Abstract:
BACKGROUND:Although primary gastric lymphoma is the most common extranodal lymphoma, no specific staging system exists. METHODS:The authors reviewed 98 cases histologically classified according to the Working Formulation, including low grade B-cell lymphoma of mucosa-associated lymphoid tissue type. Survival rates were calculated by the Kaplan-Meier method according to T, N, and M of the general rules of the International Union Against Cancer TNM system. The definitions of these categories are as follows: T1, tumor invades the lamina propria or submucosa; T2, the muscularis propria; T3, the subserosa; T4, the serosa without invasion of adjacent structures; T5, adjacent structures; N0, no regional lymph node metastasis; N1, perigastric lymph nodes within 3 cm of the edge of the primary tumor; N2, perigastric lymph nodes more than 3 cm from the edge of the primary tumor or in lymph nodes along the left gastric, common hepatic, splenic, or celiac arteries; N3, paraaortic and hepatoduodenal lymph nodes and/or other intraabdominal lymph nodes; N4, beyond N3; M0, no distant metastasis; and M1, positive. RESULTS:The overall 5-year survival rate was 83.5%; it was 100% in T1, 82.4% in T2, 84.2% in T3, 52.9% in T4, and 33.3% in T5; 93.9% in N0, 90.5% in N1, 66.2% in N2, and 44.4% in N3/N4; and 86.0% in M0 and 25.0% in M1. Based on these results, the authors proposed a new staging system as follows: Stage I, T1/N0, N1/M0; Stage II, T1/N2/M0, T2,T3/N0,N1,N2/M0; Stage III, T4,T5/any N/M0, any T/N3, N4/M0; and Stage IV, any T/any N/M1. According to this system, the 5-year survival rate significantly decreased as the stage progressed: 100% in Stage I, 88.9% in Stage II, 52.1% in Stage III, and 25.0% in Stage IV. In Stages I and II, survival rates were not significantly different whether chemotherapy was done or not, whereas in Stage III all patients treated with surgery alone died. CONCLUSIONS:This staging system is useful for assessing prognosis of and deciding a therapeutic plan for primary gastric lymphoma.
journal_name
Cancerjournal_title
Cancerauthors
Shimodaira M,Tsukamoto Y,Niwa Y,Goto H,Hase S,Hayakawa T,Nagasaka Tdoi
10.1002/1097-0142(19940601)73:11<2709::aid-cncr282subject
Has Abstractpub_date
1994-06-01 00:00:00pages
2709-15issue
11eissn
0008-543Xissn
1097-0142journal_volume
73pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:hMLH1, the human MutL homologue, has been linked to microsatellite instability (MSI) in gastrointestinal tumors. However, to the authors' knowledge, the role of hMLH1, the other mismatch repair genes (MMR), and MSI in ovarian carcinoma has not been well defined. The purpose of the current study was to determ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11770
更新日期:2003-11-15 00:00:00
abstract::The case of a 49-year-old man with the diagnosis of angioimmunoblastic lymphadenopathy is reported. The patient survived a stormy clinical course. The corticosteroids improved dramatically the clinical picture although the patient developed a staphylococcal septicemia. Before treatment immunological studies were done ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197808)42:2<447::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:In multidisciplinary assessment clinics for screen-detected breast lesions, onsite cytopathologists provide immediate results of fine-needle aspiration biopsies (FNABs) and this information is used for patient counseling and treatment planning. Such consultation is not possible for the increasing proportion ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21939
更新日期:2006-06-25 00:00:00
abstract::Ten consecutive diffuse histiocytic lymphoma (DHL) cell lines established in our laboratory were studied for the presence of Epstein-Barr virus (EBV) genomes, lysozyme, nonspecific esterase and other cytochemical reactions, phagocytic activity, cytoplasmic immunoglobulin light and heavy chains, and surface receptors t...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197811)42:5<2379::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract::Six patients with primary seminoma of the mediastinum were treated at the Cancer Control Agency of British Columbia during the period from 1970 to 1982. Primary treatment used was external beam radiotherapy. Only one patient received both radiotherapy and chemotherapy. Tumor dose ranged from 3000 cGy in 16 daily fract...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850115)55:2<450::aid-cncr28205
更新日期:1985-01-15 00:00:00
abstract::The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<906::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract:BACKGROUND:Reflex human papillomavirus (HPV) testing for atypical squamous cells of undetermined significance (ASC-US) has improved the sensitivity and specificity in detecting high-grade squamous dysplasia (cervical intraepithelial neoplasia [CIN]2+). However, to the authors' knowledge there are no guidelines for perf...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23639
更新日期:2008-08-25 00:00:00
abstract::A total of 289 cases with malignant pleuroperitoneal effusions were reviewed, and their prognosis were analyzed in relation to the following factors: (1) chronologically divided series; (2) previous tumorectomy of the primary lesion; (3) presence or absence of other metastases; (4) site of effusion; (5) site of the pr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830101)51:1<136::aid-cncr28205
更新日期:1983-01-01 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC). METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospective...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24858
更新日期:2010-02-15 00:00:00
abstract::Glucocorticoid and progesterone receptors, tyrosine aminotransferase, gamma-glutamyltransferase and alpha-fetoprotein levels were determined in human hepatocellular carcinoma (HCC) and adjacent liver tissues. Glucocorticoid receptor was present in seven of ten HCC samples, values ranged from 1.9 to 66.8 fmol/mg protei...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881115)62:10<2134::aid-cncr282
更新日期:1988-11-15 00:00:00
abstract:BACKGROUND:Pediatric renal cell carcinoma (RCC) is clinically distinct from adult RCC. Characterization of the unique biological and clinical features of pediatric RCC are required. METHODS:A retrospective review and biological analysis of all RCC cases presenting to Cincinnati Children's Hospital Medical Center (CCHM...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23331
更新日期:2008-04-01 00:00:00
abstract:BACKGROUND:Bortezomib is a proteasome inhibitor with manageable clinical toxicity and laboratory evidence of anti-melanoma activity. Therefore, it was considered for clinical testing in patients with metastatic melanoma. METHODS:Patients with metastatic melanoma and adequate hematologic, renal, and hepatic function we...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.21108
更新日期:2005-06-15 00:00:00
abstract::The role of palliative radiation treatment of prostate cancer is well recognized. Appreciation of the value of definitive radiation therapy in management of locally advanced prostate cancer is increasing. Optimal management requires careful patient selection with multidiscipline evaluation to provide accurate grading ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197702)39:2+<856::aid-cncr282039
更新日期:1977-02-01 00:00:00
abstract::The radionuclide, gallium-67, accumulates in a wide variety of neoplastic and inflammatory lesions. Diffuse bilateral lung localization of 67Ga occurred in two cases of interstitial pneumonitis associated with bleomycin therapy. Clinical symptoms and laboratory evaluation of pulmonary status correlated with scintigrap...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820360906
更新日期:1975-12-01 00:00:00
abstract:BACKGROUND:The widespread use of anthracycline chemotherapy has contributed to improved outcomes in children with cancer. The most feared complication of the anthracyclines is cardiotoxicity. Routine echocardiographic monitoring typically is used before, during, and after treatment to minimize cardiotoxicity. The ideal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26481
更新日期:2012-04-01 00:00:00
abstract:BACKGROUND:Glioblastoma multiforme (GBM) is the most prevalent and deadly brain tumor. A variety of germline and somatic, genetic and epigenetic alterations at 9p21.3, which encode CDKN2A/CDKN2B tumor suppressor genes, have been isolatedly reported to be associated with GBM risk and prognosis. METHODS:To obtain a comp...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26250
更新日期:2012-01-01 00:00:00
abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1334::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract:BACKGROUND:Hepatocyte growth factor receptor (c-met), autocrine motility factor receptor (AMFR), and urokinase-type plasminogen activator receptor (uPAR) are known to play important roles in tumor cell migration, invasion, and metastasis. The authors studied the relation between the expression patterns of these genes a...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-06-01 00:00:00
abstract::The treatment of locally advanced rectal cancer (LARC) has benefited from improved surgical techniques and from the implementation of neoadjuvant chemoradiotherapy (CRT), which have markedly decreased the rates of local recurrence. However, distant metastatic disease remains the most significant cause of death for the...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.30600
更新日期:2017-05-01 00:00:00
abstract::A series of eight plasma cell granulomas of the lung were examined. Their clinical, pathologic, and immunohistochemical characteristics as well as the ultrastructural features of one case are in agreement with those found in the literature. One patient died after a surgical intervention complicated by invasion of pulm...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870201)59:3<435::aid-cncr28205
更新日期:1987-02-01 00:00:00
abstract:BACKGROUND:US breast cancer mortality is declining, but thousands of women still die each year. METHODS:Two established simulation models examine 6 strategies that include increased screening and/or treatment or elimination of obesity versus continuation of current patterns. The models use common national data on inci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28087
更新日期:2013-07-15 00:00:00
abstract:BACKGROUND:The histogenesis of carcinosarcoma is still unknown. METHODS:A new human uterine cell line, EMTOKA, derived from a carcinosarcoma of the uterus, has been passed successfully in cell culture for more than 2 years. The cell line was established on April 11, 1989, in a uterine tumor of a 64-year-old Japanese w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930201)71:3<775::aid-cncr28207
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:There is an increase in the incidence of cutaneous malignant melanoma (CMM) among white people throughout the world. In Sweden, a fivefold increase has been recorded since 1960, but the mortality is rising at a much lower rate. Tumor thickness is the single most important prognostic factor for primary melano...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940315)73:6<1625::aid-cncr2820
更新日期:1994-03-15 00:00:00
abstract::Seventeen patients with primary or secondary liver tumors were treated by dearterialization of the liver and intraportal infusion of cytotoxic drugs. In 14 cases, ligation of the main (10), right and left (1), right and middle (1), and right (2) hepatic arteries was performed. In three in whom hepatic artery ligation ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197612)38:6<2593::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract::Data are presented on mortality from neoplasms as determined from death certificates in a cohort of 8393 college men, according to athletic status in college. Major athletes (lettermen) died significantly more often from neoplasms than nonathletes. Mean age at death from neoplasms (underlying cause) was significantly ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<382::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:The authors investigated how lymphopenia and low serum albumin levels correlate with the prognosis of patients with carcinoma of unknown primary (CUP). METHODS:Univariate and multivariate prognostic factor analyses were conducted in a population of 317 consecutive patients with CUP who were evaluated at the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22300
更新日期:2006-12-01 00:00:00
abstract:BACKGROUND:In the United States, only approximately 0.4% of all melanomas are diagnosed in patients aged <20 years. To the authors' knowledge, melanoma in pediatric members of melanoma-prone families has not been fully investigated to date. The objective of the current study was to evaluate pediatric patients with mela...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31641
更新日期:2018-09-15 00:00:00
abstract:BACKGROUND:Fear of cancer recurrence (FCR) adversely affects quality of life. Cigarette smoking increases the risk of recurrence and may exacerbate FCR among survivors who smoke. FCR also may motivate quitting, but research on whether quitting reduces long-term survivors' FCR is lacking. Among long-term survivors of va...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32431
更新日期:2019-12-01 00:00:00
abstract:BACKGROUND:Radiation therapy plays a major role in the management of patients with either locally recurrent or metastatic carcinoma of the prostate. RESULTS:In 23 patients with isolated postprostatectomy local recurrences treated with doses of 60-65 Gy, 17 (74%) had tumor control, and 45% survived relapse-free for 5 y...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19930201)71:3+<1110::aid-cncr282
更新日期:1993-02-01 00:00:00
abstract::A case is presented of a man with ulcerating skin nodules who was diagnosed by histologic and immunohistologic analysis of skin biopsy specimens as having lymphomatoid granulomatosis (LYG). Phenotypic studies showed the majority of the infiltrating cells to be activated CD4+ T-lymphocytes. The disease followed a rapid...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890215)63:4<652::aid-cncr28206
更新日期:1989-02-15 00:00:00