Combination chemotherapy in abdominal Burkitt's lymphoma.

Abstract:

:In a clinical trial, 42 patients with abdominal Burkitt's lymphoma (BL) were treated with a combination regimen, code-named CVA, consisting of cyclophosphamide (CTX), vincristine, and cystosine arabinoside. In addition, intrathecal methotrexate (i.t. MTX) was administered as prophylaxis against subsequent central nervous system (CNS) involvement. Induced remissions, relapse, and survival were compared with those in a preceding group of 44 patients with abdominal BL treated with CTX along. Remission rate did not differ significantly in the two treatment groups, although induced remissions were higher in the CVA plus i.t. MTX-treated group (94% vs. 83%). Remission duration was significantly increases (p less than .05) and CNS relapse significantly reduced (p less than .05) in the group treated with CVA and i.t. MTX. The combination therapy was associated with higher early deaths during treatment, which adversely affected the overally survival. It is suggested that a reduction of the initial chemotherapeutic doses, particularly for patients with extensive tumor load, could further improve on the results of this trial.

journal_name

Cancer

journal_title

Cancer

authors

Nkrumah FK,Perkins IV,Biggar RJ

doi

10.1002/1097-0142(197710)40:4<1410::aid-cncr282040

subject

Has Abstract

pub_date

1977-10-01 00:00:00

pages

1410-6

issue

4

eissn

0008-543X

issn

1097-0142

journal_volume

40

pub_type

杂志文章

相关文献

CANCER文献大全
  • Tobacco-induced changes in oral leukoplakic epithelium.

    abstract::A study of 112 biopsy specimens from Danish oral leukoplakia patients and 145 biopsy specimens from Indian leukoplakia patients revealed a chevron-like keratinization of the epithelium in a number of cases. Clinically, this type of keratinization was often characterized by a pumice-like appearance. The clinical and hi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19800501)45:9<2330::aid-cncr2820

    authors: Pindborg JJ,Reibel J,Roed-Peterson B,Mehta FS

    更新日期:1980-05-01 00:00:00

  • Distribution and reproducibility of aryl hydrocarbon hydroxylase inducibility in a prospective population study of middle-aged male smokers and nonsmokers.

    abstract::Aryl hydrocarbon hydroxylase (AHH) inducibility was determined in a lymphoblast test system in 2,000 consecutive middle-aged male smokers, 304 ex-smokers, and 218 never-smokers in the same birth-year cohorts. Intraindividual, intraobserver, and interobserver, as well as temporal, reproducibility was checked in a speci...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19851015)56:8<1988::aid-cncr2820

    authors: Trell L,Korsgaard R,Janzon L,Trell E

    更新日期:1985-10-15 00:00:00

  • The prognostic significance of vascular invasion by endometrial carcinoma.

    abstract:BACKGROUND:Recently, invasion of vascular spaces by endometrial carcinoma has received particular attention as a prognostic factor. The goal of the current investigation was to re-examine the effect of vascular invasion on tumor recurrence and survival in patients with endometrial carcinoma. METHODS:Surgical specimens...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(SICI)1097-0142(19961001)78:7<1447::AID-CN

    authors: Inoue Y,Obata K,Abe K,Ohmura G,Doh K,Yoshioka T,Hoshiai H,Noda K

    更新日期:1996-10-01 00:00:00

  • Trends, patterns, and outcomes in the management of malignant colonic polyps in the general population of the United States.

    abstract:BACKGROUND:Colonoscopic screening has increased detection of malignant colonic polyps (MPs). The goal of this study was to analyze trends and patterns in the surgical treatment of MPs and to assess outcomes as measured by lymph node retrieval and patient survival. METHODS:The Surveillance, Epidemiology, and End Result...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25657

    authors: Wasif N,Etzioni D,Maggard MA,Tomlinson JS,Ko CY

    更新日期:2011-03-01 00:00:00

  • Depressed adenoma of the stomach, revisited. Histologic, histochemical, and immunohistochemical profiles.

    abstract::For 52 patients with depressed adenomas of the stomach, histopathologic studies were done on 56 tumors and for 43 of them, histochemical and immunohistochemical features were examined. In addition, nondepressed adenomas (n = 57) and the depressed type of early gastric adenocarcinomas of the well-differentiated variety...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910501)67:9<2382::aid-cncr2820

    authors: Xuan ZX,Ambe K,Enjoji M

    更新日期:1991-05-01 00:00:00

  • Impact of socioeconomic status on survival for patients with anal cancer.

    abstract:BACKGROUND:Although outcomes for patients with squamous cell carcinoma of the anus (SCCA) have improved, the gains in benefit may not be shared uniformly among patients of disparate socioeconomic status. In the current study, the authors investigated whether area-based median household income (MHI) is predictive of sur...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.31186

    authors: Lin D,Gold HT,Schreiber D,Leichman LP,Sherman SE,Becker DJ

    更新日期:2018-04-15 00:00:00

  • Work-related medical rehabilitation in patients with cancer-Postrehabilitation results from a cluster-randomized multicenter trial.

    abstract:BACKGROUND:Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psych...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1002/cncr.32131

    authors: Fauser D,Wienert J,Beinert T,Schmielau J,Biester I,Krüger HU,Presl A,Bethge M

    更新日期:2019-08-01 00:00:00

  • Combination therapy with transcatheter arterial chemoembolization and percutaneous ethanol injection compared with percutaneous ethanol injection alone for patients with small hepatocellular carcinoma: a randomized control study.

    abstract:BACKGROUND:To assess whether the effectiveness of a combination of transcatheter arterial chemoembolization (TACE) and percutaneous ethanol injection (PEI) is superior to PEI alone in the treatment of patients with small hepatocellular carcinoma (HCC), a randomized controlled study was performed. METHODS:Fifty-two pat...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(20010915)92:6<1516::aid-cncr1477

    authors: Koda M,Murawaki Y,Mitsuda A,Oyama K,Okamoto K,Idobe Y,Suou T,Kawasaki H

    更新日期:2001-09-15 00:00:00

  • Hemoccult screening in selected patients. The hernia patient older than age fifty years.

    abstract::Two hundred and forty patients, asymptomatic relative to gastrointestinal disease, who applied for elective hernia repair, were tested as outpatients for occult blood in the stool. Thirty-eight patients had one or more positive specimens. Significant pathologic characteristics were identified by lower gastrointestinal...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19830401)51:7<1261::aid-cncr2820

    authors: Morris DM,Daron PB,Goldman LI

    更新日期:1983-04-01 00:00:00

  • Mucin-producing carcinoid ("composite tumor") of upper third of esophagus: a variant of carcinoid tumor.

    abstract::An unusual upper esophageal polypoid tumor was found to be predominantly a carcinoid tumor and in part a mucin-producing adenocarcinoma. A review of literature showed this to be a unique tumor in this location. ...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(197911)44:5<1853::aid-cncr282044

    authors: Chong FK,Graham JH,Madoff IM

    更新日期:1979-11-01 00:00:00

  • Understanding the impact of breast reconstruction on the surgical decision-making process for breast cancer.

    abstract:BACKGROUND:Reconstruction is rarely incorporated into the decision-making process for surgical breast cancer treatment. We examined the importance of knowing about reconstruction to patients' surgical decision-making for breast cancer. METHODS:We surveyed women aged < or =79 years with breast cancer (N = 1844) who wer...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23214

    authors: Alderman AK,Hawley ST,Waljee J,Mujahid M,Morrow M,Katz SJ

    更新日期:2008-02-01 00:00:00

  • Mental disorders in cancer patients: a study of 100 psychiatric referrals.

    abstract::Records of 100 consecutive hospitalized cancer patients referred for psychiatric consultation were reviewed. These patients constituted only 5% of those seen by the Psychiatry Consultation Service during the study period. Fifty-six percent of the referred patients were diagnosed as depressed and 40% as having organic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3<1385::aid-cncr282042

    authors: Levine PM,Silberfarb PM,Lipowski ZJ

    更新日期:1978-09-01 00:00:00

  • Carcinoma of the endometrium: I. A clinicopathologic study of clear-cell carcinoma and secretory carcinoma.

    abstract::In a pathologic review of 1224 cases of endometrial carcinoma, 1023 were confirmed cases of endometrial carcinoma. Fifty-six (5.5%) were clear-cell adenocarcinoma (CCE). Fifteen cases of "secretory carcinoma" (SCE) were examined for comparison. Fifty-five patients with CCE and all with SCE were followed for at least f...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19820415)49:8<1511::aid-cncr2820

    authors: Christopherson WM,Alberhasky RC,Connelly PJ

    更新日期:1982-04-15 00:00:00

  • High expression levels of survivin protein independently predict a poor outcome for patients who undergo surgery for clear cell renal cell carcinoma.

    abstract:BACKGROUND:In a previous study of gene array data, the authors identified survivin as a candidate marker of aggressiveness in clear cell renal cell carcinoma (ccRCC). What remained in question was whether survivin expression at the protein level is an independent predictor of disease progression and cancer-specific sur...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21952

    authors: Parker AS,Kosari F,Lohse CM,Houston Thompson R,Kwon ED,Murphy L,Riehle DL,Blute ML,Leibovich BC,Vasmatzis G,Cheville JC

    更新日期:2006-07-01 00:00:00

  • Hyperfractionated radiation therapy and 5-fluorouracil, cisplatin, and mitomycin-C (+/- granulocyte-colony stimulating factor) in the treatment of patients with locally advanced head and neck carcinoma.

    abstract:BACKGROUND:The authors had previously reported preliminary results of a treatment regimen of concurrent hyperfractionated radiation therapy and chemotherapy in patients with locally advanced head and neck carcinoma that demonstrated both feasibility and high local control. In an attempt to reduce acute mucosal and hema...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19970715)80:2<266::aid-cnc

    authors: Abitbol AA,Sridhar KS,Lewin AA,Schwade JG,Raub W Jr,Wolfson A,Gonzalez-Angulo C,Adessa A,Goodwin WJ,Markoe AM

    更新日期:1997-07-15 00:00:00

  • Prostate adenocarcinoma in men younger than 50 years. A retrospective review of 151 patients.

    abstract:BACKGROUND:Prostate adenocarcinoma is predominantly a disease of older men. Males younger than 50 years account for 1% of all patients with prostate cancer. The authors retrospectively examined cases of prostate adenocarcinoma in patients younger than 50 years of age to determine the natural history and prognosis of th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19940915)74:6<1768::aid-cncr2820

    authors: Aprikian AG,Zhang ZF,Fair WR

    更新日期:1994-09-15 00:00:00

  • Testis cancer. Ichthyosis constitutes a significant risk factor.

    abstract::Testis cancer and ichthyosis are both relatively rare diseases. Hence the finding of six individuals with both these conditions in a small population with testicular cancer is highly conspicuous and indicates some kind of connection among such persons. Despite the identical clinical appearances of their ichthyoses, th...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910201)67:3<730::aid-cncr28206

    authors: Lykkesfeldt G,Bennett P,Lykkesfeldt AE,Micic S,Rørth M,Skakkebaek NE,Svenstrup B

    更新日期:1991-02-01 00:00:00

  • Can immunohistochemical markers and mitotic rate improve prognostic precision in patients with primary melanoma?

    abstract:BACKGROUND:In addition to tumor thickness, several other prognostic parameters have been identified in primary human melanomas. Some are available readily (localization, gender, age, and ulceration). Others must be evaluated with a moderate or even substantial amount of work (mitoses and immunohistochemical markers). T...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/(sici)1097-0142(19990601)85:11<2391::aid-c

    authors: Ostmeier H,Fuchs B,Otto F,Mawick R,Lippold A,Krieg V,Suter L

    更新日期:1999-06-01 00:00:00

  • Gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists.

    abstract:BACKGROUND:The current study was conducted to examine gender differences in the effect of grief reactions and burnout on emotional distress among clinical oncologists. METHODS:The participants included a convenience sample of 178 oncologists from Israel (52 of whom were women) and Canada (48 of whom were women). Oncol...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30236

    authors: Granek L,Krzyzanowska MK,Nakash O,Cohen M,Ariad S,Barbera L,Levy R,Ben-David M

    更新日期:2016-12-01 00:00:00

  • Sperm cryopreservation before cancer chemotherapy helps in the emotional battle against cancer.

    abstract:BACKGROUND:Sperm cryopreservation before cancer chemotherapy is available for young patients with cancer. However, few patients bank their sperm. The authors evaluated by questionnaire the psychological impact of sperm cryopreservation. METHODS:The authors cryopreserved the sperm of 111 patients with cancer for free a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21185

    authors: Saito K,Suzuki K,Iwasaki A,Yumura Y,Kubota Y

    更新日期:2005-08-01 00:00:00

  • Cerebral metastases as first symptom of bronchogenic carcinoma. A prospective study of 37 cases.

    abstract::Among the patients showing evidence of cerebral metastases without previously known cancer history, lung cancer has been found 37 times as the primary tumor in our institution. There were 34 men and three women and all but two were heavy smokers. Only one presented at diagnosis with thoracic symptoms but the chest rad...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910601)67:11<2935::aid-cncr282

    authors: Trillet V,Catajar JF,Croisile B,Turjman F,Aimard G,Bourrat C,Bret P,Carrie C,Chassard JL,Chauvin F

    更新日期:1991-06-01 00:00:00

  • Prognostic value of DNA cytometry in 281 premenopausal patients with lymph node negative breast carcinoma randomized in a control trial: multivariate analysis with Ki-67 index, mitotic count, and microvessel density.

    abstract:BACKGROUND:The clinical relevance of DNA image cytometry (ICM) and flow cytometry (FCM) remains under investigation in breast carcinoma. The objective of the current work was to study the prognostic value of DNA ICM and FCM in a series of patients randomized in a control trial. A multivariate analysis has been performe...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1002/1097-0142(20001015)89:8<1748::aid-cncr15>3

    authors: Mandard AM,Denoux Y,Herlin P,Duigou F,van De Vijver MJ,Clahsen PC,van Den Broek L,Sahmoud TM,Henry-Amar M,van De Velde CJ

    更新日期:2000-10-15 00:00:00

  • Meaningful endpoints for therapies approved for hematologic malignancies.

    abstract:BACKGROUND:Overall survival (OS) is considered the gold standard for determining treatment efficacy in oncology trials, but the relation between treatment and OS can be challenging to assess because of long study durations and the impact of subsequent therapies on outcome. Using OS can be particularly difficult for new...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30622

    authors: Smith BD,DeZern AE,Bastian AW,Durie BGM

    更新日期:2017-05-15 00:00:00

  • Transition of Ki-67 index of uterine cervical tumors during radiation therapy. Immunohistochemical study.

    abstract::Histopathologic and Ki-67-staining features of cancer cells were investigated in biopsy specimens before and during radiation therapy in 29 patients with cervical squamous cell carcinoma. No morphologic changes were observed up to doses of 540 cGy. A few intact cancer cells remained up to doses of 2700 cGy. Moderate c...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19910801)68:3<517::aid-cncr28206

    authors: Nakano T,Oka K

    更新日期:1991-08-01 00:00:00

  • Loss of function of p16 gene and prognosis of pulmonary adenocarcinoma.

    abstract:BACKGROUND:Stepwise progression of peripheral-type lung adenocarcinoma was characterized morphologically and was related to prognosis. Expression of the tumor suppressor gene p16 in pulmonary adenocarcinoma decreased, mainly as a result of aberrant methylation of the CpG islands of the promoter region. METHODS:Aberran...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20827

    authors: Tanaka R,Wang D,Morishita Y,Inadome Y,Minami Y,Iijima T,Fukai S,Goya T,Noguchi M

    更新日期:2005-02-01 00:00:00

  • Complementary therapies in palliative cancer care.

    abstract:BACKGROUND:Complementary medicine has become an important aspect of palliative cancer care. This overview is primarily aimed at providing guidance to clinicians regarding some commonly used complementary therapies. METHODS:Several complementary therapies were identified as particularly relevant to palliative cancer ca...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(20010601)91:11<2181::aid-cncr124

    authors: Ernst E

    更新日期:2001-06-01 00:00:00

  • Bowenoid dysplasia of the vulva.

    abstract::The histologic findings of five patients with clinically typical Bowenoid dysplasia (BD) allowed the authors to classify the vulvar and perineal biopsies of 18 patients under 40 years as BD and the vulvar biopsies of six patients under 40 years as squamous cell carcinoma in situ (CIS). The two best criteria for BD are...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19821215)50:12<2910::aid-cncr282

    authors: Ulbright TM,Stehman FB,Roth LM,Ehrlich CE,Ransburg RC

    更新日期:1982-12-15 00:00:00

  • Squamous cell carcinoma antigen in the diagnosis and treatment follow-up of oral and facial squamous cell carcinoma.

    abstract::The squamous cell carcinoma (SCC) antigen was determined by radioimmunoassay in the serum of 40 untreated patients with SCC of the oromaxillofacial region. The mean (+/- SEM) serum concentration for these patients (3.8 +/- 0.8 ng/ml) was significantly higher than that of 52 disease-free patients coming to routine post...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19900315)65:6<1321::aid-cncr2820

    authors: Fischbach W,Meyer T,Barthel K

    更新日期:1990-03-15 00:00:00

  • Utility of prospective pathologic evaluation to inform clinical genetic testing for hereditary leiomyomatosis and renal cell carcinoma.

    abstract:BACKGROUND:Patients with hereditary leiomyomatosis and renal cell carcinoma (HLRCC) resulting from fumarate hydratase (FH) mutations may present with skin, uterine, and renal tumors, with each having unique pathologic features. This study investigated the association between prospectively identified suspicious patholog...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30605

    authors: Kopp RP,Stratton KL,Glogowski E,Schrader KA,Rau-Murthy R,Russo P,Coleman JA,Offit K

    更新日期:2017-07-01 00:00:00

  • Empowerment in adolescents and young adults with cancer: Relationship with health-related quality of life.

    abstract:BACKGROUND:The difficulties adolescents and young adults (AYAs) encounter during a cancer experience may result in a reduction in or absence of empowerment. The aims of the current study were to assess levels of empowerment and associated (demographic, clinical, or psychological) factors and examine the association bet...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.30827

    authors: Kaal SEJ,Husson O,van Duivenboden S,Jansen R,Manten-Horst E,Servaes P,Prins JB,van den Berg SW,van der Graaf WTA

    更新日期:2017-10-15 00:00:00