Effectiveness of high-dose MCNU therapy and hematopoietic stem cell autografts treatment of childhood acute leukemia/lymphoma with high-risk features.


:Clinical and pharmacokinetic studies were performed regarding the toxicity of methyl 6-[3-(2-chloroethyl)-3-nitrosoureido]-6-deoxy-alpha-D-glucopyranoside (MCNU) with other drugs, in conjunction with a peripheral blood stem cell autograft (PBSCT), for treating 26 children with acute leukemia or lymphoma associated with high-risk features. In the early phase of the study, MCNU (300 to 500 mg/m2) was administered with cytosine arabinoside (Ara-C) (1.6 to 16 g/m2), etoposide (VP-16) (0.8 to 1.6 g/m2), cyclophosphamide (CY) (100 to 200 mg/kg), or busulfan (16 mg/kg). No acute toxicity was noticed after this high-dose therapy. The dose-limiting factor of the regimens was significant but reversible interstitial pneumonitis (IP). In a subsequent trial with an MCNU/VP-16/Ara-C/CY (MCVAC) regimen in which the dose of MCNU was reduced, the risk of IP diminished. This study is still in progress, but the clinical response has so far been encouraging. Fifteen of 26 children are alive and well in unmaintained complete remission (CR) with a median follow-up period of 11 months (range, 3 to 34 months) after transplantation. This MCNU-based regimen without total body irradiation (TBI) is especially important in children to avoid the serious sequelae of irradiation. Our results justify a broader clinical trial to evaluate the effects of the MCVAC regimen followed by PBSCT.






Takaue Y,Watanabe T,Hoshi Y,Abe T,Matsunaga K,Saito S,Hirao A,Kawano Y,Ninomiya T,Kuroda Y




Has Abstract,Author List Incomplete


1991-04-01 00:00:00














  • Viral oncolysate in the management of malignant melanoma. II. Clinical studies.

    abstract::Melanoma cell oncolysate, prepared with Newcastle disease virus, was administered as an immunostimulant to 13 patients with metastatic melanoma. The oncolysate was well tolerated. Six treated patients evidenced a decrease in the size of skin nodules or diseased lymph nodes. Visceral lesions were not favorably influenc...


    pub_type: 杂志文章


    authors: Murray DR,Cassel WA,Torbin AH,Olkowski ZL,Moore ME

    更新日期:1977-08-01 00:00:00

  • Chemoprevention of digestive organs carcinogenesis by natural product protocatechuic acid.

    abstract::The worldwide increase in cancer mortality demands a practical and effective chemopreventive approach to this problem. Using animal bioassay, the authors demonstrated protocatechuic acid (PCA, 3,4-dihydroxybenzoic acid), a simple and antioxidative phenolic acid present in fruits, vegetables, and nuts, to be an efficac...


    pub_type: 杂志文章


    authors: Tanaka T,Kojima T,Kawamori T,Mori H

    更新日期:1995-03-15 00:00:00

  • Influenza in children and young adults with cancer: 20 cases.

    abstract::The purpose of this study was to characterize the clinical features of laboratory-confirmed influenza in 20 children and young adults with cancer who were receiving immunosuppressive therapy. Viruses isolated from pharyngeal and nasopharyngeal cultures were identified as the A/Hong Kong/1/68 strain or one of its varia...


    pub_type: 杂志文章


    authors: Feldman S,Webster RG,Sugg M

    更新日期:1977-01-01 00:00:00

  • Manual dissection of adenocarcinoma of the lower third of the rectum specimens for detection of lymph node metastases smaller than 5 mm.

    abstract:BACKGROUND:The question of whether manual dissection when searching for metastatic lymph nodes from rectal cancer (less than 5 mm) is a reliable method remains controversial. METHODS:We examined 50 consecutive cases of primary adenocarcinoma of the rectum treated with a sphincter-sparing total rectum resection, total ...


    pub_type: 杂志文章


    authors: Andreola S,Leo E,Belli F,Bufalino R,Tomasic G,Lavarino C,Baldini MT,Meroni E

    更新日期:1996-02-15 00:00:00

  • Benign breast lesions at risk of developing cancer--a challenging problem in breast cancer screening programs: five years' experience of the Breast Cancer Screening Program in Verona (1999-2004).

    abstract:BACKGROUND:Cytology and core-needle biopsies are not always sufficient to exclude malignancy in benign breast lesions (BBL) that are at risk of developing cancer, and open biopsy often is mandatory. In screening programs, open biopsies performed for lesions that are at risk of developing malignancy are considered benig...


    pub_type: 杂志文章


    authors: Manfrin E,Mariotto R,Remo A,Reghellin D,Falsirollo F,Dalfior D,Bricolo P,Piazzola E,Bonetti F

    更新日期:2009-02-01 00:00:00

  • Radiation therapy utilization in Medicare beneficiaries with early-stage breast cancer.

    abstract:BACKGROUND:There is increasing evidence that radiation therapy (RT) can be omitted for select older patients who are compliant with hormonal blockade, but there is no recent claim-based analysis for determining patterns of care and guiding possible treatment recommendations. METHODS:Medicare beneficiaries who were 65 ...


    pub_type: 杂志文章


    authors: Wallace AS,Keene KS,Williams CP,Jackson BE,Pisu M,Partridge EE,Rocque GB

    更新日期:2018-02-01 00:00:00

  • Pulmonary blastoma. An ultrastructural study of a case and its transplanted tumor in athymic nude mice.

    abstract::A pulmonary blastoma in a 52-year-old Japanese man was serially transplanted into athymic nude mice. This report emphasizes the characteristics of the neoplasm seen on light and electron microscopic examination. The original tumor consisted of branching tubular structures and primitive mesenchymal components with a fe...


    pub_type: 杂志文章


    authors: Tamai S,Kameya T,Shimosato Y,Tsumuraya M,Wada T

    更新日期:1980-09-15 00:00:00

  • Reverse targeting in a media-promoted breast cancer screening project.

    abstract:BACKGROUND:The American Cancer Society has sponsored community-based, low-cost, Breast Cancer Detection Awareness Projects throughout the United States. The authors hypothesized that these projects tend to exclude minorities and women of lower socioeconomic status--groups with a higher incidence of late-stage disease. ...


    pub_type: 杂志文章


    authors: Roetzheim RG,Vandurme DJ,Brownlee HJ,Herold AH,Pamies RJ,Woodard L,Blair C

    更新日期:1992-09-01 00:00:00

  • Lymphokines, monoclonal antibodies, and other biological response modifiers in the treatment of cancer.

    abstract::Biologicals and biological response modifiers (BRMs) represent a new class of agents for cancer therapy. Historically, there have been many attempts to stimulate the immune response with nonspecific immunomodulators in the form of bacterial extracts, viruses, and chemicals. Although these approaches have occasionally ...


    pub_type: 杂志文章


    authors: Oldham RK,Thurman GB,Talmadge JE,Stevenson HC,Foon KA

    更新日期:1984-12-01 00:00:00

  • Adjuvant 5-fluorouracil plus doxorubicin in D2-3 resected gastric carcinoma: 15-year experience at a single institute.

    abstract:BACKGROUND:The authors evaluated the efficacy of adjuvant chemotherapy with 5-fluorouracil (5-FU) plus doxorubicin in gastric carcinoma after D2-3 curative resection. They also evaluated the effect of dose-related factors (delivered total dose/m(2), actual dose intensity [ADI], relative dose intensity [RDI]) of this re...


    pub_type: 临床试验,杂志文章


    authors: Jeung HC,Rha SY,Noh SH,Min JS,Kim BS,Chung HC

    更新日期:2001-06-01 00:00:00

  • Recurrent gestational trophoblastic disease. Experience of the Southeastern Regional Trophoblastic Disease Center.

    abstract::Between 1968 and 1985, 28 patients with recurrent gestational trophoblastic disease (GTD) were treated at the Southeastern Regional Trophoblastic Disease Center. Sixteen patients received primary therapy at this center and had recurrence diagnosed by re-elevation of human chorionic gonadotropin (hCG) levels after thre...


    pub_type: 杂志文章


    authors: Mutch DG,Soper JT,Babcock CJ,Clarke-Pearson DL,Hammond CB

    更新日期:1990-09-01 00:00:00

  • Incidence of the superficial fascia and its relevance in skin-sparing mastectomy.

    abstract:BACKGROUND:With the move away from classical radical mastectomy to ever more skin-sparing procedures, there has been an ongoing discussion about how much skin and subcutaneous tissue should be resected to perform an adequate mastectomy while leaving viable skin flaps. One of the common recommendations is to dissect jus...


    pub_type: 杂志文章


    authors: Beer GM,Varga Z,Budi S,Seifert B,Meyer VE

    更新日期:2002-03-15 00:00:00

  • Evolution of colorectal cancer in schistsosomiasis: transitional mucosal changes adjacent to large intestinal carcinoma in colectomy specimens.

    abstract::In this study of 454 colorectal carcinoma colectomy specimens, (289 were associated with and 165 were unassociated with schistosomiasis. Schistosome infestation was found to play an etiologic role in bowel malignancy in patients having diffuse involvement of the large intestine and a history of ten years or more of co...


    pub_type: 杂志文章


    authors: Ming-Chai C,Chi-Yuan C,Pei-Yu C,Jen-Chun H

    更新日期:1980-10-01 00:00:00

  • A noninvasive technique for monitoring response to chemotherapy in human acute leukemia.

    abstract::To see whether urine enzyme activities could be used as an index in evaluating the disease status of leukemia patients, we examined the activities of four enzymes: arylsulfatases A(AS-A) and B(AS-B), alkaline phosphatase (AP), and lactate dehydrogenase (LDH). AP and LDH showed no consistent patterns. The activities of...


    pub_type: 杂志文章


    authors: Posey LE,Rainey J,Vial R,Ryan D,Bickers JH,Morgan LR Jr,Samuels MS,Hull EW

    更新日期:1979-09-01 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...


    pub_type: 杂志文章,评审


    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Risk of cerebral metastases and neurological death after pathological complete response to neoadjuvant therapy for locally advanced nonsmall-cell lung cancer: clinical implications for the subsequent management of the brain.

    abstract:BACKGROUND:The incidence and pattern of brain metastases was analyzed among patients who achieved a pathological complete response (pCR) after neoadjuvant chemotherapy or chemoradiotherapy for locally advanced nonsmall-cell lung cancer (NSCLC). METHODS:Between 1990 and 2004, 211 patients were treated with neoadjuvant ...


    pub_type: 杂志文章


    authors: Chen AM,Jahan TM,Jablons DM,Garcia J,Larson DA

    更新日期:2007-04-15 00:00:00

  • Phase 2 trial of induction and concurrent chemoradiotherapy with weekly irinotecan and cisplatin followed by surgery for esophageal cancer.

    abstract:BACKGROUND:Preoperative chemoradiation improves survival in esophageal and gastroesophageal junction (GEJ) cancer. We evaluated irinotecan and cisplatin as induction chemotherapy followed by concurrent chemoradiation in esophageal cancer. METHODS:Patients with uT1N1M0 or uT2-4NanyM0 resectable squamous cancer or adeno...


    pub_type: 杂志文章


    authors: Ilson DH,Minsky BD,Ku GY,Rusch V,Rizk N,Shah M,Kelsen DP,Capanu M,Tang L,Campbell J,Bains M

    更新日期:2012-06-01 00:00:00

  • DNA flow cytometry of stomach cancer. Prospective correlation with clinicopathologic findings.

    abstract:BACKGROUND:DNA ploidy and S-phase fraction measured by DNA flow cytometry were shown to correlate with several clinicopathologic characteristics in several types of tumors. METHODS:DNA flow cytometry was performed on 329 samples (164 normal mucosa, 165 tumors) obtained from 165 patients (112 men) with stomach cancer, ...


    pub_type: 杂志文章


    authors: Lee KH,Lee JS,Suh C,Ahn MJ,Kim SW,Doh BS,Min YI,Kim BS,Park KC,Lee IC

    更新日期:1993-09-15 00:00:00

  • Morphologic and immunohistochemical changes in prostate cancer after preoperative hormonal therapy. A comparative study of radical prostatectomies.

    abstract:BACKGROUND:Estramustine phosphate (EMP) and flutamide (FL) were used as reversible preoperative hormonal drugs in the surgical treatment of patients with localized prostate cancer. METHODS:The authors descriptive and quantitatively examined the morphologic and immunohistochemical changes in 40 of 200 step-sectioned ra...


    pub_type: 杂志文章


    authors: Van de Voorde WM,Elgamal AA,Van Poppel HP,Verbeken EK,Baert LV,Lauweryns JM

    更新日期:1994-12-15 00:00:00

  • Conservative treatment versus mastectomy in breast cancer tumors with macroscopic diameter of 20 millimeters or less. The experience of the Institut Gustave-Roussy.

    abstract::A clinical trial was conducted at the Institut Gustave Roussy between October 1972 and December 1980 to compare mastectomy with local excision plus Cobalt-irradiation, in patients with breast cancer tumors of 20 mm in diameter or less at macroscopic examination. Low-axillary dissection and extemporaneous histologic ex...


    pub_type: 临床试验,杂志文章


    authors: Sarrazin D,Lê M,Rouëssé J,Contesso G,Petit JY,Lacour J,Viguier J,Hill C

    更新日期:1984-03-01 00:00:00

  • Expected population impacts of discontinued prostate-specific antigen screening.

    abstract:BACKGROUND:Prostate-specific antigen (PSA) screening for prostate cancer has high risks of overdiagnosis, particularly among older men, and reports from screening trials indicate that it saves few lives after 11 to 13 years of follow-up. New clinical guidelines recommend against PSA screening for all men or for men age...


    pub_type: 杂志文章


    authors: Gulati R,Tsodikov A,Etzioni R,Hunter-Merrill RA,Gore JL,Mariotto AB,Cooperberg MR

    更新日期:2014-11-15 00:00:00

  • Applied cancer prevention in practice.

    abstract::In 1982, more than 125,000 cancer cases in the United States should be preventable. Every physician should advise all patients to eliminate all tobacco use, moderate alcohol use, avoid the use of drugs which are carcinogenic, minimize sun and x-ray exposure, maintain an ideal weight, and follow a "prudent" diet. Secon...


    pub_type: 杂志文章


    authors: McKenna RJ

    更新日期:1983-06-15 00:00:00

  • Antitumor electrochemotherapy: new advances in the clinical protocol.

    abstract:BACKGROUND:Electrochemotherapy (ECT) is a new antitumor approach that combines systemic bleomycin (BLM) with electric pulses (EP) delivered locally at the tumor site. These EP permeabilize the cells in the tissue, allow BLM delivery inside the cells, and increase BLM cytotoxicity. As an extension of our initial Phase I...


    pub_type: 临床试验,杂志文章


    authors: Domenge C,Orlowski S,Luboinski B,De Baere T,Schwaab G,Belehradek J Jr,Mir LM

    更新日期:1996-03-01 00:00:00

  • Risk of mortality in patients with cancer who experience febrile neutropenia.

    abstract:BACKGROUND:Febrile neutropenia (FN) is a serious and potentially life-threatening condition that may develop in patients with cancer who receive myelosuppressive chemotherapy. The risk of mortality from FN is not well characterized in current clinical practice. METHODS:Patients with cancer who were receiving chemother...


    pub_type: 杂志文章


    authors: Lyman GH,Michels SL,Reynolds MW,Barron R,Tomic KS,Yu J

    更新日期:2010-12-01 00:00:00

  • The changing landscape of phase II/III metastatic NSCLC clinical trials and the importance of biomarker selection criteria.

    abstract::Over the last decade, new cytotoxic treatments and targeted therapies have altered treatment paradigms for patients with metastatic non-small cell lung cancer (NSCLC). We sought to analyze the impact of histology and biomarker selection criteria on outcomes of clinical trials in metastatic NSCLC reported over the last...


    pub_type: 杂志文章


    authors: Gentzler RD,Yentz SE,Johnson ML,Rademaker AW,Patel JD

    更新日期:2014-12-15 00:00:00

  • Meaningful endpoints for therapies approved for hematologic malignancies.

    abstract:BACKGROUND:Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new...


    pub_type: 杂志文章


    authors: Smith BD,DeZern AE,Bastian AW,Durie BGM

    更新日期:2017-05-15 00:00:00

  • The extent of proliferative and apoptotic activity in intraductal and invasive ductal breast carcinomas detected by Ki-67 labeling and terminal deoxynucleotidyl transferase-mediated digoxigenin-11-dUTP nick end labeling.

    abstract:BACKGROUND:The balance among cell proliferation, cell differentiation, and cell death determines the cell number in a population as well as the size or even the stage of a tumor. Thus, to improve our understanding of the pathogenesis of neoplasms, it is important to investigate the regulation of both cell proliferation...


    pub_type: 杂志文章


    authors: Shen KL,Harn HJ,Ho LI,Yu CP,Chiu SC,Lee WH

    更新日期:1998-06-15 00:00:00

  • An unusual presentation of a large tumor coexisting with an unusually high nonspecific immune responsiveness. A case report.

    abstract::The authors present the case of a 40-year-old white man with an obstructing laryngeal mass. Despite considerable tumor size, results of repeated biopsies revealed widespread carcinoma in situ with chronic inflammation within the subcutaneous tissues, and only after extensive endoscopic "debulking" of the mass was a sm...


    pub_type: 杂志文章


    authors: Eskinazi DP,Mihail R,Dichtel WG

    更新日期:1985-08-01 00:00:00

  • Risk-directed therapy for childhood acute lymphoblastic leukemia. Results of the Associazione Italiana Ematologia Oncologia Pediatrica '82 studies.

    abstract:BACKGROUND:In 1982, the Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) started its third-generation study, aiming to improve previous results obtained by AIEOP '79 study and to deliver a standardized treatment to most Italian children with acute lymphoblastic leukemia (ALL). METHODS:We treated 902 child...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Vecchi V,Aricò M,Basso G,Ceci A,Madon E,Mandelli F,Masera G,Massimo L,Pession A,Zanesco L

    更新日期:1993-10-15 00:00:00

  • Soft tissue fibrosarcoma. A clinicopathologic study of 132 cases.

    abstract::Over the last 20 to 30 years, a recognition and general acceptance of the entity of malignant fibrous histiocytoma and monophasic synovial sarcoma has occurred. The introduction of these diagnostic categories among the generic group of spindle cell sarcomas now requires a reevaluation of the more traditional and histo...


    pub_type: 杂志文章,评审


    authors: Scott SM,Reiman HM,Pritchard DJ,Ilstrup DM

    更新日期:1989-08-15 00:00:00