Abstract:
:Twenty-two cases of breast tumor with infiltrating lobular carcinoma were studied. Thirteen showed the classic single-file pattern as a sole component, and 6 as a predominant pattern; the less common confluent pattern was found in 3 instances as a predominant component. Mucin secretion was evidenced in 59% of the primary tumors; it was a prominent feature in only 1 case. Nine tumors were associated with in situ lobular carcinoma. In 14, nodal metastases had occurred at the moment of diagnosis. In 50% of the metastases, intracellular mucin secretion was present. It appears that the diagnosis of infiltrating lobular carcinoma relies on the convergence of multiple histocytologic hallmarks, as much in the primary tumors as in the metastases. Deviations from the classic appearance need to be recognized as true lobular carcinomas, and even in these cases it is suggested that the well established term lobular carcinoma be maintained.
journal_name
Cancerjournal_title
Cancerauthors
Van Bogaert LJ,Maldague Pdoi
10.1002/1097-0142(19800301)45:5<979::aid-cncr28204subject
Has Abstractpub_date
1980-03-01 00:00:00pages
979-84issue
5eissn
0008-543Xissn
1097-0142journal_volume
45pub_type
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