Evolution of the team approach in breast cancer.

abstract：BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

journal_title：Cancer

authors： Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

更新日期：2004-10-15 00:00:00

abstract：BACKGROUND:The use of neoadjuvant and adjuvant chemotherapy in soft tissue sarcomas is controversial. This is a report of long-term (≥5 years) follow-up in patients with high-grade, high-risk soft tissue sarcomas treated with neoadjuvant chemotherapy, preoperative radiotherapy (RT), and adjuvant chemotherapy. METHODS:...

journal_title：Cancer

authors： Kraybill WG,Harris J,Spiro IJ,Ettinger DS,DeLaney TF,Blum RH,Lucas DR,Harmon DC,Letson GD,Eisenberg B

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND:The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma. METHODS:Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institution...

journal_title：Cancer

authors： Shikama N,Ogawa K,Tanaka S,Toita T,Nakamura K,Uno T,Ohnishi H,Itami J,Tada T,Saeki N

更新日期：2005-07-01 00:00:00

abstract：:The prognostic significance of histologic tumor grade has been evaluated in 1537 women entered into the Ludwig Trials I-IV of adjuvant therapy for node-positive breast cancer. Tumor grade was determined on histologic review of primary tumor sections by two central review pathologists using a modification of the Bloom ...

journal_title：Cancer

authors： Davis BW,Gelber RD,Goldhirsch A,Hartmann WH,Locher GW,Reed R,Golouh R,Säve-Söderbergh J,Holloway L,Russell I

更新日期：1986-12-15 00:00:00

abstract：:Twenty-four children aged 3 months to 18 years (median, 12 years) were treated for neurogenic sarcoma at the Children's Hospital of Philadelphia Cancer Research Center from 1958 through 1984. Sixteen patients had neurofibromatosis (NF). The tumors arose in an extremity or in the trunk (15 patients), the retroperitoneu...

journal_title：Cancer

authors： Raney B,Schnaufer L,Ziegler M,Chatten J,Littman P,Jarrett P

更新日期：1987-01-01 00:00:00

abstract：:Results of 567 thin-needle aspiration biopsies of head and neck lesions are reviewed. Cases included lymph nodes, salivary glands, thyroid, soft tissue and bone lesions. For the entire series, 17 patients had unsatisfactory aspirations. There were 12 false negative reports and 4 false positive reports, rates of 2.1% a...

journal_title：Cancer

authors： Frable WJ,Frable MA

更新日期：1979-04-01 00:00:00

abstract：BACKGROUND:Chemotherapy-induced nausea and vomiting remain common, distressing side effects of chemotherapy. It has been reported that acupressure prevents chemotherapy-induced nausea in adults, but it has not been well studied in children. METHODS:In this multicenter, prospective, randomized, single-blind, sham-contr...

journal_title：Cancer

authors： Dupuis LL,Kelly KM,Krischer JP,Langevin AM,Tamura RN,Xu P,Chen L,Kolb EA,Ullrich NJ,Sahler OJZ,Hendershot E,Stratton A,Sung L,McLean TW

更新日期：2018-03-15 00:00:00

abstract：BACKGROUND:The objective of this study was to determine the potential economic implications resulting from using exemestane (EXE), a new steroidal, irreversible aromatase inactivator, compared with megestrol acetate (MA) in patients with advanced breast carcinoma. METHODS:The model used the clinical results from the m...

journal_title：Cancer

authors： Hillner BE,Radice D

更新日期：2001-02-01 00:00:00

abstract：:With endometrial adenocarcinoma, several factors, such as stage and histologic grade, are well recognized as having prognostic significance. Other variables, e.g., nuclear grade, probably are also important clinically. A preliminary investigation of the prognostic value of the ploidy, cell cycle kinetics, and sex ster...

journal_title：Cancer

authors： Geisinger KR,Homesley HD,Morgan TM,Kute TE,Marshall RB

更新日期：1986-10-01 00:00:00

abstract：:An unusual thyroid carcinoma is described, showing structural, histochemical and radioimmunologic features of both a follicular and a parafollicular cell carcinoma. Radioimmunoassay revealed high levels of thyroglobulin in the patient's serum and in extracts from metastatic tumor tissue. Immunoreactive thyroglobulin w...

journal_title：Cancer

authors： Ljungberg O,Ericsson UB,Bondeson L,Thorell J

更新日期：1983-09-15 00:00:00

abstract：BACKGROUND:The incidence of bronchioloalveolar carcinoma of the lung (BAC), a pathologically distinct type of nonsmall cell lung carcinoma (NSCLC), appears to be rising. In this study, the authors compared data on the clinical presentation and clinical courses of patients with Stage IIIB and IV BAC with data on other t...

journal_title：Cancer

authors： Breathnach OS,Ishibe N,Williams J,Linnoila RI,Caporaso N,Johnson BE

更新日期：1999-10-01 00:00:00

abstract：:A 65-year-old woman had pancytopenia, splenomegaly, and an inaspirable bone marrow. Diagnostic evaluation demonstrated that she had both leukemic reticuloendotheliosis (LRE), or hairy cell leukemia, and an additional lympho-reticular neoplasm, most likely a "histiocytic" lymphoma. The diagnosis of LRE was based on the...

journal_title：Cancer

authors： Adler SS,Shetty J,Golomb HM

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND:Hormone replacement therapy (HRT) has proven and presumable benefits for women desiring postmenopausal health preservation. Among HRT-associated risks, the fear of breast carcinoma intimidates women and physicians contemplating hormonal treatment and limits long-term compliance. Identifying effective alterna...

journal_title：Cancer

authors： Diamanti-Kandarakis E,Sykiotis GP,Papavassiliou AG

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:The objective of this study was to compare the quality of life (QOL) of younger (< or =50 years) versus older (>50 years) women on recent completion of treatment of breast carcinoma. METHODS:Data reported herein were obtained from a baseline assessment of 304 breast carcinoma patients. These patients were e...

journal_title：Cancer

authors： Wenzel LB,Fairclough DL,Brady MJ,Cella D,Garrett KM,Kluhsman BC,Crane LA,Marcus AC

更新日期：1999-11-01 00:00:00

abstract：:Elevated circulating CEA levels occur in patients with benign gastrointestinal and hepatic disorders. These are usually less than 10 ng/ml. Of clinical importance is the influence of liver disease on the interpretation of CEA. At least 50% of patients with severe benign hepatic disease have elevated CEA levels, most o...

journal_title：Cancer

authors： Loewenstein MS,Zamcheck N

更新日期：1978-09-01 00:00:00

abstract：:Malignant melanoma can potentially involve any organ system in the body once it metastasizes beyond the regional lymph nodes. A survey of the radiographic and associated clinical manifestations of metastatic melanoma is presented. The findings from 74 autopsies of patients who died of metastatic melanoma are included....

journal_title：Cancer

authors： Meyer JE

更新日期：1978-07-01 00:00:00

abstract：:Based on Church records for 15,500 California Mormons during 1968 to 1975 and for 55,000 Utah Mormons during 1970 and 1975, the ratio of age-adjusted death rates for religiously active Mormon males compared with U.S. white males is 38% for ages 35 to 64 years and 50% for ages 35 years and above. The remaining life exp...

journal_title：Cancer

authors： Enstrom JE

更新日期：1978-10-01 00:00:00

abstract：:We detected cytoplasmic estrogen receptors (ER) in only 4 of 34 (12%) patients with malignant melanoma. The titers as assayed by the dextran-coated charcoal method were 3, 3, 4, and 5 fmol/mg, respectively. Our data indicate that the incidence of melanoma with detectable ER is low, which suggests that any potential cl...

journal_title：Cancer

authors： Creagan ET,Ingle JN,Woods JE,Pritchard DJ,Jiang NS

更新日期：1980-10-15 00:00:00

abstract：:A 42-year-old man was admitted to the Cancer Division of the American MedicalCenter in February, 1956. He had been treated for erythrocytosis beginning 6 months previously, with reduction of his hemoglobin to relatively normal values. On admission, a huge tumor of the left kidney was palable. Roentgenograms of the ...

journal_title：Cancer

authors： Downing V,Levine S

更新日期：1975-06-01 00:00:00

abstract：:The survival of 78 patients with resected non-small cell lung cancer entered in prospective, randomized investigational trials is compared to that of a population-based group of control patients not included in such trials. The survival of trial patients is significantly better than that of controls (P less than 0.001...

journal_title：Cancer

authors： Davis S,Wright PW,Schulman SF,Hill LD,Pinkham RD,Johnson LP,Jones TW,Kellogg HB Jr,Radke HM,Sikkema WW

更新日期：1985-10-01 00:00:00

abstract：:This clinicopathologic study concerns 27 cases of "dedifferentiated" soft tissue sarcoma (DSTS), including 14 liposarcomas, six leiomyosarcomas, five chondrosarcomas, and two rhabdomyosarcomas. In addition, the authors conducted an immunohistochemical survey of 23 cases and an electron microscopic examination of three...

journal_title：Cancer

authors： Hashimoto H,Daimaru Y,Tsuneyoshi M,Enjoji M

更新日期：1990-10-01 00:00:00

abstract：BACKGROUND:Human epidermal growth factor receptor 2 (HER2) is a therapeutic target in patients with esophageal adenocarcinoma (EAC), with gene amplification used as a selection criterion for treatment, although to the authors' knowledge the concordance between amplification and HER2 protein expression remains undefined...

journal_title：Cancer

authors： Yoon HH,Sukov WR,Shi Q,Sattler CA,Wiktor AE,Diasio RB,Wu TT,Jenkins RB,Sinicrope FA

更新日期：2014-02-01 00:00:00

abstract：BACKGROUND:The authors hypothesized that comprehensive genomic profiling of advanced-stage cutaneous squamous cell carcinoma (cSCC) could identify genomic-derived drug targets of therapy for patients with conventional therapy-resistant disease. METHODS:Comprehensive genomic profiling of 315 cancer genes was applied to...

journal_title：Cancer

authors： Al-Rohil RN,Tarasen AJ,Carlson JA,Wang K,Johnson A,Yelensky R,Lipson D,Elvin JA,Vergilio JA,Ali SM,Suh J,Miller VA,Stephens PJ,Ganesan P,Janku F,Karp DD,Subbiah V,Mihm MC,Ross JS

更新日期：2016-01-15 00:00:00

abstract：BACKGROUND:The current study was conducted to expedite international standardized reporting of bone marrow disease in children with neuroblastoma and to improve equivalence of care. METHODS:A multidisciplinary International Neuroblastoma Response Criteria Bone Marrow Working Group was convened by the US National Cance...

journal_title：Cancer

authors： Burchill SA,Beiske K,Shimada H,Ambros PF,Seeger R,Tytgat GA,Brock PR,Haber M,Park JR,Berthold F

更新日期：2017-04-01 00:00:00

abstract：BACKGROUND:Expression of neuroectodermal markers is a key feature of small cell lung carcinoma (SCLC). Although immune responses against a number of these proteins have been associated with paraneoplastic neuronal disease (PND), most patients with SCLC have anti-neuroectodermal antibodies in the absence of PND. Whether...

journal_title：Cancer

authors： Vural B,Chen LC,Saip P,Chen YT,Ustuner Z,Gonen M,Simpson AJ,Old LJ,Ozbek U,Gure AO

更新日期：2005-06-15 00:00:00

abstract：BACKGROUND:We have often encountered difficulties in identifying small liver cancers during surgery. Fluorescent imaging using indocyanine green (ICG) has the potential to detect liver cancers through the visualization of the disordered biliary excretion of ICG in cancer tissues and noncancerous liver tissues compresse...

journal_title：Cancer

authors： Ishizawa T,Fukushima N,Shibahara J,Masuda K,Tamura S,Aoki T,Hasegawa K,Beck Y,Fukayama M,Kokudo N

更新日期：2009-06-01 00:00:00

abstract：BACKGROUND:The first analysis of the ATAC (Arimidex, Tamoxifen Alone or in Combination) trial (median follow-up, 33 months) demonstrated that in adjuvant endocrine therapy for postmenopausal patients with early-stage breast cancer, anastrozole was superior to tamoxifen in terms of disease-free survival (DFS), time to r...

journal_title：Cancer

authors： Baum M,Buzdar A,Cuzick J,Forbes J,Houghton J,Howell A,Sahmoud T,ATAC (Arimidex, Tamoxifen Alone or in Combination) Trialists' Group.

更新日期：2003-11-01 00:00:00

abstract：:Etoposide underwent conventional Phase I testing in the 1970s. The dose-limiting toxicity in these studies was mild myelosuppression; other toxicities were infrequent. If a greater degree of myelosuppression is accepted, higher than standard doses could be given. This approach takes advantage of the steep dose-respons...

journal_title：Cancer

authors： Herzig RH

更新日期：1991-01-01 00:00:00

abstract：BACKGROUND:Gastric carcinoma with lymphoid stroma (GCLS) has been reported to have a more favorable prognosis than ordinary gastric carcinoma, however, the precise mechanism of the pathogenesis for GCLS remains unclear. METHODS:The authors analyzed 99 GCLS in 94 patients for Epstein-Barr virus (EBV) sequences using po...

journal_title：Cancer

authors： Nakamura S,Ueki T,Yao T,Ueyama T,Tsuneyoshi M

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:The ThinPrep Pap Test (TP), a liquid-based cervical cytology preparation, was approved for use in the U.S. in 1996. The purpose of this study was to compare TP performance and biopsy follow-up studies with a similar population of high risk patients sampled by conventional Papanicolaou (Pap) smear (CS). METH...

journal_title：Cancer

authors： Carpenter AB,Davey DD

更新日期：1999-06-25 00:00:00