Abstract:
BACKGROUND:Specialty of the endoscopist has been related to the postcolonoscopy interval risk of colorectal cancer (CRC). However, the impact of such a difference on the long-term CRC prevention rate by screening colonoscopy is largely unknown. METHODS:A Markov model was constructed to simulate the efficacy and cost of colonoscopy screening according to the specialty of the endoscopist in 100,000 individuals aged 50 years until death. The postcolonoscopy interval CRC risk (0.02%) and the relative risk (1.4) of interval CRC between gastroenterologist (GI) endoscopists and non-GI endoscopists were extracted from the literature. Both efficacy and costs were projected over a steady-state US population. Eventual increase in endoscopic capacity when assuming all procedures to be performed by GI endoscopists was simulated. RESULTS:According to the simulation model, screening colonoscopy performed by non-GI endoscopists resulted in a 11% relative reduction in the long-term CRC incidence prevention rate compared with the same procedure performed by GI endoscopists. When projected on the US population, the reduced non-GI efficacy resulted in an additional 3043 CRC cases and the loss of $200 million per year. When increasing the relative risk from 1.4 to 2.0, the difference in the prevention rate between GI endoscopists and non-GI endoscopists increased to 19%. It increased further to 38% when also assuming a 3-fold increase in the risk of interval CRC. An additional 165 screening colonoscopies per endoscopist per year would be required to shift all non-GI procedures to GI endoscopists. CONCLUSIONS:When screening colonoscopy is performed by non-GI endoscopists, a substantial reduction in the long-term CRC prevention rate may be expected. Such difference appeared to be greater when a suboptimal efficacy of colonoscopy in preventing CRC was assumed. A 10-year saving of $2 billion may be expected when shifting all screening colonoscopies from non-GI endoscopists to GI endoscopists.
journal_name
Cancerjournal_title
Cancerauthors
Hassan C,Rex DK,Zullo A,Cooper GSdoi
10.1002/cncr.27664subject
Has Abstractpub_date
2012-09-15 00:00:00pages
4404-11issue
18eissn
0008-543Xissn
1097-0142journal_volume
118pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:A rigorous assessment of the risk of colorectal cancer (CRC) among prostate cancer (PC) survivors that controls for important confounding factors and competing risks is necessary to determine the risk of CRC in this population and to inform screening guidelines. METHODS:With data from Manitoba, Canada, subj...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29919
更新日期:2016-04-15 00:00:00
abstract::Oral fluorouracil was administered weekly to 12 consecutive patients with unresectable hepatoma. Six patients showed an objective response with a significant increase in survival duration compared to nonresponders and to untreated patients. The clinical features of these cases are discussed, along with details of ther...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197705)39:5<1930::aid-cncr282039
更新日期:1977-05-01 00:00:00
abstract:METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1943::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND:Despite known benefits to needle biopsy for suspicious breast lesions, variability in the use of this technique has been documented in practice. We sought to study the use of needle biopsy and open surgical biopsy in women with breast cancer, predictors of needle biopsy use, and the effect of biopsy choice o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24085
更新日期:2009-02-15 00:00:00
abstract:BACKGROUND:Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. METHODS:The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates wer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940601)73:11<2709::aid-cncr282
更新日期:1994-06-01 00:00:00
abstract::Models play a fundamental role in all sciences. Scientific theories can be understood as "intellectual models" of the relations and interrelations between the elements of the science. Such relational models consider the scientific topics as "systems," and may therefore be called "system models." The basic elements of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840915)54:1+<1229::aid-cncr282
更新日期:1984-09-15 00:00:00
abstract:BACKGROUND:Heavy alcohol consumption, viral hepatitis, and diabetes are risk factors for hepatocellular carcinoma (HCC). However, to the authors' knowledge, the information concerning their interaction effect in patients with risk of HCC is sparse. METHODS:A population-based, case-control study of HCC was conducted du...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20427
更新日期:2004-09-01 00:00:00
abstract::Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of imp...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-15 00:00:00
abstract:BACKGROUND:Glucocorticoids can lead to weight gain during cancer treatment, but to the authors' knowledge, little is known regarding their long-term effects in childhood cancer survivors (CCS). METHODS:As part of the Swiss Childhood Cancer Survivor Study, the authors sent a questionnaire to CCS aged <21 years at diagn...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31599
更新日期:2018-09-01 00:00:00
abstract:BACKGROUND:Radiotherapy (XRT) is effective as the primary treatment modality for laryngopharyngeal cancer; however, complications of XRT can result in significant morbidity. Few previous studies have examined the effect of continued smoking on complications of XRT. The authors of this report hypothesized that patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24499
更新日期:2009-10-01 00:00:00
abstract::Meaning and purpose in life are associated with the mental and physical health of patients with cancer and survivors and also constitute highly valued outcomes in themselves. Because meaning and purpose are often threatened by a cancer diagnosis and treatment, interventions have been developed to promote meaning and p...
journal_title:Cancer
pub_type: 杂志文章,meta分析
doi:10.1002/cncr.32078
更新日期:2019-07-15 00:00:00
abstract:BACKGROUND:p53 gene mutations at codon 249 have been reported in hepatocellular carcinoma (HCC) from China and South Africa, a phenomenon shown to be closely associated with food contamination by aflatoxin. There have been few reports, however, in regard to p53 gene mutations in HCC from other geographic areas. METHOD...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<355::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract::The medical records of 243 patients admitted over a five-year period with a diagnosis of carcinoma of the cervix were reviewed to determine (1) the frequency of pulmonary metastasis, (2) the relationship between the stage of the primary lesion and the incidence of pulmonary metastasis, and (3) the relationship between...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820415)49:8<1705::aid-cncr2820
更新日期:1982-04-15 00:00:00
abstract::Flow cytometry studies of the DNA distribution of tumor cells from 92 human breast cancers showed measurable aneuploidy (hyperploidy) in 83 cases (92%). The DNA ploidy values were unimodal in each case, but there was a bimodal distribution for the entire series. One group of tumors had a diploid or near diploid DNA di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810815)48:4<980::aid-cncr28204
更新日期:1981-08-15 00:00:00
abstract:BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26435
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND:The incidence of metastasis to the thyroid gland in autopsy series varies from 1.25% to 24%. Metastasis to the thyroid gland is usually considered a terminal event, and the effectiveness of conventional treatment has been questioned. The authors assessed the effects of current methods of diagnosis and treatm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970201)79:3<574::aid-cnc
更新日期:1997-02-01 00:00:00
abstract::A classification for childhood brain tumors based upon revision of nomenclature of all brain tumors published by the World Health Organization (WHO) in 1979 is proposed. Applicability of the WHO classification scheme was tested in a combined study of the clinical and pathologic features of approximately 3300 brain tum...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7+<1869::aid-cncr282
更新日期:1985-10-01 00:00:00
abstract::Forty-five patients with advanced non-small cell lung cancer (NSCLC), with progressive inoperable tumors were treated. Twenty-three patients were of "limited" stage. Six patients had received previous thoracic radiotherapy. Patients with central nervous system (CNS) metastases, Karnofsky scores of less than 30 or more...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880101)61:1<14::aid-cncr282061
更新日期:1988-01-01 00:00:00
abstract::Thirty-eight metastatic breast cancer patients were treated with aminoglutethimide. All patients had progressive metastatic disease following initial response to Tamoxifen therapy. Thirty-two patients were evaluable for response, of these, two patients (6%) had complete remission, 13 patients (41%) had partial respons...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821101)50:9<1708::aid-cncr2820
更新日期:1982-11-01 00:00:00
abstract:BACKGROUND:Germ cell tumors (GCTs) in adolescent and young males are very sensitive to cisplatin-based chemotherapy. However, 10-20% of the patients cannot be cured by currently available therapeutic options. Once a tumor does not respond to cisplatin, current therapeutic modalities offer only a chance for short pallia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10671
更新日期:2002-07-15 00:00:00
abstract::During the period from September, 1976 to June, 1979, 70 patients with locoregional or extensive epidermoid carcinoma of the esophagus were treated with the two-drug combination of cisplatin and bleomycin (DB). For the 43 patients with locoregional disease (LRD), DB was used prior to surgery and/or radiation therapy; ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19841201)54:11<2351::aid-cncr282
更新日期:1984-12-01 00:00:00
abstract:BACKGROUND:This study sought to evaluate patient-reported health-related quality of life following proton therapy for prostate cancer in men ≤ 60 years old. METHODS:Between August 2006 and January 2010, 262 hormone-naive men ≤ 60 years old were treated with definitive proton therapy for prostate cancer. Before treatme...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27398
更新日期:2012-09-15 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a product of activated macrophages that is cytotoxic to tumor cells, could be used to purge tumor cells from bone marrow before autologous bone marrow transplantation for hematologic malignancies and/or solid tumors. To determine whether exposure to TNF-alpha would have an inhi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2965::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract::This study attempted to determine the relationship of nutritional status, menopausal status, presence of breast cancer, stage of disease, and tumor estrogen receptor levels to percent non-protein-bound estradiol (%NPBE) and percent distribution of estradiol on sex hormone-binding globulin (SHBG) and albumin in breast ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860201)57:3<558::aid-cncr28205
更新日期:1986-02-01 00:00:00
abstract:BACKGROUND:Although < 1% of men present with prostate-specific antigen (PSA)-negative prostate carcinoma, in that they have serum PSA levels much lower than the tumor burden would suggest, such patients represent a management dilemma. To the authors' knowledge, little information exists in the literature regarding patt...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11821
更新日期:2003-12-01 00:00:00
abstract:BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921115)70:10<2410::aid-cncr282
更新日期:1992-11-15 00:00:00
abstract::Five hundred forty three adult patients with acute leukemia were entered on the study designed to: (1) test efficacy of vincristine and prednisone used as primary drug therapy in patients with good prognosis as judged by a circulating blast cell count less than 30,000 cm2; (2) investigate the use of either simultaneou...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830915)52:6<958::aid-cncr28205
更新日期:1983-09-15 00:00:00
abstract:BACKGROUND:The authors have previously reported a tumor cell vaccine modified with superantigen staphylococcal enterotoxin A (SEA) and its antitumor effect. The tumor cell vaccines modified with multiple immune activators frequently elicited stronger immune responses against established tumors than single-modified vacc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20943
更新日期:2005-04-01 00:00:00
abstract::Elevated serum levels of carcinoembryonic antigen (CEA) were found in 70% of 141 patients with advanced gastrointestinal (GI) cancers. Serial CEA measurements were performed on 70 patients before and during chemotherapy. The majority were treated with 5-FU and Methyl-CCNU (33 patients), 5-FU (19 patients), or 5-FU and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197910)44:4<1222::aid-cncr282044
更新日期:1979-10-01 00:00:00
abstract:BACKGROUND:Epidemiologic studies have recently related benzene hexachloride (BHC) to breast carcinoma risk. Experimental studies have also shown that beta-BHC is weakly estrogenic, hence supporting the alleged association. By directly comparing beta-BHC levels in breast adipose tissue from incident breast carcinoma cas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990515)85:10<2212::aid-c
更新日期:1999-05-15 00:00:00