahara E,Tarin D

    更新日期:1997-01-15 00:00:00

  • Marjolin's ulcer. The LSU experience.

    abstract::Skin cancers originating in areas of chronic injury (Marjolin's ulcers) are thought to behave in a more aggressive fashion than those due to other causes. The initial surgical treatment, especially the management of the regional lymph nodes, remains controversial. This review of 37 patients with Marjolin's ulcer evalu...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830701)52:1<173::aid-cncr28205

    authors: Barr LH,Menard JW

    更新日期:1983-07-01 00:00:00

  • Lymphographic demonstration of cyclic changes in lymph node size during Pel-Epstein fever.

    abstract::Pel-Epstein fever cycles, consisting of 1-2 weeks of high fever separated by afebrile periods of the same duration, are classically characteristic of Hodgkin's disease. Clinical observation has determined that the lymph nodes enlarge during periods of fever and reduce in size as the fever subsides. To our knowledge, t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.2820360916

    authors: Scanlon GT,Castellino RA,Rudders R

    更新日期:1975-12-01 00:00:00

  • Preoperative chemotherapy for osteogenic sarcoma: selection of postoperative adjuvant chemotherapy based on the response of the primary tumor to preoperative chemotherapy.

    abstract::Since June 1978, 57 patients with primary osteogenic sarcoma of an extremity were treated with high-dose methotrexate (HDMTX) and citrovorum factor rescue (CFR), Adriamycin, and the combination of bleomycin, cyclophosphamide and dactinomycin (BCD) given for 4-16 weeks prior to definitive surgery. Histologic examinatio...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820315)49:6<1221::aid-cncr2820

    authors: Rosen G,Caparros B,Huvos AG,Kosloff C,Nirenberg A,Cacavio A,Marcove RC,Lane JM,Mehta B,Urban C

    更新日期:1982-03-15 00:00:00

  • Patient navigation: state of the art or is it science?

    abstract::First implemented in 1990, patient navigation interventions are emerging today as an approach to reduce cancer disparities. However, there is lack of consensus about how patient navigation is defined, what patient navigators do, and what their qualifications should be. Little is known about the efficacy and cost-effec...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.23815

    authors: Wells KJ,Battaglia TA,Dudley DJ,Garcia R,Greene A,Calhoun E,Mandelblatt JS,Paskett ED,Raich PC,Patient Navigation Research Program.

    更新日期:2008-10-15 00:00:00

  • Expression of aldehyde dehydrogenase 1 as a marker of mammary stem cells in benign and malignant breast lesions of Ghanaian women.

    abstract:BACKGROUND:Breast cancers that are negative for the estrogen receptor (ER), the progesterone receptor (PR), and the HER2 (human epidermal growth factor receptor 2) marker are more prevalent among African women, and the biologically aggressive nature of these triple-negative breast cancers (TNBCs) may be attributed to t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27737

    authors: Schwartz T,Stark A,Pang J,Awuah B,Kleer CG,Quayson S,Kingman S,Aitpillah F,Abantanga F,Jiagge E,Oppong JK,Osei-Bonsu E,Martin I,Yan X,Toy K,Adjei E,Wicha M,Newman LA

    更新日期:2013-02-01 00:00:00

  • Clinical features of patients with stage IIIB and IV bronchioloalveolar carcinoma of the lung.

    abstract:BACKGROUND:The incidence of bronchioloalveolar carcinoma of the lung (BAC), a pathologically distinct type of nonsmall cell lung carcinoma (NSCLC), appears to be rising. In this study, the authors compared data on the clinical presentation and clinical courses of patients with Stage IIIB and IV BAC with data on other t...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19991001)86:7<1165::aid-cn

    authors: Breathnach OS,Ishibe N,Williams J,Linnoila RI,Caporaso N,Johnson BE

    更新日期:1999-10-01 00:00:00

  • Comparison of HER-2 status determined by fluorescence in situ hybridization in primary and metastatic breast carcinoma.

    abstract:BACKGROUND:Accurate assessment of HER-2 status is necessary prior to anti-HER-2 antibody (trastuzumab) therapy for metastatic breast carcinoma. However, controversy exists regarding whether to assess HER-2 status in the primary tumor or in metastatic lesions. It is also unclear whether HER-2 status can change during di...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20987

    authors: Gong Y,Booser DJ,Sneige N

    更新日期:2005-05-01 00:00:00

  • Treatment for lymphedema of the arm--the Casley-Smith method: a noninvasive method produces continued reduction.

    abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid

    authors: Casley-Smith JR,Boris M,Weindorf S,Lasinski B

    更新日期:1998-12-15 00:00:00

  • Local relapse and contralateral tumor rates in patients with breast cancer treated with conservative surgery and radiotherapy (Institut Gustave Roussy 1970-1982). IGR Breast Cancer Group.

    abstract:BACKGROUND:Breast conservation is now established treatment for patients with small breast cancers. The authors reviewed a large series of patients with long term follow-up who underwent conservative treatment. Clinical and pathologic factors were analyzed to identify patients at an increased risk of relapse in the bre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951201)76:11<2260::aid-cncr282

    authors: Dewar JA,Arriagada R,Benhamou S,Benhamou E,Bretel JJ,Pellae-Cosset B,Marin JL,Petit JY,Contesso G,Sarrazin D

    更新日期:1995-12-01 00:00:00

  • Do hormones cause breast cancer?

    abstract::The evidence that various endogenous and exogenous sex hormones play a role in the etiology of breast cancer is reviewed. It is hypothesized that prolonged exposure to normal levels of ovarian estrogens and cyclic progesterone resulting from early menarche and late menopause, and primarily willful nulliparity and late...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19840201)53:3+<595::aid-cncr2820

    authors: Thomas DB

    更新日期:1984-02-01 00:00:00

  • Early surveillance is associated with less incidence and severity of breast cancer-related lymphedema compared with a traditional referral model of care.

    abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31873

    authors: Koelmeyer LA,Borotkanics RJ,Alcorso J,Prah P,Winch CJ,Nakhel K,Dean CM,Boyages J

    更新日期:2019-03-15 00:00:00

  • Anaerobic liver abscess and intrahepatic metastases: a case report and review of the literature.

    abstract::A patient is described in whom the first recurrence of a cloacogenic carcinoma of the rectum was an intrahepatic metastasis associated with an hepatic abscess caused by the anaerobic bacterium Peptococcus prevotii. Three previously reported cases of infection associated with hepatic tumor nodules have been found in wh...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197802)41:2<682::aid-cncr2820410

    authors: Trump DL,Fahnestock R,Cloutier CT,Dickman MD

    更新日期:1978-02-01 00:00:00

  • Involving providers and patients in cancer control and prevention efforts. Barriers to overcome.

    abstract::Although progress has been made in providing cancer prevention and control services to the population, there remain sizeable segments of the population that are either uninvolved or underinvolved with national and state efforts. One method of reaching most of the population, including those segments currently not invo...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1138::aid-cncr282

    authors: Iverson DC

    更新日期:1993-08-01 00:00:00