Frequent incidence of extrapulmonary sites of initial metastasis in patients with liposarcoma.

Abstract:

BACKGROUND:The vast majority of soft tissue sarcomas spread initially to the lungs and then to other sites. The lung has been the most carefully monitored organ system during routine surveillance for a metastasis. Liposarcoma is one of the most common soft tissue sarcomas and has been noted to have extrapulmonary sites of initial metastasis. This study was undertaken to investigate both the frequency and distinguishing features of initial extrapulmonary metastasis in patients with liposarcoma. METHODS:A review of 60 patients with liposarcoma treated at the Massachusetts General Hospital (MGH) from 1971 to 1990 was performed. Survival and regression analyses were used to analyze disease free intervals and prognostic factors. RESULTS:Metastatic disease occurred in 37% of patients and local failure in 17%. Among the subset of patients who underwent primary definitive surgery at the MGH, the incidence of local failure was 3%. An unusually high incidence of extrapulmonary site of first metastasis was found. Isolated extrapulmonary disease was the site of initial metastasis in 59% of patients. In contrast to patients with an initial pulmonary metastasis, patients with an initial extrapulmonary metastasis had a statistically significant (P = 0.001) longer disease free interval from diagnosis to first metastasis. CONCLUSIONS:Liposarcoma, in comparison with other soft tissue sarcomas, has a different pattern of metastatic spread, with a tendency toward extrapulmonary sites. In addition, patients with extrapulmonary metastases have a longer disease free interval compared with patients with pulmonary metastasis.

journal_name

Cancer

journal_title

Cancer

authors

Cheng EY,Springfield DS,Mankin HJ

doi

10.1002/1097-0142(19950301)75:5<1120::aid-cncr2820

subject

Has Abstract

pub_date

1995-03-01 00:00:00

pages

1120-7

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

75

pub_type

杂志文章

相关文献

CANCER文献大全
  • Focal heating of V-2 tumors with a hybrid radiofrequency applicator.

    abstract::A hybrid radiofrequency heating system previously reported to produce highly focused heating patterns at less than or equal to 10 cm depth in phantom models was utilized to selectively heat hypervascular, heat resistant rabbit V-2 tumors implanted in the left hindlimb. Spheroidal heating patterns 3 to 4 cm in diameter...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19850315)55:6<1172::aid-cncr2820

    authors: Boddie AW Jr,Merritt DR,Yamanashi W,Frazer JW,McBride CM,Martin RG

    更新日期:1985-03-15 00:00:00

  • Recombinant interleukin-2 activates peripheral blood lymphocytes from children with acute leukemia to kill autologous leukemic cells.

    abstract::In order to determine if recombinant interleukin-2 (rIL-2) can induce lymphokine-activated killer (LAK) cells able to lyse autologous leukemic cells, we incubated peripheral blood (PB) mononuclear cells from children with acute leukemia with 50 U/ml rIL-2 for 5 days. These PB effector cells were then tested for their ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19881101)62:9<1928::aid-cncr2820

    authors: Findley HW Jr,Abdel Mageed A,Nasr SA,Ragab AH

    更新日期:1988-11-01 00:00:00

  • Idiopathic thrombocytopenic purpura in Hodgkin's disease: a rare occurrence of no prognostic significance.

    abstract::Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197802)41:2<743::aid-cncr2820410

    authors: Cohen JR

    更新日期:1978-02-01 00:00:00

  • Therapy of meningeal melanocytomas.

    abstract:BACKGROUND:Meningeal melanocytomas are rare, benign central nervous system lesions with a high probability of recurrence. To the authors' knowledge, approximately 100 cases have been reported since 1972, when the entity first was described. In the current study, four therapies were compared with regard to local control...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20296

    authors: Rades D,Schild SE,Tatagiba M,Molina HA,Alberti W

    更新日期:2004-06-01 00:00:00

  • A front-line window of opportunity phase 2 study of sorafenib in patients with advanced nonsmall cell lung cancer: North Central Cancer Treatment Group Study N0326.

    abstract:BACKGROUND:The current study was conducted to assess the efficacy and toxicity of sorafenib as front-line therapy in patients with stage IIIB (pleural effusion) or IV nonsmall cell lung cancer (NSCLC). METHODS:Patients received sorafenib 400 mg twice daily by mouth continuously, and were evaluated every 2 weeks during...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25448

    authors: Dy GK,Hillman SL,Rowland KM Jr,Molina JR,Steen PD,Wender DB,Nair S,Mandrekar S,Schild SE,Adjei AA,North Central Cancer Treatment Group Study N0326.

    更新日期:2010-12-15 00:00:00

  • Granulocyte-macrophage-colony-stimulating factor added to a multipeptide vaccine for resected Stage II melanoma.

    abstract:BACKGROUND:Forty-eight patients with resected Stages IIA and IIB melanoma were immunized with two tumor antigen epitope peptides derived from gp100(209-217) (210M) (IMDQVPSFV) and tyrosinase(368-376) (370D) (YMDGTMSQV) emulsified with incomplete Freund's adjuvant (IFA). Patients were assigned randomly to receive either...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/cncr.11045

    authors: Weber J,Sondak VK,Scotland R,Phillip R,Wang F,Rubio V,Stuge TB,Groshen SG,Gee C,Jeffery GG,Sian S,Lee PP

    更新日期:2003-01-01 00:00:00

  • Treatment of metastatic breast cancer with aminoglutethimide.

    abstract::Seventy-three women with metastatic breast cancer were treated with aminoglutethimide and dexamethasone. No complete responses occurred. Ten patients (16%) achieved partial responses (mean duration, 12 months). The proportions of patients responding by disease site were breast (50%), nodes (33%), skin (23%), bone (16%...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810415)47:8<1954::aid-cncr2820

    authors: Asbury RF,Bakemeier RF,Fölsch E,McCune CS,Savlov E,Bennett JM

    更新日期:1981-04-15 00:00:00

  • The predictive value of estrogen and progesterone receptors' concentrations on the clinical behavior of breast cancer in women. Clinical correlation on 547 patients.

    abstract::The aims of this study were as follows: to confirm that the presence of estrogen (ER) and progesterone (PgR) receptors is an indicator of clinical behavior of human breast cancer independent of other known prognostic factors; to seek clinical correlates of those receptor values that best predict the overall disease ev...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860315)57:6<1171::aid-cncr2820

    authors: Vollenweider-Zerargui L,Barrelet L,Wong Y,Lemarchand-Béraud T,Gómez F

    更新日期:1986-03-15 00:00:00

  • Gianturco expandable wire stents in the treatment of superior vena cava syndrome recurring after maximum-tolerance radiation.

    abstract::Two patients with superior vena cava syndrome (SVCS) recurring after maximum-tolerance radiation were treated by placing a Gianturco expandable wire stent (GEWS) into the obstructed superior vena cava. The SVCS symptoms rapidly disappeared and good short-term (6 months) palliation was achieved. GEWS placement is a pro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870915)60:6<1243::aid-cncr2820

    authors: Rösch J,Bedell JE,Putnam J,Antonovic R,Uchida B

    更新日期:1987-09-15 00:00:00

  • Genetic variants of the p53 and p73 genes jointly increase risk of second primary malignancies in patients after index squamous cell carcinoma of the head and neck.

    abstract:BACKGROUND:Because of the structural and biochemical similarities between the antitumor p53 and p73 proteins, the authors hypothesized that individuals who carry high-risk genotypes of p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms have a higher risk of developing second primary malignancy (SPM) after index squamous...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.26222

    authors: Zhang Y,Sturgis EM,Huang Z,Zafereo ME,Wei Q,Li G

    更新日期:2012-01-15 00:00:00

  • A case of primary B-cell lymphoma of the breast. Light and electron microscopy, and immunologic cell markers.

    abstract::A case of primary non-Hodgkin's lymphoma of the breast was studied with light and electron microscopy and for immunologic cell markers. With light microscopy, the tumor was seen to be a poorly differentiated lymphocytic lymphoma, diffuse, according to Rappaport's classification. With electron microscopy, the tumor was...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830815)52:4<671::aid-cncr28205

    authors: Tateno M,Yoshiki T,Itoh T,Takamuro M,Saito C

    更新日期:1983-08-15 00:00:00

  • Is axillary lymph node dissection necessary in elderly patients with breast carcinoma who have a clinically uninvolved axilla?

    abstract:BACKGROUND:Axillary dissection in elderly patients with early-stage breast carcinoma who do not have palpable axillary lymph nodes is controversial because of the associated morbidity of the surgery, reduced life expectancy of the patients, and efficacy of hormone therapy in preventing recurrences and axillary events. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11173

    authors: Martelli G,Miceli R,De Palo G,Coradini D,Salvadori B,Zucali R,Galante E,Marubini E

    更新日期:2003-03-01 00:00:00

  • Surviving cancer.

    abstract::Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19940815)74:4+<1484::aid-cncr282

    authors: Andersen BL

    更新日期:1994-08-15 00:00:00

  • Primary linitis plastica of the colon: report of two cases and review of the literature.

    abstract::Two cases of primary linitis plastica of the large intestine will be presented and discussed. Characteristic clinical features of this type of adenocarcinoma of the large intestine include younger age of presentation, low incidence of hepatic metastasis and a high incidence of ovarian, lymph node and peritoneal metast...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197806)41:6<2420::aid-cncr282041

    authors: Amorn Y,Knight WA Jr

    更新日期:1978-06-01 00:00:00

  • Prognostic value of the plasminogen activation system in patients with gastric carcinoma.

    abstract:BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19960315)77:6<1035::aid-cn

    authors: Ganesh S,Sier CF,Heerding MM,van Krieken JH,Griffioen G,Welvaart K,van de Velde CJ,Verheijen JH,Lamers CB,Verspaget HW

    更新日期:1996-03-15 00:00:00

  • The diagnosis and grading of chondrosarcoma of bone: a combined cytologic and histologic approach.

    abstract::The diagnosis and grading of chondrosarcoma of bone is best established by a complementary study of its cytology, as observed in smeared preparations, and of its tissue structure and relationship to the host bone, as observed in histologic sections. Smeared preparations demonstrate the cytologic features of chondrosar...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800201)45:3<582::aid-cncr28204

    authors: Sanerkin NG

    更新日期:1980-02-01 00:00:00

  • Imaging at diagnosis impacts cancer-specific survival among patients with cancer of the oropharynx.

    abstract:BACKGROUND:The optimal imaging for the staging of oropharyngeal cancer is not well defined. METHODS:The linked Surveillance, Epidemiology, and End Results (SEER)-Medicare database for 2006 through 2011 was used to compare patient characteristics and hospital region by the initial imaging modality used for patients wit...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32148

    authors: Morgan RL,Eguchi MM,Mueller AC,Daugherty SL,Amini A,Karam SD

    更新日期:2019-08-15 00:00:00

  • Conditional survival estimates improve over time for patients with advanced melanoma: results from a population-based analysis.

    abstract:BACKGROUND:Conditional survival (CS) has emerged as a clinically relevant measure of prognosis for cancer survivors. The objective of this analysis was to provide melanoma-specific CS estimates to help clinicians promote more informed patient decision making. METHODS:Patients with melanoma and at least 5 years of foll...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.24966

    authors: Xing Y,Chang GJ,Hu CY,Askew RL,Ross MI,Gershenwald JE,Lee JE,Mansfield PF,Lucci A,Cormier JN

    更新日期:2010-05-01 00:00:00

  • The Chicago Consensus on peritoneal surface malignancies: Management of colorectal metastases.

    abstract::The Chicago Consensus Working Group provides multidisciplinary recommendations for the management of colorectal cancer specifically as it relates to the management of peritoneal surface malignancy. These guidelines are developed with input from leading experts, including surgical oncologists, medical oncologists, path...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32874

    authors: Chicago Consensus Working Group.

    更新日期:2020-06-01 00:00:00

  • Remission of rapidly growing desmoid tumors after tamoxifen therapy.

    abstract::A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbeari...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19831215)52:12<2201::aid-cncr282

    authors: Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJ

    更新日期:1983-12-15 00:00:00

  • Papillary tumors of large lactiferous ducts.

    abstract::The breast pathology files at the Institut Gustave-Russy in Villejuif, France, were searched for papillary cystadenomas and papillary carcinomas diagnosed between January 1, 1960, and December 31, 1974. A total of 158 cases were selected for this study; they were subclassified into 74 papillary cystadenomas, 63 papill...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19810701)48:1<122::aid-cncr28204

    authors: Murad TM,Contesso G,Mouriesse H

    更新日期:1981-07-01 00:00:00

  • Acute hepatic vein thrombosis occurring during therapy for Hodgkin's disease: a case report.

    abstract::A case of fatal acute hepatic vein thrombosis occurred during treatment for Hodgkin's disease. At necropsy no evidence of Hodgkin's disease or obliterative venoocclusive disease of the liver was found. We speculate that Adriamycin, DTIC and/or vinblastine may have been responsible for this unusual disorder. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197912)44:6<2324::aid-cncr282044

    authors: Houghton AN,Shafi N,Rickles FR

    更新日期:1979-12-01 00:00:00

  • Fournier's gangrene complicating aggressive therapy for hematologic malignancy.

    abstract::The authors describe two cases of Fournier's gangrene complicating aggressive therapy for hematologic malignancies. Fournier's gangrene is a fulminant necrotizing fasciitis of the scrotum and penis, often with an infectious etiology. Only one prior case has been reported in a patient receiving aggressive chemotherapy ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860615)57:12<2291::aid-cncr282

    authors: Berg A,Armitage JO,Burns CP

    更新日期:1986-06-15 00:00:00

  • Fine-needle aspiration cytology of spindle cell lesions of the breast.

    abstract:BACKGROUND:Fine-needle aspiration biopsy (FNA) has been successful in diagnosing epithelial lesions of the breast. Its role in the evaluation of spindle cell and mesenchymal lesions of the breast, which include a variety of benign and malignant conditions, is less clear. This article discusses the cytologic features an...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19991225)87:6<359::aid-cnc

    authors: Chhieng DC,Cangiarella JF,Waisman J,Fernandez G,Cohen JM

    更新日期:1999-12-25 00:00:00

  • Esthesioneuroblastoma masquerading as extramedullary plasmacytoma.

    abstract::Nine years after biopsy and radiation therapy for an extramedullary plasmacytoma of the nasal cavity, a 64-year-old man developed locally recurrent tumor. Repeat biopsy revealed tumor identical in hematoxylin and eosin stain (H & E) appearance to that found originally, leading to the diagnosis of recurrent extramedull...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19870701)60:1<88::aid-cncr282060

    authors: Abrams RA,Wilson JF,Komorowski RA,Collins D,Toohill RJ

    更新日期:1987-07-01 00:00:00

  • Basal cell carcinoma. An epidemiologic study in a defined population.

    abstract:BACKGROUND:The incidence of basal cell carcinoma (BCC) in a defined population is unknown. METHODS:The incidence of histologically diagnosed cases of BCC in a defined population of a city in southern Sweden was studied. Four 2-year periods were examined from 1970 to 1986. Cases from 1970 and 1980 were reexamined micro...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19920701)70:1<104::aid-cncr28207

    authors: Dahl E,Aberg M,Rausing A,Rausing EL

    更新日期:1992-07-01 00:00:00

  • Refined prognostic evaluation in colon carcinoma using immunohistochemical galectin fingerprinting.

    abstract:BACKGROUND:Knowledge of the expression of the galectins in human colon carcinomas is mainly restricted to galectin-3 and, to a lesser extent, galectin-1. The current study analyzed the prognostic values contributed by galectin-1, galectin-3, galectin-4, and galectin-8 in cases of colon carcinoma. METHODS:The authors s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.11268

    authors: Nagy N,Legendre H,Engels O,André S,Kaltner H,Wasano K,Zick Y,Pector JC,Decaestecker C,Gabius HJ,Salmon I,Kiss R

    更新日期:2003-04-15 00:00:00

  • Histology and DNA contents of a secondary malignancy arising in a mature residual lesion six years after chemotherapy for a disseminated nonseminomatous testicular tumor.

    abstract::The current report describes a secondary malignancy developing in a retroperitoneal mature residual lesion 6 years after chemotherapeutic treatment of a disseminated nonseminomatous testicular tumor. The histologically malignant component was not present in the primary tumor and consisted of polygonal and fusiform cel...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860715)58:2<264::aid-cncr28205

    authors: Molenaar WM,Oosterhuis JW,Meiring A,Sleyfer DT,Schraffordt Koops H,Cornelisse CJ

    更新日期:1986-07-15 00:00:00

  • Improved detection of focal lesions with computerized tomographic examination of the liver using ethiodized oil emulsion (EOE-13) liver contrast.

    abstract::A prospective study of computerized tomography (CT) of the liver using a liver contrast agent compared to conventional CT was undertaken. CT scanning without contrast agents (NC-CT), CT with water-soluble contrast (WSC-CT), and CT with ethiodized oil emulsion (EOE-CT) were performed on patients with possible or probab...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841015)54:8<1489::aid-cncr2820

    authors: Sugarbaker PH,Vermess M,Doppman JL,Miller DL,Simon R

    更新日期:1984-10-15 00:00:00

  • Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Sp gamma in frozen sections or cytosol-based ligand-binding assays.

    abstract:BACKGROUND:Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextran-coated charcoal method (DCC). Immunocytochemical assays (ICA) for ER are more recent and have been executed mostly on frozen sections with the monoclonal antibody H222...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19960615)77:12<2514::AID-C

    authors: Pertschuk LP,Feldman JG,Kim YD,Braithwaite L,Schneider F,Braverman AS,Axiotis C

    更新日期:1996-06-15 00:00:00