Prognostic factors in soft tissue sarcomas. A multivariate analysis of 109 cases.

Abstract:

:Prognostic factors were evaluated in 109 soft tissue sarcomas of the extremities, walls of the trunk, head, and neck. All lesions were graded according to the systems proposed by the National Cancer Institute (NCI) and the French Federation of Cancer Centers (FNCLCC), and a correlation was found between tumor grade and prognosis. Univariate analysis selected the following variables as unfavorable prognostic factors: invasive tumor margins, extra-compartmental status, deep tumors, tumor diameters over 5 cm, inadequate excision, presence of necrosis, high mitotic count, histologically undifferentiated tumors, and blood vessel invasion. These variables were found to be interdependent. Multivariate analysis selected quality of surgery as the most important variable for predicting local recurrences. The factors selected with regard to overall and metastasis-free survival were tumor size, tumor margins, necrosis, and adequacy of excision. These results permitted classification of patients into four prognostic groups: two with good and two with bad prognosis. Five-year survival for the four groups was 100%, 83%, 53%, and 0%; 5-year metastatic rates were 0%, 12%, 67%, and 100%. Similar groups were obtained when the variables of tumor margins and size were combined with an adaptation of the NCI grading (low-grade tumors/high-grade tumors without necrosis/high-grade tumors with necrosis). Comparative analysis showed that patients with tumors of the same histologic grade or type were not necessarily classed in the same prognostic groups. A better clinicopathologic correlation was obtained using a combination of prognostic factors than with histologic grading or typing alone.

journal_name

Cancer

journal_title

Cancer

authors

Mandard AM,Petiot JF,Marnay J,Mandard JC,Chasle J,de Ranieri E,Dupin P,Herlin P,de Ranieri J,Tanguy A

doi

10.1002/1097-0142(19890401)63:7<1437::aid-cncr2820

subject

Has Abstract,Author List Incomplete

pub_date

1989-04-01 00:00:00

pages

1437-51

issue

7

eissn

0008-543X

issn

1097-0142

journal_volume

63

pub_type

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