Abstract:
:Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated with high-risk features. In the early phase of the study, MCNU (300 to 500 mg/m2) was administered with cytosine arabinoside (Ara-C) (1.6 to 16 g/m2), etoposide (VP-16) (0.8 to 1.6 g/m2), cyclophosphamide (CY) (100 to 200 mg/kg), or busulfan (16 mg/kg). No acute toxicity was noticed after this high-dose therapy. The dose-limiting factor of the regimens was significant but reversible interstitial pneumonitis (IP). In a subsequent trial with an MCNU/VP-16/Ara-C/CY (MCVAC) regimen in which the dose of MCNU was reduced, the risk of IP diminished. This study is still in progress, but the clinical response has so far been encouraging. Fifteen of 26 children are alive and well in unmaintained complete remission (CR) with a median follow-up period of 11 months (range, 3 to 34 months) after transplantation. This MCNU-based regimen without total body irradiation (TBI) is especially important in children to avoid the serious sequelae of irradiation. Our results justify a broader clinical trial to evaluate the effects of the MCVAC regimen followed by PBSCT.
journal_name
Cancerjournal_title
Cancerauthors
Takaue Y,Watanabe T,Hoshi Y,Abe T,Matsunaga K,Saito S,Hirao A,Kawano Y,Ninomiya T,Kuroda Ydoi
10.1002/1097-0142(19910401)67:7<1830::aid-cncr2820subject
Has Abstract,Author List Incompletepub_date
1991-04-01 00:00:00pages
1830-7issue
7eissn
0008-543Xissn
1097-0142journal_volume
67pub_type
临床试验,杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Salivary gland carcinomas (SGCs) are a rare malignancy with unknown etiology. The objective of the current study was to identify genetic variants modifying the risk of SGC and its major subtypes: adenoid cystic carcinoma and mucoepidermoid carcinoma. METHODS:The authors conducted a genome-wide association s...
journal_title:Cancer
pub_type: 杂志文章,收录出版
doi:10.1002/cncr.29381
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Several of the large studies addressing prognosis and survival from hepatocellular carcinoma (HCC) have been from Europe and Asia, but only a few have emanated from North America. Survival statistics from other parts of the world may not be applicable to the North American population because of etiologic, de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950815)76:4<579::aid-cncr28207
更新日期:1995-08-15 00:00:00
abstract::Fifty-eight patients with Dukes' C classification of carcinoma of the large bowel were placed on adjuvant immuno- or chemoimmunotherapy with Bacillus calmette guerin (BCG) or combination of 5-fluorouracil (5-FU) plus BCG following primary and definitive surgery, and were followed for up to 21 months. Of twenty-six pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197512)36:6<2421::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract::Androgen deprivation therapy (ADT) is now a well-established standard of care in combination with definitive radiotherapy for patients with unfavorable intermediate-risk to high-risk locally advanced prostate cancer. It is also well established that combination modality treatment with ADT and radiotherapy is superior ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28594
更新日期:2014-06-01 00:00:00
abstract:BACKGROUND:The AKT inhibitor MK-2206 at a dose of 60 mg every other day was evaluated in gastric/gastroesophageal junction cancers. METHODS:Patients who had progressed after first-line treatment were eligible. Pertinent eligibility criteria included adequate organ function, a fasting serum glucose level ≤ 150 mg/dL, a...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.29363
更新日期:2015-07-01 00:00:00
abstract::Cross-sectional imaging is often a useful complement to clinical examination in patients with gynecologic malignancies. Patients with ovarian cancer will benefit less from the use of computed tomography and magnetic resonance imaging (MRI); however, extensive intraperitoneal disease may be evaluated and followed with ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.2820710431
更新日期:1993-02-15 00:00:00
abstract:BACKGROUND:The prognosis of pediatric patients with nonpilocytic astrocytoma, and in particular those with anaplastic astrocytoma, is somewhat unpredictable. This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric as...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980615)82:12<2459::aid-c
更新日期:1998-06-15 00:00:00
abstract:BACKGROUND:Cystic lesions of the adrenal gland are uncommon and demonstrate a spectrum of histologic changes and may vary from pseudocysts to malignant cystic neoplasms. METHODS:The authors analyzed a series of primary cystic lesions of the adrenal gland to evaluate the clinicopathologic features and histologic spectr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20555
更新日期:2004-10-01 00:00:00
abstract::An adequate operation for colorectal carcinoma involves removal of the primary tumor and wide excision of the mesentery with its contained regional lymph nodes and lymphovascular pathways. Enker and DeCosse state that radical resection, i.e., total mesenteric lymphadenectomy encompassing the origins of the complete ar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12+<2525::aid-cncr28
更新日期:1983-06-15 00:00:00
abstract:BACKGROUND:In late reproductive-aged breast cancer survivors, there is a need for real-time biomarkers of postchemotherapy ovarian function. The objective was to determine whether antimullerian hormone (AMH) and inhibin B are such biomarkers. The authors tested whether AMH and inhibin B were impacted by breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24746
更新日期:2010-02-01 00:00:00
abstract:BACKGROUND:The antiviral, proapoptotic, antiproliferative gene 2'-5' oligoadenylate synthetase (2-5OAS1) converts adenosine triphosphate into a series of 2'-5' oligoadenylates (2-5A). In turn, 2-5A activates latent ribonuclease (RNaseL), a candidate hereditary prostate cancer gene. OAS1 polymorphism (reference single n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26219
更新日期:2011-12-15 00:00:00
abstract::There is currently no adequate staging system for cerebral astrocytomas. A scheme for acquiring data that can be used to stage cerebral hemisphere tumors is suggested. This data base, in conjunction with treatment and survival information, may be useful in the management of childhood hemispheric tumors. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1784::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract:BACKGROUND:Current clinical guidelines recommend earlier, more intensive breast cancer screening with both magnetic resonance imaging (MRI) and mammography for women with breast cancer susceptibility gene (BRCA) mutations. Unspecified details of screening schedules are a challenge for implementing guidelines. METHODS:...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27864
更新日期:2013-03-15 00:00:00
abstract::Cis-diamminedichloride platinum II (DDP) was administered to eight patients with epidermoid carcinoma of the penis. Three of six adequately treated patients had an objective response: one patient achieved complete remission of 7 months duration and 2 patients had partial remissions of 8 and 2 months, respectively. DDP...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197911)44:5<1563::aid-cncr282044
更新日期:1979-11-01 00:00:00
abstract::A case of meningeal melanocytoma of the left Meckel's cave associated with ipsilateral Ota's nevus in a 43-year-old woman, was studied by light and electron microscopy. The cells of the tumor were characterized by the presence of dendritic cytoplasmic processes, melanosomes and premelanosomes; hence, they were deemed ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830615)51:12<2304::aid-cncr282
更新日期:1983-06-15 00:00:00
abstract::To assess the importance of radiation dose fraction size in the treatment of malignant melanomas, the records of 48 patients (83 sites) treated at Tufts-New England Medical Center from 1971 to 1979 have been retrospectively reviewed. During this period, the dose fractionation schemes evolved from standard fraction siz...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1262::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract:BACKGROUND:Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT. METHODS:Between March 1995 and December 2003, 59 patients dia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21043
更新日期:2005-06-01 00:00:00
abstract::Hereditary cancer represents approximately 5-10% of the total cancer burden and may account for 60,000 to 120,000 new cancer occurrences this year in the United States. New developments in molecular genetics and the cloning of cancer-prone genes have intensely fueled interest in dealing with hereditary forms of cancer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991201)86:11+<2449::aid-
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Conditional survival (CS) has emerged as a clinically relevant measure of prognosis for cancer survivors. The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making. METHODS:Patients with melanoma and at least 5 years of foll...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24966
更新日期:2010-05-01 00:00:00
abstract:BACKGROUND:Chronic myeloid leukemia (CML) may progress to blast phase (BP) at the rate of 1% to 1.5% per year. With the use of single-agent tyrosine kinase inhibitors, median overall survival ranges between 7 and 11 months. METHODS:The outcome was analyzed for 42 patients with lymphoid BP-CML who were treated with hyp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28433
更新日期:2014-02-01 00:00:00
abstract:BACKGROUND:Brain metastases from esophageal carcinoma are extremely rare, and information regarding the natural history, results of treatment, and possible prognostic factors in these patients is limited. METHODS:The records of 36 patients with brain metastases from esophageal carcinoma who were treated between 1986 a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10271
更新日期:2002-02-01 00:00:00
abstract:BACKGROUND:The current study was conducted to characterize the epidemiology, histology, and radiographic features of as well as the surgical approach to pediatric and adolescent renal cell carcinoma (pRCC). METHODS:pRCC cases prospectively enrolled on the Children's Oncology Group study AREN03B2 underwent central path...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.29368
更新日期:2015-07-15 00:00:00
abstract:BACKGROUND:Active surveillance (AS) is an accepted means of managing low-risk prostate cancer. Because of the rarity of downstream events, data from existing AS cohorts cannot yet address how differences in surveillance intensity affect metastasis and mortality. This study projected the comparative benefits of differen...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32557
更新日期:2020-02-01 00:00:00
abstract:BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30764
更新日期:2017-11-01 00:00:00
abstract:BACKGROUND:In the United States, detection of squamous carcinoma in situ (CIS) by screening has led to reduced rates for invasive squamous carcinoma and lower mortality. Adenocarcinoma in situ (AIS) rates also have increased, but invasive cervical adenocarcinoma rates have not declined similarly. To make inferences abo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20877
更新日期:2005-03-15 00:00:00
abstract::Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870601)59:11<1866::aid-cncr282
更新日期:1987-06-01 00:00:00
abstract::Bone scanning is a sensitive test for the detection of metastatic breast cancer, but not all abnormal findings on bone scan are diagnostic of skeletal metastasis. Recent studies have found a relatively low rate (less than or equal to 5%) of abnormal scans in patients with Stage I and II breast cancers, and only half o...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19810201)47:3<486::aid-cncr28204
更新日期:1981-02-01 00:00:00
abstract::The occurrence and staining patterns of Concanavalin A (Con A) binding histiocytes were studied in diagnostic lymph node specimens of 133 patients with Hodgkin's disease. Varying numbers of Con A binding histiocytes were present in all tumors. Two distinct cytoplasmic staining patterns of the Con A binding histiocytes...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830715)52:2<252::aid-cncr28205
更新日期:1983-07-15 00:00:00
abstract:BACKGROUND:Assessment of the responses of osteosarcoma patients to preoperative chemotherapy is of clinical importance. The purpose of this study was to estimate the accuracy of angiography and thallium-201 scintigraphy, compared with histology, in assessing the responses of patients with osteosarcoma to preoperative c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990915)86:6<949::aid-cnc
更新日期:1999-09-15 00:00:00
abstract::Patients with small cell bronchogenic carcinoma, in a study utilizing laminar-air-flow-protected environments, oral prophylactic broad spectrum non-absorbable antibiotics (PNAA), and intensive combination chemotherapy, were examined to determine the effects of PNAA on serum biochemical values and on gastrointestinal a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197610)38:4<1556::aid-cncr282038
更新日期:1976-10-01 00:00:00