Abstract:
:Plasminogen activator is a serine protease which exists in two forms, known as tissue-type plasminogen activator and urokinase-type plasminogen activator. Here, we show that urokinase-type plasminogen activator activity in primary breast carcinomas correlates with both size of tumor and number of axillary nodes with metastases. Patients with primary carcinomas containing high levels of urokinase-type plasminogen activator activity had a significantly shorter disease-free interval than patients with low levels of activity. It is concluded that urokinase-plasminogen activator may be a new prognostic marker in breast cancer.
journal_name
Cancerjournal_title
Cancerauthors
Duffy MJ,O'Grady P,Devaney D,O'Siorain L,Fennelly JJ,Lijnen HJdoi
10.1002/1097-0142(19880801)62:3<531::aid-cncr28206subject
Has Abstractpub_date
1988-08-01 00:00:00pages
531-3issue
3eissn
0008-543Xissn
1097-0142journal_volume
62pub_type
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