Prognostically favorable immunogens of human breast cancer tissue: antigenic similarity to murine mammary tumor virus.

Abstract:

:A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer tissues were compared with in vivo prognostically favorable lymphoreticuloendothelial (L-RE) responses seen microscopically at the time of mastectomy and with the results of skin window tests of cellular hypersensitivity. The data suggest that immunogens appear in the in situ phase of the disease and provoke prognostically favorable L-RE responses. These immunogens possess antigenic similarity to some component(s) of MuMTV. Progression of the disease is associated with or preceded by a loss of tissue immunogenicity and/or diminished specific cellular hypersensitivity. The findings are pertinent to investigations of human mammary carcinogenesis and immunoprophylaxis.

journal_name

Cancer

journal_title

Cancer

authors

Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jr

doi

10.1002/1097-0142(197501)35:1<121::aid-cncr2820350

subject

Has Abstract

pub_date

1975-01-01 00:00:00

pages

121-8

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

35

pub_type

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