Abstract:
BACKGROUND:The American Joint Committee on Cancer (AJCC) 7th edition introduced major changes in the staging of lung cancer, including the tumor (T), node (N), metastasis (M)-TNM-system and new stage/prognostic site-specific factors (SSFs), collected under the Collaborative Stage Version 2 (CSv2) Data Collection System. The intent was to improve the stage precision that could guide treatment options and ultimately lead to better survival. This report examines stage trends, the change in stage distributions from the AJCC 6th to the 7th edition, and findings of the prognostic SSFs for 2010 lung cancer cases. METHODS:Data were from the November 2012 submission of 18 Surveillance, Epidemiology, and End Results (SEER) Program population-based registries. A total of 344,797 cases of lung cancer, diagnosed in 2004-2010, were analyzed. RESULTS:The percentages of small tumors and early-stage lung cancer cases increased from 2004 to 2010. The AJCC 7th edition, implemented for 2010 diagnosis year, subclassified tumor size and reclassified multiple tumor nodules, pleural effusions, and involvement of tumors in the contralateral lung, resulting in a slight decrease in stage IB and stage IIIB and a small increase in stage IIA and stage IV. Overall about 80% of cases remained the same stage group in the AJCC 6th and 7th editions. About 21% of lung cancer patients had separate tumor nodules in the ipsilateral (same) lung, and 23% of the surgically resected patients had visceral pleural invasion, both adverse prognostic factors. CONCLUSIONS:It is feasible for high-quality population-based registries such as the SEER Program to collect more refined staging and prognostic SSFs that allows better categorization of lung cancer patients with different clinical outcomes and to assess their survival.
journal_name
Cancerjournal_title
Cancerauthors
Chen VW,Ruiz BA,Hsieh MC,Wu XC,Ries LA,Lewis DRdoi
10.1002/cncr.29045subject
Has Abstractpub_date
2014-12-01 00:00:00pages
3781-92eissn
0008-543Xissn
1097-0142journal_volume
120 Suppl 23pub_type
杂志文章相关文献
CANCER文献大全abstract::A unique case of pulmonary rhabdomyosarcoma with an isolated, symptomatic small bowel metastasis is presented. The tumor affected the middle lobe, and was treated with a right pneumonectomy. Eleven months after the operation, an isolated small bowel metastasis, which produced intestinal obstruction, was resected. The ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840501)53:9<1948::aid-cncr2820
更新日期:1984-05-01 00:00:00
abstract:BACKGROUND:Cisplatin is one of the single drugs that has shown the best documented effect in treating patients with locally recurrent or metastatic urothelial cancer. To the authors' knowledge, the effect of the combination of different platinum analogues in treating transitional cell carcinoma has not been evaluated p...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19951115)76:10<1797::aid-cncr282
更新日期:1995-11-15 00:00:00
abstract:BACKGROUND:Although almost half of all incidents of breast carcinoma occur in women age > or = 65 years, not enough is known about appropriate care for patients in this age group. The objective of the current study was to evaluate the role of breast conservation therapy in the management of breast carcinoma in women ag...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010901)92:5<1092::aid-cncr1425
更新日期:2001-09-01 00:00:00
abstract::Between February 1983 and February 1986, 132 patients with advanced urothelial tract tumors were treated with methotrexate, vinblastine, Adriamycin (doxorubicin), and cisplatin (M-VAC) chemotherapy. Analysis of prognostic factors for survival of the first 92 patients was undertaken using the Cox proportional hazards m...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910315)67:6<1525::aid-cncr2820
更新日期:1991-03-15 00:00:00
abstract::While using the natural killer (NK) cell-associated HNK-1 antibody in a panel of hematopoietic cell markers, the authors found that metastatic tumor cells in the bone marrow of a patient with disseminated prostatic carcinoma stained strongly with this antibody using an indirect immunofluorescence technique. More than ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850715)56:2<289::aid-cncr28205
更新日期:1985-07-15 00:00:00
abstract:BACKGROUND:This retrospective analysis examines the frequency, distribution, and the pattern of disease progression of bone metastasis in patients treated for cervical cancer and the use and results of palliative intent radiation therapy. METHODS:Charts, films, and other available records were reviewed for the 41 pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940501)73:9<2372::aid-cncr2820
更新日期:1994-05-01 00:00:00
abstract::Immunoblastic sarcoma is a malignancy of transformed lymphocytes with a high association of occurrence in patients with immune disorders. The youngest previously reported case occurred in a 6-year-old child with immunoblastic lymphadenopathy. The authors report the finding of immunoblastic sarcoma of B-cells in a prev...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<2032::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract::A patient with a 17-year course of metastatic lobular carcinoma of the breast is described who developed large numbers of circulating carcinoma cells which were easily detectable in several routine peripheral blood smears shortly before death. This rare complication of carcinoma has been called "carcinocythemia." Carc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197712)40:6<3107::aid-cncr282040
更新日期:1977-12-01 00:00:00
abstract::Between January 1988 and June 1990, seven previously untreated patients with histologically confirmed and clinically staged IIIa invasive thymoma (IT) were enrolled in a prospective, single treatment arm study of neoadjuvant chemotherapy (NC) followed by surgery and postoperative radiation therapy (4600 to 6000 cGy). ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<706::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract::As part of epidemiologic studies of human T-lymphotropic virus (HTLV)-I-associated malignancies in Jamaica, the authors evaluated 26 patients with non-Hodgkin's lymphoma for the presence of integrated HTLV-I provirus in their malignant cells. Fifteen of 26 patients had integrated provirus. All 15 also were HTLV-I anti...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880401)61:7<1477::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract::Multiple endocrine neoplasia, type 2b (MEN 2b) is a disorder characterized by C-cell disease of the thyroid gland (medullary carcinoma or C-cell hyperplasia, or both), pheochromocytoma, ganglioneuromatosis, and skeletal and connective tissue abnormalities. The medullary thyroid carcinoma (MTC) is bilateral and multice...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(197912)44:6<2173::aid-cncr282044
更新日期:1979-12-01 00:00:00
abstract::The natural history of the development of neoplasia in experimental systems may be separated into at least three different stages, those of initiation, promotion and progression. Evidence for such distinct stages has been demonstrated in at least half a dozen different experimental systems. The stage of promotion is t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820315)49:6<1206::aid-cncr2820
更新日期:1982-03-15 00:00:00
abstract:BACKGROUND:Nude mice with xenografted human tumors is the most exploited animal model used to elucidate the efficacy of experimental radioimmunolocalization and radioimmunotherapy. These animals accept transplants and are generally considered immunologically inert with regard to cell-mediated and humoral immune respons...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19971215)80:12+<2404::aid-
更新日期:1997-12-15 00:00:00
abstract:BACKGROUND:The aim of this study was to determine if extrapulmonary small cell carcinomas (EPSCC) should be managed using protocols similar to those for small cell lung cancer (SCLC). METHODS:Treatment strategies, survival, patterns of failure, and prognostic factors for patients with EPSCC were analyzed retrospective...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24858
更新日期:2010-02-15 00:00:00
abstract::Common myths about nutrition education and care of cancer patients are debunked and realities are discussed. First, frequently held misconceptions of nonspecialized health professionals are considered. These include the myths that diet change in the population will be rapid now that dietary guidelines to prevent cance...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8+<1887::aid-cncr282
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:Since the 1970s, incidence rates of esophageal and gastric cardia adenocarcinoma have risen substantially. Reasons for the increasing trends are not well understood. METHODS:A population-based, case-control study that included esophageal adenocarcinomas (n = 222), gastric cardia adenocarcinomas (n = 277), d...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11568
更新日期:2003-09-01 00:00:00
abstract::Despite few effective therapies, only a small percentage of patients diagnosed with myelodysplastic syndromes (MDS) in the United States are enrolled in prospective, interventional clinical trials. MDS-specific barriers to trial accrual include a high frequency of elderly patients with comorbid conditions, atypical di...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31769
更新日期:2018-12-15 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNA) has been successful in diagnosing epithelial lesions of the breast. Its role in the evaluation of spindle cell and mesenchymal lesions of the breast, which include a variety of benign and malignant conditions, is less clear. This article discusses the cytologic features an...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19991225)87:6<359::aid-cnc
更新日期:1999-12-25 00:00:00
abstract::Chemotherapy of advanced stages of large bowel cancer has until recently made little progress since the introduction of 5-FU 16 years ago. While survival is improved for patients who respond, 5-FU alone has made little impact on life span of the overall population of patients. Mitomycin-C and the chloroethyl nitrosour...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197512)36:6<2418::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract::For women who are candidates for menopausal hormone therapy (MHT), estrogen can provide relief from symptomatic menopause, decrease rates of chronic illnesses, and improve health-related quality of life. However, confusion surrounds the evidence regarding the impact of exogenous estrogen and progesterone on the breast...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.31911
更新日期:2019-02-15 00:00:00
abstract::Cases of systemic lupus erythematosus, systemic sclerosis, periarteritis nodosa, and dermato- and polymyositis autopsied in Japan during a recent, 7-year period (1972-1978) were studied to assess the incidence of cancer as a complication. In comparison with the other three groups, cases of dermato- and polymyositis (D...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1841::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:An intensive in-patient Phase II study of continuous infusion recombinant human interleukin-2 (rhIL-2) 3 X 10(6) Roche units (9 MIU/m2)/day plus intramuscular injection of interferon-alpha-2a (rIFN-alpha-2a) 5 x 10(6) U/m2/day, four consecutive days per week, was performed to determine whether four consecuti...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Cirrhosis of viral etiology due to hepatitis B virus (HBV) or hepatitis C virus (HCV) infection is a risk factor for hepatocellular carcinoma (HCC). The current study evaluated the rate of incidence of HCC in patients with compensated cirrhosis of viral etiology. METHODS:Two hundred fifty-nine cirrhotic pat...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1999-05-15 00:00:00
abstract::The clonal growth pattern of bone marrow and peripheral blood cells from 16 patients with clinically suspected chronic myelogenous leukemia (CML) was evaluated in the double-layer agar system. Cytogenetic studies were performed on parallel marrow and peripheral blood samples. In four cases a unique growth pattern emer...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841215)54:12<2956::aid-cncr282
更新日期:1984-12-15 00:00:00
abstract:BACKGROUND:p53 plays a critical role in cellular anticancer mechanisms, and has been correlated with second primary malignancy (SPM) development. A common polymorphism in codon 72 of p53 results in an amino acid substitution and could influence p53 function. The authors hypothesized that p53 codon 72 polymorphism may b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25072
更新日期:2010-05-15 00:00:00
abstract:BACKGROUND:Minority patients with cancer are at risk for undertreatment of cancer-related pain. Most studies of patient-related barriers to pain control have surveyed primarily non-Hispanic Caucasian patients. The purpose of the current study was to explore barriers to optimal pain management among African-American and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10414
更新日期:2002-04-15 00:00:00
abstract::Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197904)43:4<1541::aid-cncr282043
更新日期:1979-04-01 00:00:00
abstract::A retrospective study of all cases of seminoma treated at Roswell Park Memorial Institute from 1970 through 1979 was conducted. Fifty-six evaluable patients treated initially with radiation therapy were seen during this period, and the overall survival rate at an average follow-up period of 52 months was 82%. The surv...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840401)53:7<1451::aid-cncr2820
更新日期:1984-04-01 00:00:00
abstract:BACKGROUND:Interleukin-2 (IL-2) is used in the treatment of solid tumors and hematologic malignancies. Sudden death is a rare complication of IL-2 treatment. METHODS:A patient with lymphoma underwent chemoradiotherapy myeloablation and autologous stem cell transplantation. The stem cells were cultured in IL-2 (6000 IU...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1231::aid-cn
更新日期:1998-09-15 00:00:00
abstract:BACKGROUND:New biologic prognostic factors are needed to guide the treatment of patients with colorectal cancer. The prognostic value of the altered expression of the cell surface glycoprotein gp78, which has been implicated in tumor-cell invasion and metastasis as an autocrine motility factor (AMF) receptor, was evalu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19941001)74:7<1855::aid-cncr2820
更新日期:1994-10-01 00:00:00