HBAg-positive chronic liver disease associated with cirrhosis and hepatocellular carcinoma in the Senoi.

Abstract:

:Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirrhosis. All the 22 livers contained hepatocytes that stained with Shikata's orcein stain and specific immunoperoxidase and immunofluorescent stains for hepatitis B antigen (HBAg). This observation raises the strong possibility that hepatitis B may be an important etiologic factor in the development of cirrhosis and PHC in the Senoi. The reason for the high susceptibility of the Senoi for HB virus infection is not clear, and the role of aflatoxin in the pathogenesis of PHC in the Senoi has yet to be determined. That the Senoi are a numerically small community, maintaining their own unique dietary and social customs and living in readily accessible areas in the Malaysian jungle, makes them an ideal population for the study of factors in the etiology of liver cancer.

journal_name

Cancer

journal_title

Cancer

authors

Sumithran E,Prathap K

doi

10.1002/1097-0142(197710)40:4<1618::aid-cncr282040

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

1618-20

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

40

pub_type

杂志文章

相关文献

CANCER文献大全
  • Manipulating the chemokine-chemokine receptor network to treat cancer.

    abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/cncr.22706

    authors: Ruffini PA,Morandi P,Cabioglu N,Altundag K,Cristofanilli M

    更新日期:2007-06-15 00:00:00

  • Expression of alpha-3/4-monofucosylated polylactosaminoglycan epitope, as defined by monoclonal antibody FW6, is a marker of the colorectal adenoma-carcinoma sequence.

    abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207

    authors: Baldus SE,Vierbuchen M,Hanisch FG,Schwonzen M,Fischer R

    更新日期:1995-09-15 00:00:00

  • Pregnancy outcome in cancer patients. Experience in a large cooperative group.

    abstract::To evaluate the potential teratogenicity and mutagenicity of modern cancer treatment, the authors enumerated from a cooperative clinical trial group 133 pregnancies in 66 women with malignant neoplasms (53% with Hodgkin's disease, 26% with other lymphomas and leukemia, and 21% with solid tumors). The gestations were d...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870901)60:5<1143::aid-cncr2820

    authors: Mulvihill JJ,McKeen EA,Rosner F,Zarrabi MH

    更新日期:1987-09-01 00:00:00

  • Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.

    abstract::Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820

    authors: Athanassiou A,Begent RH,Newlands ES,Parker D,Rustin GJ,Bagshawe KD

    更新日期:1983-11-01 00:00:00

  • Hepatitis B related childhood hepatocellular carcinoma. Childhood hepatic malignancies.

    abstract::The case of hepatocellular carcinoma (HCC) with foci of hepatoblastoma in a 7-year-old boy, the son of a hepatitis B surface antigen (HBsAg) carrier mother, is described. Twelve other malignant liver tumors in children were tumors in children were also reviewed for HBsAg and hepatitis B core antigen (HBcAg). Both were...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870801)60:3<414::aid-cncr28206

    authors: De Potter CR,Robberecht E,Laureys G,Cuvelier CA

    更新日期:1987-08-01 00:00:00

  • Aggressive cutaneous malignancies following cardiothoracic transplantation: the Australian experience.

    abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Veness MJ,Quinn DI,Ong CS,Keogh AM,Macdonald PS,Cooper SG,Morgan GW

    更新日期:1999-04-15 00:00:00

  • Prognostic significance of HER-2/neu oncoprotein expression in node-positive breast cancer. The influence of the pattern of immunostaining and adjuvant therapy.

    abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/1097-0142(19940501)73:9<2359::aid-cncr2820

    authors: Têtu B,Brisson J

    更新日期:1994-05-01 00:00:00

  • DNA flow cytometry and pathologic grading as prognostic guides in axillary lymph node-negative breast cancer.

    abstract:BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19930915)72:6<1926::aid-cncr2820

    authors: Merkel DE,Winchester DJ,Goldschmidt RA,August CZ,Wruck DM,Rademaker AW

    更新日期:1993-09-15 00:00:00

  • Humoral hypercalcemia in patients with colorectal carcinoma: report of two cases and review of the literature.

    abstract:BACKGROUND:Humoral hypercalcemia rarely is associated with colorectal carcinoma; to the authors' knowledge only nine cases have been reported to date. METHODS:Two cases of advanced colorectal carcinoma with humoral hypercalcemia of malignancy (HHM) are presented. RESULTS:The two patients had severe hypercalcemia with...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:

    authors: Lortholary AH,Cadeau SD,Bertrand GM,Guerin-Meyer VI,Gamelin EC,Audran MJ

    更新日期:1999-12-01 00:00:00

  • Detection of circulating prostate carcinoma cells via an enhanced reverse transcriptase-polymerase chain reaction assay in patients with early stage prostate carcinoma. Independence from other pretreatment characteristics.

    abstract:BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19970615)79:12<2402::aid-c

    authors: Ennis RD,Katz AE,de Vries GM,Heitjan DF,O'Toole KM,Rubin M,Buttyan R,Benson MC,Schiff PB

    更新日期:1997-06-15 00:00:00

  • Cerebral metastases from ovarian carcinoma.

    abstract::Apart from choriocarcinoma, involvement of the central nervous system (CNS) by gynecologic malignancy is rare. A 10-year retrospective review at the University of Washington Medical Center (Seattle, WA) and Swedish Hospital and Medical Center Tumor Registry (Seattle, WA) identified 14 patients with cerebral metastases...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910415)67:8<2194::aid-cncr2820

    authors: LeRoux PD,Berger MS,Elliott JP,Tamimi HK

    更新日期:1991-04-15 00:00:00

  • Isolated limb reperfusion with tumor necrosis factor and melphalan in patients with extremity melanoma after failure of isolated limb perfusion with chemotherapeutics.

    abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c

    authors: Bartlett DL,Ma G,Alexander HR,Libutti SK,Fraker DL

    更新日期:1997-12-01 00:00:00

  • Embryonal craniopharyngioma. Case report of the morphogenesis of a craniopharyngioma.

    abstract:BACKGROUND:Ordinary craniopharyngiomas affecting sellar regions of children and preadolescents are composed of ameloblastomatous and/or squamous constituents. The authors encountered an autopsy case of a stillborn infant with a large craniopharyngioma with unusual manifestations. METHODS:The craniopharyngioma was anal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950615)75:12<2971::aid-cncr282

    authors: Yamada H,Haratake J,Narasaki T,Oda T

    更新日期:1995-06-15 00:00:00

  • Multimodal immunotherapy of primary gastrointestinal tumors in rats. 1. Histologic correlation.

    abstract::The effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Multimodal immune manipulation consisted of combinations of splenectomy, C. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. Such immunologic intervent...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197811)42:5<2079::aid-cncr282042

    authors: Bansal BR,Mobini J,Bansal SC

    更新日期:1978-11-01 00:00:00

  • Predictors of survival in patients with carcinoma of the gallbladder.

    abstract:BACKGROUND:The role of resectional surgery in patients with advanced stages of gallbladder carcinoma has not been fully defined. It is generally believed that the survival depends on the stage of the disease, rather than on the treatment option. METHODS:Seventeen selected risk factors were analyzed using univariate an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19951001)76:7<1145::aid-cncr2820

    authors: Pradeep R,Kaushik SP,Sikora SS,Bhattacharya BN,Pandey CM,Kapoor VK

    更新日期:1995-10-01 00:00:00

  • Familial intraocular malignant melanoma: a case report.

    abstract::A family with histopathologically proven intraocular malignant melanoma involving two generations is reported. A member of third generation was likely involved by history. Intraocular malignant melanoma, its familial occurrence, its occurrence with multiple malignancies, and its relationship to multiple malignancies o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197806)41:6<2481::aid-cncr282041

    authors: Green GJ,Hong WK,Everett JR,Bhutani R,Amick RM

    更新日期:1978-06-01 00:00:00

  • Proton therapy for low-grade gliomas: Results from a prospective trial.

    abstract:BACKGROUND:In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS:Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy we...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/cncr.29237

    authors: Shih HA,Sherman JC,Nachtigall LB,Colvin MK,Fullerton BC,Daartz J,Winrich BK,Batchelor TT,Thornton LT,Mancuso SM,Saums MK,Oh KS,Curry WT,Loeffler JS,Yeap BY

    更新日期:2015-05-15 00:00:00

  • Steroid receptors and response to endocrine ablations in women with metastatic cancer of the breast.

    abstract::Estrogen receptors in breast tumors were assayed in 55 premenopausal women undergoing bilateral oophorectomy and in 120 postmenopausal women undergoing bilateral adrenalectomy for treatment of metastatic breast cancer. The data show that 20 (60%) of the 32 patients with estrogen receptor-positive (ER+) tumors had obje...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19801215)46:12+<2779::aid-cncr28

    authors: Dao TL,Nemoto T

    更新日期:1980-12-15 00:00:00

  • Obesity is associated with breast cancer in African-American women but not Hispanic women in South Los Angeles.

    abstract:BACKGROUND:Obesity is considered a risk factor for breast cancer. Modifying life styles that reduce obesity offers the potential for prevention and improved outcomes from cancer. The effects of obesity and breast cancer among African-American women and Hispanic women have been explored in a limited number of studies. T...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25956

    authors: Sarkissyan M,Wu Y,Vadgama JV

    更新日期:2011-08-15 00:00:00

  • Phase II study of high-dose tamoxifen (NSC-180973) in patients with disseminated malignant melanoma.

    abstract::Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820401)49:7<1353::aid-cncr2820

    authors: Creagan ET,Ingle JN,Ahmann DL,Green SJ

    更新日期:1982-04-01 00:00:00

  • Chemoprevention of bladder cancer.

    abstract::There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene, vitamins C and E, and...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19870801)60:3+<650::aid-cncr2820

    authors: Malone WF,Kelloff GJ,Pierson H,Greenwald P

    更新日期:1987-08-01 00:00:00

  • Mesothelioma following Wilms' tumor in childhood.

    abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205

    authors: Antman KH,Ruxer RL Jr,Aisner J,Vawter G

    更新日期:1984-07-15 00:00:00

  • Use of p63 for distinction of glandular versus squamous lesions in cervicovaginal specimens.

    abstract:BACKGROUND:Differentiating primary glandular from high-grade squamous intraepithelial lesions (HSIL) that involve endocervical glands is not an uncommon diagnostic problem in liquid-based gynecological cytology. Squamous and atypical glandular cell lesions may show similar cytomorphologic features. The aim of this stud...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22419

    authors: Garcia MT,Acar BC,Jorda M,Gomez-Fernandez C,Ganjei-Azar P

    更新日期:2007-02-25 00:00:00

  • Calcium channel blockers, cancer incidence, and cancer mortality in a cohort of U.S. women: the nurses' health study.

    abstract:BACKGROUND:Some studies have suggested that the use of calcium channel blockers may increase the risk of cancer. A possible association of the use of calcium channel blockers with cancer incidence and cancer mortality was addressed using data from the Nurses' Health Study. METHODS:In this study, a total of 18,635 fema...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Michels KB,Rosner BA,Walker AM,Stampfer MJ,Manson JE,Colditz GA,Hennekens CH,Willett WC

    更新日期:1998-11-01 00:00:00

  • The association between soft tissue sarcomas and exposure to phenoxyacetic acids. A new case-referent study.

    abstract::A case-referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty-five male STS patients were thereby compared with 220 living and 110 dead population-based refe...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19880801)62:3<652::aid-cncr28206

    authors: Hardell L,Eriksson M

    更新日期:1988-08-01 00:00:00

  • Second solid cancers after allogeneic hematopoietic stem cell transplantation.

    abstract:BACKGROUND:The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:The authors reviewed the case files of 926 consecutive patients who underwent allo-HSCT at their institution b...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22375

    authors: Gallagher G,Forrest DL

    更新日期:2007-01-01 00:00:00

  • Characteristics of long-term survivors with multiple myeloma: A National Cancer Data Base analysis.

    abstract:BACKGROUND:There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). METHODS:The National Cancer ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32357

    authors: Hsieh RW,Go RS,Abeykoon JP,Kapoor P,Kumar SK,Gertz MA,Buadi FK,Leung N,Gonsalves WI,Kourelis TV,Warsame RM,Dispenzieri A,Lacy MQ,Kyle RA,Rajkumar SV,Paludo J

    更新日期:2019-10-15 00:00:00

  • Relationship between 5-fluorouracil (5-FU) dose intensity and therapeutic response in patients with advanced colorectal cancer receiving infusional therapy containing 5-FU.

    abstract:BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(SICI)1097-0142(19960201)77:3<441::AID-CNC

    authors: Gamelin EC,Danquechin-Dorval EM,Dumesnil YF,Maillart PJ,Goudier MJ,Burtin PC,Delva RG,Lortholary AH,Gesta PH,Larra FG

    更新日期:1996-02-01 00:00:00

  • Treatment for lymphedema of the arm--the Casley-Smith method: a noninvasive method produces continued reduction.

    abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid

    authors: Casley-Smith JR,Boris M,Weindorf S,Lasinski B

    更新日期:1998-12-15 00:00:00

  • A pilot study of interleukin-2 for adult patients with acute myelogenous leukemia in first complete remission.

    abstract:BACKGROUND:Interleukin-2 (IL-2) has immunomodulatory effects, including stimulating the activity of cytotoxic T cells and natural killer cells, and inducing the generation of lymphokine-activated killer cells. The authors investigated whether IL-2 may improve the duration of complete remission (CR) and survival in acut...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,评审

    doi:

    authors: Cortes JE,Kantarjian HM,O'Brien S,Giles F,Keating MJ,Freireich EJ,Estey EH

    更新日期:1999-04-01 00:00:00