Abstract:
BACKGROUND:Forty patients with Stage II-III breast cancer with 10 or more positive axillary nodes were treated with mastectomy followed by four cycles of standard dose CAF (cytoxan, Adriamycin, 5-FU), followed by high dose cytoxan, cisplatin, carmustine (HDCT) with autologous bone marrow transplant support (ABMT), and local-regional radiotherapy (LR XRT). During LR XRT, the hematologic toxicity experienced by these patients appeared more severe than that usually seen in patients not heavily pretreated with chemotherapy. Radiation therapy was interrupted in four patients (10%) because of thrombocytopenia and leukopenia. This observation prompted a comparison of the hematologic changes seen in this group with those seen in patients not treated previously with chemotherapy. METHODS:A detailed analysis of changes in hematologic parameters during LR XRT was performed in 33 evaluable patients who received CAF-HDCT/ABMT and compared with a "control" group of 17 women who did not receive prior chemotherapy. RESULTS:The mean pretreatment leukocyte, platelet, and hematocrit counts were lower in the CAF-HDCT/ABMT group than in the control group, with the differences indicating statistical significance for the latter two (P = 0.17, P < 0.001, and P = 0.001, respectively). None of the control patients required a treatment interruption because of hematologic toxicity, whereas four of the CAF-HDCT/ABMT patients did. Among the CAF-HDCT/ABMT patients, a leukocyte count nadir of less than 2.0, a platelet nadir of less than 50,000, and a hematocrit nadir of less than 25 occurred in 12%, 19%, and 9%, respectively. The corresponding rates of control patients were 6%, 0%, and 0%, respectively. Relative to their pretreatment levels, however, both groups experienced similar declines in platelet and leukocyte counts. CONCLUSION:The higher rate of hematologic toxicity observed in the patients who previously received conventional chemotherapy plus HDCT/ABMT appears to have been due primarily to lower preradiotherapy blood counts.
journal_name
Cancerjournal_title
Cancerauthors
Marks LB,Rosner GL,Prosnitz LR,Ross M,Vredenburgh JJ,Peters WPdoi
10.1002/1097-0142(19941201)74:11<2964::aid-cncr282subject
Has Abstractpub_date
1994-12-01 00:00:00pages
2964-71issue
11eissn
0008-543Xissn
1097-0142journal_volume
74pub_type
杂志文章相关文献
CANCER文献大全abstract::A hospital-based case-control study was done to examine the hypothesis that persons with a family history of multiple myeloma (MM) or other cancers are at increased risk of multiple myeloma. Study members were 439 cases of multiple myeloma and 1317 matched controls seen at the Duke University Medical Center. Only 3 ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851015)56:8<2133::aid-cncr2820
更新日期:1985-10-15 00:00:00
abstract::Surgical removal of bulky metastases of non-seminomatous germ-cell testicular cancer has been advocated as an adjuvant to chemotherapy in patients whose disease probably is too extensive to be cured by chemotherapy or surgery alone. However, in 8 of our patients, cytoreductive surgery was followed by a sudden and dram...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1498::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract:BACKGROUND:Intracranial primitive neuroectodermal tumors (PNETs) occur in the supratentorial and infratentorial regions of the brain. Although histologically similar, the natural history of the tumor at each site differs. The study goal was to determine whether there was evidence of a genetic difference between suprate...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19990715)86:2<331::aid-cnc
更新日期:1999-07-15 00:00:00
abstract::The records of 1,497 patients with histologically proven adenocarcinoma of the stomach were reviewed from Charity Hospital over the 25-year period, 1948 to 1973. The operability rate was 82% and the resectability rate was 48%. In this series gastric carcinoma predominated in males and Negroes. Necropsy studies indicat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197803)41:3<941::aid-cncr2820410
更新日期:1978-03-01 00:00:00
abstract::Despite relatively high response rates to chemotherapy for ovarian carcinoma, most patients eventually will have progressive disease that will require additional therapy. Most efforts to study such second-line or "salvage" chemotherapy have been single-arm trials of small numbers of patients, which report widely varia...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.2820710422
更新日期:1993-02-15 00:00:00
abstract::Two-hundred-four patients with previously untreated adenocarcinoma of rectum, rectosigmoid, and sigmoid colon were retrospectively evaluated to determine patterns of recurrence following curative resection. Seventy-eight (38%) subsequently developed recurrent disease. Of these, 40% (31/78) presented with local recurre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810915)48:6<1492::aid-cncr2820
更新日期:1981-09-15 00:00:00
abstract::A tumor that affects the central nervous system can have a dramatic impact on the individual affected, as well as his or her family and friends. The tumor, regardless of extent or location, may affect the physical, social, vocational, and emotional capabilities of the individual. Basic aspects of rehabilitation for pa...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20010815)92:4+<1029::aid-cncr141
更新日期:2001-08-15 00:00:00
abstract::Identification of BCR-ABL as the defining leukemogenic event in chronic myelogenous leukemia (CML) revolutionized the treatment of the disease. Imatinib, a potent BCR-ABL inhibitor, is the standard of care for the first-line treatment of patients with chronic-phase CML because of its high long-term response rates and ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24928
更新日期:2010-03-15 00:00:00
abstract::A broad ligament tumor with the histologic features of a female adnexal tumor of probable Wolffian origin, as described by Kariminejad and Scully, is reported. Although previous cases were thought to be benign, in the present case, hepatic metastasis occurred 6 years after resection of the primary. Cytologic features ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197605)37:5<2349::aid-cncr282037
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:A residual mediastinal mass after treatment represents a common diagnostic problem in the management of patients with Hodgkin lymphoma (HD). Conventional diagnostic radiology, computed tomography (CT), or ultrasonography (US) do not adequately reflect changes as fibrosis or necrosis. Gallium-67 (67Ga) imagin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930715)72:2<577::aid-cncr28207
更新日期:1993-07-15 00:00:00
abstract:BACKGROUND:Central nervous system (CNS) recurrence is almost invariably fatal in patients with aggressive non-Hodgkin lymphoma (NHL). Although some protocols are intended to prevent CNS disease, the value of CNS prophylaxis in patients with aggressive NHL remains to be determined. METHODS:We retrospectively analyzed a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10699
更新日期:2002-08-01 00:00:00
abstract::At the Finsen Institute, Copenhagen, from 1971 to 1981, 134 patients were treated for lymph node metastases from primary cutaneous malignant melanoma of axial localization (e.g., in the head and neck and trunk), where metastases to regional lymph node groups were the first sign of dissemination. Due to the lack of suf...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881101)62:9<2073::aid-cncr2820
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Amplification of the N-myc oncogene is associated with adverse outcomes in the common childhood tumor, neuroblastoma. Because the transforming properties of Myc are related to its ability to modulate gene expression, the authors used cDNA microarrays to identify potential Myc target genes. METHODS:Expressio...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11584
更新日期:2003-08-15 00:00:00
abstract:BACKGROUND:All edemas result from an imbalance between capillary filtration and tissue (lymph) drainage. This basic approach was adopted to investigate mechanisms for chronic arm edema following breast carcinoma treatment. METHODS:A review of causes of lymphedema is presented plus the traditional pathophysiology of br...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2798::aid
更新日期:1998-12-15 00:00:00
abstract::A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental product...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840301)53:5<1088::aid-cncr2820
更新日期:1984-03-01 00:00:00
abstract:BACKGROUND:The necessity to develop more effective chemotherapy regimens in advanced nonsmall cell lung carcinoma (NSCLC) prompted the authors to evaluate the paclitaxel-ifosfamide-cisplatin (PIC) combination, developed on the basis of high individual single-agent activity, in vitro synergism, and tolerance as determin...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20000815)89:4<774::aid-cncr9>3.0
更新日期:2000-08-15 00:00:00
abstract:BACKGROUND:Recurrent central neurocytoma is very rare and to the authors' knowledge data regarding its response to chemotherapy currently are not available. METHODS:Three patients with progressive neurocytoma received chemotherapy after their informed consent was obtained. Disease recurred in two patients after surger...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000101)88:1<169::aid-cnc
更新日期:2000-01-01 00:00:00
abstract::A prospective study was performed on 84 patients with neuroendocrine pancreatic tumors. Fifty-nine (70%) had malignant tumors and received causal medical treatment. Streptozotocin in combination with 5-fluorouracil or doxorubicin was used as first-line treatment and produced overall objective responses in 20 of 44 (45...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900501)65:9<1883::aid-cncr2820
更新日期:1990-05-01 00:00:00
abstract::The current results of trials testing combined surgery and chemotherapy in patients with breast cancer is reviewed. Information concerning eight trials utilizing nine single-agent regimens was obtained. The results at this time are conflicting. There appear to be differences among the regimens utilized in the various ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197509)36:3<881::aid-cncr2820360
更新日期:1975-09-01 00:00:00
abstract:BACKGROUND:It remains unclear whether health-related quality of life (HRQoL) measurements from patients and staff can be combined with medical data to predict survival in patients with terminal cancer. METHODS:The correlations between survival and potential health-related quality-of-life (HRQoL) prognostic variables w...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20472
更新日期:2004-09-01 00:00:00
abstract::Two siblings succumbed to glioblastoma multiforme, associated with hepatic focal nodular hyperplasia and cafe-au-lait spots. One sibling had syndactyly and multiple colonic polyps, while the other had an angiomatous malformation in the brain. Their mother died of myasthenia gravis. The findings suggest a hamartomatous...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<310::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract::Thirty white and 15 black children with neuroblastoma were compared with respect to survival. Patient age and tumor stage at diagnosis were similar in the two groups, as was duration of symptoms prior to diagnosis. There was no significant difference between the white and black children in regard to median duration of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197509)36:3<1151::aid-cncr282036
更新日期:1975-09-01 00:00:00
abstract::Bacteria-antibody complexes were used to study capping of receptors for the activated third component of complement on peripheral blood lymphocytes. The impairment of C3d receptor capping improves in patients with chronic lymphocytic leukemia responding to therapy, but this does not necessarily correspond to the fall ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19851001)56:7<1538::aid-cncr2820
更新日期:1985-10-01 00:00:00
abstract::Plasma carcinoembryonic antigen (CEA) levels were studied in all available members of 17 families in which a presumed sporadic retinoblastoma had occurred. In 9 of the 17 families, close relatives of the patient had elevated CEA levels in the absence of demonstrable disease; this we have termed the "CEA family syndrom...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197603)37:3<1397::aid-cncr282037
更新日期:1976-03-01 00:00:00
abstract:BACKGROUND:Older age has historically been an adverse prognostic factor in pediatric acute myeloid leukemia (AML). To the authors' knowledge, the impact of age relative to that of other prognostic factors on the outcome of patients treated in recent trials is unknown. METHODS:Clinical outcome and causes of treatment f...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.27659
更新日期:2012-12-15 00:00:00
abstract:BACKGROUND:The Centers for Medicare and Medicaid Services (CMS) has released quality measures regarding potentially avoidable hospitalizations visits in the 30 days after receipt of outpatient chemotherapy. This study evaluated the proportions of patients treated by Medicare-reimbursed clinicians and Veterans Health Ad...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32896
更新日期:2020-07-15 00:00:00
abstract:BACKGROUND:Modified nucleosides such as 1-methyl-adenosine and pseudouridine exist as minute components of transfer ribonucleic acid (tRNA) and are excreted in the urine in large amounts in the presence of malignancy. Although use of these modified nucleosides as tumor markers has long been studied and many reports hav...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931215)72:12<3571::aid-cncr282
更新日期:1993-12-15 00:00:00
abstract:BACKGROUND:Caveolin-1 plays a regulatory role in several signaling pathways. Recently caveolin-1 was identified as a metastasis-related gene in prostate carcinoma. However, the clinical impact of caveolin-1 expression in esophageal carcinoma remains unknown. METHODS:One hundred thirty surgical specimens of esophageal ...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2002-02-15 00:00:00
abstract::Sixty percent of all cancer occurs in persons aged > or =65 years. This article provides an overview of aspects of the burden of cancer in the elderly, highlighting certain demographic and epidemiologic data. It served as a frame of reference for participants in the Oncology Geriatric Education Retreat, San Juan, Puer...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, little is known to date regarding the prognostic relevance of measuring serum levels of vascular endothelial growth factor (VEGF), a potent stimulator of angiogenesis, in patients with colon carcinoma who undergo surgery. METHODS:Preoperative and postoperative VEGF serum levels we...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11911
更新日期:2004-01-15 00:00:00