Relationship of 4F2 antigen with local growth and metastatic potential of squamous cell carcinoma of the larynx.

Abstract:

:The 4F2 antigen is a cell-membrane glycoprotein which arises early in the G0-G1 phases of the cell cycle. This molecule is present in all established human cell lines and most malignant human cells. The authors used an indirect immunophosphatase method to study 50 squamous cell carcinomas of the larynx and ten lymph-node metastases, corresponding to six primary tumors, for 4F2 expression. The tumors showed several patterns of 4F2 staining which were correlated with different behaviors and prognoses of the neoplasms. Three different patterns (no staining, peripheral staining, and diffuse 4F2 expression) are described as are their relationships with metastatic behavior of the carcinomas. Tumors with metastases were found only in the third group (P = 0.0001). These results led to the following conclusions: (1) the 4F2 antigen is present in squamous cell carcinomas; (2) its distribution reflects the tumor-spreading pattern; and (3) it correlates with differentiation and metastatic behavior.

journal_name

Cancer

journal_title

Cancer

authors

Esteban F,Ruiz-Cabello F,Concha A,Perez Ayala M,Delgado M,Garrido F

doi

10.1002/1097-0142(19901001)66:7<1493::aid-cncr2820

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

1493-8

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

66

pub_type

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