Abstract:
:As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health policy debate. Cost-effectiveness analysis is an economic methodology widely used to inform such decisions, yet there is a dearth of information available on the economic consequences of mass breast cancer screening. The authors evaluated nine breast cancer screening cost-effectiveness studies that are based on computer simulations, observational trial data, or a combination of both. The results of these studies, conducted in the United States and other countries, indicate that the cost-effectiveness of screening for breast cancer generally compares favorably with other expenditures in the health-care field, although screening younger women does not appear to be as favorable. However, there is considerable variability in the methodology used and a need for more comprehensive research in this area.
journal_name
Cancerjournal_title
Cancerauthors
Mushlin AI,Fintor Ldoi
10.1002/1097-0142(19920401)69:7+<1957::aid-cncr282subject
Has Abstractpub_date
1992-04-01 00:00:00pages
1957-62issue
7 Suppleissn
0008-543Xissn
1097-0142journal_volume
69pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Topoisomerase I inhibitors, like topotecan, have activity in myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML). 9-Nitro-camptothecin (9-NC) is a new oral topoisomerase inhibitor with a good safety profile. The aims of the current study were to evaluate the activity and safety of 9-NC ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.22186
更新日期:2006-10-01 00:00:00
abstract::Sixty-two patients with acute leukemia who remained in continuous complete remission for 8 to 45 months received three courses of intensified therapy with new chemotherapeutic agents, after which they received no further chemotherapy. Immunotherapy with BCG was then administered to 55 of these patients. They have been...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810415)47:8<1937::aid-cncr2820
更新日期:1981-04-15 00:00:00
abstract:BACKGROUND:Children with diffuse brainstem glioma (BSG) commonly undergo novel therapies because their outcome is poor with radiation therapy (RT). Although recent clinical trials using new biologic agents documented intratumoral hemorrhage (IH) among several children with BSG, to the authors' knowledge little is known...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21749
更新日期:2006-03-15 00:00:00
abstract:METHODS:Between 1983 and 1989, 42 patients with Stage II, III, and IV, node-negative, squamous cell head and neck cancer were treated with concurrent 5-fluorouracil, cisplatin, and radiation therapy. Two courses of chemotherapy with 30 Gy of concurrent radiation therapy were to be followed in all patients by definitive...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19921201)70:11<2685::aid-cncr282
更新日期:1992-12-01 00:00:00
abstract::The authors describe a new technique for the subcutaneous heterotopic transplantation of the ovary before pelvic irradiation to treat Hodgkin's disease. Creation of a cavity to receive the transplant and the use of two surgical teams and the surgical microscope during the operation ensured its successful outcome. The ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871101)60:9<2201::aid-cncr2820
更新日期:1987-11-01 00:00:00
abstract:BACKGROUND:The results of a Phase II study of concurrent chemotherapy and accelerated fractionation radiation therapy followed by surgical resection for patients with both adenocarcinoma and squamous cell carcinoma of the esophagus are presented. Pretreatment and postinduction staging were correlated with pathologic fi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1997-09-15 00:00:00
abstract:BACKGROUND:The authors examined whether survivors from the Childhood Cancer Survivor Study were less likely to be in higher-skill occupations than a sibling comparison and whether certain survivors were at higher risk for lower-skill jobs. METHODS:The authors created 3 mutually exclusive occupational categories for pa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25867
更新日期:2011-07-01 00:00:00
abstract::A case of a dermal nerve sheath myxoma arising in a digital nerve is reported. Similar tumors and its variants have been termed neurothekeoma, pacinian neurofibroma, bizarre cutaneous neurofibroma, and plexiform neurofibroma. The perineural sheath or the Schwann cell have been presumed to be the cell of origin by seve...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890315)63:6<1215::aid-cncr2820
更新日期:1989-03-15 00:00:00
abstract::This study evaluates residual disease in 28 B-cell chronic lymphocytic leukemia (B-CLL) patients who obtained a clinicohematologic remission after intensive chemotherapy. Sixteen of 28 patients (57%) showed a normal number of circulating B-lymphocytes, as demonstrated by the low percentage of mouse rosette-forming cel...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890515)63:10<1979::aid-cncr282
更新日期:1989-05-15 00:00:00
abstract:BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.29986
更新日期:2016-06-15 00:00:00
abstract:BACKGROUND:Cancer of the pancreas is a highly malignant illness with a very poor prognosis. Unfortunately, there has been little in the way of improvement in prognosis over the past 20 years. It is feared by patients because of its reputation as a deadly and often painful disease. Given these realities, it is not surpr...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0142(19960801)78:3<615::AID-CNC
更新日期:1996-08-01 00:00:00
abstract:BACKGROUND:Extrapulmonary inflammatory pseudotumor (plasma cell granuloma) is an uncommon lesion in adults and children, and little is known either of its etiology or clinical characteristics. However, it remains a significant source of morbidity to patients and confusion to clinicians. METHODS:Case reports are presen...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19940301)73:5<1433::aid-cncr2820
更新日期:1994-03-01 00:00:00
abstract::The relationship between DNA content, clinicopathologic findings, and patient survival in synovial sarcoma was investigated. Patient age at diagnosis (P less than 0.001), tumor size (P less than 0.001), and ploidy status (P less than 0.003) correlated significantly with patient survival. A marginally significant corre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2295::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract:BACKGROUND:Approximately 30% of breast carcinoma patients with negative lymph nodes die of their disease. Biologic markers such p53 protein and c-erb B-2 have been related to tumor progression, but their prognostic value remains controversial. METHODS:Two large series of a total of 613 lymph node negative breast carci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000215)88:4<804::aid-cnc
更新日期:2000-02-15 00:00:00
abstract::Tumor necrosis factor-alpha (TNF-alpha), a product of activated macrophages that is cytotoxic to tumor cells, could be used to purge tumor cells from bone marrow before autologous bone marrow transplantation for hematologic malignancies and/or solid tumors. To determine whether exposure to TNF-alpha would have an inhi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<2965::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract::The feasibility of employing adjuvant topical mechlorethamine after electron beam therapy in the treatment of patients with mycosis fungoides is demonstrated. Patients treated with a planned adjuvant topical mechlorethamine schedule had a median disease-free interval of 25 months compared to 17 months for the group tr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197712)40:6<2851::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract::Numerous examples exist of prognostic factors that have been conclusively established and that can segregate the target patient population into subgroups with vastly different outcomes. At the same time, we can expect, in the majority of trials being conducted, that if a new treatment turns out to be successful, it ge...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860715)58:2+<461::aid-cncr2820
更新日期:1986-07-15 00:00:00
abstract::Serum CEA levels were determined serially by the Hansen Z gel technique on 41 patients with carcinoma of the esophagus and compared to 276 controls. Seventy percent of patients with carcinomas of the esophagus had elevated CEA levels. CEA levels greater than 10.0 ng/ml after therapy correlated with significantly short...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197809)42:3+<1492::aid-cncr28204
更新日期:1978-09-01 00:00:00
abstract:BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26222
更新日期:2012-01-15 00:00:00
abstract::Nineteen postmenopausal patients with metastatic breast cancer refractory to conventional combination chemotherapy were treated with monthly cycles with the combinations of vinblastine, adriamycin, thiotepa and halotestin. Ten patients (52%) responded with a greater than 50% regression of measurable tumor. The median ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197812)42:6<2534::aid-cncr282042
更新日期:1978-12-01 00:00:00
abstract::Reported is the case of a 24-year-old white man with inoperable giant cell carcinoma of the thyroid who achieved tumor regression following therapy with bleomycin, Adriamycin and cisplatinum. After 2 courses of chemotherapy, the tumor was deemed operable, and the patient underwent total thyroidectomy followed by radia...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2252::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Previous studies have shown that the levels of 15-lipoxygenase 1 (15-LOX-1) and 15-LOX-2 as well as their metabolites 13-S-hydroxyoctadecadienoic acid (13(S)-HODE) and 15(S)-hydroxyeicosatetraenoic acid (15(S)-HETE) are significantly reduced in smokers with non-small cell lung carcinoma (NSCLC). Furthermore,...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29547
更新日期:2015-09-01 00:00:00
abstract::Five cases of squamous cell carcinoma of the cervix associated with widespread squamous cell carcinoma in situ of the endometrial surface are reported. In one case, carcinoma in situ was also found in one fallopian tube in continuity with the cervicoendometrial lesion. A survey of the literature reveals only 20 cases ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197808)42:2<570::aid-cncr2820420
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Although >70% of younger women with nonmetastatic breast cancer (BC) received adjuvant chemotherapy, only approximately 15% to 20% of elderly women with BC received chemotherapy. The decision to treat may be associated with nonmedical factors, such as patient, physician, or practice characteristics. In the c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24448
更新日期:2009-09-01 00:00:00
abstract:BACKGROUND:The mortality rate associated with fever accompanied by pulmonary infiltrates after chemotherapy for hematologic malignancies remains higher than the corresponding rate associated with febrile neutropenia without pulmonary infiltrates. Nonetheless, few studies have focused on the factors that predict outcome...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20406
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:The response to antifungal therapy alone often is suboptimal in patients with cancer who have therapy-refractory neutropenia, and even donor-derived granulocyte transfusions (GTX) are not always successful. The authors evaluated the safety and efficacy of immune enhancement using recombinant interferon gamma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21929
更新日期:2006-06-15 00:00:00
abstract::A clinicopathologic analysis of 35 cases of lymphocyte predominance Hodgkin's disease (LPHD) was performed, and the relationship between various histologic features and stage at presentation was examined. The series comprised 31 male and 4 female patients with a median age of 32 years. Twenty patients had Ann Arbor St...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870101)59:1<99::aid-cncr282059
更新日期:1987-01-01 00:00:00
abstract:BACKGROUND:The altered and anomalous expression of carbohydrate antigens (CA) occur in patients with lung carcinomas. METHODS:To investigate the relationship between prognosis and immunohistochemical findings of CA in serum and pulmonary adenocarcinomas (PA), PA specimens surgically resected from 102 patients were stu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930901)72:5<1581::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract::Few epidemiologic studies have been undertaken to investigate the etiology of cancer of the vulva. To identify risk factors associated with this cancer, a case-control study was conducted in 149 patients with histologically proven vulvar carcinoma and the same number of control patients matched for age, race, marital ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1843::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract::Certain features of nodular sclerosing Hodgkin's disease predispose toward achievement of excellent radiotherapeutic results using clinical staging rather than currently advocated surgical staging including laparatomy. These include a distinct pattern of contiguous lymphatic involvement and the infrequent disseminatio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197704)39:4<1439::aid-cncr282039
更新日期:1977-04-01 00:00:00