Abstract:
:Seventeen patients were given DTIC, 200 mg/m2/day in five-day courses every four to six weeks. In four patients (stage II) treated on an adjuvant basis, tumor recurrence has been verified in three. Four of the palliatively treated patients were also given DTIC by regional intra-arterial infusion with minimal positive tumor effect and minimal toxicity. 5-S-cysteinyldopa excretion in urine was checked continuously in all patients. Tumor recurrence was revealed in two patients given DTIC on an adjuvant basis three and four months before clinical signs of tumor. In the palliatively treated patients, 5-S-cysteinyldopa excretion increased in 5/6 patients judged to have stable disease, before tumor progression was clinically detectable. The use of 5-S-cysteinyldopa examination is a valuable adjunct to the follow-up of the effect of DTIC therapy in melanoma patients.
journal_name
Cancerjournal_title
Cancerauthors
Jönsson PE,Agrup G,Arnbjörnsson E,Hafström L,Rorsman Hdoi
10.1002/1097-0142(19800115)45:2<245::aid-cncr28204subject
Has Abstractpub_date
1980-01-15 00:00:00pages
245-8issue
2eissn
0008-543Xissn
1097-0142journal_volume
45pub_type
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