Abstract:
BACKGROUND:Seminal vesicle (SV) invasion at the time of radical prostatectomy (RP) generally is considered to be indicative of poor outcome. The authors examined whether there was a subset of men with SV invasion who had long-term prostate-specific antigen (PSA) progression-free survival. METHODS:Data were examined from 1687 men who underwent RP between 1988 and 2002 at 5 equal-access medical centers. Patients were grouped based on the presence or absence of SV invasion at the time of RP. Clinical and pathologic variables as well as biochemical outcome data were compared across the groups using rank-sum, chi-square, and log-rank tests. Multivariate Cox proportional hazards analysis was used to determine the significant predictors of time to PSA failure among men with SV invasion. RESULTS:Men with SV invasion had significantly higher PSA values, higher clinical stage, higher grade tumors, and were more likely to have concomitant extracapsular extension or a positive surgical margin. The 5-year PSA progression-free rates for men who had SV invasion was 36%, compared with 70% among men who had no SV invasion. Among men who had SV invasion, using multivariate analysis, only age (P = 0.023), pathologic Gleason score (P = 0.041), and surgical margin status (P = 0.019) were found to be independent predictors of PSA failure. By combining significant prognostic variables, the authors identified a subset of men with SV invasion, low-grade tumors (Gleason score 2-6), and negative surgical margins who had a 5-year PSA progression-free rate of 69%. Men with SV invasion, Gleason scores 2-6 tumors, negative surgical margins, and age > or = 60 years (n = 11; 8%) had a 5-year PSA progression-free rate of 100%. CONCLUSIONS:Although the majority of men with SV invasion have high-grade disease and a short time to biochemical failure, the authors identified a subset of men with low-grade disease, negative surgical margins, and older age who, despite SV invasion, had an extremely favorable clinical course. Thus, SV invasion does not uniformly suggest an unfavorable prognosis. prognosis.
journal_name
Cancerjournal_title
Cancerauthors
Freedland SJ,Aronson WJ,Presti JC Jr,Amling CL,Terris MK,Trock B,Kane CJdoi
10.1002/cncr.20122subject
Has Abstractpub_date
2004-04-15 00:00:00pages
1633-8issue
8eissn
0008-543Xissn
1097-0142journal_volume
100pub_type
杂志文章,多中心研究相关文献
CANCER文献大全abstract:BACKGROUND:In various neoplasms expression of the proliferation-related Ki-67 antigen has successfully been linked with parameters of progression of disease. While a definite grading scheme for oligodendrogliomas has still not been agreed upon, any parameter of tumor proliferation that might be helpful in predicting cl...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960901)78:5<1107::AID-CN
更新日期:1996-09-01 00:00:00
abstract:BACKGROUND:The mortality of patients with colorectal carcinoma depends mainly upon subsequent liver metastasis even after curative operation. However, it is very difficult to predict the incidence of liver metastasis by analyzing conventional tumor markers or pathologic findings. In the current study, the authors exami...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0142(19960415)77:8<1729::AID-CN
更新日期:1996-04-15 00:00:00
abstract::Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6+) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821201)50:11<2486::aid-cncr282
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Vascular endothelial growth factor C (VEGF-C) plays an important role in lymphangiogenesis and activates VEGF receptor 3 (VEGFR-3). By contrast, lymphatic spread is an important prognostic factor in patients with nonsmall cell lung carcinoma (NSCLC). The objective of the current study was to determine whethe...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11073
更新日期:2003-01-15 00:00:00
abstract:BACKGROUND:Prostate adenocarcinoma is predominantly a disease of older men. Males younger than 50 years account for 1% of all patients with prostate cancer. The authors retrospectively examined cases of prostate adenocarcinoma in patients younger than 50 years of age to determine the natural history and prognosis of th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19940915)74:6<1768::aid-cncr2820
更新日期:1994-09-15 00:00:00
abstract::A brother and sister with Fanconi's anemia, having typical skeletal deformity and characteristic chromosomal breaks in their lymphocytes and who followed the typical clinical course, with progressive bone marrow insufficiency beginning late in the first decade, are described. The natural history of the disease before ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19841101)54:9<1850::aid-cncr2820
更新日期:1984-11-01 00:00:00
abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25758
更新日期:2011-05-15 00:00:00
abstract::A 17-year-old girl was operated for a solitary well-circumscribed pulmonary parenchymal tumor and reoperated ten times for multiple recurrent similar pulmonary tumors during 24 years. Histologic examination revealed the so-called intravascular bronchioloalveolar tumor (IVBAT) in all instances. The patient died from pn...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19871115)60:10<2471::aid-cncr282
更新日期:1987-11-15 00:00:00
abstract::Six patients with breast cancer developed pulmonary toxicity following mitomycin therapy. The presenting symptoms were shortness of breath and a dry cough. The radiological pictures varied from a normal chest x-ray to extensive bilateral pneumonitis. The histological findings consisted of diffuse alveolar damage progr...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19800115)45:2<236::aid-cncr28204
更新日期:1980-01-15 00:00:00
abstract::In a randomized series of 70 patients with with colo rectal adenocarcinoma, a comparison of systemic 5-fluorouracil chemotherapy administered as a continuous 120-hours infusion vs. intravenous bolus injection daily for 5 days demonstrated superiority of prolonged intravenous infusion. The most striking advantage of pr...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/1097-0142(197507)36:1<123::aid-cncr2820360
更新日期:1975-07-01 00:00:00
abstract::The case of a European patient with a malignant lymphoepithelial lesion of epithelial type is presented. This type of tumor has an exceptionally high incidence among Eskimos. To the authors' knowledge this is the first case reported with an ultrastructural study that demonstrates the squamous nature of the tumor cells...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:2<289::aid-cncr28204
更新日期:1981-07-15 00:00:00
abstract::Chemotherapy of advanced stages of large bowel cancer has until recently made little progress since the introduction of 5-FU 16 years ago. While survival is improved for patients who respond, 5-FU alone has made little impact on life span of the overall population of patients. Mitomycin-C and the chloroethyl nitrosour...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/1097-0142(197512)36:6<2418::aid-cncr282036
更新日期:1975-12-01 00:00:00
abstract::Twenty-eight peritoneovenous shunts were placed to relieve ascites in 26 patients with a variety of underlying malignancies. Nine of the patients had documented liver metastases and hyperbilirubinemia. Severe thrombocytopenia with laboratory evidence of disseminated intravascular coagulation (DIC) occurred in four of ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850601)55:11<2718::aid-cncr282
更新日期:1985-06-01 00:00:00
abstract:BACKGROUND:Posttreatment prostate biopsy is a method of assessing local control after irradiation for prostate carcinoma. An analysis of the effect of disease- and treatment-related factors on biopsy results after prostate brachytherapy was performed to aid in patient selection and treatment optimization. METHODS:Two ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(20001015)89:8<1829::aid-cncr25>3
更新日期:2000-10-15 00:00:00
abstract::Parathyroid adenomas are subdivided into chief cell and oxyphil cell variants. However, the parathyroid carcinomas described thus far have been only of the chief cell type. Two cases of oxyphil cell carcinoma of the parathyroid gland are reported, with light and electron microscopic study. The patients presented appar...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19850401)55:7<1482::aid-cncr2820
更新日期:1985-04-01 00:00:00
abstract:BACKGROUND:To the authors' knowledge, relatively little is known regarding the interaction of risk factors for hepatocellular carcinoma (HCC) with age, sex, and liver disorder status. METHODS:The authors followed 504,646 Korean patients aged 40 to 80 years who underwent routine health checkups between 2002 and 2003 un...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31406
更新日期:2018-07-01 00:00:00
abstract::Cancer tissues from 30 patients with squamous cell carcinoma of the oral cavity were examined immunohistopathologically as to the responsiveness of the host against its own cancer cells in both biopsy and surgically resected specimens from the same patients. Subpopulations of the infiltrating lymphocytes in cancer tis...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840601)53:11<2456::aid-cncr282
更新日期:1984-06-01 00:00:00
abstract::One hundred four endocrine tumors found in the body and tail of the pancreas of a patient with the Zollinger-Ellison syndrome (ZES) and multiple endocrine neoplasia (MEN-I) were investigated by immunohistochemistry for insulin, glucagon, somatostatin, pancreatic polypeptide (PP), and gastrin. The results for each tumo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1815::aid-cncr2820
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:The National Pediatric Oncology Unit (UNOP) is the only pediatric hemato-oncology center in Guatemala. METHODS:Patients ages 1 to 17 years with acute lymphoblastic leukemia (ALL) were treated according to modified ALL Intercontinental Berlin-Frankfurt-Münster (IC-BFM) 2002 protocol. Risk classification was ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30257
更新日期:2017-02-01 00:00:00
abstract:BACKGROUND:Outcomes have improved significantly in multiple myeloma (MM), but racial disparities in health care access and survival exist. A comprehensive analysis exploring MM care and racial disparities is warranted. METHODS:Patients with MM from 1991 to 2010 in the Surveillance, Epidemiology, and End Results-Medica...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.31237
更新日期:2018-04-15 00:00:00
abstract::A primitive neuroectodermal tumor of peripheral nerve origin was examined by light and electron microscopy. The lesion arose in association with the S1 nerve root of the lumbosacral plexus in a 22-year-old female. Following a surgical biopsy, the patient received systemic chemotherapy; however, approximately one-and-a...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19801201)46:11<2456::aid-cncr282
更新日期:1980-12-01 00:00:00
abstract::A series of experiments was devised to determine possible modifying effects of stress, aspirin, and sodium taurocholate on the activity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in the Buffalo rat stomach. MNNG is a well known, direct-reacting carcinogen, and has been a reliable agent for the experimental product...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840301)53:5<1088::aid-cncr2820
更新日期:1984-03-01 00:00:00
abstract::Individualization of treatment using judicious combinations of external and intracavitary irradiation remains the cornerstone of the radiation management of carcinoma of the cervix. The inherent propensity of this cancer to either confine itself to the pelvis or else spread in a systematic and predictable manner throu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19810715)48:1+<560::aid-cncr2820
更新日期:1981-07-15 00:00:00
abstract::Low-dose continuous infusion 5-fluorouracil (LDCI-FU) was administered to 28 women with advanced breast carcinoma. Daily doses ranged from 175 to 250 mg/m2. The LDCI-FU was delivered continuously until the appearance of toxicity and was reinstituted at a 20% dose reduction after toxicity completely resolved. Patients ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19890201)63:3<419::aid-cncr28206
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Black females have lower breast carcinoma survival rates compared with white females. One possible reason is that black females have more advanced-stage breast disease. Another factor may be racial differences in the utilization of cancer treatments. METHODS:The authors determined racial differences in 6-ye...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11411
更新日期:2003-06-01 00:00:00
abstract::Peripheral blood lymphocytes of patients with multiple myeloma, macroglobulinemia, and monoclonal gammopathy of uncertain significance were analyzed for B cells, and cells bearing kappa light chains and lambda light chains on their surfaces. Compared with controls, the number of B cells were decreased in all three gro...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19811115)48:10<2211::aid-cncr282
更新日期:1981-11-15 00:00:00
abstract::Alkylating agents form the basis of most combination treatment regimens for low-grade lymphoproliferative disorders. Bendamustine is a unique alkylating agent that has distinctive preclinical activity in cell lines resistant to other alkylators. Furthermore, clinical activity has been demonstrated in patients with alk...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.24057
更新日期:2009-02-01 00:00:00
abstract::In order to determine if recombinant interleukin-2 (rIL-2) can induce lymphokine-activated killer (LAK) cells able to lyse autologous leukemic cells, we incubated peripheral blood (PB) mononuclear cells from children with acute leukemia with 50 U/ml rIL-2 for 5 days. These PB effector cells were then tested for their ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19881101)62:9<1928::aid-cncr2820
更新日期:1988-11-01 00:00:00
abstract::Autopsy data of 423 cases of primary tumor of the lung over a 36-year period were evaluated for the presence of gastrointestinal tract metastases. Fifty-eight cases (14%) were found and were analyzed for histologic nature of tumor, anatomic location, symptomatology and complications. The most common histologic type of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19820101)49:1<170::aid-cncr28204
更新日期:1982-01-01 00:00:00
abstract:BACKGROUND:In the phase 3 MARIANNE trial, trastuzumab emtansine (T-DM1) with or without pertuzumab showed noninferior progression-free survival and better tolerability than trastuzumab plus a taxane (HT) for the first-line treatment of human epidermal growth factor receptor 2 (HER2)-positive advanced breast cancer. Thi...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32392
更新日期:2019-11-15 00:00:00