Multiple primary malignant neoplasms in breast cancer patients in Israel.

Abstract:

:The data of an epidemiologic study of multiple primary malignant neoplasms in breast cancer patients in Israel are presented. During the 18-year period of the study 12,302 cases of breast carcinoma were diagnosed, and, of these, 984 patients (8%) had multiple primary malignant tumors. Forty-seven of these patients developed two multiple primary cancers. A significantly higher than expected incidence of second primary cancers occurred at the following five sites: the opposite breast, salivary glands, uterine corpus, ovary, and thyroid. Cancers of the stomach and gallbladder were fewer than expected. Treatment of the breast cancer by irradiation was associated with an increased risk of subsequent cancers of lung and hematopoietic system. The prognosis was mainly influenced by the site and malignancy of the second primary cancer. The incidence of multiple primary malignancies justifies a high level of alertness to this possibility in the follow-up of breast cancer patients.

journal_name

Cancer

journal_title

Cancer

authors

Schenker JG,Levinsky R,Ohel G

doi

10.1002/1097-0142(19840701)54:1<139::aid-cncr28205

subject

Has Abstract

pub_date

1984-07-01 00:00:00

pages

145-50

issue

1

eissn

0008-543X

issn

1097-0142

journal_volume

54

pub_type

杂志文章

相关文献

CANCER文献大全
  • Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma.

    abstract:BACKGROUND:Diagnosis of nasopharyngeal carcinoma (NPC) at an early disease stage is important for successful treatment and improving the outcome of patients. The use of serum protein profiles and a classification tree algorithm were explored to distinguish NPC from noncancer. METHODS:Serum samples were applied to meta...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21970

    authors: Ho DW,Yang ZF,Wong BY,Kwong DL,Sham JS,Wei WI,Yuen AP

    更新日期:2006-07-01 00:00:00

  • Etiology of gastric remnant cancer with special reference to the effects of denervation of the gastric mucosa.

    abstract:BACKGROUND:Gastric mucosal blood flow, secretion of mucin, and renewal of the gastric mucosal cells are considered to be defensive factors against gastric mucosal injuries. These factors are regulated by the nervous system and neuropeptides. Gastrectomy may affect this regulation and induce gastric mucosal changes, suc...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950315)75:6+<1490::aid-cncr282

    authors: Kaminishi M,Shimizu N,Shiomoyama S,Yamaguchi H,Ogawa T,Sakai S,Kuramoto S,Oohara T

    更新日期:1995-03-15 00:00:00

  • Absence of V599E BRAF mutations in desmoplastic melanomas.

    abstract:BACKGROUND:Desmoplastic melanoma is an uncommon variant of cutaneous melanoma that mimics soft tissue sarcoma both clinically and morphologically. An activating point mutation of the BRAF oncogene has been identified in a high proportion of conventional cutaneous melanomas, but its frequency in the desmoplastic subtype...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20861

    authors: Davison JM,Rosenbaum E,Barrett TL,Goldenberg D,Hoque MO,Sidransky D,Westra WH

    更新日期:2005-02-15 00:00:00

  • Radiation recall skin toxicity with bleomycin in a patient with Kaposi sarcoma related to acquired immune deficiency syndrome.

    abstract:BACKGROUND:Radiation recall is a recurrence of acute toxicity within a previously quiescent radiation field that occurs with subsequent administration of chemotherapy. METHODS:A patient with acquired immune deficiency syndrome (AIDS)-related Kaposi sarcoma (KS) who had radiation recall is reported. The patient was par...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19930215)71:4<1322::aid-cncr2820

    authors: Stelzer KJ,Griffin TW,Koh WJ

    更新日期:1993-02-15 00:00:00

  • Remission of rapidly growing desmoid tumors after tamoxifen therapy.

    abstract::A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbeari...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831215)52:12<2201::aid-cncr282

    authors: Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJ

    更新日期:1983-12-15 00:00:00

  • Metronomic therapy with cyclophosphamide and dexamethasone for prostate carcinoma.

    abstract:BACKGROUND:The current study was designed to evaluate the efficacy and toxicity of the continuous oral administration of a combination of cyclophosphamide (50 mg/day given in the morning) and dexamethasone (1 mg/day given in the evening) in patients with prostate specific antigen (PSA) progression despite single or mul...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11713

    authors: Glode LM,Barqawi A,Crighton F,Crawford ED,Kerbel R

    更新日期:2003-10-15 00:00:00

  • Cell proliferative activity in adenomatous hyperplasia of the liver and small hepatocellular carcinoma. An immunohistochemical study demonstrating proliferating cell nuclear antigen.

    abstract:BACKGROUND:Recently, adenomatous hyperplasia (AH) of the liver, a sizable parenchymal nodule in the cirrhotic liver, has been considered a preneoplastic lesion in human hepatocarcinogenesis. METHODS:The authors evaluated cell proliferative activity by immunostaining for proliferating cell nuclear antigen (PCNA) in AH ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920801)70:3<591::aid-cncr28207

    authors: Terada T,Nakanuma Y

    更新日期:1992-08-01 00:00:00

  • Significance of plasma PTH-rp in patients with hypercalcemia of malignancy treated with bisphosphonate.

    abstract:BACKGROUND:Hypercalcemia of malignancy (HM) is one of the commonest metabolic complications associated with cancer. Plasma parathyroid hormone-related peptide (PTH-rp) is known to cause hypercalcemia in the vast majority of patients with HM. METHODS:Fifty-two patients with HM were treated with a single infusion of 60 ...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(19940415)73:8<2223::aid-cncr2820

    authors: Wimalawansa SJ

    更新日期:1994-04-15 00:00:00

  • Different age limits for elderly patients with indolent and aggressive non-hodgkin lymphoma and the role of relative survival with increasing age.

    abstract:BACKGROUND:There is no consistent definition at what age patients with non-Hodgkin lymphoma (NHL) are considered "elderly." This might hamper well balanced decisions with respect to treatment. METHODS:From a population-based NHL registry the age groups younger than 60 years, 60-64 years, 65-69 years, 70-74 years, and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(20001215)89:12<2667::aid-cncr21>

    authors: Maartense E,Kluin-Nelemans HC,le Cessie S,Kluin PM,Snijder S,Noordijk EM

    更新日期:2000-12-15 00:00:00

  • Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital.

    abstract::Between 1957 and February 1981, 782 patients received cytotoxic chemotherapy for gestational trophoblastic tumors (GTT) in the Department of Medical Oncology, Charing Cross Hospital (London, England). Sixty-nine (8.8%) patients had central nervous system (CNS) metastases. Thirty-three of them (48%) presented with CNS ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831101)52:9<1728::aid-cncr2820

    authors: Athanassiou A,Begent RH,Newlands ES,Parker D,Rustin GJ,Bagshawe KD

    更新日期:1983-11-01 00:00:00

  • A comparison of cancer risk in Crohn's disease and ulcerative colitis.

    abstract::The authors estimated cancer risk among 589 patients hospitalized with Crohn's disease between 1960-1976 by calculating the ratios of observed number of cancers (O) in our hospital sample to the expected number of cancers (E) based on the age- and sex-specific cancer rates of a standard population. The authors then co...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19811215)48:12<2742::aid-cncr282

    authors: Greenstein AJ,Sachar DB,Smith H,Janowitz HD,Aufses AH Jr

    更新日期:1981-12-15 00:00:00

  • Glandular cardiac myxomas. Histologic, immunohistochemical, and ultrastructural evidence of epithelial differentiation.

    abstract::Histologic, histochemical, immunocytochemical, and ultrastructural features of two cardiac myxomas containing glandular elements are reported. Glandular elements in both cases stained positively with both mucicarmine and periodic acid-Schiff reagent with diastase pretreatment (DPAS). Immunoperoxidase studies demonstra...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870515)59:10<1767::aid-cncr282

    authors: Goldman BI,Frydman C,Harpaz N,Ryan SF,Loiterman D

    更新日期:1987-05-15 00:00:00

  • The impact of conventional plus high dose chemotherapy with autologous bone marrow transplantation on hematologic toxicity during subsequent local-regional radiotherapy for breast cancer.

    abstract:BACKGROUND:Forty patients with Stage II-III breast cancer with 10 or more positive axillary nodes were treated with mastectomy followed by four cycles of standard dose CAF (cytoxan, Adriamycin, 5-FU), followed by high dose cytoxan, cisplatin, carmustine (HDCT) with autologous bone marrow transplant support (ABMT), and ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19941201)74:11<2964::aid-cncr282

    authors: Marks LB,Rosner GL,Prosnitz LR,Ross M,Vredenburgh JJ,Peters WP

    更新日期:1994-12-01 00:00:00

  • Treatment of polycythemia vera with hydroxyurea.

    abstract::Thirty-six patients with polycythemia vera were treated with hydroxyurea for 12 to 67 months. Nineteen patients were previously treated with other drugs. In the vast majority of patients, an average dose of 1 g/day was sufficient to control hematocrit value and platelet count. Half of the patients experienced relief o...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860215)57:4<718::aid-cncr28205

    authors: Sharon R,Tatarsky I,Ben-Arieh Y

    更新日期:1986-02-15 00:00:00

  • Immunogenicity and safety of single-dose, 13-valent pneumococcal conjugate vaccine in pediatric and adolescent oncology patients.

    abstract:BACKGROUND:Children receiving immunosuppressive treatment for cancer are at high risk for invasive pneumococcal disease. The 13-valent pneumococcal conjugate vaccine (PCV13) can prevent pneumococcal disease in healthy children; however, there is an absence of literature regarding the benefit of PCV13 in immunocompromis...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30764

    authors: Hung TY,Kotecha RS,Blyth CC,Steed SK,Thornton RB,Ryan AL,Cole CH,Richmond PC

    更新日期:2017-11-01 00:00:00

  • Adjuvant chemotherapy for advanced nasopharyngeal carcinoma in childhood.

    abstract::Seven children with advanced nasopharyngeal carcinoma younger than 20 years of age diagnosed between 1975 and 1986 (inclusive) were treated with a uniform adjuvant chemotherapy regimen, which consisted of vincristine (1.5 mg/m2; day 1), doxorubicin (45 mg/m2; day 1), 5-fluorouracil (8 mg/kg; days 1 through 5), and cyc...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19890515)63:10<1922::aid-cncr282

    authors: Kim TH,McLaren J,Alvarado CS,Wyly JB,Crocker I,Winn K,Singhapakdi S,Ragab A

    更新日期:1989-05-15 00:00:00

  • Self-examination and clinical examination of the breast.

    abstract::The techniques of self breast examination and the clinical examination of the breasts are described briefly. The potential value and the limitations of these tests in screening for breast cancer are reviewed. In a Cancer Society Monograph in 1958, Haagensen said, "It is probable that, from the point of view of the gre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800815)46:4+<930::aid-cncr2820

    authors: Venet L

    更新日期:1980-08-15 00:00:00

  • Birth weight and risk of cancer.

    abstract:BACKGROUND:It is well established that prenatal biologic processes are important for the development of some childhood cancers, whereas less is known regarding their influence on adult cancer risk. High birth weight has been associated with risk of breast cancer, whereas studies of other specific cancers and all cancer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.22773

    authors: Ahlgren M,Wohlfahrt J,Olsen LW,Sørensen TI,Melbye M

    更新日期:2007-07-15 00:00:00

  • Is screening for breast cancer cost-effective?

    abstract::As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920401)69:7+<1957::aid-cncr282

    authors: Mushlin AI,Fintor L

    更新日期:1992-04-01 00:00:00

  • Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma.

    abstract:BACKGROUND:Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma. METHODS:To elucidate its clinicopathologic and genetic features, the authors studied 71 adult patients (median age, 57 years), including 22 patients who were ide...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20625

    authors: Perry A,Aldape KD,George DH,Burger PC

    更新日期:2004-11-15 00:00:00

  • Evaluation of size in prognosis of oral cancer.

    abstract::Greatest surface diameter of a cancer, together with suspicion of regional node metastasis, forms the basis for prognosis through the clinical TNM staging system for many cancers. In oral cancer, however, surface size sometimes fails to correlate, or sometimes inversely correlates, with tumor aggressiveness. To shed l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860701)58:1<158::aid-cncr28205

    authors: Moore C,Flynn MB,Greenberg RA

    更新日期:1986-07-01 00:00:00

  • Amsacrine is safe and effective therapy for patients with myocardial dysfunction and acute leukemia.

    abstract::The role of amsacrine in inducing remission in patients with cardiac disease and acute leukemia was evaluated. There were 17 patients with acute myelogenous leukemia (AML), six with acute lymphocytic leukemia (ALL), and one with biphenotypic leukemia. In this series of 24 patients whose disease had relapsed and who ha...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910915)68:6<1198::aid-cncr2820

    authors: Arlin ZA,Feldman EJ,Mittelman A,Ahmed T,Puccio C,Chun HG,Cook P,Baskind P,Marboe C,Mehta R

    更新日期:1991-09-15 00:00:00

  • Fas (CD95/APO-1) and Fas ligand expression in normal pancreas and pancreatic tumors. Implications for immune privilege and immune escape.

    abstract:BACKGROUND:Fas (CD95/APO-1) and Fas ligand (FasL) play key roles in immunologic homeostasis and immune privilege and may regulate normal cell turnover. Earlier studies had suggested that FasL-positive pancreatic carcinoma cell lines can induce apoptosis in T cells, thereby evading host immune surveillance. In the curre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10549

    authors: Bernstorff WV,Glickman JN,Odze RD,Farraye FA,Joo HG,Goedegebuure PS,Eberlein TJ

    更新日期:2002-05-15 00:00:00

  • Adriamycin, BCNU plus cyclophosphamide (ABC) in advanced carcinoma of the head and neck.

    abstract::Forty-four patients with advanced carcinoma of the head and neck were treated with cyclophosphamide, 400 mg/m2 plus BCNU, 100 mg/m2 day 1 followed by adriamycin 40 mg/m2 day 2, with therapy repeated every 4 weeks. Of 31 evaluable patients, there were 1 complete response, and 10 partial responses (35%). Four of 8 patie...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197911)44:5<1571::aid-cncr282044

    authors: Presant CA,Ratkin G,Klahr C,Brown C

    更新日期:1979-11-01 00:00:00

  • The influence of surgical margins and prognostic factors predicting the risk of local recurrence in 3445 patients with primary cutaneous melanoma.

    abstract::Risk factors associated with local recurrences were analyzed from a series of 3445 clinical Stage I melanoma patients. In single-factor analysis, tumor thickness, ulceration, and increasing age were highly significantly predictive of recurrence (p less than 0.00001). After 5 years of follow-up, local recurrence rates ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850315)55:6<1398::aid-cncr2820

    authors: Urist MM,Balch CM,Soong S,Shaw HM,Milton GW,Maddox WA

    更新日期:1985-03-15 00:00:00

  • Reverse targeting in a media-promoted breast cancer screening project.

    abstract:BACKGROUND:The American Cancer Society has sponsored community-based, low-cost, Breast Cancer Detection Awareness Projects throughout the United States. The authors hypothesized that these projects tend to exclude minorities and women of lower socioeconomic status--groups with a higher incidence of late-stage disease. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920901)70:5<1152::aid-cncr2820

    authors: Roetzheim RG,Vandurme DJ,Brownlee HJ,Herold AH,Pamies RJ,Woodard L,Blair C

    更新日期:1992-09-01 00:00:00

  • Endogenous anti-tumor antibody responses in nude mice.

    abstract:BACKGROUND:Nude mice with xenografted human tumors is the most exploited animal model used to elucidate the efficacy of experimental radioimmunolocalization and radioimmunotherapy. These animals accept transplants and are generally considered immunologically inert with regard to cell-mediated and humoral immune respons...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19971215)80:12+<2404::aid-

    authors: Stigbrand T,Ullén A,Sandström P,Rathsman S,Rossi Norrlund R,Arlestig L,Riklund Ahlström K,Hietala SO

    更新日期:1997-12-15 00:00:00

  • Improvement in protection against adenocarcinoma of the cervix resulting from participation in cervical screening.

    abstract:BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11835

    authors: Mitchell H,Hocking J,Saville M

    更新日期:2003-12-25 00:00:00

  • Hormone replacement therapy and lung cancer risk in Chinese.

    abstract:BACKGROUND:The association between hormone replacement therapy (HRT) and a reduced lung cancer risk has been reported in previous studies. There is a high female to male ratio in Chinese lung cancer patients, and female patients have different clinicopathological characteristics compared with Western patient population...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.22987

    authors: Chen KY,Hsiao CF,Chang GC,Tsai YH,Su WC,Perng RP,Huang MS,Hsiung CA,Chen CJ,Yang PC,GEFLAC Study Group.

    更新日期:2007-10-15 00:00:00

  • Lethal midline granuloma with a novel T-cell phenotype as found in peripheral T-cell lymphoma.

    abstract::Lethal midline granuloma (LMG), initially a clinical description, includes an uncommon group of disorders characterized by a relentless, destructive process involving the upper respiratory structures. Its etiology and pathogenesis are uncertain, probably varied, and the distinction between inflammatory and malignant p...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870301)59:5<936::aid-cncr28205

    authors: Lippman SM,Grogan TM,Spier CM,Koopmann CF Jr,Gall EP,Shimm DS,Durie BG

    更新日期:1987-03-01 00:00:00