Breast cancer.


BACKGROUND:Breast cancer is the most common cancer and the second leading cause of cancer death among women in the United States; annual breast cancer deaths are exceeded only by those for lung cancer. METHODS:Data from the Surveillance, Epidemiology, and End Results (SEER) program registry of the National Cancer Institute comprising 158,621 invasive and 10,639 in situ cases of microscopically confirmed breast carcinomas registered for the years 1973-1987 have been analyzed. Relative frequencies, incidence rates, and 5-year relative survival rates were examined by selected variables of interest. Invasive and in situ breast carcinomas and sarcomas were analyzed separately. RESULTS:Infiltrating duct carcinoma was the largest group of female breast cancer, constituting 67.9% of the total with a 5-year relative survival of 79%. All other invasive carcinomas were compared with this group. Lobular carcinoma was the second largest group, only 6.3%, and a 5-year relative survival of 84%. Medullary carcinoma was the third most common with 2.8% and a 5-year relative survival of 82%. Other types included mucinous (colloid) adenocarcinoma, 2.2%, 5-year relative survival of 95%; comedocarcinoma, 1.4%, 5-year relative survival of 87%; Paget's disease (nipple and other breast), 1.1%, 5-year relative survival of 79%; papillary carcinoma, 0.9%, 5-year relative survival of 95%; tubular adenocarcinoma, 0.7%, 5-year relative survival of 96% and inflammatory carcinoma, 0.5%, 5-year relative survival of 18%. Carcinoma in situ was registered as intraductal, lobular, combined ductal and lobular, papillary, and carcinoma in situ, not otherwise specified. The relative survival for all forms of carcinomas in situ was approximately 100%. Sarcomas and malignant tumors not further classified are also considered. CONCLUSIONS:The various histologic types of breast cancer exhibit differences in regard to relative frequency, site pattern within the breast, and patient survival. The SEER program data base of breast cancer is the largest single population-based reference source for breast cancer in the United States. This program is a valuable resource for information on frequency, percentage, and incidence rates by histologic type as well as survival rates of patients with breast cancer.






Berg JW,Hutter RV




Has Abstract


1995-01-01 00:00:00




1 Suppl










  • Surgical palliation for recurrent rectal cancers ulcerating in the perineum.

    abstract::This report describes a unique palliative approach of radical surgical debridement for uncontrollable, recurrent pelvic tumors ulcerating through the perineum. All conservative treatment attempts with radiotherapy and chemotherapy had failed. Seven patients have been treated with resection of the tumor including a por...


    pub_type: 杂志文章


    authors: Temple WJ,Ketcham AS

    更新日期:1990-03-01 00:00:00

  • Racial disparities in postmastectomy breast reconstruction: National trends in utilization from 2005 to 2014.

    abstract:BACKGROUND:Evidence of racial disparities in the receipt of postmastectomy breast reconstruction is well documented. The objective of this study was to describe trends in racial disparities overall and by reconstructive technique. METHODS:The American College of Surgeons National Surgical Quality Improvement Program d...


    pub_type: 杂志文章


    authors: Epstein S,Tran BN,Cohen JB,Lin SJ,Singhal D,Lee BT

    更新日期:2018-07-01 00:00:00

  • Ultrasound examination of regional lymph nodes significantly improves early detection of locoregional metastases during the follow-up of patients with cutaneous melanoma: results of a prospective study of 1288 patients.

    abstract:BACKGROUND:In regional lymph node metastasis of cutaneous melanoma, the number and volume of involved lymph nodes are the most important prognostic factors. Several studies have revealed that palpation of the lymphatic drainage area(s) and regional lymph nodes has a high rate of false-negative results during follow-up....


    pub_type: 杂志文章


    authors: Blum A,Schlagenhauff B,Stroebel W,Breuninger H,Rassner G,Garbe C

    更新日期:2000-06-01 00:00:00

  • Prophylaxis in ovarian cancer.

    abstract::The only prophylaxis for ovarian cancer is oophorectomy, except in the very rare case when an ovarian cancer appears to arise from the mesothelial tissue of the abdominal cavity. It has been shown that women who have taken the oral contraceptive pill for 4 or 5 years decreases the incidence of ovarian cancer by approx...


    pub_type: 杂志文章


    authors: Barber HR

    更新日期:1993-02-15 00:00:00

  • A prospective, observational cohort study comparing cancer clinical trial availability and enrollment between early adolescents/young adults and children.

    abstract:BACKGROUND:Poor enrollment of adolescents and young adults (AYAs) (ages 15-39 years) onto cancer clinical trials (CCTs) may contribute to inferior survival gains compared with children. In this study, the authors assessed whether differences in CCT availability would explain lower CCT enrollment for early AYAs (eAYAs) ...


    pub_type: 杂志文章


    authors: Thomas SM,Malvar J,Tran H,Shows J,Freyer DR

    更新日期:2018-03-01 00:00:00

  • A phase 2 study of estramustine, docetaxel, and bevacizumab in men with castrate-resistant prostate cancer: results from Cancer and Leukemia Group B Study 90006.

    abstract:BACKGROUND:The use of docetaxel prolongs survival for patients with castrate-resistant prostate cancer (CRPC). Inhibition of vascular endothelial growth factor (VEGF) with bevacizumab may further enhance the antitumor effect of docetaxel and estramustine in patients with CRPC. METHODS:This cooperative group trial enro...


    pub_type: 杂志文章,多中心研究


    authors: Picus J,Halabi S,Kelly WK,Vogelzang NJ,Whang YE,Kaplan EB,Stadler WM,Small EJ,Cancer and Leukemia Group B.

    更新日期:2011-02-01 00:00:00

  • Pathology correlates of a Papanicolaou diagnosis of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion.

    abstract:BACKGROUND:The objective of this study was to compare findings after a cytologic report of low-grade squamous intraepithelial lesion, cannot exclude high-grade squamous intraepithelial lesion (LSIL-H) with findings after a report of low-grade squamous intraepithelial lesion (LSIL). METHODS:A review of patient records ...


    pub_type: 杂志文章


    authors: Al-Nourhji O,Beckmann MJ,Markwell SJ,Massad LS

    更新日期:2008-12-25 00:00:00

  • SARC025 arms 1 and 2: A phase 1 study of the poly(ADP-ribose) polymerase inhibitor niraparib with temozolomide or irinotecan in patients with advanced Ewing sarcoma.

    abstract:BACKGROUND:In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomid...


    pub_type: 杂志文章


    authors: Chugh R,Ballman KV,Helman LJ,Patel S,Whelan JS,Widemann B,Lu Y,Hawkins DS,Mascarenhas L,Glod JW,Ji J,Zhang Y,Reinke D,Strauss SJ

    更新日期:2020-12-08 00:00:00

  • Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA.

    abstract:BACKGROUND:Biomarker-guided clinical trials are increasingly common in metastatic urothelial carcinoma (mUC), yet patients for whom contemporary tumor tissue is not available are not eligible. Technological advancements in sequencing have made cell-free circulating DNA (cfDNA) next-generation sequencing (NGS) readily a...


    pub_type: 杂志文章


    authors: Agarwal N,Pal SK,Hahn AW,Nussenzveig RH,Pond GR,Gupta SV,Wang J,Bilen MA,Naik G,Ghatalia P,Hoimes CJ,Gopalakrishnan D,Barata PC,Drakaki A,Faltas BM,Kiedrowski LA,Lanman RB,Nagy RJ,Vogelzang NJ,Boucher KM,Vaishampa

    更新日期:2018-05-15 00:00:00

  • Risk of oral tongue cancer among immunocompromised transplant recipients and human immunodeficiency virus-infected individuals in the United States.

    abstract:BACKGROUND:Oral tongue cancer incidence has increased among whites in the United States; however, the cause remains unknown. If an infectious agent is implicated, then elevated risk would be expected among immunosuppressed individuals. METHODS:By using population-based registry linkage information from the US Transpla...


    pub_type: 杂志文章


    authors: Tota JE,Engels EA,Madeleine MM,Clarke CA,Lynch CF,Ortiz AP,Hernandez BY,Chaturvedi AK

    更新日期:2018-06-15 00:00:00

  • Cyclophosphamide-induced hemorrhagic cystitis in children with leukemia.

    abstract::The records of 314 children with acute lymphocytic leukemia (ALL) were reviewed to determine the frequency, clinical and laboratory features; contributing factors; and prognosis of cyclophosphamide-induced hemorrhagic cystitis. Twenty-five well-documented cases of hemorrhagic cystitis were identified. While most of th...


    pub_type: 杂志文章


    authors: Lawrence HJ,Simone J,Aur RJ

    更新日期:1975-11-01 00:00:00

  • Childhood sarcomas and lymphomas. Characterization of new cell lines and search for type-C virus.

    abstract::Four cell lines were derived from childhood malignancies: rhabdomyosarcoma, sarcoma, lymphosarcoma and an American Burkitt's lymphoma. Cells of the four lines formed tumors in immunosuppressed newborn hamsters. The tumors had a microscopic appearance like that of the tumors from which the cell lines were derived. No ...


    pub_type: 杂志文章


    authors: McAllister RM,Nelson-Rees WA,Peer M,Laug WE,Isaacs H Jr,Gilden RV,Rongey RW,Gardner MB

    更新日期:1975-11-01 00:00:00

  • Pathologic classification of prostate carcinoma: the impact of margin status.

    abstract:BACKGROUND:A proposed pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen (PSA) era. The impact of margin status on the survival outcome of patients with otherwise organ-confined disease (i.e., without extraprostatic extension o...


    pub_type: 杂志文章


    authors: Blute ML,Bostwick DG,Seay TM,Martin SK,Slezak JM,Bergstralh EJ,Zincke H

    更新日期:1998-03-01 00:00:00

  • Onycholysis as a complication of systemic chemotherapy: report of five cases associated with prolonged weekly paclitaxel therapy and review of the literature.

    abstract:BACKGROUND:Onycholysis has been reported in association with the use of several noncytotoxic drugs and with chemotherapy in 135 patients. Onycholysis may be precipitated by exposure to ultraviolet radiation. METHODS:The authors studied 91 patients who received paclitaxel and 187 patients who received doxorubicin. RES...


    pub_type: 杂志文章,评审


    authors: Hussain S,Anderson DN,Salvatti ME,Adamson B,McManus M,Braverman AS

    更新日期:2000-05-15 00:00:00

  • Cost-effectiveness of systemic and regional chemotherapy for the treatment of patients with unresectable colorectal liver metastases.

    abstract:BACKGROUND:Management of unresectable colorectal liver metastases (CLM) can be by regional (hepatic arterial infusion [HAI]) or systemic chemotherapy, or by symptom control alone. In this study the costs of each type of management were related to clinical outcome in 134 patients with CLM. METHODS:The costs (both in te...


    pub_type: 杂志文章


    authors: Durand-Zaleski I,Earlam S,Fordy C,Davies M,Allen-Mersh TG

    更新日期:1998-09-01 00:00:00

  • Treatment of childhood acute lymphoblastic leukemia with delayed first intrathecal therapy and omission of prophylactic cranial irradiation: Results of the TPOG-ALL-2002 study.

    abstract:BACKGROUND:To eliminate cranial irradiation (CrRT)-related sequelae and to minimize the adverse impact of traumatic lumbar puncture (TLP) with blasts, the Taiwan Pediatric Oncology Group (TPOG) introduced a modified central nervous system (CNS)-directed regimen characterized by delayed triple intrathecal therapy (TIT) ...


    pub_type: 临床试验,杂志文章


    authors: Yeh TC,Liang DC,Hou JY,Jaing TH,Lin DT,Yang CP,Peng CT,Hung IJ,Lin KH,Hsiao CC,Jou ST,Chiou SS,Chen JS,Wang SC,Chang TK,Wu KH,Sheen JM,Yen HJ,Chen SH,Lu MY,Li MJ,Chang TT,Huang TH,Chang YH,Chen SH,Yang Y

    更新日期:2018-12-01 00:00:00

  • Racial disparities in breast carcinoma survival rates: seperating factors that affect diagnosis from factors that affect treatment.

    abstract:BACKGROUND:Black females have lower breast carcinoma survival rates compared with white females. One possible reason is that black females have more advanced-stage breast disease. Another factor may be racial differences in the utilization of cancer treatments. METHODS:The authors determined racial differences in 6-ye...


    pub_type: 杂志文章


    authors: Chu KC,Lamar CA,Freeman HP

    更新日期:2003-06-01 00:00:00

  • Carbon nanotube-enhanced thermal destruction of cancer cells in a noninvasive radiofrequency field.

    abstract:BACKGROUND:Single-walled carbon nanotubes (SWNTs) have remarkable physicochemical properties that may have several medical applications. The authors have discovered a novel property of SWNTs-heat release in a radiofrequency (RF) field-that they hypothesized may be used to produce thermal cytotoxicity in malignant cells...


    pub_type: 杂志文章


    authors: Gannon CJ,Cherukuri P,Yakobson BI,Cognet L,Kanzius JS,Kittrell C,Weisman RB,Pasquali M,Schmidt HK,Smalley RE,Curley SA

    更新日期:2007-12-15 00:00:00

  • K-ras mutations in incident sporadic colorectal adenomas.

    abstract:BACKGROUND:Although K-ras is the most frequently mutated protooncogene in colorectal carcinoma, the specific role and timing of K-ras mutations in colorectal carcinogenesis remains controversial. In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas tha...


    pub_type: 杂志文章


    authors: Barry EL,Baron JA,Grau MV,Wallace K,Haile RW

    更新日期:2006-03-01 00:00:00

  • Significance of urinary neopterin in patients with malignant tumors of the genitourinary tract.

    abstract::The urinary neopterin excretion was measured by high-performance liquid chromatography in 417 healthy subjects and in 76 patients with clinically and pathohistologically verified neoplasias of the urinary tract (bladder tumor, carcinoma of the prostate, and renal cell carcinoma). The patients with early tumor stages b...


    pub_type: 杂志文章


    authors: Aulitzky W,Frick J,Fuchs D,Hausen A,Reibnegger G,Wachter H

    更新日期:1985-03-01 00:00:00

  • Supratentorial gangliogliomas: histopathologic grading and tumor recurrence in 184 patients with a median follow-up of 8 years.

    abstract:BACKGROUND:Supratentorial gangliogliomas (GGs) are rare tumors of the central nervous system and are commonly associated with chronic seizures. To date, only case reports and small series of patients with short-term follow-up have been available for the assessment of the potential of GGs to recur and progress. METHODS...


    pub_type: 杂志文章


    authors: Luyken C,Blümcke I,Fimmers R,Urbach H,Wiestler OD,Schramm J

    更新日期:2004-07-01 00:00:00

  • Breast cancer patient advocacy: A qualitative study of the challenges and opportunities for civil society organizations in low-income and middle-income countries.

    abstract:BACKGROUND:Breast cancer advocacy movements, driven by advocate-led civil society organizations (CSOs), have proven to be a powerful force for the advancement of cancer control in high-income countries (HICs). However, although patient advocacy movements are growing in low-income and middle-income countries (LMICs) in ...


    pub_type: 杂志文章


    authors: Dvaladze A,Kizub DA,Cabanes A,Nakigudde G,Aguilar B,Zujewski JA,Duggan C,Anderson BO,Pritam Singh RK,Gralow JR

    更新日期:2020-05-15 00:00:00

  • Association of the highly prevalent TP53 R337H mutation with pediatric choroid plexus carcinoma and osteosarcoma in southeast Brazil.

    abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...


    pub_type: 杂志文章


    authors: Seidinger AL,Mastellaro MJ,Paschoal Fortes F,Godoy Assumpção J,Aparecida Cardinalli I,Aparecida Ganazza M,Correa Ribeiro R,Brandalise SR,Dos Santos Aguiar S,Yunes JA

    更新日期:2011-05-15 00:00:00

  • The frequency of a concomitant early esophageal cancer in male patients with oral and oropharyngeal cancer. Screening results using Lugol dye endoscopy.

    abstract:BACKGROUND:Male patients with oral and oropharyngeal cancer are known to have high risk of concomitant esophageal cancer developing. Thus, mass screening programs are pursued to detect such esophageal cancer early, and in a mass screening trial of patients with early oral and oropharyngeal cancer, the efficacy of Lugol...


    pub_type: 临床试验,杂志文章


    authors: Ina H,Shibuya H,Ohashi I,Kitagawa M

    更新日期:1994-04-15 00:00:00

  • Thoracoscopy in pleural malignant mesothelioma: a prospective study of 188 consecutive patients. Part 1: Diagnosis.

    abstract:BACKGROUND:To compare the diagnostic value of thoracoscopic biopsy, fluid cytology, and Abrams needle biopsy, the authors analyzed prospectively the records of 188 patients with malignant pleural mesothelioma examined between 1973 and 1990. Symptoms were pleural effusion in 173 patients, empyema in 1, spontaneous pneum...


    pub_type: 临床试验,杂志文章


    authors: Boutin C,Rey F

    更新日期:1993-07-15 00:00:00

  • Everolimus in combination with octreotide long-acting repeatable in a first-line setting for patients with neuroendocrine tumors: an ITMO group study.

    abstract:BACKGROUND:Preclinical and clinical studies suggest synergistic activity between somatostatin analogues and mammalian target of rapamycin inhibitors. The activity and safety of everolimus was assessed in combination with octreotide long-acting repeatable (LAR) in patients with neuroendocrine tumors (NETs) of gastroente...


    pub_type: 杂志文章,多中心研究


    authors: Bajetta E,Catena L,Fazio N,Pusceddu S,Biondani P,Blanco G,Ricci S,Aieta M,Pucci F,Valente M,Bianco N,Mauri CM,Spada F

    更新日期:2014-08-15 00:00:00

  • Cost-effectiveness of human papillomavirus vaccination for adolescent girls in Punjab state: Implications for India's universal immunization program.

    abstract:BACKGROUND:Introduction of human papillomavirus (HPV) vaccination for adolescent girls is being considered in the Punjab state of India. However, evidence regarding cost-effectiveness is sought by policy makers when making this decision. The current study was undertaken to evaluate the incremental cost per quality-adju...


    pub_type: 杂志文章


    authors: Prinja S,Bahuguna P,Faujdar DS,Jyani G,Srinivasan R,Ghoshal S,Suri V,Singh MP,Kumar R

    更新日期:2017-09-01 00:00:00

  • Feasibility and early results of accelerated radiotherapy for head and neck carcinoma in the elderly.

    abstract:BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...


    pub_type: 杂志文章


    authors: Allal AS,Maire D,Becker M,Dulguerov P

    更新日期:2000-02-01 00:00:00

  • Factor VIII related antigen in adenomatoid tumors: implications for histogenesis.

    abstract::The current study was undertaken to reevaluate the histogenesis of adenomatoid tumor by an immunoperoxidase method of detecting factor VIII related antigen, a tissue specific marker for vascular endothelium. Three of eight adenomatoid tumors showed diffuse cytoplasmic staining of the cells lining the lumina. When thes...


    pub_type: 杂志文章


    authors: Bell DA,Flotte TJ

    更新日期:1982-09-01 00:00:00

  • Quality of life and symptoms in a randomized trial of radiotherapy versus deferred treatment of localized prostate carcinoma.

    abstract:BACKGROUND:Treatment of localized prostate carcinoma (LPC) using radiotherapy (RT) can induce disturbances in a patient's quality of life (QOL) and urinary and intestinal function. Late symptoms and QOL were evaluated in a randomized trial between RT and deferred treatment (DT). METHODS:Quality of life was evaluated w...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fransson P,Damber JE,Tomic R,Modig H,Nyberg G,Widmark A

    更新日期:2001-12-15 00:00:00