Therapy-related leukemia: a panmyelosis.

abstract：:Patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of T cells, Fc receptor cells, and in derangements of T lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of develop...

journal_title：Cancer

authors： Zighelboim J,Dorey F,Parker NH,Calcaterra T,Ward P,Fahey JL

更新日期：1979-07-01 00:00:00

abstract：BACKGROUND:Pancreatic-duodenal homeobox 1 (PDX-1) is a transcription factor that regulates embryologic pancreas development and insulin expression in the adult islet; however, it is overexpressed in many types of cancer, including pancreatic cancer. The purpose of this study was to investigate the role of PDX-1 in tumo...

journal_title：Cancer

authors： Liu SH,Patel S,Gingras MC,Nemunaitis J,Zhou G,Chen C,Li M,Fisher W,Gibbs R,Brunicardi FC

更新日期：2011-02-15 00:00:00

abstract：:A 30-year Memorial Hospital experience with 146 patients with malignant mixed tumor is reviewed. These comprised 5% of 2,743 patients who were treated for salivary neoplasms from 1939 through 1968. The tumors arose in the parotid gland in 108 patients, submaxillary gland in 23 patients, mucus or so-called minor saliva...

journal_title：Cancer

authors： Spiro RH,Huvos AG,Strong EW

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Cytotoxic analogs of somatostatin (SST), such as AN-238, which consists of 2-pyrrolinodoxorubicin (AN-201) linked to the SST carrier RC-121, can be targeted to tumors that express SST receptors. Because SST receptors are present in ovarian carcinoma cells, the authors evaluated the effect of AN-238 on the UC...

journal_title：Cancer

authors： Plonowski A,Schally AV,Koppan M,Nagy A,Arencibia JM,Csernus B,Halmos G

更新日期：2001-09-01 00:00:00

abstract：BACKGROUND:Sunitinib and sorafenib are small-molecule tyrosine kinase inhibitors (TKI) with antitumor activity in advanced renal cell carcinoma. A retrospective study was conducted to assess the response of renal cell carcinoma to sequential treatment with these two agents. METHODS:Tumor response was evaluated by usin...

journal_title：Cancer

authors： Dudek AZ,Zolnierek J,Dham A,Lindgren BR,Szczylik C

更新日期：2009-01-01 00:00:00

abstract：:In contrast with the expectations of the authors and with reports suggesting a decline in risk for scrotal cancer, Connecticut Tumor Registry data neither showed detectable decrease in risk over the 45-year-period for all 95 scrotal malignancies nor for the 71 epithelial cancers. The age distribution of scrotal cancer...

journal_title：Cancer

authors： Roush GC,Schymura MJ,Flannery JT

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND:According to the overview of Early Breast Cancer Trialists' Collaborative Group, anthracycline containing regimens are superior to cyclophosphamide, methotrexate, and 5-fluorouracil (CMF) as adjuvant chemotherapy for breast carcinoma, but no comparative information is available in terms of primary chemothera...

journal_title：Cancer

authors： Cocconi G,Di Blasio B,Boni C,Bisagni G,Ceci G,Rondini E,Bella M,Leonardi F,Savoldi L,Camisa R,Bruzzi P

更新日期：2002-07-15 00:00:00

abstract：:The role of the adult oncologists in the area of pediatric cancer treatment previously has been unmeasured. A questionnaire bearing regarding the practice of 447 adult oncologists was administered in June 1991. The membership list of the Association of Community Cancer Centers was used to identify contact oncologists....

journal_title：Cancer

authors： Brady AM,Harvey C

更新日期：1993-05-15 00:00:00

abstract：:The authors evaluated specific gamma-GTP isoenzyme (specific gamma-GTP) found in sera of patients with hepatocellular carcinoma (HCC). In addition to band II and II' which had been reported in our previous publication, band I' also had a high specificity for HCC. One or more of these bands were detectable in 109 (55%)...

journal_title：Cancer

authors： Sawabu N,Nakagen M,Ozaki K,Wakabayashi T,Toya D,Hattori N,Ishii M

更新日期：1983-01-15 00:00:00

abstract：:For men diagnosed with clinically localized prostate cancer, definitive therapy with radical prostatectomy, external beam radiation therapy, or brachytherapy offers a high chance of cure. Currently, there are insufficient data to recommend 1 treatment approach over another, leaving physicians and patients to decide ba...

journal_title：Cancer

authors： Nguyen CT,Zelefsky MJ,Kattan MW

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Consumers increasingly consult the Internet for breast cancer information. Concerned about accuracy, multiple organizations developed quality criteria for online content. However, the effectiveness of these tools is unknown. The authors determined whether existing quality criteria can identify inaccurate bre...

journal_title：Cancer

authors： Bernstam EV,Walji MF,Sagaram S,Sagaram D,Johnson CW,Meric-Bernstam F

更新日期：2008-03-15 00:00:00

abstract：:The worldwide increase in cancer mortality demands a practical and effective chemopreventive approach to this problem. Using animal bioassay, the authors demonstrated protocatechuic acid (PCA, 3,4-dihydroxybenzoic acid), a simple and antioxidative phenolic acid present in fruits, vegetables, and nuts, to be an efficac...

journal_title：Cancer

authors： Tanaka T,Kojima T,Kawamori T,Mori H

更新日期：1995-03-15 00:00:00

abstract：:The authors retrospectively searched for human papillomavirus (HPV) types 16 and 18 in 60 cases of carcinoma arising from the nasal cavities (NC) and paranasal sinuses (PS) by using the polymerase chain reaction (PCR) on DNA extracted from formalin-fixed, paraffin-embedded tissues. In cases of SCC (n = 49), the author...

journal_title：Cancer

authors： Furuta Y,Takasu T,Asai T,Shinohara T,Sawa H,Nagashima K,Inuyama Y

更新日期：1992-01-15 00:00:00

abstract：:Twenty patients with malignant hepatoma were treated with sequential intraarterial doxorubicin (72-hour continuous infusion) followed by systemic 5-fluorouracil (5-FU) and semustine (methyl CCNU). Objective tumor responses were seen in three patients (15%). The durations of response were 6, 19, and 27+ months, respect...

journal_title：Cancer

authors： O'Connell MJ,Hahn RG,Rubin J,Moertel CG

更新日期：1988-09-15 00:00:00

abstract：BACKGROUND:Various chemotherapy agents, especially of the alkylating category, have been associated with premature ovarian failure but there is no quantitative evidence of chemotherapy-induced ovarian damage in humans. The aim was to quantify the impact of chemotherapy on primordial follicle reserve and stromal functio...

journal_title：Cancer

authors： Oktem O,Oktay K

更新日期：2007-11-15 00:00:00

abstract：:Acquired myeloperoxidase deficiency has been reported in several hematological malignancies. The clinical course of a patient with acute myelomonocytic leukemia is described which was characterized by staphylococcal infections prior to therapy and again during a period of relapse. Neutropenia was not a feature of thes...

journal_title：Cancer

authors： Kitahara M,Kushner JP

更新日期：1979-12-01 00:00:00

abstract：BACKGROUND:DNA ploidy and S-phase fraction measured by DNA flow cytometry were shown to correlate with several clinicopathologic characteristics in several types of tumors. METHODS:DNA flow cytometry was performed on 329 samples (164 normal mucosa, 165 tumors) obtained from 165 patients (112 men) with stomach cancer, ...

journal_title：Cancer

authors： Lee KH,Lee JS,Suh C,Ahn MJ,Kim SW,Doh BS,Min YI,Kim BS,Park KC,Lee IC

更新日期：1993-09-15 00:00:00

abstract：:K-ras gene mutation in colorectal tumors from patients with familial polyposis coli were investigated using oligonucleotide probes specific for a mutation at codon 12, 13, or 61 of the K-ras gene. The authors examined 22 colorectal carcinomas and 51 colorectal adenomas from 41 familial polyposis coli patients and obse...

journal_title：Cancer

authors： Sasaki M,Sugio K,Sasazuki T

更新日期：1990-06-01 00:00:00

abstract：:Aziridinylbenzoquinone (AZQ) was studied in a Phase II protocol for persons with glioma of the central nervous system (CNS) recurrent or progressive after surgery and radiotherapy. Patients received AZQ, 30 mg/m2 intravenously every 3 weeks if previously untreated or 27.5 mg/m2 if previously exposed to cytotoxic drugs...

journal_title：Cancer

authors： Haid M,Khandekar JD,Christ M,Johnson CM,Miller SJ,Locker GY,Merrill JM,Reisel H,Hatfield A,Lanzotti V

更新日期：1985-09-15 00:00:00

abstract：:The authors treated 32 patients with Stage IIIB or IV non-small cell lung cancer (NSCLC) with an outpatient regimen of edatrexate (10-ethyl-10-deaza-aminopterin) (10-EdAM) on days 1 and 8, cyclophosphamide on day 1, and cisplatin on day 1, repeated every 3 weeks with dose modification. The 22 men and 10 women (median ...

journal_title：Cancer

authors： Lee JS,Libshitz HI,Fossella FV,Murphy WK,Pang AC,Lippman SM,Shin DM,Dimery IW,Glisson BS,Hong WK

更新日期：1991-09-01 00:00:00

abstract：:Between 1964 and 1982, 862 patients with acute leukemia who were collected from medical institutions throughout the country had a survival of 5 years or longer. Their remission has been achieved mainly with a combination therapy of vincristine and prednisone in childhood acute leukemia and daunomycin, cytosine arabino...

journal_title：Cancer

authors： Kawashima K,Nagura E,Yamada K,Hamajima N

更新日期：1985-07-01 00:00:00

abstract：BACKGROUND:Patients with superficial (mucosal or submucosal) esophageal carcinoma (SEC) have significantly better survival rates than patients with advanced carcinoma. Some patients with advanced esophageal carcinoma have been reported to test positive for serum p53 antibodies (Abs). Because very few patients with supe...

journal_title：Cancer

authors： Shimada H,Takeda A,Arima M,Okazumi S,Matsubara H,Nabeya Y,Funami Y,Hayashi H,Gunji Y,Suzuki T,Kobayashi S,Ochiai T

更新日期：2000-10-15 00:00:00

abstract：BACKGROUND:Primary central nervous system lymphoma (PCNSL) is the most common brain tumor occurring in patients with acquired immune deficiency syndrome (AIDS). After diagnosis of PCNSL, the median survival time is 2-5 months with treatment with whole brain irradiation (WBI). METHODS:Four (of approximately 40) patient...

journal_title：Cancer

authors： Chamberlain MC

更新日期：1994-03-15 00:00:00

abstract：:Alkylating agents form the basis of most combination treatment regimens for low-grade lymphoproliferative disorders. Bendamustine is a unique alkylating agent that has distinctive preclinical activity in cell lines resistant to other alkylators. Furthermore, clinical activity has been demonstrated in patients with alk...

journal_title：Cancer

authors： Kalaycio M

更新日期：2009-02-01 00:00:00

abstract：BACKGROUND:Thalidomide is an antiangiogenic agent with immune modulating potential. The objective of this study was to determine response rates among women who were treated for recurrent ovarian cancer using topotecan with or without thalidomide. METHODS:Women were enrolled in this multicenter, prospective, randomized...

journal_title：Cancer

authors： Downs LS Jr,Judson PL,Argenta PA,Ghebre R,Geller MA,Bliss RL,Boente MP,Nahhas WA,Abu-Ghazaleh SZ,Chen MD,Carson LF

更新日期：2008-01-15 00:00:00

abstract：:An unusual case of myeloproliferative disorder in which mature and immature myeloid cells were found to contain unusual cytoplasmic inclusions is reported. By light microscopy, these inclusions could be observed with Wright's stain. By electron microscopy they appeared to consist of a pale, finely granular material wi...

journal_title：Cancer

authors： Coppola A,O'Connor J

更新日期：1977-11-01 00:00:00

abstract：BACKGROUND:The objectives of this study were to evaluate survival among current smokers, former smokers, and never smokers who are diagnosed with non-small cell lung cancer (NSCLC). METHODS:The study included patients who participated in the National Comprehensive Cancer Network's NSCLC Database Project. Current, form...

journal_title：Cancer

authors： Ferketich AK,Niland JC,Mamet R,Zornosa C,D'Amico TA,Ettinger DS,Kalemkerian GP,Pisters KM,Reid ME,Otterson GA

更新日期：2013-02-15 00:00:00

abstract：:The records of 51 patients with esophageal carcinoma were reviewed. Twenty-two patients underwent attempted curative resection with a mean survival of 7.7 months. Twenty patients underwent primary radiotherapy (mean survival, 4.3 months). Nine patients received palliative therapy alone (mean survival, 2.8 months). Sur...

journal_title：Cancer

authors： Adelstein DJ,Forman WB,Beavers B

更新日期：1984-09-01 00:00:00

abstract：:Between June 1977 and December 1978, occult testicular leukemia (OTL) was discovered at three years of continual complete remission (CCR) from the time of diagnosis of acute lymphoblastic leukemia (ALL) in 5 of 59 (8.5%) of males undergoing bilateral wedge testicular biopsy at 1 of 15 participating Southwest Oncology ...

journal_title：Cancer

authors： Askin FB,Land VJ,Sullivan MP,Ragab AH,Steuber CP,Dyment PG,Talbert J,Moore T

更新日期：1981-02-01 00:00:00

abstract：:To evaluate the potential teratogenicity and mutagenicity of modern cancer treatment, the authors enumerated from a cooperative clinical trial group 133 pregnancies in 66 women with malignant neoplasms (53% with Hodgkin's disease, 26% with other lymphomas and leukemia, and 21% with solid tumors). The gestations were d...

journal_title：Cancer

authors： Mulvihill JJ,McKeen EA,Rosner F,Zarrabi MH

更新日期：1987-09-01 00:00:00