Abstract:
:A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental production of gastric adenocarcinoma. The authors were able to produce adenocarcinomas in rats, but found a great number of gastric leiomyosarcomas. These occurred only in the groups given MNNG in combination with stress, aspirin, or sodium taurocholate, and did not occur in experimental groups given either MNNG, stress, aspirin, or sodium taurocholate alone, and did not occur in the control group.
journal_name
Cancerjournal_title
Cancerauthors
Cohen A,Geller SA,Horowitz I,Toth LS,Werther JLdoi
10.1002/1097-0142(19840301)53:5<1088::aid-cncr2820subject
Has Abstractpub_date
1984-03-01 00:00:00pages
1088-92issue
5eissn
0008-543Xissn
1097-0142journal_volume
53pub_type
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