Abstract:
BACKGROUND:The authors studied the benefit of performing histopathologic grading and DNA ploidy characterization with respect to patient survival in a series of 206 astrocytomas (AST) for which they obtained 134 complete clinical follow-ups. METHODS:The material analyzed came from archival material, i.e., formalin-fixed paraffin-embedded tissues. DNA ploidy was assessed by means of a cell image processor computing the integrated optical density (IOD) on Feulgen-stained nuclei. RESULTS:Results showed that histopathologic diagnosis in three grades, i.e., AST, anaplastic astrocytoma (ANA), and glioblastoma multiforme (GBM), had a significant prognostic value. Patients with AST showed a mean survival time (between histopathologic diagnosis and death) of more than 36 +/- 6 months (AST versus ANA or GBM) (P less than 0.001). Patients with ANA and GBM showed a mean survival time of 15 +/- 2 and 10 +/- 1 months, respectively, (ANA versus GBM) (P less than 0.05). Patient age strongly correlated with survival. Patients younger than 40 years of age had a mean survival time of 20 +/- 4 months. Patients between 41 and 60 years of age had a mean survival time of 12 +/- 2 months, and patients older than 60 years of age had a mean survival time of 11 +/- 1 months. CONCLUSIONS:Considering DNA ploidy characterization, the authors noticed that aneuploid ANA (DNA index [DI] more than 1.30) were associated with a significantly higher mean patient survival time compared with that associated with euploid ANA. In contrast, the authors did not find this in either of the groups with AST and GBM. Recognizing six DNA histogram types (diploid, triploid, tetraploid, hyperdiploid, hypertriploid, and polymorphic), the authors observed that hypertriploid tumors were associated with greater patient survival compared with what happened in the cases of the five other DNA histogram types. This was true with respect to the three AST histopathologic types. Thus, DNA ploidy determination seemed helpful in characterizing aggressiveness in adult AST.
journal_name
Cancerjournal_title
Cancerauthors
Salmon I,Kiss R,Dewitte O,Gras T,Pasteels JL,Brotchi J,Flament-Durand Jdoi
10.1002/1097-0142(19920715)70:2<538::aid-cncr28207subject
Has Abstractpub_date
1992-07-15 00:00:00pages
538-46issue
2eissn
0008-543Xissn
1097-0142journal_volume
70pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:Survival trends provide a measure of improvement in detection and treatment over time. In the current study, updated childhood and adolescent cancer survival statistics are presented, overall and among demographic subgroups, including Hispanics, for whom to the authors' knowledge national rates have not been...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23866
更新日期:2008-11-01 00:00:00
abstract::Between the years 1973-1977, 152 male patients from 28 participating Veterans Hospitals with histologically proven nonresectable cancer of the pancreas were randomized in a two-arm study. The treated group was to receive combination chemotherapy with 5-FU and CCNU, and the controls were to receive no chemotherapy. Bot...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19810101)47:1<27::aid-cncr282047
更新日期:1981-01-01 00:00:00
abstract:BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26132
更新日期:2011-11-01 00:00:00
abstract::Small-cell lung cancer (SCLC) represents 15% to 20% of all lung carcinomas. Approximately 30% to 40% of these cases are diagnosed in patients older than 70 years of age. Staging of SCLC classifies patients as having either limited or extensive-stage disease. The standard treatment for limited-stage disease is platinum...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24833
更新日期:2010-03-01 00:00:00
abstract:BACKGROUND:Colonoscopy is the most widely used colorectal cancer (CRC) screening test in the United States. Through the detection and removal of potentially precancerous polyps, it can prevent CRC. However, CRC screening remains low among adults who are recommended for screening. The New Hampshire Colorectal Cancer Scr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31864
更新日期:2019-02-15 00:00:00
abstract::In 79 cases of histologically verified anaplastic giant-cell carcinoma, symptoms, treatment, and prognosis were documented. Seventy-eight patients are dead, the mean survival time being 2.5 months. One patient is cured. It was concluded that surgery and/or radiotherapy alone are not sufficient. The results from an add...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197505)35:5<1293::aid-cncr282035
更新日期:1975-05-01 00:00:00
abstract:BACKGROUND:Currently, no standard therapy exists for patients with relapsed and/or refractory non-Hodgkin lymphoma (NHL) who are ineligible for transplantation or who have failed after bone marrow transplantation. The authors of this report investigated the safety and efficacy of clofarabine (CLO) in these patients. M...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25603
更新日期:2011-04-01 00:00:00
abstract:BACKGROUND:Lysosomal proteases are implicated in cancer progression and metastasis. In the current study, using subtraction cloning for genes that are differentially expressed in metastasis, the authors isolated a clone encoding ceroid lipofuscinosis, neuronal 2 (CLN2), which is a lysosomal serine protease defective in...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21764
更新日期:2006-04-01 00:00:00
abstract::The DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocarcinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K-ras codon 12, 1 in K-ras codon 13, 1 in K-ras codon 61, and 1 in N-ras codon 12. The inciden...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820690509
更新日期:1992-03-01 00:00:00
abstract::The current classification of cutaneous malignant lymphomas (ML) into low-grade and high-grade lymphomas was found to be of limited reproducibility and permitted only a rough prediction about outcome. With this in mind, the relationship between nuclear DNA content and both prognosis and histologic grading according to...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910901)68:5<1095::aid-cncr2820
更新日期:1991-09-01 00:00:00
abstract:BACKGROUND:Intensity-modulated radiation therapy (IMRT) is a novel approach to the planning and delivery of radiation therapy. The prevalence of IMRT use among radiation oncologists in the U.S. appears to be increasing, despite limited data evaluating its risks and benefits. METHODS:A random sample of radiation oncolo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21284
更新日期:2005-09-15 00:00:00
abstract::Increased in vitro tetraploidy occurred in skin cultures derived from all affected patients and some family members at risk studied in families with heritable colon cancer syndromes (15 of 16 Gardner syndrome families, three Oldfield syndrome families, and four families with heritable colon cancer syndrome without pol...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811001)48:7<1596::aid-cncr2820
更新日期:1981-10-01 00:00:00
abstract:BACKGROUND:Pretreatment serum prostate specific antigen (PSA) level is a powerful prognostic factor for clinically localized prostate carcinoma. The traditional prognostic factors, T classification and Gleason score, appear to have been relegated to a minor position. This study was conducted to evaluate the relative pr...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-04-01 00:00:00
abstract:BACKGROUND:Ductal carcinoma in situ (DCIS) of the male breast is an uncommon disease, accounting for approximately 7% of all male breast carcinomas. Compared with invasive carcinomas of the breast, the prognosis associated with DCIS in men is excellent; however, clinical features, pathology, and treatment of this disea...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940815)74:4<1289::aid-cncr2820
更新日期:1994-08-15 00:00:00
abstract:BACKGROUND:The current study was conducted to assess the efficacy and toxicity of sorafenib as front-line therapy in patients with stage IIIB (pleural effusion) or IV nonsmall cell lung cancer (NSCLC). METHODS:Patients received sorafenib 400 mg twice daily by mouth continuously, and were evaluated every 2 weeks during...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25448
更新日期:2010-12-15 00:00:00
abstract::Quantitative counts of ferruginous bodies were performed on digests of lungs from 100 control and 30 lung cancer patients. It was found that the lung cancer group had significantly higher levels, although only 1 patient was known to be occupationally exposed to asbestos. It is suggested that even extremely low levels ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197504)35:4<1236::aid-cncr282035
更新日期:1975-04-01 00:00:00
abstract:METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1943::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract::The records of 52 patients younger than 40 years of age who had bronchogenic carcinoma diagnosed between 1965 and 1985 were reviewed. The preponderance of adenocarcinoma (54%), the lower male-female ratio in this age group compared with patients age 40 or older (2:1), the importance of cigarette smoking as a causative...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910301)67:5<1436::aid-cncr2820
更新日期:1991-03-01 00:00:00
abstract::There are few cases of catecholamine-secreting paragangliomas of the neck reported in the literature, most of these being of the carotid body and glomus-jugulare type. This report cites the second case of a functioning vagal body tumor secreting norepinephrine predominantly and producing labile hypertension and sympto...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19830901)52:5<932::aid-cncr28205
更新日期:1983-09-01 00:00:00
abstract::Nine patients from 34 to 74 years of age (median, 67 years of age) with uterine papillary serous carcinoma (UPSC) were treated with whole-abdominal radiation therapy (WART) on an adjuvant basis after cytoreductive surgery. All patients were treated with megavoltage photons to an abdominopelvic field to a median dose o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19911001)68:7<1516::aid-cncr2820
更新日期:1991-10-01 00:00:00
abstract:BACKGROUND:RUNX3 is a tumor suppressor that plays important roles in cell proliferation, apoptosis, and metastasis. The authors investigated the role of RUNX3 in melanoma pathogenesis and analyzed the prognostic impact of RUNX3 expression in a large series of melanoma patients. METHODS:Two sets of tissue microarrays w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25838
更新日期:2011-06-15 00:00:00
abstract:BACKGROUND:Breast cancer is the second most common source of brain metastasis. Stereotactic radiosurgery (SRS) can be an effective treatment for some patients with brain metastasis (BM). Necrosis is a common feature of many brain tumors, including BM; however, the influence of tumor necrosis on treatment efficacy of SR...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26314
更新日期:2012-03-01 00:00:00
abstract:BACKGROUND:Patients' estimates of their chances of therapeutic benefit from participation in early phase trials greatly exceed historical data. Ethicists worry that this therapeutic misestimation undermines the validity of informed consent. METHODS:The authors interviewed 45 patients enrolled in phase 1 or 2 oncology ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25201
更新日期:2010-08-01 00:00:00
abstract:BACKGROUND:The vast majority of soft tissue sarcomas spread initially to the lungs and then to other sites. The lung has been the most carefully monitored organ system during routine surveillance for a metastasis. Liposarcoma is one of the most common soft tissue sarcomas and has been noted to have extrapulmonary sites...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19950301)75:5<1120::aid-cncr2820
更新日期:1995-03-01 00:00:00
abstract:BACKGROUND:Studies regarding different ethnic populations of children with Wilms' tumor (WT) in the U. S. have shown differences between age and gender incidence and the type of its precursor lesions (nephrogenic rests). To the authors' knowledge there are few reports in the literature regarding nephrogenic rests in a ...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:
更新日期:1998-11-15 00:00:00
abstract::One hundred ninety-one patients with gastrointestinal leiomyosarcomas were analyzed to determine the prevalence in patterns of failure and the factors predicting those at higher risk of relapse at specific sites. Of 100 assessable patients who died of disease, 89% were found to have peritoneal tumor, 78% had liver met...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920315)69:6<1334::aid-cncr2820
更新日期:1992-03-15 00:00:00
abstract::A rare case of malignant fibrous histiocytoma of the aorta is reported. Review of the literature revealed that primary tumors of the aorta are exclusively mesenchymal tumors that almost invariably pursue a fatal course. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810801)48:3<840::aid-cncr28204
更新日期:1981-08-01 00:00:00
abstract:BACKGROUND:It remains unclear whether primary tumor resection benefits patients with metastatic neuroblastoma. The authors assessed the impact of extent and timing of resection on outcome in these patients. METHODS:The authors reviewed the records of 124 patients > 1 year of age at diagnosis of International Neuroblas...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21566
更新日期:2005-12-15 00:00:00
abstract::Quality assurance for the management of multicenter clinical trials requires timely patient and data accrual and consistency with design parameters. Data from central pathology review, treatment modality, and follow-up as well as trial end points direct the selection of appropriate compliance measures. To integrate th...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19941101)74:9+<2647::aid-cncr282
更新日期:1994-11-01 00:00:00
abstract::Scanning electron microscopy was used to examine the appearances of the colonic mucus layer of rats during chemical carcinogenesis with dimethylhydrazine. The normal colonic mucus layer had a dense homogeneous appearance and provided a complete cover for the mucosal epithelium. At high magnifications tiny fenestration...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1847::aid-cncr282
更新日期:1983-05-15 00:00:00