Chromosome changes in 17 human neoplasms studied with banding.

abstract：:Among the patients showing evidence of cerebral metastases without previously known cancer history, lung cancer has been found 37 times as the primary tumor in our institution. There were 34 men and three women and all but two were heavy smokers. Only one presented at diagnosis with thoracic symptoms but the chest rad...

journal_title：Cancer

authors： Trillet V,Catajar JF,Croisile B,Turjman F,Aimard G,Bourrat C,Bret P,Carrie C,Chassard JL,Chauvin F

更新日期：1991-06-01 00:00:00

abstract：BACKGROUND:The incidence of adenocarcinoma of the cervix did not decline in Western countries in the 1970s and 1980s despite the availability and use of cervical cytologic screening. The impact of improved endocervical sampling and better recognition of the cytologic precursors to adenocarcinoma during the 1990s in red...

journal_title：Cancer

authors： Mitchell H,Hocking J,Saville M

更新日期：2003-12-25 00:00:00

abstract：BACKGROUND:Various chemotherapy agents, especially of the alkylating category, have been associated with premature ovarian failure but there is no quantitative evidence of chemotherapy-induced ovarian damage in humans. The aim was to quantify the impact of chemotherapy on primordial follicle reserve and stromal functio...

journal_title：Cancer

authors： Oktem O,Oktay K

更新日期：2007-11-15 00:00:00

abstract：BACKGROUND:Clinical trials of monoclonal antibodies in combination with chemotherapy have reported previously unattained response rates in patients with B-cell chronic lymphocytic leukemia (B-CLL); however, the analysis of ZAP-70 protein and/or CD38 may explain better the discordant outcomes independent of treatment. ...

journal_title：Cancer

authors： Del Poeta G,Del Principe MI,Consalvo MA,Maurillo L,Buccisano F,Venditti A,Mazzone C,Bruno A,Gianní L,Capelli G,Lo Coco F,Cantonetti M,Gattei V,Amadori S

更新日期：2005-12-15 00:00:00

abstract：BACKGROUND:Soft tissue sarcomas (STSs) are heterogeneous neoplasms that have variable clinical outcome. Several clinical parameters and few molecular markers, including Ki-67 proliferative index, have been shown to correlate with patient prognosis. To the authors' knowledge, no definitive report exists to identify one ...

journal_title：Cancer

authors： Hoos A,Stojadinovic A,Mastorides S,Urist MJ,Polsky D,Di Como CJ,Brennan MF,Cordon-Cardo C

更新日期：2001-08-15 00:00:00

abstract：:The clinical and laboratory features of nine patients with chronic myelomonocytic leukemia are described. Hepatic or splenic enlargement accompanied by an absolute monocytosis in an older patient with an elevated serum or urine lysozyme and serum vitamin B12 levels were characteristic of the majority of patients in th...

journal_title：Cancer

authors： Gingrich RD,Burns CP

更新日期：1979-12-01 00:00:00

abstract：:A total of 63 surgically resected esophageal carcinomas (including 49 superficial esophageal carcinomas) and histologically normal tissue adjacent to the superficial carcinoma (nontumorous epithelium) were examined immunohistochemically for the blood group antigens (BGA) A, B, H, Lewisa, Lewisb, Lewisx, and Lewisy. De...

journal_title：Cancer

authors： Tauchi K,Kakudo K,Machimura T,Makuuchi H,Mitomi T

更新日期：1991-06-15 00:00:00

abstract：BACKGROUND:Despite recent improvements in the treatment of acute lymphoblastic leukemia (ALL), adult patients still have an overall poor outcome. The future of ALL management relies on the introduction of novel targeted therapies. The authors sought to assess if protein kinases (PKs), frequently deregulated in cancer, ...

journal_title：Cancer

authors： Messina M,Chiaretti S,Tavolaro S,Peragine N,Vitale A,Elia L,Sica S,Levis A,Guarini A,Foà R

更新日期：2010-07-15 00:00:00

abstract：:If women examine their breasts thoroughly and regularly they may promptly recognize abnormal tissue changes. The level of skill and motivation required for effective breast self-examination (BSE), however, is very high. In a prospective study of 304 patients with newly diagnosed breast cancer, 165 (54%) claimed to pra...

journal_title：Cancer

authors： Philip J,Harris WG,Flaherty C,Joslin CA

更新日期：1986-08-15 00:00:00

abstract：BACKGROUND:Uterine leiomyosarcoma (ULMS) is identified in 0.1% to 0.2% of hysterectomy specimens of presumed leiomyoma. To date, there is no preoperative technique that reliably differentiates ULMS from uterine leiomyoma. Increasing use of minimally invasive approaches for the management of leiomyomas may result in ina...

journal_title：Cancer

authors： George S,Barysauskas C,Serrano C,Oduyebo T,Rauh-Hain JA,Del Carmen MG,Demetri GD,Muto MG

更新日期：2014-10-15 00:00:00

abstract：BACKGROUND:Activating mutations in RAS are frequently present in patients with acute myeloid leukemia (AML), but their overall prognostic impact is not clear. METHODS:A retrospective analysis was performed to establish the clinical characteristics of patients with RAS-mutated (RAS(mut) ) AML, to analyze their outcome ...

journal_title：Cancer

authors： Kadia TM,Kantarjian H,Kornblau S,Borthakur G,Faderl S,Freireich EJ,Luthra R,Garcia-Manero G,Pierce S,Cortes J,Ravandi F

更新日期：2012-11-15 00:00:00

abstract：BACKGROUND:Previous studies in the literature have suggested that radiolabeled F(ab')2 fragments might be superior to whole immunoglobulin G (IgG) for imaging and therapy of cancer because of their greater penetration in tumors. To test this hypothesis, the authors compared tumor and normal tissue uptake along with pla...

journal_title：Cancer

authors： Murray JL,Rosenblum MG,Zhang HZ,Podoloff DA,Kasi LP,Curley SA,Chan JC,Roh M,Hohn DC,Brewer H

更新日期：1994-02-01 00:00:00

abstract：:The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" ...

journal_title：Cancer

authors： Lehane DE,Watson S,Lane M

更新日期：1975-05-01 00:00:00

abstract：:This study is a clinicopathologic evaluation of seven patients with endometrial stromal sarcoma of pure homologous type. Histologic distinction from endometrial stromatosis was based on the presence of high mitotic activity and nuclear anaplasia. One sarcoma appeared to have originated from invasive stromatosis. All p...

journal_title：Cancer

authors： Yoonessi M,Hart WR

更新日期：1977-08-01 00:00:00

abstract：BACKGROUND:Since the introduction of the TNM residual tumor (R) classification, the involvement of resection margins has been defined either as a microscopic (R1) or a macroscopic (R2) demonstration of tumor directly at the resection margin ("tumor transected"). METHODS:The recognition of the importance of the circumf...

journal_title：Cancer

authors： Wittekind C,Compton C,Quirke P,Nagtegaal I,Merkel S,Hermanek P,Sobin LH

更新日期：2009-08-01 00:00:00

abstract：:We detected cytoplasmic estrogen receptors (ER) in only 4 of 34 (12%) patients with malignant melanoma. The titers as assayed by the dextran-coated charcoal method were 3, 3, 4, and 5 fmol/mg, respectively. Our data indicate that the incidence of melanoma with detectable ER is low, which suggests that any potential cl...

journal_title：Cancer

authors： Creagan ET,Ingle JN,Woods JE,Pritchard DJ,Jiang NS

更新日期：1980-10-15 00:00:00

abstract：:Cases of childhood cancer (less than 15 years of age at diagnosis), diagnosed between 1960 and 1984, were obtained from the Hawaii Tumor Registry, a population-based Surveillance, Epidemiology, and End Results (SEER) participant covering the entire State of Hawaii. During the 25 years of data collection, cancer was di...

journal_title：Cancer

authors： Goodman MT,Yoshizawa CN,Kolonel LN

更新日期：1989-10-15 00:00:00

abstract：:Postmenopausal patients with metastatic breast cancer were treated with medroxyprogesterone acetate (MPA) (Clinovir) in dosages between 500 and 1500 mg orally per day. The relation of MPA plasma concentrations and endocrine effects were studied in a longitudinal fashion. MPA exerted suppressive effects on the basal an...

journal_title：Cancer

authors： Blossey HC,Wander HE,Koebberling J,Nagel GA

更新日期：1984-09-15 00:00:00

abstract：:Two cases of occult seminoma were observed which showed left-sided lymph node metastases without clinically demonstrable testicular tumors. The peculiar histology of the lymph node metastases, namely PAS-positive tumor cells with clear cytoplasm together with a granulomatous stromal reaction, was highly suggestive of ...

journal_title：Cancer

authors： Richter HJ,Leder LD

更新日期：1979-07-01 00:00:00

abstract：METHODS:Three-hundred seventy patients with borderline tumors treated between 1970 and 1982 at the Norwegian Radium Hospital were analyzed retrospectively for clinicopathologic features, treatment, and survival characteristics. RESULTS:One hundred seventy-eight patients had mucinous tumors, 174 patients had serous tum...

journal_title：Cancer

authors： Kaern J,Tropé CG,Abeler VM

更新日期：1993-03-01 00:00:00

abstract：BACKGROUND:To the authors' knowledge there are few data that correlate the expression of the epidermal growth factor receptor (EGFR) with the outcome of patients who have breast carcinoma and are treated with anthracycline chemotherapy. METHODS:Pretreatment tumor tissue samples were available from 82 patients who had ...

journal_title：Cancer

authors： Buchholz TA,Tu X,Ang KK,Esteva FJ,Kuerer HM,Pusztai L,Cristofanilli M,Singletary SE,Hortobagyi GN,Sahin AA

更新日期：2005-08-15 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...

journal_title：Cancer

authors： Cass I,Baldwin RL,Varkey T,Moslehi R,Narod SA,Karlan BY

更新日期：2003-05-01 00:00:00

abstract：BACKGROUND:To evaluate the prevalence and significance of abnormal ovarian findings in asymptomatic postmenopausal women, screening for ovarian cancer with color Doppler ultrasound was performed. METHODS:One thousand three hundred sixty-four asymptomatic women aged 56-61 years (mean, 59 years) were examined by color D...

journal_title：Cancer

authors： Vuento MH,Pirhonen JP,Mäkinen JI,Laippala PJ,Grönroos M,Salmi TA

更新日期：1995-10-01 00:00:00

abstract：:Since 1981, 20 patients with anaplastic giant cell carcinoma of the thyroid have been prospectively treated according to a combination regimen of chemotherapy and external beam radiation therapy. Two types of chemotherapy were used every 4 weeks, depending on the patient's age. For those younger than 65 years, a combi...

journal_title：Cancer

authors： Schlumberger M,Parmentier C,Delisle MJ,Couette JE,Droz JP,Sarrazin D

更新日期：1991-02-01 00:00:00

abstract：BACKGROUND:Tumor-related temporal lobe epilepsy (TLE) has a high likelihood of medical intractability and requires surgical treatment. The aims of this study were to analyze the long-term surgical outcomes of and to present appropriate surgical strategies for tumor-related TLE. METHODS:The clinical data of 87 consecut...

journal_title：Cancer

authors： Phi JH,Kim SK,Cho BK,Lee SY,Park SY,Park SJ,Lee SK,Kim KJ,Chung CK

更新日期：2009-12-15 00:00:00

abstract：:The nuclear DNA content of 98 operable breast cancers was determined by flow cytometric analysis using paraffin-embedded tissue. All patients were on follow-up and failure of treatment or recurrences were identified. DNA ploidy data in the form of ploidy status and DNA index (DI) has been correlated with various clini...

journal_title：Cancer

authors： Sharma S,Mishra MC,Kapur BM,Verma K,Nath I

更新日期：1991-12-15 00:00:00

abstract：BACKGROUND:Low-grade gliomas (LGGs) and low-grade glioneuronal tumors (LGGNTs) diagnosed during the first year of life carry unique clinical characteristics and challenges in management. However, data on the treatment burden, outcomes, and morbidities are lacking. METHODS:A retrospective study of LGGs and LGGNTs diagn...

journal_title：Cancer

authors： Liu APY,Hastings C,Wu S,Bass JK,Heitzer AM,Ashford J,Vestal R,Hoehn ME,Ghazwani Y,Acharya S,Conklin HM,Boop F,Merchant TE,Gajjar A,Qaddoumi I

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Telomerase is a ribonucleoprotein that maintains telomeric base pair repeats at the ends of mammalian chromosomes during DNA replication. Telomerase is expressed in various human tumors, some normal tissues, and immortalized cell lines. The assay of telomerase activity has potential as an adjunct for cancer ...

journal_title：Cancer

authors： Mu XC,Brien TP,Ross JS,Lowry CV,McKenna BJ

更新日期：1999-04-25 00:00:00

abstract：:A patient is described with Gardner's syndrome manifested initially by an extra-abdominal desmoid which was resected. The case was complicated by metastatic adenocarcinoma of the colon and recurrence of several large painful desmoid lesions. In view of the predilection of desmoids to occur in women in their childbeari...

journal_title：Cancer

authors： Kinzbrunner B,Ritter S,Domingo J,Rosenthal CJ

更新日期：1983-12-15 00:00:00

abstract：:Human melanoma synthesizes a large quantity of gangliosides, glycosphingolipids containing sialic acid. The authors previously have demonstrated that the ganglioside profile differs among individual melanomas and is widely heterogeneous. In the current study, a retrospective study was performed to compare the relation...

journal_title：Cancer

authors： Tsuchida T,Saxton RE,Morton DL,Irie RF

更新日期：1989-03-15 00:00:00