Abstract:
:Necropsy and clinical data show that primary hepatocellular carcinoma (PHC) is the commonest cancer among the Senoi (a Malaysian aboringine group). The other aboringine tribes do not appear to have this high predilection for liver cancer. In the necropsy series, PHS was present in 10 out of 22 Senoi patients with cirrhosis. All the 22 livers contained hepatocytes that stained with Shikata's orcein stain and specific immunoperoxidase and immunofluorescent stains for hepatitis B antigen (HBAg). This observation raises the strong possibility that hepatitis B may be an important etiologic factor in the development of cirrhosis and PHC in the Senoi. The reason for the high susceptibility of the Senoi for HB virus infection is not clear, and the role of aflatoxin in the pathogenesis of PHC in the Senoi has yet to be determined. That the Senoi are a numerically small community, maintaining their own unique dietary and social customs and living in readily accessible areas in the Malaysian jungle, makes them an ideal population for the study of factors in the etiology of liver cancer.
journal_name
Cancerjournal_title
Cancerauthors
Sumithran E,Prathap Kdoi
10.1002/1097-0142(197710)40:4<1618::aid-cncr282040subject
Has Abstractpub_date
1977-10-01 00:00:00pages
1618-20issue
4eissn
0008-543Xissn
1097-0142journal_volume
40pub_type
杂志文章相关文献
CANCER文献大全abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22706
更新日期:2007-06-15 00:00:00
abstract:BACKGROUND:The expression of a distinct alpha-3/4-monofucosylated polylactosaminoglycan epitope, which is detected by monoclonal antibody FW6, was investigated by comparative immunohistochemical analysis of colorectal tissue specimens exhibiting different grades of premalignant and malignant transformation. The presenc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950915)76:6<954::aid-cncr28207
更新日期:1995-09-15 00:00:00
abstract::To evaluate the potential teratogenicity and mutagenicity of modern cancer treatment, the authors enumerated from a cooperative clinical trial group 133 pregnancies in 66 women with malignant neoplasms (53% with Hodgkin's disease, 26% with other lymphomas and leukemia, and 21% with solid tumors). The gestations were d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870901)60:5<1143::aid-cncr2820
更新日期:1987-09-01 00:00:00
abstract::Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820
更新日期:1983-11-01 00:00:00
abstract::The case of hepatocellular carcinoma (HCC) with foci of hepatoblastoma in a 7-year-old boy, the son of a hepatitis B surface antigen (HBsAg) carrier mother, is described. Twelve other malignant liver tumors in children were tumors in children were also reviewed for HBsAg and hepatitis B core antigen (HBcAg). Both were...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3<414::aid-cncr28206
更新日期:1987-08-01 00:00:00
abstract:BACKGROUND:The development of malignancies in recipients of a cardiothoracic transplant (CTT)--that is, heart, lung, or heart and lung recipients-is of concern. Cutaneous and lymphoproliferative malignancies comprise the two major groups of malignancies encountered. A small subgroup of patients will develop potentially...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-04-15 00:00:00
abstract:BACKGROUND:The influence of HER-2/neu on prognosis of breast cancer is controversial. The authors investigated by immunohistochemistry in node-positive disease the influence of the pattern of immunostaining (membranous or cytoplasmic) on outcome and the prognostic significance of this marker in patients receiving or no...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/1097-0142(19940501)73:9<2359::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract:BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930915)72:6<1926::aid-cncr2820
更新日期:1993-09-15 00:00:00
abstract:BACKGROUND:Humoral hypercalcemia rarely is associated with colorectal carcinoma; to the authors' knowledge only nine cases have been reported to date. METHODS:Two cases of advanced colorectal carcinoma with humoral hypercalcemia of malignancy (HHM) are presented. RESULTS:The two patients had severe hypercalcemia with...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1999-12-01 00:00:00
abstract:BACKGROUND:Circulating prostate cells can be detected in the venous blood of patients with clinically localized prostate carcinoma by applying reverse transcriptase-polymerase chain reaction (RT-PCR) techniques using primers specific for the prostate specific antigen (PSA) gene. This study evaluates whether the detecti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19970615)79:12<2402::aid-c
更新日期:1997-06-15 00:00:00
abstract::Apart from choriocarcinoma, involvement of the central nervous system (CNS) by gynecologic malignancy is rare. A 10-year retrospective review at the University of Washington Medical Center (Seattle, WA) and Swedish Hospital and Medical Center Tumor Registry (Seattle, WA) identified 14 patients with cerebral metastases...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910415)67:8<2194::aid-cncr2820
更新日期:1991-04-15 00:00:00
abstract:BACKGROUND:This retrospective study evaluated the benefit of using tumor necrosis factor (TNF) and melphalan administered via an isolated limb perfusion (ILP) in a series of patients with metastatic melanoma who failed initial ILP with chemotherapeutics. METHODS:Seventeen patients with extremity melanoma who underwent...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971201)80:11<2084::aid-c
更新日期:1997-12-01 00:00:00
abstract:BACKGROUND:Ordinary craniopharyngiomas affecting sellar regions of children and preadolescents are composed of ameloblastomatous and/or squamous constituents. The authors encountered an autopsy case of a stillborn infant with a large craniopharyngioma with unusual manifestations. METHODS:The craniopharyngioma was anal...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950615)75:12<2971::aid-cncr282
更新日期:1995-06-15 00:00:00
abstract::The effect of multimodal immunotherapy was studied in rats bearing primary gastrointestinal tumors induced by 1,2-dimethylhydrazine dihydrochloride. Multimodal immune manipulation consisted of combinations of splenectomy, C. parvum, unblocking serum, unblocked lymphoid cells, and levamisole. Such immunologic intervent...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197811)42:5<2079::aid-cncr282042
更新日期:1978-11-01 00:00:00
abstract:BACKGROUND:The role of resectional surgery in patients with advanced stages of gallbladder carcinoma has not been fully defined. It is generally believed that the survival depends on the stage of the disease, rather than on the treatment option. METHODS:Seventeen selected risk factors were analyzed using univariate an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19951001)76:7<1145::aid-cncr2820
更新日期:1995-10-01 00:00:00
abstract::A family with histopathologically proven intraocular malignant melanoma involving two generations is reported. A member of third generation was likely involved by history. Intraocular malignant melanoma, its familial occurrence, its occurrence with multiple malignancies, and its relationship to multiple malignancies o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197806)41:6<2481::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS:Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy we...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.29237
更新日期:2015-05-15 00:00:00
abstract::Estrogen receptors in breast tumors were assayed in 55 premenopausal women undergoing bilateral oophorectomy and in 120 postmenopausal women undergoing bilateral adrenalectomy for treatment of metastatic breast cancer. The data show that 20 (60%) of the 32 patients with estrogen receptor-positive (ER+) tumors had obje...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801215)46:12+<2779::aid-cncr28
更新日期:1980-12-15 00:00:00
abstract:BACKGROUND:Obesity is considered a risk factor for breast cancer. Modifying life styles that reduce obesity offers the potential for prevention and improved outcomes from cancer. The effects of obesity and breast cancer among African-American women and Hispanic women have been explored in a limited number of studies. T...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25956
更新日期:2011-08-15 00:00:00
abstract::Seventeen patients with disseminated malignant melanoma received a daily oral regimen of tamoxifen, 100 mg/m2. All patients had prior chemotherapy and predominantly visceral involvement. None of the patients had an objective regression and most (71%) had progressive disease at the time of first reassessment. Moderate ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820401)49:7<1353::aid-cncr2820
更新日期:1982-04-01 00:00:00
abstract::There is a growing body of basic science and epidemiologic evidence to support a research thrust to determine whether several natural or synthetic agents, given alone or together, can lower cancer incidence. Candidate agents include analogs of vitamin A and the vitamin A precursor, beta-carotene, vitamins C and E, and...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19870801)60:3+<650::aid-cncr2820
更新日期:1987-08-01 00:00:00
abstract::A high percentage of children with Wilms' tumor are cured with multimodal treatment. A small percentage of these children will develop second tumors, perhaps related to a genetic predisposition to neoplasia or possibly secondary to the treatment utilized for Wilms' tumor. Malignant mesothelioma has been associated wit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840715)54:2<367::aid-cncr28205
更新日期:1984-07-15 00:00:00
abstract:BACKGROUND:Differentiating primary glandular from high-grade squamous intraepithelial lesions (HSIL) that involve endocervical glands is not an uncommon diagnostic problem in liquid-based gynecological cytology. Squamous and atypical glandular cell lesions may show similar cytomorphologic features. The aim of this stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22419
更新日期:2007-02-25 00:00:00
abstract:BACKGROUND:Some studies have suggested that the use of calcium channel blockers may increase the risk of cancer. A possible association of the use of calcium channel blockers with cancer incidence and cancer mortality was addressed using data from the Nurses' Health Study. METHODS:In this study, a total of 18,635 fema...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-11-01 00:00:00
abstract::A case-referent study on soft tissue sarcomas (STS) was conducted, to see if previous findings regarding an association between exposure to phenoxyacetic acids or chlorophenols and this tumor type could be reproduced. Fifty-five male STS patients were thereby compared with 220 living and 110 dead population-based refe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880801)62:3<652::aid-cncr28206
更新日期:1988-08-01 00:00:00
abstract:BACKGROUND:The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:The authors reviewed the case files of 926 consecutive patients who underwent allo-HSCT at their institution b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22375
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). METHODS:The National Cancer ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32357
更新日期:2019-10-15 00:00:00
abstract:BACKGROUND:A phase II prospective trial was carried out to study the concept of 5-fluorouracil (5-FU) dose-intensity in patients with advanced colorectal cancer. Forty patients were treated with 5-FU plus leucovorin (LV), with individually increasing doses of 5-FU. A 5-FU pharmacokinetic follow up was performed and a r...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(SICI)1097-0142(19960201)77:3<441::AID-CNC
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) has immunomodulatory effects, including stimulating the activity of cytotoxic T cells and natural killer cells, and inducing the generation of lymphokine-activated killer cells. The authors investigated whether IL-2 may improve the duration of complete remission (CR) and survival in acut...
journal_title:Cancer
pub_type: 临床试验,杂志文章,评审
doi:
更新日期:1999-04-01 00:00:00