Tumor cell origin of histaminase activity in ascites fluid from patients with ovarian carcinoma.

Abstract:

:We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (greater than 3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.

journal_name

Cancer

journal_title

Cancer

authors

Ettinger DS,Rosenshein NB,Parmley TH,Mendelsohn G,Baylin SB

doi

10.1002/1097-0142(19800515)45:10<2568::aid-cncr282

subject

Has Abstract

pub_date

1980-05-15 00:00:00

pages

2568-72

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

45

pub_type

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