The role of menopausal hormone therapy in women with or at risk of ovarian and breast cancers: Misconceptions and current directions.

Abstract:

:For women who are candidates for menopausal hormone therapy (MHT), estrogen can provide relief from symptomatic menopause, decrease rates of chronic illnesses, and improve health-related quality of life. However, confusion surrounds the evidence regarding the impact of exogenous estrogen and progesterone on the breast and ovary. Available data regarding the risks of MHT (estrogen and/or progestin) related to the development of breast and ovarian cancer are often inconsistent or incomplete. Modern molecular and genetic techniques have improved our understanding of the heterogeneity of breast and ovarian cancer. This enhanced understanding of the disease has impacted our understanding of carcinogenesis. Treatment options have evolved to be more targeted toward hormonal therapy for certain subtypes of disease, whereas cytotoxic chemotherapy remains the standard for other histological and molecular subtypes. The role of MHT in the breast and ovarian cancer survivor, as well as women who are at high risk for the development of hereditary breast and ovarian cancer, remains controversial despite evidence that this treatment can improve quality of life and survival outcomes. Through this article, we examine the evidence for and against the use of MHT with a focus on women who have or are at high risk for breast and ovarian cancer.

journal_name

Cancer

journal_title

Cancer

authors

Temkin SM,Mallen A,Bellavance E,Rubinsak L,Wenham RM

doi

10.1002/cncr.31911

keywords:

["breast cancer","cancer risk","hormone maintenance therapy","hormone replacement therapy","menopausal hormone therapy","ovarian cancer"]

subject

Has Abstract

pub_date

2019-02-15 00:00:00

pages

499-514

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

125

pub_type

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