Abstract:
:Familial polyposis is a genetically-transmitted disease characterized by multiple adenomatous colorectal polyps and a high risk for development of adenocarcinoma. Familial polyposis and Gardner's syndrome should be differentiated from other penetically-linked polyposis syndromes lacking a predisposition for cancer. Total colectomy and ileorectal anastomosis, aggressive follow-up and intensive surveillance of non-polyp bearing relatives can reduce the risk of developing cancer. From an epidemiologic point of veiw, polyposis is a valuable model for the study of the interaction of genetic and environmental factors in the genesis of colon cancer.
journal_name
Cancerjournal_title
Cancerauthors
DeCosse JJ,Adams MB,Condon REdoi
10.1002/1097-0142(197701)39:1<267::aid-cncr2820390subject
Has Abstractpub_date
1977-01-01 00:00:00pages
267-73issue
1eissn
0008-543Xissn
1097-0142journal_volume
39pub_type
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