Abstract:
:For women who are candidates for menopausal hormone therapy (MHT), estrogen can provide relief from symptomatic menopause, decrease rates of chronic illnesses, and improve health-related quality of life. However, confusion surrounds the evidence regarding the impact of exogenous estrogen and progesterone on the breast and ovary. Available data regarding the risks of MHT (estrogen and/or progestin) related to the development of breast and ovarian cancer are often inconsistent or incomplete. Modern molecular and genetic techniques have improved our understanding of the heterogeneity of breast and ovarian cancer. This enhanced understanding of the disease has impacted our understanding of carcinogenesis. Treatment options have evolved to be more targeted toward hormonal therapy for certain subtypes of disease, whereas cytotoxic chemotherapy remains the standard for other histological and molecular subtypes. The role of MHT in the breast and ovarian cancer survivor, as well as women who are at high risk for the development of hereditary breast and ovarian cancer, remains controversial despite evidence that this treatment can improve quality of life and survival outcomes. Through this article, we examine the evidence for and against the use of MHT with a focus on women who have or are at high risk for breast and ovarian cancer.
journal_name
Cancerjournal_title
Cancerauthors
Temkin SM,Mallen A,Bellavance E,Rubinsak L,Wenham RMdoi
10.1002/cncr.31911keywords:
["breast cancer","cancer risk","hormone maintenance therapy","hormone replacement therapy","menopausal hormone therapy","ovarian cancer"]subject
Has Abstractpub_date
2019-02-15 00:00:00pages
499-514issue
4eissn
0008-543Xissn
1097-0142journal_volume
125pub_type
杂志文章,评审相关文献
CANCER文献大全abstract::A leukocyte migration procedure was utilized to test cellular hypersensitivity of breast cancer patients' leukocytes to autologous and homologous breast cancer tissues and to murine milk containing murine mammary tumor virus (MuMTV). The in vitro responsiveness of the leukocytes and the antigenicity of breast cancer t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197501)35:1<121::aid-cncr2820350
更新日期:1975-01-01 00:00:00
abstract:BACKGROUND:In the United States, neoadjuvant chemoradiotherapy (NACRT) is widely accepted as the standard of care in the treatment of patients with locally advanced rectal cancer. In the current study, the authors attempted to examine patterns of treatment in the United States over the past decade. METHODS:Using the N...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29993
更新日期:2016-07-01 00:00:00
abstract::The cases of three patients with primary carcinoid tumor of the testis were reported. The patients were 41, 44, and 83 years of age. At initial examination, all three had testicular masses with or without associated pain, and none had the carcinoid syndrome. The tumors measured 4.3 cm, 3.0 cm, and 6.5 cm in dimension....
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930901)72:5<1726::aid-cncr2820
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND:The treatment of advanced, inoperable, or recurrent parotid tumors represents a clinical challenge. The results obtained with conventional radiotherapy are disappointing. To improve the early response and local control of parotid tumors, local microwave hyperthermia was used in combination with ionizing radi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19950215)75:4<908::aid-cncr28207
更新日期:1995-02-15 00:00:00
abstract:BACKGROUND:The MAGE, BAGE, and GAGE gene families code for distinct, tumor specific antigens that are recognized by cytotoxic T lymphocytes in the context of HLA molecules. The purpose of this study was to analyze MAGE, BAGE, and GAGE gene expression in the two major histologic types of esophageal carcinoma, squamous c...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2001-05-15 00:00:00
abstract:BACKGROUND:There exist insufficient data characterizing patients with multiple myeloma (MM) who experienced prolonged survival. A population-based analysis of long-term survivors was conducted to investigate the roles of sociodemographic factors and upfront stem cell transplantation (SCT). METHODS:The National Cancer ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32357
更新日期:2019-10-15 00:00:00
abstract:BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960915)78:6<1267::AID-CN
更新日期:1996-09-15 00:00:00
abstract:BACKGROUND:Children with average-risk acute lymphoblastic leukemia (AR-ALL) face many challenges that can adversely affect their quality of life (QOL). However, to the authors' knowledge, patterns and predictors of QOL impairment during therapy have not been well characterized to date. METHODS:Patients with AR-ALL who...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31085
更新日期:2018-02-01 00:00:00
abstract::The clinical diagnosis of lymphangitic carcinomatosis of the lung has generally been confirmed by open lung or transthoracic needle biopsy, precedures with significant morbidity and mortality, particularly in patients with respiratory insufficiency. We present six cases of lymphangitic carcinomatosis diagnosed by tran...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197810)42:4<1995::aid-cncr282042
更新日期:1978-10-01 00:00:00
abstract::The reactivity of serum alpha-fetoprotein (AFP) from 20 patients with hepatocellular carcinoma (HCC) with immobilized lentil lectin was examined and found to be significantly greater (39% +/- 18%) than that of the same protein from seven patients with chronic liver disease (CLD, 11.2% +/- 3.3%), seven with fulminant h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910115)67:2<476::aid-cncr28206
更新日期:1991-01-15 00:00:00
abstract:BACKGROUND:Ewing's sarcomas, osteosarcomas, and rhabdomyosarcomas are significantly more responsive to chemotherapy than other sarcomas. Adjuvant chemotherapy is used routinely based on data from randomized trials. Although a percentage of children with locally advanced or metastatic tumors remain curable, few data exi...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract:BACKGROUND:Population-based studies suggest that, because of inequalities in treatment, black women with localized endometrial cancer have shorter survival compared with white women. The objective of the current investigation was to determine whether there is a racial disparity in outcome between black patients and whi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23717
更新日期:2008-09-15 00:00:00
abstract::To surgery, radiation, and chemotherapy for cancer has been added a fourth modality: multidisciplinary therapy, which is improving the survival and cure rate among children. Specialists working together in a coordinated effort suspect, confirm, then treat cancer; follow and rehabilitate the patient; analyze and report...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197503)35:3+<876::aid-cncr282035
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:An intensive in-patient Phase II study of continuous infusion recombinant human interleukin-2 (rhIL-2) 3 X 10(6) Roche units (9 MIU/m2)/day plus intramuscular injection of interferon-alpha-2a (rIFN-alpha-2a) 5 x 10(6) U/m2/day, four consecutive days per week, was performed to determine whether four consecuti...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:The antiviral, proapoptotic, antiproliferative gene 2'-5' oligoadenylate synthetase (2-5OAS1) converts adenosine triphosphate into a series of 2'-5' oligoadenylates (2-5A). In turn, 2-5A activates latent ribonuclease (RNaseL), a candidate hereditary prostate cancer gene. OAS1 polymorphism (reference single n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26219
更新日期:2011-12-15 00:00:00
abstract:BACKGROUND:Desmoplastic melanoma is an uncommon variant of cutaneous melanoma that mimics soft tissue sarcoma both clinically and morphologically. An activating point mutation of the BRAF oncogene has been identified in a high proportion of conventional cutaneous melanomas, but its frequency in the desmoplastic subtype...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20861
更新日期:2005-02-15 00:00:00
abstract::Congenital self-healing histiocytosis (CSHH) is a rare primary histiocytic skin disorder. Only a few cases have been studied by ultrastructure and immunohistochemistry. Here we report a new case that was investigated using an electron microscope and a panel of monoclonal (MCA) and polyclonal (PCA) antibodies. CSHH cel...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880201)61:3<508::aid-cncr28206
更新日期:1988-02-01 00:00:00
abstract:BACKGROUND:Bioimpedance spectroscopy (BIS) has enabled the early identification of breast cancer-related lymphedema. In this study, differences in health service metrics and in the incidence of breast cancer-related lymphedema are evaluated in an early surveillance model of care compared with a traditional referral mod...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31873
更新日期:2019-03-15 00:00:00
abstract::Previous studies and those of the authors have reported about raised levels of lipid-bound sialic acid (LSA) in sera of patients with various neoplasms. Most authors have used the method of Katopodis and Stock for isolating serum LSA. Because of the discrepancy of the amount of extracted LSA with the content of pure g...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19891201)64:11<2279::aid-cncr282
更新日期:1989-12-01 00:00:00
abstract::Adjuvant systemic treatments have greatly improved the prognosis of women with early breast cancer. Combination chemotherapy and, for patients with oestrogen receptor-positive (ER+) tumours, endocrine treatment has been found to reduce the frequency of relapse and improve survival. New adjuvant strategies include the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11124
更新日期:2003-02-01 00:00:00
abstract:BACKGROUND:Current salvage therapy for recurrent high-risk neuroblastoma is rarely curative. Assessment of the effectiveness of new, primarily cytostatic agents requires the redefinition of study endpoints to reflect disease stabilization rather than tumor response or regression. The intervals of disease control in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23507
更新日期:2008-06-15 00:00:00
abstract::During 6375 patient-years of observation, 136 new cancers developed in 117 of 1429 patients with squamous cell carcinoma of the oral cavity. The risk of multiple cancers was excessive in the upper digestive or respiratory tract in patients with squamous cell carcinoma of the oral cavity, accounting for 87 (64%) of the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871215)60:12<3083::aid-cncr282
更新日期:1987-12-15 00:00:00
abstract:BACKGROUND:The clinical features and natural history of adrenocortical carcinoma are highly dependent on the type of center reporting their experience. Observations from oncology services suggest a high incidence of nonfunctioning tumors, whereas reports from endocrine clinics emphasize excessive corticoid and androgen...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:2000-02-15 00:00:00
abstract:BACKGROUND:The delivery of effective treatment for pediatric solid tumors poses a particular challenge to centers in middle-income countries (MICs) that already are vigorously addressing pediatric cancer. The objective of this study was to improve the current understanding of barriers to effective treatment of pediatri...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.28339
更新日期:2014-01-01 00:00:00
abstract:BACKGROUND:Lesions of the thyroid gland composed of Hurthle cells encompass pathologic entities ranging from hyperplastic nodules with Hurthle cell metaplasia to Hurthle cell carcinomas. The cytologic distinction between these entities can be diagnostically challenging. Many cytologic features of Hurthle cell lesions t...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21716
更新日期:2006-04-25 00:00:00
abstract:BACKGROUND:Hispanics comprise almost one-third of the population of California, are the most rapidly increasing racial/ethnic group in the state, and represent almost one-third of all Hispanics in the U.S. California has among the highest rates of melanoma in the world, yet little is known about trends in melanoma in i...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21654
更新日期:2006-03-01 00:00:00
abstract::The potential role of paraneoplastic Cushing's syndrome (CS) was assessed on the clinical course of patients with small cell lung cancer. A retrospective comparison was done of complications and survival rates according to the presence or absence of CS in patients with small cell lung cancer who died within 90 days of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<66::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract::A case of gastric plasmacytoma is reported in an 81-year-old woman. Immunofluorescent and immunoelectrophoretic studies showed that the tumor cells produced IgM-lambda molecules, whereas no monoclonal immunoglobulin could be detected both in the serum and in the urine. Of more than 60 reported cases of gastric plasmac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(1984)54:4<638::aid-cncr282054040
更新日期:1984-08-15 00:00:00
abstract::A primary cardiac spindle cell tumor with immunoreactivity for keratin proteins is reported. Cytogenetic analysis of the tumor demonstrated a translocation (X;18), an aberration almost exclusively reported in synovial sarcomas. Postmortem examination revealed amphibole asbestos within the lungs and diaphragmatic pleur...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940101)73:1<74::aid-cncr282073
更新日期:1994-01-01 00:00:00
abstract::Thrombocytosis above 40.0 X 10(4)/mm3 occurred in five of six (83%) patients with malignant mesothelioma. In contrast, the incidence of thrombocytosis was 7.5% in patients with lung adenocarcinoma, 12.5% in squamous cell carcinoma, 5.1% in small cell carcinoma, and 41.7% in large cell carcinoma, respectively. The plat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8<1699::aid-cncr2820
更新日期:1986-10-15 00:00:00