Abstract:
:We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a value higher than that for normal tissues other than kidney and intestine. The presence of elevated ascitic fluid histaminase activity (greater than 3.5 U/ml) correlates with the presence of high histaminase activity in tumor tissue. Histaminase activity is higher in ascitic fluid from the patients than it is in their plasma, probably reflecting the direct entry of histaminase into the peritoneal cavity.
journal_name
Cancerjournal_title
Cancerauthors
Ettinger DS,Rosenshein NB,Parmley TH,Mendelsohn G,Baylin SBdoi
10.1002/1097-0142(19800515)45:10<2568::aid-cncr282subject
Has Abstractpub_date
1980-05-15 00:00:00pages
2568-72issue
10eissn
0008-543Xissn
1097-0142journal_volume
45pub_type
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