Abstract:
:Unexpected nephrotoxicity has been described in high-dose, bolus ifosfamide (IFF) therapy. Renal injury is not thought to occur in patients receiving fractionated schedules, although microscopic hematuria from bladder irritation is not uncommon. IFF is undergoing trials in patients with malignant lymphomas, gynecologic malignancies, and advanced sarcomas and has shown promising results. This report describes renal abnormalities in four patients with malignant lymphoma receiving single-agent, fractionated IFF and suggests a proximal tubular defect in two patients who were studied in greater detail. These findings suggest an unreported and unique toxicity of IFF when given in smaller, fractionated doses.
journal_name
Cancerjournal_title
Cancerauthors
Patterson WP,Khojasteh Adoi
10.1002/1097-0142(19890215)63:4<649::aid-cncr28206subject
Has Abstractpub_date
1989-02-15 00:00:00pages
649-51issue
4eissn
0008-543Xissn
1097-0142journal_volume
63pub_type
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