Treatment of fludarabine-refractory chronic lymphocytic leukemia.

abstract：BACKGROUND:Some studies have suggested that women with metastatic malignant melanoma have a better survival rate than men. However, little is known about the effect of gender on survival in combination with other clinical variables and treatment variables. Thus, an analysis of 813 eligible patients from 15 consecutive ...

journal_title：Cancer

authors： Unger JM,Flaherty LE,Liu PY,Albain KS,Sondak VK

更新日期：2001-03-15 00:00:00

abstract：:The clinicopathologic features of 60 patients with thymic carcinoma were studied. Patients ranged in age from 10 to 76 years (mean, 46), of whom 24 were females and 36 were males. Overall survival at 1, 3, and 5 years was 56.6%, 40%, and 33.3%, respectively. The following morphologic features were correlated with surv...

journal_title：Cancer

authors： Suster S,Rosai J

更新日期：1991-02-15 00:00:00

abstract：:The clinical course of 29 patients with idiopathic refractory sideroblastic anemia studied by us was reviewed. Four patients developed acute leukemia. We were able to find 27 out of 268 cases of idiopathic refractory sideroblastic anemia reported in the literature which terminated in acute leukemia. Nine of these were...

journal_title：Cancer

authors： Cheng DS,Kushner JP,Wintrobe MM

更新日期：1979-08-01 00:00:00

abstract：BACKGROUND:Tropisetron (ICS 205-930) antagonizes the serotonin type 3 receptor and has antiemetic activity in animals given cisplatin. Its mean serum half-life in 11.1 hours. METHODS:In this dose-ranging trial, 22 patients undergoing anti-cancer chemotherapy received 24 courses of a single intravenous infusion of trop...

journal_title：Cancer

authors： Pisters KM,Kris MG,Tyson LB,Clark RA,Gralla RJ

更新日期：1993-01-01 00:00:00

abstract：BACKGROUND:The purpose of this study was to evaluate the results of thyroid fine-needle aspiration (FNA) and to determine the reasons for the discrepancies between the cytologic and histologic diagnoses. METHODS:The authors evaluated the cytologic and histologic results of 133 FNAs obtained from 92 patients who underw...

journal_title：Cancer

authors： Sidawy MK,Del Vecchio DM,Knoll SM

更新日期：1997-08-25 00:00:00

abstract：BACKGROUND:Ideally, screening detects cancer at a more curable stage and, as a result, decreases the rate of subsequent diagnosis at a late stage. Although it is suggested that some cancer screening tests have led to substantial increases in early-stage incidence with only marginal reductions in late-stage incidence (e...

journal_title：Cancer

authors： Yang DX,Gross CP,Soulos PR,Yu JB

更新日期：2014-09-15 00:00:00

abstract：BACKGROUND:The aims of this study were to compare human epidermal growth factor receptor 2 (HER2) results between immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and to investigate the clinicopathological characteristics and outcomes according to their results. METHODS:Using consecutive tissu...

journal_title：Cancer

authors： Park S,Park HS,Koo JS,Yang WI,Kim SI,Park BW

更新日期：2012-02-15 00:00:00

abstract：BACKGROUND:High mobility group AT-hook 1 (HMGA1) proteins are architectural transcription factors that are overexpressed by pancreatic adenocarcinomas. The authors hypothesized that tumor HMGA1 status represents a novel prognostic marker in pancreatic adenocarcinoma. They also tested the hypothesis that HMGA1 promotes ...

journal_title：Cancer

authors： Liau SS,Rocha F,Matros E,Redston M,Whang E

更新日期：2008-07-15 00:00:00

abstract：BACKGROUND:After surgical resection, the residual, invasive glioblastoma (GBM) cells give rise to a recurrent tumor, which, in 96% of patients, arises adjacent to the resection margin. METHODS:In this study, the authors prospectively enrolled 25 patients with GBM who underwent gross total resection followed by adjuvan...

journal_title：Cancer

authors： Mangiola A,de Bonis P,Maira G,Balducci M,Sica G,Lama G,Lauriola L,Anile C

更新日期：2008-08-15 00:00:00

abstract：:Werner's syndrome, a relatively rare and autosomal recessive disorder, is well known to be characterized by a high frequency of malignant neoplasm. The occurrence of familial neoplasm in patients with this condition, however, has been recorded only once before in the literature. Reported are the findings with regard t...

journal_title：Cancer

authors： Usui M,Ishii S,Yamawaki S,Hirayama T

更新日期：1984-12-01 00:00:00

abstract：:Prostatic intra-epithelial neoplasia (PIN, or intraductal dysplasia) is considered a precursor of invasive carcinoma, characterized by proliferation and anaplasia of cells lining prostatic ducts and acini. The highest grade of PIN, Grade 3, is thought to represent carcinoma in situ. To quantitate the degree of disrupt...

journal_title：Cancer

authors： Bostwick DG,Brawer MK

更新日期：1987-02-15 00:00:00

abstract：:During the past eight years, 137 patients with mycosis fungoides were given total skin electron beam therapy (TSEB) using 2.5 to 4 MeV electrons. A single treatment delivers 400 rads to the entire skin surface, and patients are treated once a week for six to eight consecutive weeks. All have been followed for a median...

journal_title：Cancer

authors： Nisce LZ,Safai B,Kim JH

更新日期：1981-03-01 00:00:00

abstract：BACKGROUND:In light of the steadily improving capability to treat opportunistic infections, the authors reviewed their recent experience with short course empiric radiotherapy for the treatment of human immunodeficiency virus (HIV)-associated presumed central nervous system (CNS) lymphoma. METHODS:Medical records were...

journal_title：Cancer

authors： Donahue BR,Sullivan JW,Cooper JS

更新日期：1995-07-15 00:00:00

abstract：:A case of an extramedullary intrathoracic plasmacytoma causing superior vena cava syndrome is described. Review of the literature on intrathoracic plasmacytomas and superior vena cava syndrome revealed that no similar cases have been described to date. The initial presentation, management, and response to treatment ar...

journal_title：Cancer

authors： Davis SR,King HS,Le Roux I,Bolding E

更新日期：1991-09-15 00:00:00

abstract：BACKGROUND:CXC chemokine receptor 4 (CXCR4) is activated by phosphorylation (pCXCR4) and is essential for the migration of hematopoietic precursors to bone marrow. CXCR4 overexpression predicts a poor prognosis in patients with acute myeloid leukemia. Data regarding the prognostic impact of CXCR4 in patients with B-acu...

journal_title：Cancer

authors： Konoplev S,Jorgensen JL,Thomas DA,Lin E,Burger J,Kantarjian HM,Andreeff M,Medeiros LJ,Konopleva M

更新日期：2011-10-15 00:00:00

abstract：BACKGROUND:The growing number of individuals surviving childhood cancer has increased the awareness of adverse long-term sequelae. One of the most worrisome complications after cancer therapy is the development of second malignant neoplasms (SMNs). METHODS:The authors describe the incidence of solid organ SMN in survi...

journal_title：Cancer

authors： Goldsby R,Burke C,Nagarajan R,Zhou T,Chen Z,Marina N,Friedman D,Neglia J,Chuba P,Bhatia S

更新日期：2008-11-01 00:00:00

abstract：:Jaundice and hepatomegaly developed in a boy with Fanconi anemia after he had undergone treatment with oxymetholone for nine years. A liver scan showed patchy uptake consistent with the presence of space-occupying lesions. After oxymetholone treatment was stopped, the jaundice resolved, the liver size decreased, and t...

journal_title：Cancer

authors： Obeid DA,Hill FG,Harnden D,Mann JR,Wood BS

更新日期：1980-09-15 00:00:00

abstract：BACKGROUND:Despite improvements in survival rates, cancer treatments have significant side effects that affect the quality of life of children and their families. When an ill child cannot self-report symptoms (eg, he or she is too ill), caregiver (parent) reporting becomes critical. This study evaluates the validity an...

journal_title：Cancer

authors： Reeve BB,McFatrich M,Lin L,Lucas NR,Mack JW,Jacobs SS,Withycombe JS,Baker JN,Freyer DR,Hinds PS

更新日期：2020-12-17 00:00:00

abstract：BACKGROUND:An increased understanding of the biology of prostate carcinoma has led to the clinical evaluation of mechanism-based and targeted therapies. Modulating the immune system has been pursued through the use of both active and passive immunity as well as the ex vivo genetic manipulation of effector cells. A vari...

journal_title：Cancer

authors： Morris MJ,Scher HI

更新日期：2000-09-15 00:00:00

abstract：BACKGROUND:Several studies have shown that Ashkenazi Jews in the United States and Israel have a high prevalence of the founder mutations BRCA1 185delAG, BRCA1 5382insC, BRCA2 6174delT, and APC I1307K at frequencies of 1.0--1.1%, 0.2--0.3%, 0.6--1.4%, and 6.1--7.0%, respectively. The objective of this study was to comp...

journal_title：Cancer

authors： Bahar AY,Taylor PJ,Andrews L,Proos A,Burnett L,Tucker K,Friedlander M,Buckley MF

更新日期：2001-07-15 00:00:00

abstract：BACKGROUND:The current study was designed to evaluate the efficacy and toxicity of the continuous oral administration of a combination of cyclophosphamide (50 mg/day given in the morning) and dexamethasone (1 mg/day given in the evening) in patients with prostate specific antigen (PSA) progression despite single or mul...

journal_title：Cancer

authors： Glode LM,Barqawi A,Crighton F,Crawford ED,Kerbel R

更新日期：2003-10-15 00:00:00

abstract：BACKGROUND:Early stage lung cancer has a variable prognosis, and there are currently no markers that predict which patients will recur. This study examined the relation between tumor-regulatory T (Treg) cells and total tumor-infiltrating T-cell lymphocytes (TIL) to determine whether they correlated with recurrence. ME...

journal_title：Cancer

authors： Petersen RP,Campa MJ,Sperlazza J,Conlon D,Joshi MB,Harpole DH Jr,Patz EF Jr

更新日期：2006-12-15 00:00:00

abstract：:Both cytogenetic analysis and flow cytometry (FCM) have prognostic efficacy in the analysis of transitional cell carcinoma (TCC) of urinary bladder. To correlate results of the two methods, we studied a unique group of patients whose tumors had undergone prospective conventional cytogenetic analysis. Paraffin blocks o...

journal_title：Cancer

authors： Coon JS,Schwartz D,Summers JL,Miller AW 3rd,Weinstein RS

更新日期：1986-04-15 00:00:00

abstract：:A case of thymoma in a 12-year-old boy is presented. The patient had a history of thymic irradiation in infancy, and a family history of leukemia. The mass was readily resected and the patient is well 10 years later. The tumor contained an unusual admixture of normal thymic tissue with the neoplastic epithelial elemen...

journal_title：Cancer

authors： Chatten J,Katz SM

更新日期：1976-02-01 00:00:00

abstract：BACKGROUND:Transitional cell carcinoma (TCC) of the bladder displays an unpredictable biologic behavior and the morphologic methods of grading tumor malignancy are often insufficient to predict the clinical outcome of patients with TCC of the bladder. Thus, the new indicator should reliably reflect prognosis. In this s...

journal_title：Cancer

authors： Shiina H,Igawa M,Nagami H,Yagi H,Urakami S,Yoneda T,Shirakawa H,Ishibe T,Kawanishi M

更新日期：1996-10-15 00:00:00

abstract：BACKGROUND:National and international bodies acknowledge the benefit of exercise for people with cancer, yet limited accessibility to related programing remains. Given their involvement in managing the disease, cancer centers can play a central role in delivering exercise-oncology services. The authors developed and im...

journal_title：Cancer

authors： Santa Mina D,Au D,Auger LE,Alibhai SMH,Matthew AG,Sabiston CM,Oh P,Ritvo PG,Chang EB,Jones JM

更新日期：2019-10-01 00:00:00

abstract：BACKGROUND:The current study assessed the feasibility of a mentored home-based vegetable gardening intervention and examined changes in health-related outcomes among breast cancer survivors (BCS). METHODS:BCS were randomized to either a year-long vegetable gardening intervention to begin immediately or a wait-list con...

journal_title：Cancer

authors： Bail JR,Frugé AD,Cases MG,De Los Santos JF,Locher JL,Smith KP,Cantor AB,Cohen HJ,Demark-Wahnefried W

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND:Allogeneic hematopoietic cell transplantation (HCT) is a curative therapy for patients with acute myeloid leukemia (AML). However, post-HCT relapse and regimen-related toxicity remain significant barriers to long-term survival. In recent years, new conditioning regimens have been explored to improve transpla...

journal_title：Cancer

authors： Nagler A,Labopin M,Beelen D,Ciceri F,Volin L,Shimoni A,Foá R,Milpied N,Peccatori J,Polge E,Mailhol A,Mohty M,Savani BN

更新日期：2017-07-15 00:00:00

abstract：BACKGROUND:Radiofrequency (RF)-induced tissue coagulation represents a new approach for the thermal destruction of tumors within the liver. The purpose of the current study was to 1) assess technique safety; 2) determine the extent and evolution of induced cellular damage; and 3) correlate the observed pathologic effec...

journal_title：Cancer

authors： Goldberg SN,Gazelle GS,Compton CC,Mueller PR,Tanabe KK

更新日期：2000-06-01 00:00:00

abstract：:Doxorubicin is an effective antineoplastic agent, but it frequently causes dose-related cardiotoxic effects. Because the atrial natriuretic peptide (ANP) level is elevated in children with heart defects, the authors measured the ANP levels in children to determine whether ANP might serve as a simple diagnostic indicat...

journal_title：Cancer

authors： Bauch M,Ester A,Kimura B,Victorica BE,Kedar A,Phillips MI

更新日期：1992-03-15 00:00:00