Abstract:
:The DNA sequences around codons 12, 13, and 61 of the ras gene were analyzed by polymerase chain reaction and direct sequencing in 18 intrahepatic cholangiocarcinomas. The ras gene mutations were found in 9 of 18 (50%): 6 in K-ras codon 12, 1 in K-ras codon 13, 1 in K-ras codon 61, and 1 in N-ras codon 12. The incidence of mutations was higher in the hilar type of intrahepatic cholangiocarcinomas, especially when these tumors were large. The incidence and spectrum of the mutations were almost the same as those reported in colon cancers, possibly indicating similar etiologic agent(s) in the carcinogenesis of both cancers.
journal_name
Cancerjournal_title
Cancerauthors
Tada M,Omata M,Ohto Mdoi
10.1002/cncr.2820690509subject
Has Abstractpub_date
1992-03-01 00:00:00pages
1115-8issue
5eissn
0008-543Xissn
1097-0142journal_volume
69pub_type
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