Carcinoid tumors of the thymus. An immunohistochemical study.

Abstract:

:Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients exhibited local symptoms evoked by growing tumor masses in the upper mediastinum without any clinical evidence of endocrine activity. Light and electron microscopic examination showed characteristic uniform large epithelial cells in polar or palisade arrangement, containing variable amounts of electron-dense secretory granules. Only a few of the tested neuropeptide antisera reacted with the investigated tumors. Cholecystokinin-immunoreactive cell populations were seen in all tumors. Expression of neurotensin could be observed in three neoplasms, two of which also exhibited ACTH immunoreactivity. Chromogranin A-immunoreactive cells were found in two neoplasms. Neuron-specific enolase showed strong staining in three tumors, one of the tumors also being immunoreactive for calcitonin. The results were confirmed by control reactions. Apart from the demonstration that conventional marker proteins are not reliable in identifying all carcinoid tumors, the present study proves that the visualization of neuropeptide-immunoreactive cells in thymus carcinoids does not necessarily correspond to the manifestation of the clinical symptoms. Furthermore, each of the investigated neoplasms, as also known from other carcinoid tumors, appears to be able to produce more than one hormone.

journal_name

Cancer

journal_title

Cancer

authors

Herbst WM,Kummer W,Hofmann W,Otto H,Heym C

doi

10.1002/1097-0142(19871115)60:10<2465::aid-cncr282

subject

Has Abstract

pub_date

1987-11-15 00:00:00

pages

2465-70

issue

10

eissn

0008-543X

issn

1097-0142

journal_volume

60

pub_type

杂志文章

相关文献

CANCER文献大全
  • Desmoplastic malignant melanoma of the oral mucosa. An underrecognized diagnostic pitfall.

    abstract:BACKGROUND:Although cutaneous desmoplastic malignant melanoma (DMM) has been well characterized, those arising from the oral mucosa have been less well defined. METHODS:We evaluated the clinical and pathologic features of three patients with biopsy-proven DMM examined at the North Carolina Baptist Hospital. Routine he...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960801)78:3<383::AID-CNC

    authors: Kilpatrick SE,White WL,Browne JD

    更新日期:1996-08-01 00:00:00

  • DNA ploidy of ovarian granulosa cell tumors. Lack of correlation between DNA index or proliferative index and outcome in 40 patients.

    abstract:BACKGROUND:Most cases of granulosa cell tumor of the ovary are characterized by relatively good outcome; however, some tumors behave aggressively, and some tend to recur many years after the initial diagnosis. Because DNA ploidy has been shown to predict biologic behavior better than conventional prognostic variables i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950501)75:9<2295::aid-cncr2820

    authors: Evans MP,Webb MJ,Gaffey TA,Katzmann JA,Suman VJ,Hu TC

    更新日期:1995-05-01 00:00:00

  • Automated tobacco assessment and cessation support for cancer patients.

    abstract:BACKGROUND:Tobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients. METHODS:A structured tobacco assessment was incorporated into the electronic heal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28440

    authors: Warren GW,Marshall JR,Cummings KM,Zevon MA,Reed R,Hysert P,Mahoney MC,Hyland AJ,Nwogu C,Demmy T,Dexter E,Kelly M,O'Connor RJ,Houstin T,Jenkins D,Germain P,Singh AK,Epstein J,Dobson Amato KA,Reid ME

    更新日期:2014-02-15 00:00:00

  • Heat shock protein 60 levels in tissue and circulating exosomes in human large bowel cancer before and after ablative surgery.

    abstract:BACKGROUND:Heat shock protein 60 (Hsp60) is a chaperonin involved in tumorigenesis, but its participation in tumor development and progression is not well understood and its value as a tumor biomarker has not been fully elucidated. In the current study, the authors presented evidence supporting the theory that Hsp60 ha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.29499

    authors: Campanella C,Rappa F,Sciumè C,Marino Gammazza A,Barone R,Bucchieri F,David S,Curcurù G,Caruso Bavisotto C,Pitruzzella A,Geraci G,Modica G,Farina F,Zummo G,Fais S,Conway de Macario E,Macario AJ,Cappello F

    更新日期:2015-09-15 00:00:00

  • Phytohemagglutinin skin tests in cancer patients.

    abstract::Phytohemagglutinin (PHA) stimulates blastic transformation of normal lymphocytes in vitro and when injected intradermally produces a skin response histologically similar to a delayed hypersensitivity reaction. We investigated the skin test responses to PHA, mumps, candida, and varidase (SK-SD) and the PHA-induced lymp...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197706)39:6<2355::aid-cncr282039

    authors: Zuckerman KS,LoBuglio AF

    更新日期:1977-06-01 00:00:00

  • Impairment of rosette-forming T lymphocytes in patients with primary intracranial tumors.

    abstract::The percentage of T lymphocytes that form rosettes (RFC) with sheep erythrocytes (E rosettes), cutaneous delayed-type hypersensitivity, and in vitro lymphocyte transformation was measured in 15 patients with primary intracranial tumors. The ability of T lymphocytes to form E rosettes was significantly impaired. Thes...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(197604)37:4<1869::aid-cncr282037

    authors: Brooks WH,Roszman TL,Rogers AS

    更新日期:1976-04-01 00:00:00

  • Soluble FAS ligand as a biomarker of disease recurrence in differentiated thyroid cancer.

    abstract:BACKGROUND:Reliable predictive biomarkers are required to address the challenge of disease recurrence after thyroid cancer surgery. For this study, the authors assessed the association of cellular-based and serum-based immunologic mediators with thyroid cancer recurrence. METHODS:Leukocyte subset counts and immune reg...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.27937

    authors: Owonikoko TK,Hossain MS,Bhimani C,Chen Z,Kim S,Ramalingam SS,Sun SY,Shin DM,Waller EK,Khuri FR

    更新日期:2013-04-15 00:00:00

  • Patient issues in breast reconstruction.

    abstract::Breast reconstruction is not a new idea. Techniques have been developing since the late 1800s. The state of the art is such that the knowledge of its availability and success has significant effect on the willingness of women to seek earlier diagnosis and treatment. However, reconstruction is not for everyone. This pa...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19910901)68:5+<1167::aid-cncr282

    authors: Brown HG

    更新日期:1991-09-01 00:00:00

  • Autopsy findings in squamous-cell carcinoma of the esophagus.

    abstract::The findings at autopsy of 79 patients with esophageal carcinoma over a period of 15 years were reviewed. Five patients were free of tumor, and another seven had disease localized to the esophagus and other mediastinal structures. Sixty-seven (85%) had metastatic disease. The average number of metastatic sites per pat...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821015)50:8<1587::aid-cncr2820

    authors: Anderson LL,Lad TE

    更新日期:1982-10-15 00:00:00

  • Enzyme pattern and marker antigens in nodular "regenerative" hyperplasia of the liver.

    abstract::Characteristic alterations of marker enzymes and tumor-associated antigens have been detected in the preneoplastic lesions of experimental hepatocarcinogenesis. An identical pattern of enzyme activity (increased gammaglutamyl transferase, loss of glucose-6-phosphatase, and canalicular adenosine triphosphatase) was dem...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810401)47:7<1796::aid-cncr2820

    authors: Thung SN,Gerber MA

    更新日期:1981-04-01 00:00:00

  • The use of oncofetal ferritin-bearing lymphocytes as a marker for the screening, diagnosis, and follow-up of patients with early breast malignancy screening of 3400 women.

    abstract::The potential of using a blood test enumerating oncofetal ferritin-bearing lymphocytes (FBL) as a biomarker for early breast cancer was further explored. Nine hundred women attending a high-risk breast cancer clinic and 2500 normal-risk women were physically examined and their blood drawn for FBL determination using a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890801)64:3<691::aid-cncr28206

    authors: Moroz C,Kahn M,Ron E,Luria H,Chaimoff C

    更新日期:1989-08-01 00:00:00

  • Treatment of advanced breast cancer with aminoglutethimide after therapy with tamoxifen.

    abstract::Thirty-eight metastatic breast cancer patients were treated with aminoglutethimide. All patients had progressive metastatic disease following initial response to Tamoxifen therapy. Thirty-two patients were evaluable for response, of these, two patients (6%) had complete remission, 13 patients (41%) had partial respons...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821101)50:9<1708::aid-cncr2820

    authors: Buzdar AU,Powell KC,Legha SS,Blumenschein GR

    更新日期:1982-11-01 00:00:00

  • Acid phosphatase in prostatic tissue homogenates from patients with benign prostatic hyperplasia and prostatic carcinoma.

    abstract::Acid phosphatase activity biochemically in the primary tumor of 20 patients with prostatic carcinoma, was studied in an attempt to understand the basis for a correlation or lack of correlation between serum and/or bone marrow acid phosphatase levels and the presence and/or clinical behavior of prostatic carcinoma. The...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830701)52:1<155::aid-cncr28205

    authors: Copland GT,Whitehurst GB,Pretlow TP,Boohaker EA,Bartolucci AA,Pretlow TG 2nd

    更新日期:1983-07-01 00:00:00

  • Comparison of two total body irradiation fractionation regimens with respect to acute and late pulmonary toxicity.

    abstract:BACKGROUND:Total body irradiation (TBI) is commonly used with autologous bone marrow transplantation (BMT) for treatment of hematologic malignancies. Pulmonary complications of TBI can cause long-term morbidity and mortality. The authors have compared the pulmonary toxicity and efficacy of two different TBI fractionati...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(20011001)92:7<1949::aid-cncr1714

    authors: Gopal R,Ha CS,Tucker SL,Khouri IF,Giralt SA,Gajewski JL,Andersson BS,Cox JD,Champlin RE

    更新日期:2001-10-01 00:00:00

  • Loss of material from chromosome arm 1p during malignant progression of meningioma revealed by fluorescent in situ hybridization.

    abstract:BACKGROUND:Atypical and anaplastic meningiomas tend to recur and to invade adjacent brain, bone, and skin. They also can metastasize to extracranial organs such as the lung, liver, or bone, causing death. Recent reports have indicated that allelic deletion of chromosome 1p is associated with malignant progression of me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Ishino S,Hashimoto N,Fushiki S,Date K,Mori T,Fujimoto M,Nakagawa Y,Ueda S,Abe T,Inazawa J

    更新日期:1998-07-15 00:00:00

  • Lobular neoplasia. Long term risk of breast cancer and relation to other factors.

    abstract:BACKGROUND:Lobular neoplasia (LN), also known as lobular carcinoma in situ, is an incidental histologic finding in tissue removed at breast surgery. Patients with LN are known to be predisposed to develop invasive or intraductal carcinoma (CA). This study investigates factors that influence the cancer risk in LN patien...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960901)78:5<1024::AID-CN

    authors: Bodian CA,Perzin KH,Lattes R

    更新日期:1996-09-01 00:00:00

  • Non-small cell lung cancer. Neuroresection of the solitary intracranial metastasis followed by radiochemotherapy.

    abstract::Fifteen selected patients with advanced intrathoracic non-small cell lung cancer and solitary metastasis were treated by a combined program including craniotomy, brain and chest irradiation, and systemic chemotherapy. One patient died because of cerebral hemorrhage after the operation. Five patients failed to achieve ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2569::aid-cncr282

    authors: Tummarello D,Porfiri E,Rychlicki F,Miseria S,Cellerino R

    更新日期:1985-12-01 00:00:00

  • Biliary reflux as a causal factor in hypopharyngeal carcinoma: New clinical evidence and implications.

    abstract:BACKGROUND:Recent preclinical explorations strongly support the tumorigenic potential of bile on laryngopharyngeal mucosa. Herein, the authors describe, in bile-related human hypopharyngeal squamous cell carcinoma (HSCC), NF-κB-related messenger RNA (mRNA) and microRNA (miRNA) oncogenic phenotypes similar to those prev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32369

    authors: Sasaki CT,Doukas SG,Costa J,Vageli DP

    更新日期:2019-10-15 00:00:00

  • Activity of 9-nitro-camptothecin, an oral topoisomerase I inhibitor, in myelodysplastic syndrome and chronic myelomonocytic leukemia.

    abstract:BACKGROUND:Topoisomerase I inhibitors, like topotecan, have activity in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). 9-Nitro-camptothecin (9-NC) is a new oral topoisomerase inhibitor with a good safety profile. The aims of the current study were to evaluate the activity and safety of 9-NC ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.22186

    authors: Quintas-Cardama A,Kantarjian H,O'Brien S,Jabbour E,Giles F,Ravandi F,Faderl S,Pierce S,Shan J,Verstovsek S,Cortes J

    更新日期:2006-10-01 00:00:00

  • Rehabilitation of persons with central nervous system tumors.

    abstract::A tumor that affects the central nervous system can have a dramatic impact on the individual affected, as well as his or her family and friends. The tumor, regardless of extent or location, may affect the physical, social, vocational, and emotional capabilities of the individual. Basic aspects of rehabilitation for pa...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20010815)92:4+<1029::aid-cncr141

    authors: Kirshblum S,O'Dell MW,Ho C,Barr K

    更新日期:2001-08-15 00:00:00

  • Occupational physical activity and the incidence of cancer of the breast, corpus uteri, and ovary in Shanghai.

    abstract:BACKGROUND:A sedentary life style has been consistently associated with an increased risk of colon cancer, but the evidence for its association with breast and other gynecologic cancers is limited. METHODS:Occupational information for 3783 incident patients with cancer (breast, 2736; corpus uteri, 452; and ovary, 595)...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930601)71:11<3620::aid-cncr282

    authors: Zheng W,Shu XO,McLaughlin JK,Chow WH,Gao YT,Blot WJ

    更新日期:1993-06-01 00:00:00

  • Ganglioside composition of human neuroblastomas. Correlation with prognosis. A Pediatric Oncology Group Study.

    abstract::The ganglioside composition of neuroblastoma samples from 53 patients was determined. Tumor sites included the adrenals (15), and the thoracic (20), abdominal (15), and pelvic (3) areas. Age of the patients at the time of surgery ranged from 1 day to over 10 years and the Stage of the tumors from A to D. Differences i...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851201)56:11<2640::aid-cncr282

    authors: Schengrund CL,Repman MA,Shochat SJ

    更新日期:1985-12-01 00:00:00

  • Results of intermediate measures from a population-based, randomized trial of mammographic screening prevalence and detection of breast carcinoma among Asian women: the Singapore Breast Screening Project.

    abstract:BACKGROUND:Although increasing rates of breast carcinoma incidence have been observed in Asian countries, appropriate strategies for detecting early stage breast carcinoma in such communities have been difficult to formulate, particularly because no large population screening trial specifically involving Asian women ha...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:

    authors: Ng EH,Ng FC,Tan PH,Low SC,Chiang G,Tan KP,Seow A,Emmanuel S,Tan CH,Ho GH,Ng LT,Wilde CC

    更新日期:1998-04-15 00:00:00

  • A nomogram predicting long-term biochemical recurrence after radical prostatectomy.

    abstract:BACKGROUND:Men who undergo radical prostatectomy (RP) are at long-term risk of biochemical recurrence (BCR). In this report, the authors have described a model capable of predicting BCR up to at least 15 years after RP that can adjust predictions according to the disease-free interval. METHODS:Cox regression was used ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23293

    authors: Suardi N,Porter CR,Reuther AM,Walz J,Kodama K,Gibbons RP,Correa R,Montorsi F,Graefen M,Huland H,Klein EA,Karakiewicz PI

    更新日期:2008-03-15 00:00:00

  • Estrogen and progesterone receptors in the prediction of response of breast cancer to endocrine therapy.

    abstract::This review presents our experience with the use of estrogen receptors (ER) and progesterone receptors (PgR) in the prediction of response to endocrine therapy in stage IV breast cancer. Presence of ER (> 3 fmol/mg cytosol protein) significantly predicted response to the antiestrogen tamoxifen and to hypophysectomy. E...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12+<2838::aid-cncr28

    authors: Manni A,Arafah B,Pearson OH

    更新日期:1980-12-15 00:00:00

  • Some observations concerning the demographic and geographic incidence of carcinoma of the lip and buccal cavity.

    abstract::The geographic and demographic data obtained during the Third National Cancer Survey have provided a perspective on etiologic factors and incidence trends for cancers of low frequency. The incidence of cancer of the lip, oral cavity and skin from this survey was compared to similar studies in 1947 and intra-regional p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197707)40:1<343::aid-cncr2820400

    authors: Szpak CA,Stone MJ,Frenkel EP

    更新日期:1977-07-01 00:00:00

  • A study of cyproheptadine in the treatment of metastatic carcinoid tumor and the malignant carcinoid syndrome.

    abstract::Sixteen patients with metastatic neuroendocrine tumors and the malignant carcinoid syndrome were treated with cyproheptadine (Periactin, Merck, Sharp & Dohme, West Point, PA) at maximum tolerable doses that ranged from 12 to 48 mg daily. Usual side effects were mild sedation and dry mouth, but three patients found it ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19910101)67:1<33::aid-cncr282067

    authors: Moertel CG,Kvols LK,Rubin J

    更新日期:1991-01-01 00:00:00

  • Immunohistochemical expression of Ets-1 transcription factor and the urokinase-type plasminogen activator is correlated with the malignant and invasive potential in meningiomas.

    abstract:BACKGROUND:The Ets-1 transcription factor has been proposed to play an important role in the invasive process of tumor cells through the induction of urokinase-type plasminogen activator (u-PA). METHODS:Because meningiomas are potentially invasive tumors, irrespective of their malignancy grades, the authors immunohist...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001201)89:11<2292::aid-cncr18>

    authors: Kitange G,Tsunoda K,Anda T,Nakamura S,Yasunaga A,Naito S,Shibata S

    更新日期:2000-12-01 00:00:00

  • Intensive systemic chemotherapy in localized Ewing's sarcoma in childhood. A historical trial.

    abstract::To assess the value in Ewing's sarcoma of a new multiagent therapy (vincristine, cyclophosphamide, Adriamycin, (doxorubicin) procarbazine), 30 children with a localized tumor (eight distal, nine proximal, 13 central lesions) treated at the Institut Gustave-Roussy between 1973 and 1976 (E3), were pair-matched by site o...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19830801)52:3<415::aid-cncr28205

    authors: Zucker JM,Henry-Amar M,Sarrazin D,Blache R,Patte C,Schweisguth O

    更新日期:1983-08-01 00:00:00

  • T-cell large granular lymphocyte leukemia: A report on the treatment of 29 patients and a review of the literature.

    abstract:BACKGROUND:To the authors' knowledge, there is no standard treatment for patients with T-cell large granular lymphocyte (LGL) leukemia. Available data are limited by patient numbers and coexisting pathologies. METHODS:The authors report on the use of immunosuppressants (cyclosporin A [CSA] and low-dose oral methotrexa...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22032

    authors: Osuji N,Matutes E,Tjonnfjord G,Grech H,Del Giudice I,Wotherspoon A,Swansbury JG,Catovsky D

    更新日期:2006-08-01 00:00:00