Abstract:
BACKGROUND:The current study assessed the contribution of spinal irradiation to the treatment outcome of patients with intracranial germinoma. METHODS:Clinical data from 180 patients with intracranial germinoma, who were treated with radiotherapy and/or chemotherapy from 1980 to 2001, were collected from 6 institutions. The patients' median age was 16 years (range, 1-47 yrs), and the male-to-female ratio was 133:47. Pathologic verification was obtained in 88 patients. A solitary tumor was seen in 129 patients, and multifocal or disseminated tumors were detected in 51 patients. The median tumor size was 2.5 cm (range, 0.6-7.0 cm). Local field and/or whole brain irradiation was performed in 114 patients, and craniospinal irradiation was performed in 66 patients. Fifty-five patients were treated with chemotherapy. The median follow-up time was 89 months (range, 3-297 mos). RESULTS:Eight-year overall and event-free survival rates were 91% and 89%, respectively. The 8-year recurrence rates at the primary site, intracranial space, and the spinal space were 1%, 6%, and 6%, respectively. Cox regression analysis showed that spinal irradiation (hazard ratio, 1.050; 95% confidence interval [CI], 0.355-3.170) did not contribute to a favorable event-free survival. CONCLUSIONS:Spinal irradiation did not contribute to favorable event-free survival in patients with intracranial germinoma.
journal_name
Cancerjournal_title
Cancerauthors
Shikama N,Ogawa K,Tanaka S,Toita T,Nakamura K,Uno T,Ohnishi H,Itami J,Tada T,Saeki Ndoi
10.1002/cncr.21169subject
Has Abstractpub_date
2005-07-01 00:00:00pages
126-34issue
1eissn
0008-543Xissn
1097-0142journal_volume
104pub_type
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