Treatment of intrahepatic malignancy with radiofrequency ablation: radiologic-pathologic correlation.

Abstract:

BACKGROUND:Radiofrequency (RF)-induced tissue coagulation represents a new approach for the thermal destruction of tumors within the liver. The purpose of the current study was to 1) assess technique safety; 2) determine the extent and evolution of induced cellular damage; and 3) correlate the observed pathologic effects with radiologic studies. METHODS:Twenty-three tumors measuring 3 days after ablation showed definite, contiguous coagulative necrosis without intervening areas of viable tumor. CT and MRI scans demonstrated circumscribed hypodense, nonenhancing regions surrounding the electrode tract as early as 15 minutes after ablation. These corresponded within 2 mm to measurements of coagulation at pathology. CONCLUSIONS:RF ablation is a minimally invasive and safe approach to the treatment of tumors in the liver. Tumors treated with RF energy do not immediately demonstrate coagulative necrosis, but do show evidence of irreversible cellular damage. The extent of tumor necrosis correlates closely with findings at contrast-enhanced imaging.

journal_name

Cancer

journal_title

Cancer

authors

Goldberg SN,Gazelle GS,Compton CC,Mueller PR,Tanabe KK

subject

Has Abstract

pub_date

2000-06-01 00:00:00

pages

2452-63

issue

11

eissn

0008-543X

issn

1097-0142

pii

10.1002/1097-0142(20000601)88:11<2452::AID-CNCR5>3

journal_volume

88

pub_type

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