Urokinase-plasminogen activator, a marker for aggressive breast carcinomas. Preliminary report.

Abstract:

:Plasminogen activator is a serine protease which exists in two forms, known as tissue-type plasminogen activator and urokinase-type plasminogen activator. Here, we show that urokinase-type plasminogen activator activity in primary breast carcinomas correlates with both size of tumor and number of axillary nodes with metastases. Patients with primary carcinomas containing high levels of urokinase-type plasminogen activator activity had a significantly shorter disease-free interval than patients with low levels of activity. It is concluded that urokinase-plasminogen activator may be a new prognostic marker in breast cancer.

journal_name

Cancer

journal_title

Cancer

authors

Duffy MJ,O'Grady P,Devaney D,O'Siorain L,Fennelly JJ,Lijnen HJ

doi

10.1002/1097-0142(19880801)62:3<531::aid-cncr28206

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

531-3

issue

3

eissn

0008-543X

issn

1097-0142

journal_volume

62

pub_type

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