Work-related medical rehabilitation in patients with cancer-Postrehabilitation results from a cluster-randomized multicenter trial.

Abstract:

BACKGROUND:Effective multidisciplinary rehabilitation programs supporting the return to work have become increasingly relevant for cancer survivors. In Germany, inpatient work-related medical rehabilitation programs consider treatment modules of work-related diagnostics, work-related functional capacity training, psychosocial groups, and intensified social counseling. The authors tested the effectiveness of a work-related medical rehabilitation program compared with conventional medical rehabilitation using a cluster-randomized multicenter trial (German Clinical Trial Register: DRKS00007770). METHODS:In total, 484 patients with cancer were recruited at 4 rehabilitation centers. Patients at a center who started their rehabilitation in the same week represented a cluster. These clusters were randomly assigned using computer-generated randomization schedules either to an intervention group (IG) or to a control group (CG). The primary outcome was role functioning. Secondary outcomes were other quality-of-life domains and the return to work. RESULTS:In total, 425 patients (210 in the IG) were included in the analysis at the 3-month follow-up. There was no significant difference between the IG and CG in role functioning (b = 3.55; 95% CI, -1.18 to 8.29; P = .142). Participants in the IG reported better physical functioning (b = 5.99; 95% CI, 3.33-8.65; P < .001), less physical fatigue (b = -5.09; 95% CI, -9.62 to -0.56; P = .028), and less pain (b = -6.24; 95% CI, -11.24 to -1.23; P = .015). CONCLUSIONS:Work-related medical rehabilitation had no effect on the primary outcome compared with conventional medical rehabilitation but may enhance physical functioning and reduce physical fatigue and pain.

journal_name

Cancer

journal_title

Cancer

authors

Fauser D,Wienert J,Beinert T,Schmielau J,Biester I,Krüger HU,Presl A,Bethge M

doi

10.1002/cncr.32131

subject

Has Abstract

pub_date

2019-08-01 00:00:00

pages

2666-2674

issue

15

eissn

0008-543X

issn

1097-0142

journal_volume

125

pub_type

杂志文章,多中心研究,随机对照试验

相关文献

CANCER文献大全
  • Non-Hodgkin's lymphomas of stage III extent. Is total lymphoid irradiation appropriate treatment?

    abstract::Many investigators have regarded Stage III lymphomas as a generalized form of disease and have accordingly recommended systemic treatment programs. Between 1961 and 1973, 68 patients with clinical or pathologic Stage III non-Hodgkin's lymphomas were seen in the Division of Radiation Therapy at Stanford University Medi...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197606)37:6<2806::aid-cncr282037

    authors: Glatstein E,Fuks Z,Goffinet DR,Kaplan HS

    更新日期:1976-06-01 00:00:00

  • Surgical resection of colorectal carcinoma metastases to the liver. A prognostic scoring system to improve case selection, based on 1568 patients. Association Française de Chirurgie.

    abstract:BACKGROUND:Five-year survival rates after resection of liver metastases from colorectal carcinoma are close to 25%. Recurrences occur in two-thirds of the patients after surgery. Selection of patients likely to benefit from surgery remains controversial and subjective. METHODS:Data from 1568 patients with resected liv...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Nordlinger B,Guiguet M,Vaillant JC,Balladur P,Boudjema K,Bachellier P,Jaeck D

    更新日期:1996-04-01 00:00:00

  • Immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy.

    abstract::Patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of T cells, Fc receptor cells, and in derangements of T lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of develop...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197907)44:1<117::aid-cncr2820440

    authors: Zighelboim J,Dorey F,Parker NH,Calcaterra T,Ward P,Fahey JL

    更新日期:1979-07-01 00:00:00

  • Contemporary prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction: Defining the population at risk for harms of prostate cancer treatment.

    abstract:BACKGROUND:The authors investigated the prevalence of pretreatment urinary, sexual, hormonal, and bowel dysfunction in a contemporary, population-based prostate cancer cohort. They also explored the associations between baseline function and age, comorbidity, and timing of baseline survey completion with respect to tre...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28563

    authors: Resnick MJ,Barocas DA,Morgans AK,Phillips SE,Chen VW,Cooperberg MR,Goodman M,Greenfield S,Hamilton AS,Hoffman KE,Kaplan SH,Paddock LE,Stroup AM,Wu XC,Koyama T,Penson DF

    更新日期:2014-04-15 00:00:00

  • Prognostic value of the plasminogen activation system in patients with gastric carcinoma.

    abstract:BACKGROUND:Patients with gastric cancer have a poor prognosis and can be cured by surgery only if the cancer is detected in an early stage. Extended surgery, down staging with chemotherapy before operation, and new postoperative treatments are recent approaches to increase survival rates. Categorizing patients' prognos...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/(sici)1097-0142(19960315)77:6<1035::aid-cn

    authors: Ganesh S,Sier CF,Heerding MM,van Krieken JH,Griffioen G,Welvaart K,van de Velde CJ,Verheijen JH,Lamers CB,Verspaget HW

    更新日期:1996-03-15 00:00:00

  • Three-dimensional conformal radiotherapy for portal vein thrombosis of hepatocellular carcinoma.

    abstract:BACKGROUND:Portal vein thrombosis (PVT) is a common complication in patients with advanced-stage hepatocellular carcinoma (HCC). The authors evaluated the impact of radiotherapy (RT) for PVT of HCC and analyzed the dose-response relation between RT and PVT. METHODS:Between March 1995 and December 2003, 59 patients dia...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21043

    authors: Kim DY,Park W,Lim DH,Lee JH,Yoo BC,Paik SW,Kho KC,Kim TH,Ahn YC,Huh SJ

    更新日期:2005-06-01 00:00:00

  • A multicenter study of the prognosis and treatment of adult brain ependymal tumors.

    abstract:BACKGROUND:The current analysis of outcomes in a large series of adult patients with intracranial ependymal tumors contributes to the characterization of the primary prognostic factors and to the therapeutic management of this rare disease, for which limited information is available in the literature. METHODS:The auth...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.20074

    authors: Reni M,Brandes AA,Vavassori V,Cavallo G,Casagrande F,Vastola F,Magli A,Franzin A,Basso U,Villa E

    更新日期:2004-03-15 00:00:00

  • Serum immunoglobulin levels in patients with breast cancer.

    abstract::Serum immunoglobulin levels IgA, IgG, and IgM have been estimated in 92 patients with breast cancer and 50 control patients, 40 of whom had benign disease of the breast. In patients with breast cancer, IgA was significantly raised at all stages and IgG was significantly reduced, but the two abnormalities were not nece...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197507)36:1<221::aid-cncr2820360

    authors: Roberts MM,Bathgate EM,Stevenson A

    更新日期:1975-07-01 00:00:00

  • A multivariate analysis of the survival of patients with aggressive lymphoma: variations in the predictive value of prognostic factors during the course of the disease. Groupe d'Etudes des Lymphomes de l'Adulte.

    abstract:BACKGROUND:Aggressive non-Hodgkin's lymphoma is now often curable with chemotherapy. The International Prognostic Index (IPI) was recently developed to predict patient survival on the basis of pretreatment clinical features. However, classical multivariate regression models such as the IPI fail to detect time-dependent...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:

    authors: Mounier N,Morel P,Haioun C,Coiffier B,Tilly H,Chatelain C,Lederlin P,Thyss A,Herbrecht R,Gisselbrecht C,Lepage E

    更新日期:1998-05-15 00:00:00

  • French registry of acute leukemia and myelodysplastic syndromes. Age distribution and hemogram analysis of the 4496 cases recorded during 1982-1983 and classified according to FAB criteria. Groupe Francais de Morphologie Hematologique.

    abstract::During 1982 and 1983, 4496 new cases were recorded in the French Registry of acute leukemia and myelodysplastic syndromes by the French Group of Hematologic Morphology. This cooperative group associated members of 37 university centers spread throughout France; these centers handle the overwhelming majority of acute l...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors:

    更新日期:1987-09-15 00:00:00

  • Prostate cancer risk in the Swedish AMORIS study: the interplay among triglycerides, total cholesterol, and glucose.

    abstract:BACKGROUND:In a cohort including 5112 prostate cancer (pCa) patients, the authors investigated associations among triglycerides (TG), total cholesterol (TC), and pCa while taking into account glucose. METHODS:A cohort (n = 200,660) based on 4 groups of men, according to age at cohort entry, with TG, TC, and glucose me...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.25758

    authors: Van Hemelrijck M,Garmo H,Holmberg L,Walldius G,Jungner I,Hammar N,Lambe M

    更新日期:2011-05-15 00:00:00

  • Development of a chemoresistant orthotopic human nonsmall cell lung carcinoma model in nude mice: analyses of tumor heterogenity in relation to the immunohistochemical levels of expression of cyclooxygenase-2, ornithine decarboxylase, lung-related resista

    abstract:BACKGROUND:Nonsmall cell lung carcinomas (NSCLCs) are associated with very dismal prognoses, and adjuvant chemotherapy, including irinotecan, taxanes, platin, and vinca alkaloid derivatives, offer patients only slight clinical benefits. Part of the chemoresistance of NSCLC results from the expression in NSCLC cells of ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20571

    authors: Mathieu A,Remmelink M,D'Haene N,Penant S,Gaussin JF,Van Ginckel R,Darro F,Kiss R,Salmon I

    更新日期:2004-10-15 00:00:00

  • Influence of nandrolone decanoate on weight loss in advanced non-small cell lung cancer.

    abstract::The short term addition of nandrolone decanoate to combination chemotherapy given to patients with unresectable non-small cell lung cancer was evaluated in a randomized, prospective trial. Patients were treated with doxorubicin 50 mg/M2 intravenously, cyclophosphamide 300 mg/M2 intravenously, CCNU 50 mg/M2 orally, vin...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1002/1097-0142(19860701)58:1<183::aid-cncr28205

    authors: Chlebowski RT,Herrold J,Ali I,Oktay E,Chlebowski JS,Ponce AT,Heber D,Block JB

    更新日期:1986-07-01 00:00:00

  • Short telomere lengths in peripheral blood leukocytes are associated with an increased risk of oral premalignant lesion and oral squamous cell carcinoma.

    abstract:BACKGROUND:Oral premalignant lesions (OPLs) are precursors of oral squamous cell carcinoma (OSCC). Short telomeres in peripheral blood leukocytes (PBLs) are associated with increased risks of several cancers. However, it is unclear whether short leukocyte telomere length (LTL) predisposes individuals to OPL and OSCC. ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.28367

    authors: Bau DT,Lippman SM,Xu E,Gong Y,Lee JJ,Wu X,Gu J

    更新日期:2013-12-15 00:00:00

  • A phase II study of paclitaxel-ifosfamide-cisplatin combination in advanced nonsmall cell lung carcinoma.

    abstract:BACKGROUND:The necessity to develop more effective chemotherapy regimens in advanced nonsmall cell lung carcinoma (NSCLC) prompted the authors to evaluate the paclitaxel-ifosfamide-cisplatin (PIC) combination, developed on the basis of high individual single-agent activity, in vitro synergism, and tolerance as determin...

    journal_title:Cancer

    pub_type: 临床试验,杂志文章

    doi:10.1002/1097-0142(20000815)89:4<774::aid-cncr9>3.0

    authors: Kosmas C,Tsavaris NB,Polyzos A,Kalofonos HP,Sepsas E,Malamos NA,Vadiaka M,Dosios T,Antonopoulos MJ

    更新日期:2000-08-15 00:00:00

  • Ovarian cancer: incidence and case-control study.

    abstract::The incidence of ovarian cancer in Rochester, Minnesota over the 40-year period 1935 through 1974 was determined; and risk factors for epithelial ovarian cancer occurring in Rochester from 1945 to 1974 were examined in 116 patients and 464 controls. Among the characteristics studied, only nulliparity was found to be a...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197902)43:2<723::aid-cncr2820430

    authors: Annegers JF,Strom H,Decker DG,Dockerty MB,O'Fallon WM

    更新日期:1979-02-01 00:00:00

  • Angioimmunoblastic lymphadenopathy. Review of 44 patients with emphasis on prognostic behavior.

    abstract::In order to investigate the relationship between histologic findings and clinical behavior in angioimmunoblastic lymphadenopathy (AILD), 44 patients with AILD were reviewed. These patients comprised 24 men and 20 women with age range from 25 to 84 years of age (median, 64 years). Lymphadenopathy was observed in all pa...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19890415)63:8<1625::aid-cncr2820

    authors: Aozasa K,Ohsawa M,Fujita MQ,Kanayama Y,Tominaga N,Yonezawa T,Matsubuchi T,Hirata M,Uda H,Kanamaru A

    更新日期:1989-04-15 00:00:00

  • Quality of life and survival prediction in terminal cancer patients: a multicenter study.

    abstract:BACKGROUND:It remains unclear whether health-related quality of life (HRQoL) measurements from patients and staff can be combined with medical data to predict survival in patients with terminal cancer. METHODS:The correlations between survival and potential health-related quality-of-life (HRQoL) prognostic variables w...

    journal_title:Cancer

    pub_type: 杂志文章,多中心研究

    doi:10.1002/cncr.20472

    authors: Vigano A,Donaldson N,Higginson IJ,Bruera E,Mahmud S,Suarez-Almazor M

    更新日期:2004-09-01 00:00:00

  • Atypical fibroxanthoma of the skin with metastasis.

    abstract::Cutaneous atypical fibroxanthoma (AFX) occurs in elderly persons as a small nodule or ulcernodule in actinically damaged skin of the head and neck area. The vast majority of AFX behave in a benign manner, and metastasis is rare. Eight examples of metastasizing AFX are reported. Factors that portend aggressive behavior...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19860115)57:2<368::aid-cncr28205

    authors: Helwig EB,May D

    更新日期:1986-01-15 00:00:00

  • Predictors of radiation response in lung cancer. A clinico-pathobiological analysis.

    abstract::From February 1972 to July 1975, 200 lung cancer patients were seen at the University of Rochester Cancer Center's Division of Radiation Oncology; 40% had squamous cell tumors and 87.5% had advanced disease localized to the thorax. Of the 160 patients who completed treatment, 101 were treated with continuous therapy s...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197606)37:6<2636::aid-cncr282037

    authors: Salazar OM,Rubin P,Brown JC,Feldstein ML,Keller BE

    更新日期:1976-06-01 00:00:00

  • Oral testing for high-risk human papillomavirus DNA and E6/E7 messenger RNA in healthy individuals at risk for oral infection.

    abstract:BACKGROUND:Testing for oral high-risk human papillomavirus (HPV) DNA may be useful for identifying individuals at increased risk for HPV-driven oropharyngeal cancer (OPC). However, positivity for HPV DNA provides no information on the transforming potential of the infection. In contrast, the detection of high-risk HPV ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.32152

    authors: Rollo F,Pichi B,Benevolo M,Giuliani M,Latini A,Lorenzon L,Colafigli M,Frasca M,Pellini R,Cristaudo A,Donà MG

    更新日期:2019-08-01 00:00:00

  • Risk factors associated with earlier age of onset in familial pancreatic carcinoma.

    abstract:BACKGROUND:An estimated 5-10% of all pancreatic adenocarcinomas have a hereditary association. The objective of the current study was to characterize the clinical and pathologic features of familial pancreatic carcinoma and to determine potential differences in demographics, risk factors, and outcomes between familial ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.20700

    authors: James TA,Sheldon DG,Rajput A,Kuvshinoff BW,Javle MM,Nava HR,Smith JL,Gibbs JF

    更新日期:2004-12-15 00:00:00

  • Clonal divergence and genetic heterogeneity in clear cell renal cell carcinomas with sarcomatoid transformation.

    abstract:BACKGROUND:Approximately 5% of clear cell renal cell carcinomas contain components with sarcomatoid differentiation. It has been suggested that the sarcomatoid elements arise from the clear cell tumors as a consequence of clonal expansions of neoplastic cells with progressively more genetic alterations. Analysis of the...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.21288

    authors: Jones TD,Eble JN,Wang M,Maclennan GT,Jain S,Cheng L

    更新日期:2005-09-15 00:00:00

  • Acute megakaryoblastic leukemia in childhood.

    abstract::Routine morphologic and cytochemical study of the leukemic cells of a 13-month-old child did not permit definitive determination of either a lymphoid or a myeloid cell origin. However, ultrastructural cytochemical analysis revealed platelet peroxidase (PPO) reactivity. The malignant cells expressed PPO in both unfixed...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19841001)54:7<1423::aid-cncr2820

    authors: Sariban E,Oliver C,Corash L,Cossman J,Whang-Peng J,Jaffe ES,Gralnick HR,Poplack DG

    更新日期:1984-10-01 00:00:00

  • Saporin toxins directed to basic fibroblast growth factor receptors effectively target human ovarian teratocarcinoma in an animal model.

    abstract:BACKGROUND:The antitumor activity of the chemical conjugate and recombinant forms of the mitotoxin basic fibroblast growth factor (bFGF) saporin (SAP) and the bFGF receptor-directed immunotoxin 11A8-SAP against human ovarian teratocarcinoma PA-1 was examined in athymic nude mice. Alternative administration schedules to...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(19950701)76:1<79::aid-cncr282076

    authors: Davol P,Beitz JG,Mohler M,Ying W,Cook J,Lappi DA,Frackelton AR Jr

    更新日期:1995-07-01 00:00:00

  • Mental disorders in cancer patients: a study of 100 psychiatric referrals.

    abstract::Records of 100 consecutive hospitalized cancer patients referred for psychiatric consultation were reviewed. These patients constituted only 5% of those seen by the Psychiatry Consultation Service during the study period. Fifty-six percent of the referred patients were diagnosed as depressed and 40% as having organic ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/1097-0142(197809)42:3<1385::aid-cncr282042

    authors: Levine PM,Silberfarb PM,Lipowski ZJ

    更新日期:1978-09-01 00:00:00

  • Quality-of-life outcomes for men with prostate carcinoma detected by screening.

    abstract:BACKGROUND:There is limited information on outcomes of prostate carcinoma treatments given to screened patient populations for whom cancer is usually detected at an earlier stage. METHODS:The authors conducted a cross-sectional evaluation of quality-of-life outcomes for men with prostate carcinoma detected in screenin...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:

    authors: Smith DS,Carvalhal GF,Schneider K,Krygiel J,Yan Y,Catalona WJ

    更新日期:2000-03-15 00:00:00

  • Treatment with bevacizumab and irinotecan for recurrent high-grade glial tumors.

    abstract:BACKGROUND:Response rates to second-line chemotherapy in recurrent high-grade glial tumors are low and new effective treatments are needed. The objective of this study was to evaluate response rates and tolerability of chemotherapy with bevacizumab and irinotecan in recurrent high-grade gliomas. METHODS:Twenty patient...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.23401

    authors: Bokstein F,Shpigel S,Blumenthal DT

    更新日期:2008-05-15 00:00:00

  • A survival-stratification model of human colorectal carcinomas with beta-catenin and p27kip1.

    abstract:BACKGROUND:The stabilization and nuclear translocation of beta-catenin are early events in the majority of sporadic colorectal carcinomas (CRC). beta-catenin up-regulates c-Myc and cyclin D1, which antagonize the association of the cyclin-dependent kinase (Cdk) inhibitor, p27(kip1), with Cdk2, thus allowing cell cycle ...

    journal_title:Cancer

    pub_type: 杂志文章

    doi:10.1002/cncr.10986

    authors: Cheah PY,Choo PH,Yao J,Eu KW,Seow-Choen F

    更新日期:2002-12-15 00:00:00

  • The Save our Sisters Project. A social network strategy for reaching rural black women.

    abstract::Why are older black women screened less for breast cancer? What can be done to narrow the racial gap in mammography screening? These are the questions addressed by the Save Our Sisters (SOS) Project, a pilot demonstration study funded by the National Cancer Institute in a rural county of North Carolina. The target pop...

    journal_title:Cancer

    pub_type: 杂志文章,评审

    doi:10.1002/1097-0142(19930801)72:3+<1071::aid-cncr282

    authors: Eng E

    更新日期:1993-08-01 00:00:00