Abstract:
:A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer tissues were compared with in vivo prognostically favorable lymphoreticuloendothelial (L-RE) responses seen microscopically at the time of mastectomy and with the results of skin window tests of cellular hypersensitivity. The data suggest that immunogens appear in the in situ phase of the disease and provoke prognostically favorable L-RE responses. These immunogens possess antigenic similarity to some component(s) of MuMTV. Progression of the disease is associated with or preceded by a loss of tissue immunogenicity and/or diminished specific cellular hypersensitivity. The findings are pertinent to investigations of human mammary carcinogenesis and immunoprophylaxis.
journal_name
Cancerjournal_title
Cancerauthors
Black MM,Zachrau RE,Shore B,Moore DH,Leis HP Jrdoi
10.1002/1097-0142(197501)35:1<121::aid-cncr2820350subject
Has Abstractpub_date
1975-01-01 00:00:00pages
121-8issue
1eissn
0008-543Xissn
1097-0142journal_volume
35pub_type
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