Intensive systemic chemotherapy in localized Ewing's sarcoma in childhood. A historical trial.

abstract：:Bleomycin (BLM)-inactivating enzyme activity, which is probably a parameter for the efficacy of this antibiotic in cancer therapy, was determined in biopsies from human carcinomas in the head and neck region. Twenty-three cases were studied. It was found that highly differentiated as well as moderately differentiated ...

journal_title：Cancer

authors： Müller WE,Schmidseder R,Rohde HJ,Zahn RK,Scheunemann H

更新日期：1977-12-01 00:00:00

abstract：:A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...

journal_title：Cancer

authors： Niell HB,Soloway MS,Wood CA,McCallum LW,Webster K

更新日期：1983-08-15 00:00:00

abstract：BACKGROUND:Some patients with chronic myeloid leukemia (CML) have a history of previous malignancies. To the authors' knowledge, outcomes for CML diagnosed in these patients have not been well described. The current study was conducted to determine the outcome of patients with CML and a history of prior malignancies. ...

journal_title：Cancer

authors： Koller PB,Kantarjian HM,Nogueras-Gonzalez GM,Jabbour E,Verstovsek S,Borthakur G,Estrov Z,Wierda WG,Garcia-Manero G,Ferrajoli A,Ravandi F,O'Brien SM,Cortes JE

更新日期：2017-02-15 00:00:00

abstract：:Three patients with biopsy-proven lentigo maligna were treated with topical 5-fluorouracil. Treatment consisted of twice daily application of 5% 5-fluorouracil cream for 13, 6, and 9 weeks, respectively. Two patients demonstrated presence of invasive melanoma; in one the melanoma was evident before chemotherapy, and i...

journal_title：Cancer

authors： Litwin MS,Krementz ET,Mansell PW,Reed RJ

更新日期：1975-03-01 00:00:00

abstract：BACKGROUND:Patients with aggressive non-Hodgkin lymphoma (NHL) develop central nervous system (CNS) progression or recurrence during the course of their disease. Patients with human immunodeficiency virus (HIV)-NHL often develop CNS progression despite the use of prophylaxis. Liposomal cytarabine (DepoCyte) has shown a...

journal_title：Cancer

authors： Spina M,Chimienti E,Martellotta F,Vaccher E,Berretta M,Zanet E,Lleshi A,Canzonieri V,Bulian P,Tirelli U

更新日期：2010-03-15 00:00:00

abstract：:Twenty-two cases of breast tumor with infiltrating lobular carcinoma were studied. Thirteen showed the classic single-file pattern as a sole component, and 6 as a predominant pattern; the less common confluent pattern was found in 3 instances as a predominant component. Mucin secretion was evidenced in 59% of the prim...

journal_title：Cancer

authors： Van Bogaert LJ,Maldague P

更新日期：1980-03-01 00:00:00

abstract：:Thirty-nine untreated patients with either lymphocytic or nodular mixed/nodular histiocytic non-Hodgkin's lymphoma, stage II--IV, were randomized to treatment with total body irradiation (TBI), 100 rads in 10 fractions over 12 days, plus combination chemotherapy with either cyclophosphamide, vincristine and prednisone...

journal_title：Cancer

authors： Brereton HD,Young RC,Longo DL,Kirkland LR,Berard CW,Jaffe ES,DeVita VT,Johnson RE

更新日期：1979-06-01 00:00:00

abstract：:We have tested methyl glyoxal bis-guanyl hydrazone (NSC 32946) for antitumor activity in patients with colorectal carcinoma and non-small cell bronchogenic carcinoma. The drug dose was 500 mg/m2 administered by single weekly injection, and with a provision dose escalation. No responses were seen in 38 evaluable patien...

journal_title：Cancer

authors： Killen JY,Mitchell EP,Hoth DF,Willis LL,Gullo JJ,Smith FP,Schein PS,Woolley PV

更新日期：1982-10-01 00:00:00

abstract：BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...

journal_title：Cancer

authors： Miettinen M,Kraszewska E,Sobin LH,Lasota J

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:The current randomized, controlled, multicenter clinical trial was conducted to investigate the efficacy of concurrent neoadjuvant chemotherapy (NCT) and estrogen deprivation in patients with estrogen receptor (ER)-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer. METHODS:Eli...

journal_title：Cancer

authors： Yu KD,Wu SY,Liu GY,Wu J,Di GH,Hu Z,Hou YF,Chen CM,Fan L,Tang LC,Shen ZZ,Wu KJ,Zhuang ZG,Zhang HW,Shao ZM

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

journal_title：Cancer

authors： Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:This study explores whether externalizing religious and spiritual beliefs is associated with advanced-stage colon cancer at initial oncology presentation and whether this association is stronger for blacks than for whites. METHODS:Patients who had newly diagnosed, invasive colon cancer were recruited at 9 s...

journal_title：Cancer

authors： Polite BN,Cipriano-Steffens TM,Hlubocky FJ,Jean-Pierre P,Cheng Y,Brewer KC,Rauscher GH,Fitchett GA

更新日期：2018-06-15 00:00:00

abstract：BACKGROUND:Racial disparity in the incidence of multiple myeloma is well established; however, to the authors' knowledge, little is known regarding the impact of racial differences on disease characteristics, response to therapy, and clinical outcome. METHODS:The authors studied 453 patients (174 of whom were black an...

journal_title：Cancer

authors： Bhatnagar V,Wu Y,Goloubeva OG,Ruehle KT,Milliron TE,Harris CG,Rapoport AP,Yanovich S,Sausville EA,Baer MR,Badros AZ

更新日期：2015-04-01 00:00:00

abstract：:The effect of cyclophosphamide (CY) on ovarian function was studied in patients with breast cancer receiving prolonged daily administration of this agent (100 mg/day) after radical surgery. Out of 18 premenopausal patients that received 8.4-39.9 g CY, 15 developed permanent amenorrhea. The average dose given before th...

journal_title：Cancer

authors： Koyama H,Wada T,Nishizawa Y,Iwanaga T,Aoki Y

更新日期：1977-04-01 00:00:00

abstract：:A series of case-control studies was conducted to investigate cancer risks among farmers. These studies were based on Missouri Cancer Registry data for 15,000 white male patients, including 1720 subjects classified as farmers, registered between 1984 and 1988. For each cancer site, all other cancer registrations forme...

journal_title：Cancer

authors： Brownson RC,Reif JS,Chang JC,Davis JR

更新日期：1989-12-01 00:00:00

abstract：BACKGROUND:A rigorous assessment of the risk of colorectal cancer (CRC) among prostate cancer (PC) survivors that controls for important confounding factors and competing risks is necessary to determine the risk of CRC in this population and to inform screening guidelines. METHODS:With data from Manitoba, Canada, subj...

journal_title：Cancer

authors： Desautels D,Czaykowski P,Nugent Z,Demers AA,Mahmud SM,Singh H

更新日期：2016-04-15 00:00:00

abstract：BACKGROUND:There is no clear consensus between pediatric and adult providers about the treatment of adolescents and young adults (AYAs) with Hodgkin lymphoma (HL). METHODS:Failure-free survival (FFS) and overall survival (OS) were compared between 114 patients ages 17 to 21 years with HL who were treated on the Easter...

journal_title：Cancer

authors： Henderson TO,Parsons SK,Wroblewski KE,Chen L,Hong F,Smith SM,McNeer JL,Advani RH,Gascoyne RD,Constine LS,Horning S,Bartlett NL,Shah B,Connors JM,Leonard JI,Kahl BS,Kelly KM,Schwartz CL,Li H,Friedberg JW,Friedman D

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:The incidence, risk factors, time course, and impact on survival of venous thromboembolism (VTE) in a large, population-based study of patients with bladder cancer have not been identified previously. METHODS:The California Cancer Registry was merged with the California Patient Discharge Data Set to determi...

journal_title：Cancer

authors： Sandhu R,Pan CX,Wun T,Harvey D,Zhou H,White RH,Chew HK

更新日期：2010-06-01 00:00:00

abstract：:The yield of additional information from anteroposterior full-lung tomograms that changed stage or treatment, in comparison to that obtained from routine chest radiographs, was prospectively evaluated in 243 previously untreated patients with Hodgkin's disease and non-Hodgkin's lymphoma. Although new information was f...

journal_title：Cancer

authors： Castellino RA,Filly R,Blank N

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:A rare occurrence, about 1500 men in the United States develop breast carcinoma each year. Little is known about survival patterns at the population level, particularly about racial/ethnic variation. METHODS:Using data from the Surveillance, Epidemiology, and End Results Program, we examined survival rates ...

journal_title：Cancer

authors： O'Malley CD,Prehn AW,Shema SJ,Glaser SL

更新日期：2002-06-01 00:00:00

abstract：:The National Comprehensive Cancer Network (NCCN) describes the presence of extracapsular spread and/or positive margins in oropharynx cancer (OPC) as an indication for the addition of chemotherapy to postoperative radiation. The guideline's category 1 consensus is based on what they term high-level evidence. For this ...

journal_title：Cancer

authors： Sinha P,Piccirillo JF,Kallogjeri D,Spitznagel EL,Haughey BH

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Specialty of the endoscopist has been related to the postcolonoscopy interval risk of colorectal cancer (CRC). However, the impact of such a difference on the long-term CRC prevention rate by screening colonoscopy is largely unknown. METHODS:A Markov model was constructed to simulate the efficacy and cost o...

journal_title：Cancer

authors： Hassan C,Rex DK,Zullo A,Cooper GS

更新日期：2012-09-15 00:00:00

abstract：BACKGROUND:This study was conducted to determine if pelvic computed tomography (CT) should routinely be appended to abdominal CT in the workup of patients with breast carcinoma. METHODS:The abdominal-pelvic CTs of 139 breast carcinoma patients (195 exams) were reviewed. Scans were grouped by indication and whether pel...

journal_title：Cancer

authors： Meyer JI,Herts BR,Einstein DM,Singer AA,Budd GT,Cohen MA

更新日期：1997-02-01 00:00:00

abstract：BACKGROUND:In spite of many reports, it remains unclear whether the presence of tumor cells in circulating blood flow predicts a poor prognosis. METHODS:Competitive seminested reverse transcriptase-polymerase chain reaction (RT-PCR), a technique for the quantitative detection of tumor cells, was applied to detect the ...

journal_title：Cancer

authors： Sadahiro S,Suzuki T,Tokunaga N,Yurimoto S,Yasuda S,Tajima T,Makuuchi H,Murayama C,Matsuda K

更新日期：2001-09-01 00:00:00

abstract：:The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When thes...

journal_title：Cancer

authors： Bell DA,Flotte TJ

更新日期：1982-09-01 00:00:00

abstract：BACKGROUND:The efficacy of postoperative radiotherapy (PORT) for thymic epithelial tumors is still controversial. Using the Japanese Association for Research on the Thymus (JART) database, this study was aimed at clarifying the efficacy of PORT for Masaoka stage II and III thymic carcinoma and thymoma. METHODS:The JAR...

journal_title：Cancer

authors： Omasa M,Date H,Sozu T,Sato T,Nagai K,Yokoi K,Okamoto T,Ikeda N,Tanaka F,Maniwa Y,Japanese Association for Research on the Thymus.

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:The current study reports on the significance of cervical smears identified as atypical squamous cells of undetermined significance (ASCUS) in the largest Asian screening population to date. METHODS:From January 1998 to December 1999, 190,000 cervical smears were evaluated by the cervical cytology laborator...

journal_title：Cancer

authors： Cheung AN,Szeto EF,Ng KM,Fong KW,Yeung AC,Tsun OK,Khoo US,Chan KY,Ng AW

更新日期：2004-04-25 00:00:00

abstract：:Mitomycin C (MMC) has been evaluated in combination with several antitumor agents. Full dose response curves were established for all drugs and drug combinations. Synergy was shown with MMC plus either cyclophosphamide (CYC) or methotrexate (MTX). In testing MMC and CYC against P388 leukemia, the combined treatment yi...

journal_title：Cancer

authors： Mabel JA,Wodinsky I

更新日期：1983-02-15 00:00:00

abstract：:Postmenopausal patients with metastatic breast cancer were treated with medroxyprogesterone acetate (MPA) (Clinovir) in dosages between 500 and 1500 mg orally per day. The relation of MPA plasma concentrations and endocrine effects were studied in a longitudinal fashion. MPA exerted suppressive effects on the basal an...

journal_title：Cancer

authors： Blossey HC,Wander HE,Koebberling J,Nagel GA

更新日期：1984-09-15 00:00:00

abstract：:Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...

journal_title：Cancer

authors： Amorn Y,Knight WA Jr

更新日期：1978-06-01 00:00:00