Abstract:
:An atypical case of adult T-cell leukemia/lymphoma (ATL) associated with human T-cell lymphotropic virus type I (HTLV-I) occurred in a 46-year-old Inupiat Eskimo man with no behavioral risk factors for HTLV-I infection. The case was characterized by lack of atypical circulating lymphocytes, hypercalcemia, and opportunistic infections; and by complete remission of the initial renal parenchymal lymphoma. The lymphoma cells had a helper T-cell (CD4) immunophenotype. Serum antibodies to HTLV I/II, detected by Western immunoblot, were identified in specimens collected 31 months before the onset of illness, at the time of diagnosis, and up to 37 months later, shortly before the patient's death. Polymerase chain reaction was used to identify HTLV-I DNA in peripheral blood mononuclear cells and in lymphoma in involved skin. Clinicians should be alert to sporadic cases of both atypical and classic ATL, even in populations in which the prevalence of HTLV-I infection is low.
journal_name
Cancerjournal_title
Cancerauthors
Davidson M,Braziel RM,Lairmore MD,Jacobson S,Sprott JM,Tucker SB,Levine PH,Kaplan JEdoi
10.1002/1097-0142(19930615)71:12<4072::aid-cncr282subject
Has Abstractpub_date
1993-06-15 00:00:00pages
4072-6issue
12eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
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