The risk for cancer among children of women who underwent in vitro fertilization.

Abstract:

BACKGROUND:The possible association between ovarian carcinoma and ovulation-inducing drugs has led to renewed interest in the potential carcinogenic risks of these drugs. In vitro fertilization (IVF) has been linked to multiple pregnancies and possibly congenital malformations. However, to the authors' knowledge the association between IVF and pediatric cancer has been described only in sporadic case reports. The aim of this study was to assess the incidence rate of pediatric cancer among a cohort of children born after IVF. METHODS:A historic prospective study based on a cohort of 332 children from 1254 women who underwent IVF treatment between 1981-1994 was performed. Medical files were reviewed and names were linked to the National Population and Cancer Registries. Pediatric cancer incidence rates were compared with the expected age-adjusted rates of the general population during the respective time period. RESULTS:No cancer cases were observed among the study cohort with respect to 1.7 cases that were expected. CONCLUSIONS:Because the small cohort analysis in the current study lacked the necessary power to reach definite conclusions, larger prospective studies are needed to assess the potential carcinogenic effect on children born after ovulation induction and IVF.

journal_name

Cancer

journal_title

Cancer

authors

Lerner-Geva L,Toren A,Chetrit A,Modan B,Mandel M,Rechavi G,Dor J

doi

10.1002/1097-0142(20000615)88:12<2845::aid-cncr26>

subject

Has Abstract

pub_date

2000-06-15 00:00:00

pages

2845-7

issue

12

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20000615)88:12<2845::AID-CNCR26>

journal_volume

88

pub_type

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