Abstract:
:In order to determine if recombinant interleukin-2 (rIL-2) can induce lymphokine-activated killer (LAK) cells able to lyse autologous leukemic cells, we incubated peripheral blood (PB) mononuclear cells from children with acute leukemia with 50 U/ml rIL-2 for 5 days. These PB effector cells were then tested for their ability to lyse autologous leukemic cells in a 51CR release assay. The PB cells before incubation with rIL-2 showed little or no cytotoxicity for autologous blasts (range, 0 to 12%; mean, 2%). However, after incubation with rIL-2, PB cells from four of five children with acute lymphoblastic leukemia (ALL) at diagnosis or in relapse, and from six of eight children with ALL in remission were able to lyse autologous blasts. The percent lysis (range) was 0 to 69% (mean, 37%) for the former group, and 0 to 113% (mean, 43%) for the latter group. The PB cells from three patients (one in relapse and two in remission) failed to develop LAK activity after incubation with rIL-2. However, in each case cytotoxicity versus K562 was increased after incubation with rIL-2. Furthermore, in a Phase I study of rIL-2 for the treatment of refractory leukemia, a patient was treated with rIL-2 for 3 weeks (nine injections of 3 x 10(6) U/m2 each). Her fresh PB mononuclear cells developed a low level of cytotoxicity (11% lysis) against her autologous blasts during this time. The finding that rIL-2 in vitro and in vivo induces LAK cells with cytotoxicity against autologous leukemic cells provides the rationale for the clinical trial of this agent in the treatment of children with ALL.
journal_name
Cancerjournal_title
Cancerauthors
Findley HW Jr,Abdel Mageed A,Nasr SA,Ragab AHdoi
10.1002/1097-0142(19881101)62:9<1928::aid-cncr2820subject
Has Abstractpub_date
1988-11-01 00:00:00pages
1928-31issue
9eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
杂志文章相关文献
CANCER文献大全abstract::To determine whether steroid hormone receptor expression is clinically relevant in ovarian cancer, cytoplasmic and nuclear estrogen (ER) and progesterone (PR) receptor levels have been measured and their concentration calculated by Scatchard analysis. Of 89 samples from patients with non-pretreated epithelial ovarian ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19900201)65:3<486::aid-cncr28206
更新日期:1990-02-01 00:00:00
abstract::The physiologic consequences of malnutrition in children with cancer are reviewed. It is stressed that the child with cancer has a nutritional state that is no different from the average population from which the child comes. What little malnutrition is seen is calorie malnutrition. The physiologic consequences are th...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19861015)58:8+<1874::aid-cncr282
更新日期:1986-10-15 00:00:00
abstract:BACKGROUND:In vitro studies have shown an antiproliferative effect of tumor necrosis factor (TNF) against various nonsmall cell lung carcinoma (NSCLC) cell lines. However, clinical trials of combined interleukin-2 and TNF-alpha in patients with advanced NSCLC have demonstrated both conflicting and disappointing results...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1998-07-15 00:00:00
abstract:BACKGROUND:The objective of this study was to determine the clinical characteristics, treatment response, and frequency of p53 overexpression in Ashkenazi Jewish women with hereditary ovarian carcinoma. METHODS:Seventy-one Jewish women with epithelial ovarian carcinoma (EOC) were tested for the three BRCA founder muta...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.11310
更新日期:2003-05-01 00:00:00
abstract:BACKGROUND:Fine-needle aspiration biopsy (FNAB) is a reliable, rapid, minimally invasive alternative to surgical biopsy when it is performed by physician specialists for the diagnosis of palpable masses. FNAB may be under-utilized in community hospitals in the U.S. because physicians without specialty training commonly...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21976
更新日期:2006-07-15 00:00:00
abstract:METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921001)70:7<1943::aid-cncr2820
更新日期:1992-10-01 00:00:00
abstract::Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. To...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197701)39:1<267::aid-cncr2820390
更新日期:1977-01-01 00:00:00
abstract:BACKGROUND:Clear cell tumors of the thyroid gland in general are uncommon. Metastatic renal cell carcinoma (RCC) to the thyroid gland is a rare occurrence but must be considered in the differential diagnosis of a thyroid gland clear cell neoplasm to prevent misclassification, potentially resulting in inappropriate clin...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.10901
更新日期:2002-11-01 00:00:00
abstract::Pleural fluid and serum protein electrophoresis and quantitative immunoglobulin measurements were carried out in patients with pleural effusions. The mean pleural fluid/serum ratios of IgA, IgG, and IgM were elevated in patients with malignant pleural effusions compared with patients with nonmalignant pleural effusion...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19831201)52:11<2151::aid-cncr282
更新日期:1983-12-01 00:00:00
abstract:BACKGROUND:The purpose of this study was to define an optimal administration schedule of granisetron for patients receiving moderately emetogenic chemotherapy by comparing the antiemetic efficacy and safety of 2 mg of the drug administrated orally. METHODS:In this double-blind, randomized, parallel study, 2-dose regim...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1002/(SICI)1097-0142(19960701)78:1<144::AID-CNC
更新日期:1996-07-01 00:00:00
abstract:BACKGROUND:A proposed pathologic (pTNM) classification system for prostate carcinoma was analyzed for its impact on survival outcome in the prostate specific antigen (PSA) era. The impact of margin status on the survival outcome of patients with otherwise organ-confined disease (i.e., without extraprostatic extension o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0142(19980301)82:5<902::aid-cnc
更新日期:1998-03-01 00:00:00
abstract:BACKGROUND:Sunitinib malate is an orally bioavailable tyrosine kinase inhibitor that is active against many tyrosine kinase receptors involving crucial pathways in both healthy tissues and malignant tissues. Because its use in clinical practice is quite recent, many of its possible side effects remain unknown. In this ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26435
更新日期:2012-06-15 00:00:00
abstract:BACKGROUND:Pericolorectal tumor deposits (TDs) are associated with adverse outcomes in patients with colorectal cancer, and the seventh edition of the American Joint Committee on Cancer (AJCC) staging system recently classified TDs without regional lymph node metastasis as category N1c. However, the definition of TDs h...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.25968
更新日期:2011-09-01 00:00:00
abstract::The literature examining obesity as a barrier to screening for breast, cervical, and colorectal cancer has not been evaluated systematically. With the increasing prevalence of obesity and its impact on cancer incidence and mortality, it is important to determine whether obesity is a barrier to screening so that cancer...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.23408
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:Although K-ras is the most frequently mutated protooncogene in colorectal carcinoma, the specific role and timing of K-ras mutations in colorectal carcinogenesis remains controversial. In the current study, the authors investigated associations with K-ras mutation in incident sporadic colorectal adenomas tha...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.21721
更新日期:2006-03-01 00:00:00
abstract::Single meningiomas are histologically classified as benign tumors, but clearly malignant types have been encountered. The standard mode of management is total macroscopic removal with excision of the dural attachment and abnormal bone, if there is any. Despite this aggressive surgery, recurrence rates of approximately...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19880401)61:7<1447::aid-cncr2820
更新日期:1988-04-01 00:00:00
abstract::Fatigue has been described as the most common, most debilitating side effect of cancer treatment and is frequently reported as a long-term complication of treatment as well. Despite the prevalence of fatigue and its profoundly negative effect on patients' quality of life, little is known about the specific mechanisms ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(20010915)92:6+<1699::aid-cncr150
更新日期:2001-09-15 00:00:00
abstract:BACKGROUND:Little is known about the size and characteristics of the decision-support networks of women newly diagnosed with breast cancer and whether their involvement improves breast cancer treatment decisions. METHODS:A population-based sample of patients newly diagnosed with breast cancer in 2014 and 2015, as repo...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.30848
更新日期:2017-10-15 00:00:00
abstract::The glucose consumption rate of 9L rat brain tumor cells was determined as a function of concentration. Glucose uptake followed Michaelis-Menten kinetics with a Km of 0.58 mM and a Vmax of 1.6 pg/cell-min. The glucose diffusion coefficient in spheroids of 9L tumor cells was determined to be 1.5 x 10(-6) cm2/s at 37 de...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821115)50:10<2066::aid-cncr282
更新日期:1982-11-15 00:00:00
abstract:BACKGROUND:Differentiating primary glandular from high-grade squamous intraepithelial lesions (HSIL) that involve endocervical glands is not an uncommon diagnostic problem in liquid-based gynecological cytology. Squamous and atypical glandular cell lesions may show similar cytomorphologic features. The aim of this stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22419
更新日期:2007-02-25 00:00:00
abstract::A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197905)43:5<1872::aid-cncr282043
更新日期:1979-05-01 00:00:00
abstract:BACKGROUND:The sensitivity of the intraoperative diagnosis of sentinel lymph node (SLN) micrometastases and the metastases of invasive lobular carcinoma (ILC) is low. The goal of the current study was to assess whether the use of intraoperative, rapid immunohistochistochemistry (IHC) enhances the intraoperative detecti...
journal_title:Cancer
pub_type: 临床试验,杂志文章
doi:10.1002/cncr.21133
更新日期:2005-07-01 00:00:00
abstract:BACKGROUND:The authors investigated the prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction in a contemporary, population-based prostate cancer cohort. They also explored the associations between baseline function and age, comorbidity, and timing of baseline survey completion with respect to tre...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.28563
更新日期:2014-04-15 00:00:00
abstract:BACKGROUND:Adult T-cell leukemia/lymphoma (ATLL) is a neoplasm of the mature helper T-lymphocyte. Human T-lymphotropic virus type 1 (HTLV-1) has been shown to be the cause of this neoplasm. Recently, however, the HTLV-1 genome has been found in some patients with cutaneous T-cell lymphoma (CTCL), which suggests a causa...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:1997-01-15 00:00:00
abstract::Ovarian cancer disproportionately affects women 65 years of age and older who are likely to have concomitant changes in physical ability, physiological functioning, and other chronic conditions associated with advancing age. The National Institute on Aging, National Cancer Institute, and the American Cancer Society co...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.2820710204
更新日期:1993-01-15 00:00:00
abstract::The possibility that urinary pepsinogen I is a tumor marker of stomach cancer after total gastrectomy was examined. To decide the cutoff level of urinary pepsinogen I after total gastrectomy, urine samples from 15 patients who had undergone total gastrectomy for stomach cancer in the early or advanced stages and had b...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910815)68:4<906::aid-cncr28206
更新日期:1991-08-15 00:00:00
abstract::Myelofibrosis occurs in various hematologic neoplasias, including myelodysplastic syndrome (MDS), with a relatively low incidence. To gain insight into the clinical and cytogenetic implications of MDS patients in whom myelofibrosis develops, statistical analysis was done on 82 primary MDS patients with successful cyto...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910701)68:1<178::aid-cncr28206
更新日期:1991-07-01 00:00:00
abstract::The authors observed the clinical course of 24 women with surgically removed prolactinomas for a mean postoperative interval of 62 months. The frequency of late tumor recurrence and probable factors responsible for the recurrence were investigated. Hyperprolactinemia recurred in 4 of 13 patients with microadenomas (31...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19860615)57:12<2422::aid-cncr282
更新日期:1986-06-15 00:00:00
abstract:BACKGROUND:The authors originally demonstrated the tissue-specific expression of the rab3A gene in the mouse brain. In the current study, they analyze the activity of this gene in fresh human tumors associated with neuronal phenotype compared with normal and malignant cells from other origins. METHODS:The authors stud...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19921115)70:10<2552::aid-cncr282
更新日期:1992-11-15 00:00:00
abstract::A tumor colony assay (TCA) was evaluated for its ability to predict anticancer drug responses in an N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide (FANFT)-induced murine bladder tumor (MBT) model. Ten anticancer drugs were evaluated in vivo and in vitro using four MBT cell lines (40 drug responses). Using the optimum c...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830815)52:4<619::aid-cncr28205
更新日期:1983-08-15 00:00:00