Leukemia relapse in long-term survivors of acute leukemia.

abstract：BACKGROUND:The authors tested the hypothesis that the metabolic syndrome (> or =3 of the following components: high blood pressure, increased waist circumference, hypertriglyceridemia, low levels of high-density lipoprotein cholesterol, or diabetes/hyperglycemia) is a risk factor for colorectal cancer. METHODS:Data fr...

journal_title：Cancer

authors： Ahmed RL,Schmitz KH,Anderson KE,Rosamond WD,Folsom AR

更新日期：2006-07-01 00:00:00

abstract：:With the improved survival of children with cancer, increased attention is being focused on the health status of survivors. The ultimate objective of this research is to use the results to design and test rational intervention strategies directed toward reduction of morbidity and mortality associated with the diagnosi...

journal_title：Cancer

authors： Robison LL

更新日期：1993-05-15 00:00:00

abstract：:Preoperative evaluation should focus on techniques that either preclude surgery entirely, alter the planned operation either preoperatively or intraoperatively, or suggest the need for preoperative adjuvant therapy. The presence of a synchronous colonic neoplasia should be excluded by colonoscopy or air-contrast bariu...

journal_title：Cancer

authors： Cohen AM

更新日期：1992-09-01 00:00:00

abstract：:Although the conference could not provide a definitive etiologic explanation for the observed increase in incidence of human brain tumors, particularly among the elderly, nevertheless, this interdisciplinary gathering of prominent scientists and clinicians proved invaluable in identifying new avenues of research. Clea...

journal_title：Cancer

authors： Brem S,Rozental JM,Moskal JR

更新日期：1995-08-15 00:00:00

abstract：:Proficiency testing in cytopathology and in other disciplines should be based on firm statistical and scientific foundations, because test theory in general is a heavily statistical subject. Statistical considerations have demonstrated that the design of "short" proficiency tests in cytopathology, including the curren...

journal_title：Cancer

authors： Nagy GK,Naryshkin S

更新日期：2007-12-25 00:00:00

abstract：BACKGROUND:The objective of the current study was to correlate pretreatment computed tomography and magnetic resonance imaging studies with outcomes for patients with squamous or basal cell carcinoma of the skin and clinical perineural invasion. METHODS:Between 1986 and 2002, 45 patients were treated with radiotherapy...

journal_title：Cancer

authors： Galloway TJ,Morris CG,Mancuso AA,Amdur RJ,Mendenhall WM

更新日期：2005-03-15 00:00:00

abstract：BACKGROUND:Cyclooxygenase 2 (COX-2)-dependent signaling represents a potential mechanism of resistance to therapy with epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors. This is mediated in part through an EGFR-independent activation of mitogen-activated protein kinase (MAPK)/extracellular signal-regul...

journal_title：Cancer

authors： Reckamp KL,Koczywas M,Cristea MC,Dowell JE,Wang HJ,Gardner BK,Milne GL,Figlin RA,Fishbein MC,Elashoff RM,Dubinett SM

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:The purpose of the current study was to examine patient selection for an aromatase inhibitor in breast cancer patients who were free from adverse events 5 years after treatment with tamoxifen. METHODS:In all, 471 women were treated with breast-conserving surgery, axillary lymph node dissection, and radiatio...

journal_title：Cancer

authors： Freedman GM,Anderson P,Li T,Ross E,Swaby R,Goldstein L

更新日期：2006-12-01 00:00:00

abstract：:Six patients with Hodgkin's disease who developed idiopathic thrombocytopenic purpura (ITP) are presented. In contrast to prior cases reported in the literature, none of these patients developed recurrent Hodgkin's disease at the time of or subsequent to their thrombocytopenia, with follow-up data available up to 10 y...

journal_title：Cancer

authors： Cohen JR

更新日期：1978-02-01 00:00:00

abstract：:Eighteen patients with unresectable ductal adenocarcinoma of the pancreas received definitive, high-dose, small-volume radiation therapy. All patients had at least one laparotomy, at which time a biopsy was obtained, radio-opaque clips were placed to define the extent of the gross tumor, and usually some form of bypas...

journal_title：Cancer

authors： Dobelbower RR Jr,Borgelt BB,Suntharalingam N,Strubler KA

更新日期：1978-03-01 00:00:00

abstract：:When 70 children with disseminated neuroblastoma were treated for 4 months with a course of cyclophosphamide and doxorubicin (Adriamycin) 35 (52%) of 68 assessable patients achieved complete remissions, 13 had partial responses, and 20 had either less than a 50% regression of tumor or evidence of tumor progression. Of...

journal_title：Cancer

authors： Green AA,Hayes FA,Hustu HO

更新日期：1981-11-15 00:00:00

abstract：:Seventy-three women with metastatic breast cancer were treated with aminoglutethimide and dexamethasone. No complete responses occurred. Ten patients (16%) achieved partial responses (mean duration, 12 months). The proportions of patients responding by disease site were breast (50%), nodes (33%), skin (23%), bone (16%...

journal_title：Cancer

authors： Asbury RF,Bakemeier RF,Fölsch E,McCune CS,Savlov E,Bennett JM

更新日期：1981-04-15 00:00:00

abstract：BACKGROUND:Although significant advances have been made in the treatment of some malignancies, the prognosis of patients with metastatic tumors remains poor. Differentiating agents redirect cells toward their normal phenotype and therefore may reverse or suppress evolving malignant lesions or prevent cancer invasion. I...

journal_title：Cancer

authors： Miller WH Jr

更新日期：1998-10-15 00:00:00

abstract：:Clinical, histological and ultrastructural features of three small cell carcinomas arising in the parotid gland are presented. The light microscopic appearance of two of the neoplasms suggested neuroendocrine cell derivation, confirmed by electron microscopy in both instances. The fine structure of the third neoplasm ...

journal_title：Cancer

authors： Kraemer BB,Mackay B,Batsakis JG

更新日期：1983-12-01 00:00:00

abstract：:Forty-nine specimens of carcinoma of the breast were analyzed for estrogen receptor content using the sucrose gradient method and a histochemical method using a conjugate of estradiol (6-BSA-Fluor-CMO-17 beta-estradiol). The specimens analyzed by the histochemical method were graded for fluorescent intensity, percenta...

journal_title：Cancer

authors： Panko WB,Mattioli CA,Wheeler TM

更新日期：1982-05-15 00:00:00

abstract：BACKGROUND:Nipple duct lavage (NDL) may be useful for breast cancer risk stratification. Published guidelines recommend that women with a 5-year Gail risk >/=1.7% should consider undergoing lavage for any fluid-yielding ducts, but it is not known whether increased breast cancer risk or nipple fluid production predict l...

journal_title：Cancer

authors： Bushnaq ZI,Ashfaq R,Leitch AM,Euhus D

更新日期：2007-04-01 00:00:00

abstract：BACKGROUND:The clinical dose of 3-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-1-(2-chloroethyl)-1-nitro- sourea hydrochloride (ACNU) is limited by the bone marrow suppression it produces. The authors investigated whether bone marrow transplantation (BMT) associated with a high dose of ACNU could alleviate marrow toxicity ...

journal_title：Cancer

authors： Soma M,Shoin K,Yamashita J

更新日期：1993-01-15 00:00:00

abstract：BACKGROUND:Historically, estrogen receptor (ER) determinations have been made by the ligand-binding assay of tumor homogenates, primarily by the dextran-coated charcoal method (DCC). Immunocytochemical assays (ICA) for ER are more recent and have been executed mostly on frozen sections with the monoclonal antibody H222...

journal_title：Cancer

authors： Pertschuk LP,Feldman JG,Kim YD,Braithwaite L,Schneider F,Braverman AS,Axiotis C

更新日期：1996-06-15 00:00:00

abstract：:The development of monoclonal antibodies has led to renewed interest in the use of antibodies to treat malignant disease. Unfortunately, treatment with unmodified antibodies has been disappointing. Therapy with unmodified antibodies has been limited by the failure of host effector mechanisms to eliminate antibody-coat...

journal_title：Cancer

authors： Badger CC,Bernstein ID

更新日期：1986-07-15 00:00:00

abstract：:In certain experimental tumor models, tumor growth is less pronounced in immune deficient animals. Characteristically, tumors such as the murine B16 melanoma and Lewis lung carcinoma (3LL) are weakly antigenic. We proposed that with such tumors that are weakly antigenic, growth is enhanced by T-cell factors. Young mic...

journal_title：Cancer

authors： Ershler WB,Tuck D,Moore AL,Klopp RG,Kramer KE

更新日期：1988-05-01 00:00:00

abstract：BACKGROUND:The effect on prognosis of adding imatinib mesylate to the treatment of patients with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) has not been explored fully. The objective of the current study was to evaluate the benefit of adding imatinib to the treatment sequence of patients w...

journal_title：Cancer

authors： Kantarjian H,O'Brien S,Cortes J,Shan J,Giles F,Garcia-Manero G,Verstovsek S,Faderl S,Rios MB,Talpaz M

更新日期：2003-10-01 00:00:00

abstract：:Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...

journal_title：Cancer

authors： Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

更新日期：1987-06-01 00:00:00

abstract：BACKGROUND AND METHODS:Predictors of distant relapse following conservative surgery for breast cancer were studied in a review of 425 women. Five steps of breast cancer patient management were defined in which increasing amounts of information, potentially relevant to prognosis for metastasis-free survival (MFS), were ...

journal_title：Cancer

authors： Tubiana-Hulin M,Le Doussal V,Hacene K,Rouëssé J,Brunet M

更新日期：1993-08-15 00:00:00

abstract：:Dr. Wendell G. Scott hailed mammography as the first significant contribution to the control of breast cancer since Halsted described the radical mastectomy in 1903. Mammography as engendered new approaches and has supplied new concepts of breast cancer. Through the tenacity of a few physicians convinced something cou...

journal_title：Cancer

authors： Egan RL

更新日期：1975-11-01 00:00:00

abstract：:The diagnosis of malignant melanoma is based on clinical grounds and a properly performed biopsy, preferably excision, so that the type of melanoma and the thickness can be assessed by methods described by Clark and Breslow. These facilitate clinical and pathologic staging. Excisions with conservative margins for thin...

journal_title：Cancer

authors： Harris MN,Shapiro RL,Roses DF

更新日期：1995-01-15 00:00:00

abstract：:Serum complements, C3, C4, and C3 proactivator (C3PA), were evaluated prospectively for their diagnostic power in detecting hepatocellular carcinoma (HCC) in patients with liver cirrhosis (LC). Sixty-three LC patients, including 36 LC with HCC patients, were recruited for this study during the period from March to Nov...

journal_title：Cancer

authors： Chang WY,Chuang WL

更新日期：1988-07-15 00:00:00

abstract：:The first three well-documented cases of pure, extraskeletal telangiectatic osteosarcoma of the soft tissues are presented in this article. The distinctive gross features were a predominance of large, blood-filled spaces, which, on histologic examination, were large blood-filled cavities in association with cyst-like ...

journal_title：Cancer

authors： Mirra JM,Fain JS,Ward WG,Eckardt JJ,Eilber F,Rosen G

更新日期：1993-05-15 00:00:00

abstract：:To examine the relationship between smoking and stage of colorectal cancer at diagnosis, data on 2788 current smokers and 6313 nonsmokers with known stage at diagnosis were obtained from the Massachusetts Cancer Registry. The stage at diagnosis was treated as a polytomous response variable in a logit-type, log-linear ...

journal_title：Cancer

authors： Longnecker MP,Clapp RW,Sheahan K

更新日期：1989-09-15 00:00:00

abstract：BACKGROUND:Hyperglycemia is often observed in medically ill patients. Previous studies have shown that patients with hyperglycemia during induction therapy for acute lymphoblastic leukemia develop more infections and have shorter disease-free survival. The authors hypothesized that hyperglycemia may be associated with ...

journal_title：Cancer

authors： Ali NA,O'Brien JM Jr,Blum W,Byrd JC,Klisovic RB,Marcucci G,Phillips G,Marsh CB,Lemeshow S,Grever MR

更新日期：2007-07-01 00:00:00

abstract：BACKGROUND:The recurrence or mortality rate of axillary lymph node-negative invasive breast cancer has been associated with the tumor S-phase fraction, which is measured by DNA flow cytometry. Because many of the studies that established this association were performed using frozen, pulverized tumor specimens, this ass...

journal_title：Cancer

authors： Merkel DE,Winchester DJ,Goldschmidt RA,August CZ,Wruck DM,Rademaker AW

更新日期：1993-09-15 00:00:00