Biology of metastasis.

abstract：:Results of cytogenetic studies of a patient with acute granulocytic leukemia are described. The modal number of chromosomes in cells from bone marrow samples was 43; the karyotype was characterized by missing chromosomes in groups B, C, and E. According to successive studies of the same metaphases by fluorescent stain...

journal_title：Cancer

authors： Sofuni T,Okada H

更新日期：1975-02-01 00:00:00

abstract：:Laparoscopy is highly effective in diagnosing malignant liver disease, with overall accuracy in the 90% range. Up to 80% of the liver surface can be inspected, and biopsies can be directed with precision. A major advantage over scan guided percutaneous techniques is the ability to detect and biopsy lesions only a few ...

journal_title：Cancer

authors： Lightdale CJ

更新日期：1982-12-01 00:00:00

abstract：BACKGROUND:Low-dose computed tomography (LDCT) lung screening has been associated with a 20% reduction in lung cancer mortality. A major barrier to the adoption of lung screening is the potential negative psychological impact of a false-positive (FP) screen, occurring in 20% to 50% of those screened. The objective of t...

journal_title：Cancer

authors： Gareen IF,Duan F,Greco EM,Snyder BS,Boiselle PM,Park ER,Fryback D,Gatsonis C

更新日期：2014-11-01 00:00:00

abstract：BACKGROUND:4'-0-tetrahydropyranyladriamycin (Pirarubicin, Meiji Seika (USA) Inc., New York, NY) may be less toxic than doxorubicin. METHODS:A Phase II trial of Pirarubicin was done in 26 patients who had not previously had chemotherapy and who had measurable and incurable head and neck carcinoma. All patients received...

journal_title：Cancer

authors： Sridhar KS,Hussein AM,Benedetto P,Ardalan B,Savaraj N,Richman SP

更新日期：1992-09-15 00:00:00

abstract：:The anniversary of the first publication of Cancer provides an opportunity to review the progress in liver cancer surgery in the past 60 years. Indeed, the past half century has been witness to remarkable advances in liver surgery that have provided benefit to so many patients afflicted with primary or secondary liver...

journal_title：Cancer

authors： Tanabe KK

更新日期：2008-10-01 00:00:00

abstract：BACKGROUND:The authors are interested in identifying molecular markers that can aid in the diagnosis of adrenocortical carcinoma (ACC). The aim of this study was to identify microRNAs (miRNAs or miRs) that are differentially expressed in malignant adrenocortical tumors as compared with benign tumors and assess their po...

journal_title：Cancer

authors： Patterson EE,Holloway AK,Weng J,Fojo T,Kebebew E

更新日期：2011-04-15 00:00:00

abstract：:Two siblings succumbed to glioblastoma multiforme, associated with hepatic focal nodular hyperplasia and cafe-au-lait spots. One sibling had syndactyly and multiple colonic polyps, while the other had an angiomatous malformation in the brain. Their mother died of myasthenia gravis. The findings suggest a hamartomatous...

journal_title：Cancer

authors： Everson RB,Fraumeni JF Jr

更新日期：1976-07-01 00:00:00

abstract：BACKGROUND:: Histologic parameters of melanoma deposits in sentinel lymph nodes (SLNs) have been shown to be predictive of clinical outcome and the presence or absence of tumor in non-SLNs, but assessment of these parameters is prone to interobserver variation. METHODS:: Histologic sections of 44 SLNs containing metas...

journal_title：Cancer

authors： Murali R,Cochran AJ,Cook MG,Hillman JD,Karim RZ,Moncrieff M,Starz H,Thompson JF,Scolyer RA

更新日期：2009-11-01 00:00:00

abstract：:Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...

journal_title：Cancer

authors： Bartolucci AA,Liu C,Durant JR,Gams RA

更新日期：1983-12-15 00:00:00

abstract：:Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...

journal_title：Cancer

authors： Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

更新日期：1987-11-15 00:00:00

abstract：BACKGROUND:The prognosis of patients with clinically staged hilar nodal involvement (Stage N1) or clinical Stage II non-small cell lung cancer (NSCLC, Stage T1-2N1M0) treated with radiation therapy (RT) alone is not well established. METHODS:Records of 758 patients with clinical Stage I-III NSCLC treated with RT were ...

journal_title：Cancer

authors： Rosenthal SA,Curran WJ Jr,Herbert SH,Hughes EN,Sandler HM,Stafford PM,McKenna WG

更新日期：1992-11-15 00:00:00

abstract：:Fifteen selected patients with advanced intrathoracic non-small cell lung cancer and solitary metastasis were treated by a combined program including craniotomy, brain and chest irradiation, and systemic chemotherapy. One patient died because of cerebral hemorrhage after the operation. Five patients failed to achieve ...

journal_title：Cancer

authors： Tummarello D,Porfiri E,Rychlicki F,Miseria S,Cellerino R

更新日期：1985-12-01 00:00:00

abstract：:Carcinoembryonic antigen (CEA) was measured in 147 patients at diagnosis of small cell lung cancer; 17% of patients with limited disease and 51% with extensive disease had an abnormal CEA level (greater than 10 ng/ml). The median level was higher in extensive than in limited disease (11 ng/ml and 5.8 ng/ml, respective...

journal_title：Cancer

authors： Laberge F,Fritsche HA,Umsawasdi T,Carr DT,Welch S,Murphy WK,Chiuten DF,Dhingra HM,Farha P,Spitzer G

更新日期：1987-06-15 00:00:00

abstract：BACKGROUND:The FHIT gene, located at human chromosome 3p14.2, frequently is deleted in a number of human tumors, including breast carcinoma. Its protein product (Fhit) is presumed to have tumor suppressor function. Loss of expression of a tumor suppressor gene is an important step in tumor progression from premalignant...

journal_title：Cancer

authors： Gatalica Z,Lele SM,Rampy BA,Norris BA

更新日期：2000-03-15 00:00:00

abstract：:The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

journal_title：Cancer

authors： Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

更新日期：1983-01-15 00:00:00

abstract：BACKGROUND:The regulation of parathyroid hormone-related protein (PTH-rP) mRNA levels and immunoreactive (ir)PTH-rP formation by peptide growth factors, particularly transforming growth factor-beta (TGF-beta) and epidermal growth factor (EGF), in squamous cell carcinomas of gynecologic origin is largely unknown. METHO...

journal_title：Cancer

authors： Tait DL,MacDonald PC,Casey ML

更新日期：1994-03-01 00:00:00

abstract：:Cancer of the penis is infrequent in the United States because of good genital hygiene and circumcision of male babies at birth. In other countries, it represents 11-12% of all cancer in males. Tumors of the penis consist mainly of squamous cell carcinoma. Mesenchymal tumors are rare. The treatment is based on the sur...

journal_title：Cancer

authors： Merrin CE

更新日期：1980-04-01 00:00:00

abstract：:Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...

journal_title：Cancer

authors： Goseki N,Yamazaki S,Endo M,Onodera T,Kosaki G,Hibino Y,Kuwahata T

更新日期：1992-04-01 00:00:00

abstract：:Thirteen patients with regional or distant metastases from Merkel cell carcinoma were treated with combination chemotherapy. Three patients had a complete response to therapy. In two patients with nodal disease the duration of response was 10+ and 4+ years. In addition, three patients had a partial response, and six p...

journal_title：Cancer

authors： Feun LG,Savaraj N,Legha SS,Silva EG,Benjamin RS,Burgess MA

更新日期：1988-08-15 00:00:00

abstract：BACKGROUND:Recent studies revealed that incidence rates of cutaneous melanoma (CM) were leveling off predominantly among younger people and patterns suggested birth-cohort effects. The current study analyzed the development of prognostic factors and survival in incident CM over 25 years. METHODS:All 45,483 patients wi...

journal_title：Cancer

authors： Buettner PG,Leiter U,Eigentler TK,Garbe C

更新日期：2005-02-01 00:00:00

abstract：:This report describes 11 adults with non-Hodgkin's lymphoma who presented with symptoms caused by large mediastinal masses. Patients with lymphoblastic lymphoma were excluded from this analysis. Most of the patients were young women with localized disease at presentation. Ten tumors were diffuse large cell ("histiocyt...

journal_title：Cancer

authors： Trump DL,Mann RB

更新日期：1982-07-15 00:00:00

abstract：BACKGROUND:Mantle cell lymphoma (MCL) is an incurable B-cell malignancy, and patients with this disease have the poorest prognosis among all patients with B-cell lymphomas. The signaling pathways that trigger MCL escape from immune surveillance are unclear. Because Toll-like receptors (TLRs) initiate innate and adaptiv...

journal_title：Cancer

authors： Wang L,Zhao Y,Qian J,Sun L,Lu Y,Li H,Li Y,Yang J,Cai Z,Yi Q

更新日期：2013-02-15 00:00:00

abstract：:Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

journal_title：Cancer

authors： Loewenstein MS,Zamcheck N

更新日期：1978-09-01 00:00:00

abstract：BACKGROUND:BRAF inhibitors are effective in melanoma and other cancers with BRAF mutations; however, patients ultimately develop therapeutic resistance through the activation of alternative signaling pathways such as RAF/RAS or MET. The authors hypothesized that combining the BRAF inhibitor vemurafenib with either the ...

journal_title：Cancer

authors： Janku F,Sakamuri D,Kato S,Huang HJ,Call SG,Naing A,Holley VR,Patel SP,Amaria RN,Falchook GS,Piha-Paul SA,Zinner RG,Tsimberidou AM,Hong DS,Meric-Bernstam F

更新日期：2021-02-01 00:00:00

abstract：:Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target pop...

journal_title：Cancer

authors： Eng E

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...

journal_title：Cancer

authors： Cass I,Baldwin RL,Varkey T,Moslehi R,Narod SA,Karlan BY

更新日期：2003-05-01 00:00:00

abstract：:Progress in the treatment of pancreatic cancer in the past several decades has been very modest. Several new agents with activity against this disease have been identified. Of these, gemcitabine appears to be the most promising when used in combination with other drugs. Gemcitabine and cisplatin combinations have been...

journal_title：Cancer

authors： Philip PA

更新日期：2002-08-15 00:00:00

abstract：:A total of 1026 patients with gastric cancer was followed up for five years after surgery and classified into different groups according to surgeons' assessment of nodal involvement, serosal invasion, peritoneal spread, and hepatic metastasis. The survival of each group was studied by parametric analysis, using the lo...

journal_title：Cancer

authors： Maetani S,Tobe T,Hirakawa A,Kashiwara S,Kuramoto S

更新日期：1980-12-15 00:00:00

abstract：:Prolymphocytic leukemia (PL) is a clinically distinct leukemic disorder. Cytochemical and surface marker characteristics help to differentiate PL from other types of leukemia, including chronic lymphocytic leukemia (CLL). In contrast to patients with CLL, those with PL frequently require early therapeutic intervention...

journal_title：Cancer

authors： Taylor HG,Butler WM,Rhoads J,Karcher DS,Detrick-Hooks B

更新日期：1982-04-15 00:00:00

abstract：:Management of testis cancer in children differs from that in adults due to the histological types and varying tolerances to chemotherapy agents. Embryonal adrenocarcinoma (endodermal sinus tumor, Teilum's tumor) is a tumor of infancy and young children and less aggressive than other testis cancers. Most cases require ...

journal_title：Cancer

authors： Exelby PR

更新日期：1980-04-01 00:00:00