Treatment of advanced breast cancer with aminoglutethimide after therapy with tamoxifen.

abstract：BACKGROUND:This multicenter, retrospective study explored the value of oncogene driver subtype, programmed death-1 ligand (PD-L1) status, and smoking status for predicting which patients with oncogene-driven non-small cell lung cancer (NSCLC) would benefit from treatment with programmed death-1 (PD-1)/PD-L1 inhibitors....

journal_title：Cancer

authors： Ng TL,Liu Y,Dimou A,Patil T,Aisner DL,Dong Z,Jiang T,Su C,Wu C,Ren S,Zhou C,Camidge DR

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were asses...

journal_title：Cancer

authors： Locati LD,Licitra L,Agate L,Ou SH,Boucher A,Jarzab B,Qin S,Kane MA,Wirth LJ,Chen C,Kim S,Ingrosso A,Pithavala YK,Bycott P,Cohen EE

更新日期：2014-09-01 00:00:00

abstract：:The clinical and histologic data from 12 patients with "reticulum cell sarcoma" (large cell lymphoma) presenting in the skin were reviewed. Moreover, when appropriate material was available additional immunological, cytochemical and ultrastructural techniques were used to define the nature of the neoplastic cells. Eig...

journal_title：Cancer

authors： Willemze R,Ruiter DJ,Van Vloten WA,Meijer CJ

更新日期：1982-10-01 00:00:00

abstract：:Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck. Tamo...

journal_title：Cancer

authors： Itri LM

更新日期：1993-12-01 00:00:00

abstract：BACKGROUND:Surgery alone is the appropriate first-line treatment for patients with mesoblastic nephroma (MN). Nevertheless, there are reports of local recurrences and metastasis, especially in the cellular subtype. The authors evaluated the outcome of patients with MN who were enrolled in either the International Socie...

journal_title：Cancer

authors： Furtwaengler R,Reinhard H,Leuschner I,Schenk JP,Goebel U,Claviez A,Kulozik A,Zoubek A,von Schweinitz D,Graf N,Gesellschaft fur Pädiatrische Onkologie und Hämatologie (GPOH) Nephroblastoma Study Group.

更新日期：2006-05-15 00:00:00

abstract：BACKGROUND:Prognosis of patients with adenocarcinoma of the pancreatic body and tail is extremely poor. Anatomically, this part of the pancreas is thin, and cancerous invasion to the retropancreatic structures occurs easily. The majority of patients have residual tumor in the retroperitoneal tissues after conventional ...

journal_title：Cancer

authors： Ozaki H,Kinoshita T,Kosuge T,Yamamoto J,Shimada K,Inoue K,Koyama Y,Mukai K

更新日期：1996-06-01 00:00:00

abstract：BACKGROUND:For patients who have chondrosarcoma with unresectable disease, because of tumor location, tumor size, or extensive metastatic disease, treatment options are very limited because of their relative resistance to radiotherapy and chemotherapy. The overall survival of this patient population is poor; however, s...

journal_title：Cancer

authors： van Maldegem AM,Gelderblom H,Palmerini E,Dijkstra SD,Gambarotti M,Ruggieri P,Nout RA,van de Sande MA,Ferrari C,Ferrari S,Bovée JV,Picci P

更新日期：2014-10-15 00:00:00

abstract：:We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a valu...

journal_title：Cancer

authors： Ettinger DS,Rosenshein NB,Parmley TH,Mendelsohn G,Baylin SB

更新日期：1980-05-15 00:00:00

abstract：:Because we found it illogical to attempt measurement of nonmeasurable but visible tumors in patients with advanced lung cancer, we devised and used a separate set of response criteria for patients with evaluable, nonmeasurable tumors. Patients with evaluable disease who had obtained a tumor regression after therapy we...

journal_title：Cancer

authors： Eagan RT,Fleming TR,Schoonover V

更新日期：1979-09-01 00:00:00

abstract：BACKGROUND:Based on prior experience with dacarbazine (DTIC) and an outpatient interleukin-2 (IL-2) regimen, the current study was conducted to improve the antitumor efficacy and assess the immunologic interactions between chemotherapy and IL-2. METHODS:Thirty-two patients were registered onto a treatment program, whi...

journal_title：Cancer

authors： Flaherty LE,Robinson W,Redman BG,Gonzalez R,Martino S,Kraut M,Valdivieso M,Rudolph AR

更新日期：1993-06-01 00:00:00

abstract：BACKGROUND:Previously, the patient-reported Total Illness Burden Index for Prostate Cancer (TIBI-CaP) questionnaire and/or the physician-reported Charlson Comorbidity Index (CCI) have provided assessments of competing comorbidity during treatment decisions for patients with prostate cancer. In the current study, the au...

journal_title：Cancer

authors： Liss MA,Billimek J,Osann K,Cho J,Moskowitz R,Kaplan A,Szabo RJ,Kaplan SH,Greenfield S,Dash A

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:The optimal weekly oral dose of sirolimus and intravenous nanoparticle albumin-bound paclitaxel (nab-paclitaxel) were evaluated. METHODS:A phase 1b study was performed to evaluate escalating doses of oral sirolimus (5-60 mg) on days 2, 9, and 16 with intravenous nab-paclitaxel (100 mg/m(2) ) on days 1, 8, a...

journal_title：Cancer

authors： Abu-Khalaf MM,Baumgart MA,Gettinger SN,Doddamane I,Tuck DP,Hou S,Chen N,Sullivan C,Lezon-Geyda K,Zelterman D,Hatzis C,Deshpande H,Digiovanna MP,Azodi M,Schwartz PE,Harris LN

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Nearly 50% of urothelial carcinoma patients with lymph node-negative invasive cancers recur after radical surgery. In many cases, occult local or lymph node disease may be present but undetectable by current approaches. Reverse-transcriptase polymerase chain reaction (RT-PCR)-detectable mRNA of Uroplakin II ...

journal_title：Cancer

authors： Copp HL,Chin JL,Conaway M,Theodorescu D

更新日期：2006-07-01 00:00:00

abstract：BACKGROUND:Patients with metachronous multiple colorectal carcinomas have been reported to have a higher frequency of a family history of colorectal carcinoma, associated colorectal adenomas, and extracolonic malignancies. These clinicopathologic factors also are considered to be related to the development of metachron...

journal_title：Cancer

authors： Masubuchi S,Konishi F,Togashi K,Okamoto T,Senba S,Shitoh K,Kashiwagi H,Kanazawa K,Tsukamoto T

更新日期：1999-05-01 00:00:00

abstract：BACKGROUND:The current study was conducted to evaluate the Patient-Reported Outcomes Measurement Information System Depression Short Form (PROMIS-D-SF) as a screening measure for young adult cancer survivors (YACS) compared with a structured diagnostic interview. METHODS:A total of 249 YACS (aged 18-40 years) complete...

journal_title：Cancer

authors： Recklitis CJ,Blackmon JE,Chang G

更新日期：2020-04-01 00:00:00

abstract：:A 21-year-old male with Ph1 positive acute myeloid leukemia (AML) became constipated, experienced pain in the sacral area and retained urine. These were the principle presenting complaints of his disease. With local radiotherapy and systemic chemotherapy, all neurologic symptoms and signs disappeared within three days...

journal_title：Cancer

authors： Petursson SR,Boggs DR

更新日期：1981-01-15 00:00:00

abstract：:Our simple rapid autoradiography for 3H-thymidine (3H-TdR) labeling index (LI) of leukemic cells was introduced. Thirty-nine adult patients with acute nonlymphocytic leukemia were treated under a new protocol using 3H-TdR LI as a parameter and inserting a trial of partial synchronization by Ara-C. The success rate of ...

journal_title：Cancer

authors： Yoshida T,Hattori KI,Nakamura S,Mitamura E,Kobayashi S,Ohtake S,Tanimoto K

更新日期：1980-11-15 00:00:00

abstract：:Fifty-one cases of acinic cell carcinoma (ACC) arising in major and minor salivary glands are reported (primary sites: parotid 37, submandibular, six, and oral cavity, eight.) These lesions usually produced painless slowly growing masses. Of 49 patients with follow-up information, 17 (35%) developed local recurrences ...

journal_title：Cancer

authors： Perzin KH,LiVolsi VA

更新日期：1979-10-01 00:00:00

abstract：BACKGROUND:The current study evaluated whether the risk of developing thyroid cancer in Asian women was associated with infertility and the use of fertility drugs. METHODS:The authors conducted a large, retrospective cohort study using Taiwan's National Health Insurance Research Database. From the insurance claims dat...

journal_title：Cancer

authors： Ding DC,Chen W,Wang JH,Lin SZ,Sung FC

更新日期：2019-05-15 00:00:00

abstract：BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...

journal_title：Cancer

authors： Mirkin KA,Greenleaf EK,Hollenbeak CS,Wong J

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:Smoking and alcoholic beverage drinking habits as well as a family history of cancer are well known risk factors for the multifocal occurrence of squamous cell carcinoma of the esophagus and the head and neck region. However, the role of these risk factors in multiple gastric carcinoma remains to be clarifie...

journal_title：Cancer

authors： Morita M,Kuwano H,Baba H,Taketomi A,Kohnoe S,Tomoda H,Araki K,Saeki H,Kitamura K,Sugimachi K

更新日期：1998-10-01 00:00:00

abstract：:A case of meningeal melanocytoma of the left Meckel's cave associated with ipsilateral Ota's nevus in a 43-year-old woman, was studied by light and electron microscopy. The cells of the tumor were characterized by the presence of dendritic cytoplasmic processes, melanosomes and premelanosomes; hence, they were deemed ...

journal_title：Cancer

authors： Botticelli AR,Villani M,Angiari P,Peserico L

更新日期：1983-06-15 00:00:00

abstract：BACKGROUND:There is accumulating evidence that galanin receptors (GALRs) may be tumor suppressors in head and neck squamous cell carcinoma (HNSCC). Promoter methylation status and gene expression were assessed in a large panel of head and neck primary tumors, based on the hypothesis that cytosine-guanine dinucleotide (...

journal_title：Cancer

authors： Misawa Y,Misawa K,Kanazawa T,Uehara T,Endo S,Mochizuki D,Yamatodani T,Carey TE,Mineta H

更新日期：2014-01-15 00:00:00

abstract：BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...

journal_title：Cancer

authors： Sengeløv L,Nielsen OS,Kamby C,von der Maase H

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:Despite advances in first-line therapy, there are few data on treatment of glioblastoma multiforme (GBM) at recurrence. Temozolomide (TMZ) is well tolerated and may have activity despite prior TMZ exposure if novel dose schedules are used. METHODS:The authors reviewed their experience with a continuous TMZ ...

journal_title：Cancer

authors： Perry JR,Rizek P,Cashman R,Morrison M,Morrison T

更新日期：2008-10-15 00:00:00

abstract：BACKGROUND:Fulvestrant (ICI 182,780) is a new type of estrogen receptor (ER) antagonist that down-regulates the ER and has no known agonist effects. The authors report the prospectively planned combined analysis of data from 2 Phase III trials comparing fulvestrant 250 mg monthly (n=428) and anastrozole 1 mg daily (n=4...

journal_title：Cancer

authors： Robertson JF,Osborne CK,Howell A,Jones SE,Mauriac L,Ellis M,Kleeberg UR,Come SE,Vergote I,Gertler S,Buzdar A,Webster A,Morris C

更新日期：2003-07-15 00:00:00

abstract：:A human liposarcoma cell line COLO 222, derived from a primary tumor in a 62-year-old male, elaborates hyaluronic acid. COLO 222 is characterized on the basis of histochemical, ultramorphological, and cytogenetic properties, along with isozyme phenotype and cell products. A chromosome mode of 53 predominates and uniqu...

journal_title：Cancer

authors： Morgan RT,Quinn LA,Moore GE,Semple TU,Woods LK

更新日期：1980-03-15 00:00:00

abstract：:The metabolism of 5-fluorouracil (5-FU) was studied in biopsy specimens of primary colorectal cancer and healthy colonic mucosa obtained from previously untreated patients immediately after surgical removal. The conversion of 5-FU to anabolites was measured under saturating substrate (5-FU) and cosubstrate concentrati...

journal_title：Cancer

authors： Peters GJ,van Groeningen CJ,Laurensse EJ,Pinedo HM

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND:A crossover in breast carcinoma incidence at ages 45-49 years has been observed between black and white women, with blacks experiencing higher incidence at younger ages and lower incidence after age 50 years. Can this phenomenon be partially explained by the differences in the distributions of reproductive r...

journal_title：Cancer

authors： Pathak DR,Osuch JR,He J

更新日期：2000-03-01 00:00:00

abstract：:The unusual genetic disorder epidermolysis bullosa dystrophica has been reported in several patients in whom the chronic cutaneous scars led to the development of cutaneous squamous cell carcinoma. However, only one of these previously reported cases involved the autosomal dominant form of the disease; the remainder o...

journal_title：Cancer

authors： Schwartz RA,Birnkrant AP,Rubenstein DJ,Kim U,Burgess GH,Stoll HL Jr,Chai SW,Southwick GJ,Milgrom H

更新日期：1981-02-01 00:00:00