Abstract:
:The nitroblue tetrazolium test (NBT) was evaluated in 111 patients with cancer. Patients were placed into control and "presumed infected" groups. The mean NBT score for the control group, 6.3, was significantly greater than the mean for a group of normal volunteers, 3.1, but the mean score for the "presumed infected" group, 15.6 was significantly higher. Less than 10 percent of the patients with bacterial infection had scores below 10, while 15 percent of the control patients had unexplained high scores. A method for concentrating leukocytes is described which makes the NBT test feasible in patients with granulocytopenia. Morphological changes in granulocytes used as indicators of infection are unreliable markers in cancer patients, in whom such changes occur frequently in the absence of infection. We have found that the NBT test is more useful as an indicator of infection in patients with cancer.
journal_name
Cancerjournal_title
Cancerauthors
Lehane DE,Watson S,Lane Mdoi
10.1002/1097-0142(197505)35:5<1421::aid-cncr282035subject
Has Abstractpub_date
1975-05-01 00:00:00pages
1421-5issue
5eissn
0008-543Xissn
1097-0142journal_volume
35pub_type
杂志文章相关文献
CANCER文献大全abstract::The histologic features of a malignant clear cell acrospiroma were those of infiltrative local growth, frequent mitoses and angiolymphatic invasion. The histochemical and ultrastructural findings were similar to those reported for benign clear cell acrospriomas. Amputation of the leg and regional node dissection were ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197802)41:2<641::aid-cncr2820410
更新日期:1978-02-01 00:00:00
abstract::Screening for the early detection of cancer offers the potential of increasing the number of patients whose cancer is diagnosed in a localized, curable stage. The operation of an efficient and effective early detection program requires that a number of conditions be fulfilled, some of which are difficult to attain. Fi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810301)47:5+<1142::aid-cncr282
更新日期:1981-03-01 00:00:00
abstract::On the basis of previous findings at this institution, VM-26 and Cytosine Arabinoside (ara-C) were used in combination to treat 33 children with refractory acute lymphocytic leukemia (ALL). Chemotherapy was given by vein twice a week for four weeks at dosage of 300 mg/m2 for ara-C and 50, 75, 110, 165, or 200 mg/m2 fo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800315)45:6<1284::aid-cncr2820
更新日期:1980-03-15 00:00:00
abstract:BACKGROUND:The inherited, low-penetrance arginine-to-histidine substitution at codon 337 (R337H) of the tumor protein 53 gene (TP53) is clustered in southeast Brazil (estimated frequency, 0.3%). Although its tumorigenic effect initially appeared to be tissue-specific, recent evidence suggests its association with a bro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25826
更新日期:2011-05-15 00:00:00
abstract::The unusual course of a lymphoma in a woman with a chromosome abnormality is reported. When aged 30 years, the right lobe of her thyroid gland was found to be infiltrated by a follicular lymphoma. Two years later, poorly differentiated diffuse lymphoctic lymphoma recurred locally, grew rapidly, and infiltrated the adj...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197607)38:1<259::aid-cncr2820380
更新日期:1976-07-01 00:00:00
abstract:BACKGROUND:Surveillance, Epidemiology, and End Results (SEER) data for the years 1973-1992 documented that patients age < 50 years presented with more advanced disease. Because of the increase in the incidence rate of lung adenocarcinoma in the past few decades and the presentation of more advanced disease in young pat...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(20000415)88:8<1837::aid-cn
更新日期:2000-04-15 00:00:00
abstract::Two consecutive trials for the treatment of childhood non-Hodgkin's lymphoma were evaluated, carried out by the same cooperative groups. Group A: From June, 1973 to December, 1975, 50 evaluable patients under 16 years of age participated in a study that included vincristine and prednisone plus surgery and/or radiother...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(19841215)54:12<2863::aid-cncr282
更新日期:1984-12-15 00:00:00
abstract::Four cases of an ulcero-proliferative lesion of putative histiocytic origin, arising in the oral cavity, are described. This lesion, which has not been defined previously, is easily confused histologically with a malignant process of lymphoid origin, thereby representing a pseudolymphomatous proliferation. Light micro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850415)55:8<1722::aid-cncr2820
更新日期:1985-04-15 00:00:00
abstract:BACKGROUND:Stenotrophomonas maltophilia is responsible for an increasing number of infections, especially in hospitalized patients. Therapy options are limited and trimethoprim/sulfamethoxazole (TMP/SMX) is often the main treatment option for this infection. In the current study, the risk factors were determined for th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22705
更新日期:2007-06-15 00:00:00
abstract::Adrenal involvement in the course of a non-Hodgkin's lymphoma (NHL) appears to occur relatively often, but only seven cases of NHL-induced adrenal insufficiency were found in a recent review of the literature. The authors report four cases of hypoadrenalism in 127 patients treated for NHL; the cases were staged and cl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920501)69:9<2333::aid-cncr2820
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:Deletion or loss of heterozygosity (LOH) at the polymorphic loci on the short arm of chromosome 3 has been reported in a large number of renal cell, small cell lung, non-small cell lung, and cervical carcinomas, suggesting the presence of one or more putative tumor suppressor genes at chromosome 3p. Similar ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930801)72:3<881::aid-cncr28207
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND:There are few reports comparing the clinicopathologic features of sarcomas of the aorta (SA), sarcomas of the inferior vena cava (SIVC), and sarcomas of the pulmonary artery (SPA). METHODS:The authors retrospectively reviewed 11 SA, 16 SIVC, and 16 SPA, and compared clinical, pathologic, and immunohistochem...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19930301)71:5<1761::aid-cncr2820
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND:Surgical resection with adjuvant chemotherapy is the standard of care for patients with pancreatic cancer, but to the authors' knowledge, little is known regarding the temporal relationship between chemotherapy initiation and survival. The current study analyzed the impact of time to the initiation of adjuva...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30163
更新日期:2016-10-01 00:00:00
abstract::Melanomas of the choroid, ciliary body, and iris of the eye are collectively known as uveal melanomas. These cancers represent 5% of all melanoma diagnoses in the United States, and their age-adjusted risk is 5 per 1 million population. These less frequent melanomas are dissimilar to their more common cutaneous melano...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.29727
更新日期:2016-08-01 00:00:00
abstract::Histologic groups in 231 cases of malignant lymphoma were correlated with survival data at 100 months from the time of initiation of the study. Patients in the first two decades of life fared comparably with adults, but those over 60 years of age showed a poorer survival trend. Seven favorable and four unfavorable his...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810615)47:12<2894::aid-cncr282
更新日期:1981-06-15 00:00:00
abstract::Methionine-depleting total parenteral nutrition (methionine-depleting TPN), which infuses an amino acid solution devoid of L-methionine and L-cysteine as the sole protein source, showed enhancement of the effect of several anti-cancer agents. In this study, the combined effect of the methionine-depleting TPN with the ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920401)69:7<1865::aid-cncr2820
更新日期:1992-04-01 00:00:00
abstract:BACKGROUND:Seminal vesicle (SV) invasion at the time of radical prostatectomy (RP) generally is considered to be indicative of poor outcome. The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival. METHODS:Data were examined fr...
journal_title:Cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/cncr.20122
更新日期:2004-04-15 00:00:00
abstract:BACKGROUND:Chronic disseminated candidiasis (CDC) is a serious complication of treatment in patients with acute leukemia. Although some general risk factors are known to predispose to systemic fungal infections, few studies have addressed the relevance of certain clinical and laboratory features in patients with CDC. ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20010915)92:6<1349::aid-cncr1457
更新日期:2001-09-15 00:00:00
abstract:BACKGROUND:An intensive in-patient Phase II study of continuous infusion recombinant human interleukin-2 (rhIL-2) 3 X 10(6) Roche units (9 MIU/m2)/day plus intramuscular injection of interferon-alpha-2a (rIFN-alpha-2a) 5 x 10(6) U/m2/day, four consecutive days per week, was performed to determine whether four consecuti...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:BACKGROUND:Breast carcinoma is one of the leading causes of excess mortality rates in Harlem, an inner-city neighborhood with the highest mortality rates and worst life expectancy in New York City. This study reports the results of a breast carcinoma screening and diagnostic program in Harlem. METHODS:Retrospective re...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10640
更新日期:2002-07-01 00:00:00
abstract::We have demonstrated by tissue assay and immunohistochemical techniques that tumor cells appear to be the source of the increased histaminase activity found in 60% of ascitic fluids from patients with ovarian carcinoma. The histaminase activity in 64% of tumor tissues studied was greater than 100 U/g of tissue, a valu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800515)45:10<2568::aid-cncr282
更新日期:1980-05-15 00:00:00
abstract::A brother and sister with Fanconi's anemia, having typical skeletal deformity and characteristic chromosomal breaks in their lymphocytes and who followed the typical clinical course, with progressive bone marrow insufficiency beginning late in the first decade, are described. The natural history of the disease before ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1850::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:Patient safety is a critical concern in clinical oncology, but the ability to measure adverse events (AEs) across cancer care is limited by a narrow focus on treatment-related toxicities. The objective of this study was to assess the nature and extent of AEs among cancer patients across inpatient and outpati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30916
更新日期:2017-12-01 00:00:00
abstract:BACKGROUND:A survey of the distribution of human papillomavirus (HPV) types across the spectrum of cervical cytologic categories defined by the Bethesda 2001 guidelines was conducted with the objective of examining how HPV detection by polymerase chain reaction (PCR) analysis may benefit the management of patients who ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21664
更新日期:2006-03-01 00:00:00
abstract:BACKGROUND:Significant antitumor effects were previously observed with radioimmunotherapy (RIT) using an anti-carcinoembryonic antigen (CEA) monoclonal antibody (F6) labeled with iodine-131 in medullary thyroid cancer (MTC)-bearing nude mice. Nevertheless, no complete response was achieved. Because angiogenesis is crit...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24792
更新日期:2010-02-15 00:00:00
abstract::Amputation is often a component in the treatment of bone tumors such as osteogenic sarcoma, which is most prevalent in the adolescent age group. Adaptation to cancer and loss of a limb requires a significant multidimensional effort. To examine the role of social support systems, 27 adolescents who had undergone amputa...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850815)56:4<965::aid-cncr28205
更新日期:1985-08-15 00:00:00
abstract:BACKGROUND:Metastasectomy is standard of care for pediatric patients with metastatic sarcoma with limited disease. For patients with unresectable disease, stereotactic body radiotherapy (SBRT) may serve as an alternative. Herein, the authors report the results of a prospective, multi-institutional phase 2 trial of SBRT...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33306
更新日期:2020-11-10 00:00:00
abstract::High calcitonin levels noted on a totally healthy 49-year-old man participating in a calcitonin control project led to a presumptive diagnosis of medullary carcinoma. Complete thyroid studies augmented by selective catheterization and quantitative calcitonin studies confirmed the clinical impression of medullary carci...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810315)47:6<1364::aid-cncr2820
更新日期:1981-03-15 00:00:00
abstract:BACKGROUND:Prior literature has suggested synergy between immune checkpoint therapy (ICT) and radiotherapy (RT) for the treatment of brain metastases (BrM), but to the authors' knowledge the optimal timing of therapy to maximize this synergy is unclear. METHODS:A total of 199 patients with melanoma and non-small cell ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.33196
更新日期:2020-12-15 00:00:00
abstract:BACKGROUND:In the United States, neoadjuvant chemoradiotherapy (NACRT) is widely accepted as the standard of care in the treatment of patients with locally advanced rectal cancer. In the current study, the authors attempted to examine patterns of treatment in the United States over the past decade. METHODS:Using the N...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29993
更新日期:2016-07-01 00:00:00