Abstract:
BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cells. To explore the mechanisms underlying PN invasion by prostate carcinoma cells, the authors investigated the influence of neural components on the growth potential of prostate carcinoma cells. METHODS:Proliferative and apoptotic activities of PN and NPN carcinoma cells were analyzed on whole-mount sections of human prostates using immunohistochemical techniques in conjunction with a polyclonal Ki-67 antiserum, and the terminal deoxynucleotidyl transferase (TdT) mediated dUTP biotin nick end labeling (TUNEL) technique, respectively. RESULTS:The proliferative index (Ki-67 positive cells per 100 carcinoma cells) of PN carcinoma cells (median, 4.10) was higher than that of their intraprostatic, NPN counterparts (median, 3.25), although the difference was not statistically significant (median difference, 0.38; 95% confidence interval [CI] = -0.99 to 1.32; P = 0.52). In contrast, the apoptotic index (AI = apoptotic bodies per 1000 carcinoma cells) in the NPN carcinoma cells was significantly lower (median, 4.10), than the PN carcinoma cells (median, 7.23) with a median difference of -3.45 (95% CI = -5 to -1.39; P = 0.02). The authors also found that AI was lower in the carcinoma cells surrounding nerves with a large diameter (P = 0.0005). CONCLUSIONS:These results suggest that PN invasion by prostate carcinoma cells may not be only a volume effect of growing carcinomas; the neural components may favor the growth of carcinoma cells by inhibiting apoptosis, presumably through a paracrine mechanism, and thereby facilitate the spread of carcinoma cells along nerves. The data also suggest that heterogeneity in growth potential of prostate carcinoma cells may be determined by their local microenvironments, such as an association with neural components.
journal_name
Cancerjournal_title
Cancerauthors
Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TCdoi
10.1002/(SICI)1097-0142(19960915)78:6<1267::AID-CNsubject
Has Abstractpub_date
1996-09-15 00:00:00pages
1267-71issue
6eissn
0008-543Xissn
1097-0142pii
10.1002/(SICI)1097-0142(19960915)78:6<1267::AID-CNjournal_volume
78pub_type
杂志文章相关文献
CANCER文献大全abstract:BACKGROUND:The Edmonton Symptom Assessment Scale (ESAS) is a nine-item patient-rated symptom visual analogue scale developed for use in assessing the symptoms of patients receiving palliative care. The purpose of this study was to validate the ESAS in a different population of patients. METHODS:In this prospective stu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000501)88:9<2164::aid-cn
更新日期:2000-05-01 00:00:00
abstract:BACKGROUND:There is concern that antioxidant supplement use during chemotherapy and radiation therapy may decrease treatment effects, yet the effects of such supplements on recurrence and survival are largely unknown. METHODS:The authors prospectively examined the associations between antioxidant use after breast canc...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26526
更新日期:2012-04-15 00:00:00
abstract:BACKGROUND:Most patients with cutaneous squamous cell carcinoma (cSCC) of the head and neck (HN) are at low-risk (<5%) of developing metastatic SCC to regional lymph nodes. However, patients with unfavorable clinicopathologic factors often are under appreciated by clinicians but remain at higher risk for developing met...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21898
更新日期:2006-06-01 00:00:00
abstract:BACKGROUND:Some patients with gastric carcinoma experience local disease recurrence despite undergoing curative resection of the tumor and regional lymph nodes (LNs), suggesting the presence of occult micrometastases. To evaluate the presence of gastric carcinoma micrometastasis in patients with otherwise histologicall...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20011015)92:8<2056::aid-cncr1545
更新日期:2001-10-15 00:00:00
abstract::Formal cancer survivorship care is a growing focus internationally. This article provides a broad overview of the national strategies currently in progress for the development of survivorship programs and care plans within the United States and across Europe. The different approaches taken in their implementation, sta...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.28068
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:The objective of this study was to establish the incidence and risk factors for the development of second solid cancers after allogeneic hematopoietic stem cell transplantation (allo-HSCT). METHODS:The authors reviewed the case files of 926 consecutive patients who underwent allo-HSCT at their institution b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22375
更新日期:2007-01-01 00:00:00
abstract:BACKGROUND:Receipt of chemotherapy at the end of life (EOL) is considered an indicator of poor quality of care for medical oncology. The objective of this study was to characterize the use of radiotherapy (RT) in patients with nonsmall cell lung cancer (NSCLC) during the same period. METHODS:Treatment characteristics ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.27401
更新日期:2012-09-01 00:00:00
abstract::Available information suggests that individuals with breast cancer gain weight during adjuvant treatment and that this weight gain may be associated with poor prognosis. Exploration of the factors which affect weight gain may aid in developing weight control interventions for these patients. To determine the factors w...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910401)67:7<1954::aid-cncr2820
更新日期:1991-04-01 00:00:00
abstract::Prognostic factors were evaluated in 109 soft tissue sarcomas of the extremities, walls of the trunk, head, and neck. All lesions were graded according to the systems proposed by the National Cancer Institute (NCI) and the French Federation of Cancer Centers (FNCLCC), and a correlation was found between tumor grade an...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19890401)63:7<1437::aid-cncr2820
更新日期:1989-04-01 00:00:00
abstract::Five carcinoid tumors of the thymus were screened immunohistochemically for the occurrence of neuropeptides (ACTH, calcitonin, calcitonin gene-related peptide, cholecystokinin, gastrin, neurotensin, somatostatin, substance P), as well as of serotonin, chromogranin A, and neuron-specific enolase. Most of the patients e...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19871115)60:10<2465::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract:BACKGROUND:Gene expression profiling (GEP) has been rapidly adopted for early breast cancer and can aid in chemotherapy decision making. Study results regarding racial disparities in testing are conflicting, and may reflect different care settings. To the authors' knowledge, data regarding the influence of provider fac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31222
更新日期:2018-04-15 00:00:00
abstract::One promising area of current research in chemoprevention is the possibility that micronutrients, including vitamin A analogues, may decrease cancer incidence. The term "vitamin A" refers either to retinol (preformed vitamin A) and its synthetic analogues, or to certain carotenoids (provitamin A), which are converted ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19861015)58:8+<1837::aid-cncr282
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:The authors suggested that the loss of collagen IV and laminin-containing basement membrane and the loss of Disabled-2 (Dab2) expression were two critical events associated with morphologic dysplastic changes of the ovarian surface epithelium as a step in tumorigenicity. Both the basement membrane and Dab2, ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11847
更新日期:2003-12-15 00:00:00
abstract::Radiotherapy was applied to 14 esophageal carcinomas with respiratory tract fistulas using various treatment regimens. Closure of the fistulas was observed in four cases after irradiation at a daily dose of 1.5 Gy. The period of closure was transient in two cases but long-term in the other two. One long-term closure c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890901)64:5<1026::aid-cncr2820
更新日期:1989-09-01 00:00:00
abstract::Hodgkin's disease (HD) was diagnosed in 24 patients who were either seropositive for human immunodeficiency virus (HIV) (21) or members of a high-risk group (three), but had not developed acquired immune deficiency syndrome (AIDS). Clinical presentation of the disease was characterized by constitutional symptoms in al...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910315)67:6<1614::aid-cncr2820
更新日期:1991-03-15 00:00:00
abstract:BACKGROUND:Helicobacter pylori recently was identified as a risk factor for gastric cancer. Its association with preneoplastic conditions of the stomach, however, is undocumented. METHODS:Gastric biopsy specimens from 245 symptomatic patients were examined for neoplastic and preneoplastic lesions and for gastric H. py...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930115)71:2<297::aid-cncr28207
更新日期:1993-01-15 00:00:00
abstract::Oncologic therapy demands technologic sophistication to meet the clinical challenges of proper drug administration for chemotherapeutic agents, pain management, antibiotics, hydration, antiemetic drugs, and total parenteral nutrition. Drug administration systems for patient-controlled analgesia include benefits of imp...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:
更新日期:1992-08-15 00:00:00
abstract::Ependymomas originating in the sacrum or extraspinal parasacral soft tissues are rare tumors. The majority are of the myxopapillary type and may be locally destructive. Even though metastases are not uncommon in retrosacral ependymomas, they have been rarely described in intrasacral locations. A case is reported of a ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900515)65:10<2353::aid-cncr282
更新日期:1990-05-15 00:00:00
abstract:BACKGROUND:Human pancreatic ribonuclease (RNase 1) is a pancreatic enzyme that is present at high levels in the serum of most patients with pancreatic adenocarcinoma. For this reason, the authors studied its patterns of expression at the single-cell level in pancreatic adenocarcinoma tissues by immunohistochemical anal...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-09-15 00:00:00
abstract:BACKGROUND:Previous studies have shown that matrix metalloproteinase-2 (MMP-2) (a 72-kilodalton Type IV collagenase/gelatinase A) is associated with breast carcinoma, but to the authors' knowledge there are no reports showing that it is prognostic for overall survival. METHODS:Expression of the immunoreactive protein ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980915)83:6<1153::aid-cn
更新日期:1998-09-15 00:00:00
abstract::Chemokines are chemoattractant cytokines that regulate the trafficking and activation of leukocytes and other cell types under a variety of inflammatory and noninflammatory conditions. Over the past few years, studies have increasingly shown that chemokines play an important role in several aspects of tumor progressio...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.22706
更新日期:2007-06-15 00:00:00
abstract::Of 209 Hodgkin's disease patients treated at least 6 months with a five-drug combination of induction chemotherapy and having a complete remission, four patients developed acute myelogenous leukemia (AML) as a second malignant neoplasm. The overall relative risk for development of AML is 185.0 (P less than 0.05) and t...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(19831215)52:12<2209::aid-cncr282
更新日期:1983-12-15 00:00:00
abstract::Seventeen cases of intranasal epithelial tumors are reviewed. Thirteen were epithelial papillomas and four were squamous cell carcinomas associated with epithelial papillomas. In two cases followed over a 10 year period, transformation from an initial papilloma into a carcinoma was demonstrated. The histopathologic ca...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197612)38:6<2503::aid-cncr282038
更新日期:1976-12-01 00:00:00
abstract:BACKGROUND:Patients who have aggressive, refractory or recurrent non-Hodgkin lymphomas (NHLs) that are refractory to first-line anthracycline-containing regimens (ACRs) have a dismal outcome. Achieving complete remission (CR) is essential for a favorable outcome. To improve the CR rate in these patients, the authors de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21150
更新日期:2005-08-01 00:00:00
abstract:BACKGROUND:Cervical carcinoma remains a significant health risk for the older woman. In the current study the yield of screening of mature women in an established, opportunistic screening program was examined. Strategies for improving screening in this age group were identified through examination of recent Pap test hi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10723
更新日期:2002-08-25 00:00:00
abstract:BACKGROUND:Insular thyroid carcinoma was described originally as a tumor with aggressive behavior. However, whether a predominant insular component is an independent factor for poor prognosis is unclear. METHODS:The authors compared the clinical behavior of tumors in three groups of patients with thyroid carcinoma--13...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10947
更新日期:2002-11-15 00:00:00
abstract::Transgenic model systems provide tools for obtaining information that clarifies important relationships between genetic alterations and carcinogenesis. One such relationship is the induction of specific growth factor activities by dominantly acting oncogenes. Using a "transgenic organ" model referred to as mouse prost...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19930201)71:3+<1165::aid-cncr282
更新日期:1993-02-01 00:00:00
abstract::Unexpected nephrotoxicity has been described in high-dose, bolus ifosfamide (IFF) therapy. Renal injury is not thought to occur in patients receiving fractionated schedules, although microscopic hematuria from bladder irritation is not uncommon. IFF is undergoing trials in patients with malignant lymphomas, gynecologi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890215)63:4<649::aid-cncr28206
更新日期:1989-02-15 00:00:00
abstract:BACKGROUND:The Early Lung Cancer Action Project (ELCAP) is designed to evaluate baseline and annual repeat screening by low radiation dose computed tomography (low-dose CT) in persons at high-risk for lung cancer. The authors report on the baseline screening experience. For full evaluation of screening, they await the ...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(20001201)89:11+<2474::aid-cncr26
更新日期:2000-12-01 00:00:00
abstract:BACKGROUND:The aim of this retrospective study was to determine those prognostic factors associated with response to a second-line chemotherapy in patients with metastatic breast carcinoma (MBC) that was previously responsive to a first-line chemotherapy. METHODS:The 70 MBC patients studied had previously responded to...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-06-01 00:00:00