Predictors of radiation response in lung cancer. A clinico-pathobiological analysis.

abstract：BACKGROUND:A single-institution, prospective, randomized open trial was performed to compare ondansetron and granisetron in the prevention of chemotherapy-related nausea and vomiting. The effect of antemetic drugs was analyzed indipendently for patients treated with highly emetogenic chemotherapy (Study 1), and those t...

journal_title：Cancer

authors： Gebbia V,Cannata G,Testa A,Curto G,Valenza R,Cipolla C,Latteri MA,Gebbia N

更新日期：1994-10-01 00:00:00

abstract：:Rational treatment of pediatric malignancies requires a detailed knowledge of the clinical pharmacology of those antineoplastic agents used therapeutically. A number of different agents are administered by the oral route. Recently, the clinical pharmacology of 6-mercaptopurine (6-MP) and methotrexate (MTX), the two ag...

journal_title：Cancer

authors： Poplack DG,Balis FM,Zimm S

更新日期：1986-07-15 00:00:00

abstract：:The findings at autopsy of 79 patients with esophageal carcinoma over a period of 15 years were reviewed. Five patients were free of tumor, and another seven had disease localized to the esophagus and other mediastinal structures. Sixty-seven (85%) had metastatic disease. The average number of metastatic sites per pat...

journal_title：Cancer

authors： Anderson LL,Lad TE

更新日期：1982-10-15 00:00:00

abstract：BACKGROUND:A feasibility study examining the effects of supervised aerobic exercise training on cardiopulmonary and quality of life (QOL) endpoints among postsurgical nonsmall cell lung cancer (NSCLC) patients was conducted. METHODS:Using a single-group design, 20 patients with stage I-IIIB NSCLC performed 3 aerobic c...

journal_title：Cancer

authors： Jones LW,Eves ND,Peterson BL,Garst J,Crawford J,West MJ,Mabe S,Harpole D,Kraus WE,Douglas PS

更新日期：2008-12-15 00:00:00

abstract：:The statistical analysis documented in this article was performed to determine the accuracy of mammography in diagnosing a palpable cancer of the breast. All of the women studied underwent mammography after the discovery of the cancer, which was proven by biopsy; the cancer did not involve the skin. All mammograms tha...

journal_title：Cancer

authors： Edeiken S

更新日期：1988-01-15 00:00:00

abstract：:Fiberoptic endoscopic examination and biopsy of the nasopharynx was done in 130 patients as a prospective study. They all had elevated titers of antibodies against the viral capsid antigen of Epstein-Barr virus but no symptoms or signs of nasopharyngeal carcinoma. Each underwent a biopsy from six fixed sites in the na...

journal_title：Cancer

authors： Wei WI,Sham JS,Zong YS,Choy D,Ng MH

更新日期：1991-06-15 00:00:00

abstract：:There is now considerable interest in gastrointestinal stromal tumor (GIST) because it can be treated effectively with a targeted molecular agent. The majority of GISTs contain an activating mutation in the KIT protooncogene or, occasionally, in the platelet-derived growth factor-alpha (PDGFRA) gene. Five years ago, i...

journal_title：Cancer

authors： van der Zwan SM,DeMatteo RP

更新日期：2005-11-01 00:00:00

abstract：:Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell-mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was...

journal_title：Cancer

authors： Fuith LC,Fuchs D,Hausen A,Hetzel H,Reibnegger G,Werner ER,Wachter H

更新日期：1990-03-01 00:00:00

abstract：BACKGROUND:This study was conducted to determine the efficacy and safety of irinotecan (CPT-11) as second-line therapy in patients with advanced cervical carcinoma. METHODS:Sixteen patients with platinum-resistant squamous cell carcinoma were treated with CPT-11 as second-line therapy. CPT-11 was administered in repea...

journal_title：Cancer

authors： Irvin WP,Price FV,Bailey H,Gelder M,Rosenbluth R,Durivage HJ,Potkul RK

更新日期：1998-01-15 00:00:00

abstract：:Of 55 patients with Ollier's disease seen at the Mayo Clinic between 1907 and 1985, 16 had malignant bone neoplasms: 12 chondrosarcomas, two dedifferentiated chondrosarcomas, one chordoma, and one osteosarcoma. One patient had a chondrosarcoma in two different bones. These findings suggest that approximately 30% of pa...

journal_title：Cancer

authors： Liu J,Hudkins PG,Swee RG,Unni KK

更新日期：1987-04-01 00:00:00

abstract：BACKGROUND:Amplification of the N-myc oncogene is associated with adverse outcomes in the common childhood tumor, neuroblastoma. Because the transforming properties of Myc are related to its ability to modulate gene expression, the authors used cDNA microarrays to identify potential Myc target genes. METHODS:Expressio...

journal_title：Cancer

authors： Raetz EA,Kim MK,Moos P,Carlson M,Bruggers C,Hooper DK,Foot L,Liu T,Seeger R,Carroll WL

更新日期：2003-08-15 00:00:00

abstract：:Twenty-four women with ovarian carcinoma that had metastasized to the liver were treated with intrahepatic infusional therapy. No consistent drug regimen was used. There were no complete responders; however, 33% had a partial response. All responses were noticed after the first course of therapy. The median length of ...

journal_title：Cancer

authors： Malone JM Jr,Gershenson DM,Carrasco CH,Charansangavej C,Copeland LJ,Larson DM,Kavanagh JJ,Edwards CL,Wallace S

更新日期：1987-06-01 00:00:00

abstract：:Autopsy slides from 22 melanoma patients who received bacille Calmette-Guérin BCG immunotherapy and who had a postmortem examination at the UCLA Center for the Health Sciences were examined for the presence of granulomas. Granulomas were found in six patients (29%) who received BCG but not in a group of 25 melanoma pa...

journal_title：Cancer

authors： Hatzitheofilou C,Obenchain DF,Porter DD,Morton DL

更新日期：1982-01-01 00:00:00

abstract：:Earlier literature suggests a high incidence of multicentricity and bilaterality, with an overall poor prognosis, in patients with invasive lobular carcinoma of the breast. Consequently, there is considerable disagreement regarding appropriate local management of this disease. To determine the influence of invasive lo...

journal_title：Cancer

authors： Poen JC,Tran L,Juillard G,Selch MT,Giuliano A,Silverstein M,Fingerhut A,Lewinsky B,Parker RG

更新日期：1992-06-01 00:00:00

abstract：BACKGROUND:The objective of this study was to evaluate changes in clinical and pathologic characteristics of prostate cancer in patients who underwent surgery at a large tertiary care center in the context of increased use of active surveillance (AS) and minimally invasive surgery (MIS). METHODS:The authors retrospect...

journal_title：Cancer

authors： Silberstein JL,Vickers AJ,Power NE,Fine SW,Scardino PT,Eastham JA,Laudone VP

更新日期：2011-11-01 00:00:00

abstract：:Head and neck cancer (H&N CA) patients have known depression of cell-mediated immunity. There is suggestive evidence that prostaglandin (PGE2)-secreting cells may be a major factor. The authors have sought to determine the role of PGE2-releasing monocytes-macrophages in this immune depression by determining the effect...

journal_title：Cancer

authors： Wanebo HJ,Riley T,Katz D,Pace RC,Johns ME,Cantrell RW

更新日期：1988-02-01 00:00:00

abstract：BACKGROUND:Cervical carcinoma remains a significant health risk for the older woman. In the current study the yield of screening of mature women in an established, opportunistic screening program was examined. Strategies for improving screening in this age group were identified through examination of recent Pap test hi...

journal_title：Cancer

authors： Colgan TJ,Clarke A,Hakh N,Seidenfeld A

更新日期：2002-08-25 00:00:00

abstract：BACKGROUND:Greater than one-half of children who are treated for acute lymphoblastic leukemia (ALL) develop ≥1 treatment-related medical conditions in their lifetime, many of which are known risk factors for diabetes mellitus. In the current study, the authors evaluated the prevalence and risk factors of diabetes melli...

journal_title：Cancer

authors： Williams HE,Howell CR,Chemaitilly W,Wilson CL,Karol SE,Nolan VG,Smeltzer MP,Green DM,Ehrhardt MJ,Mulrooney DA,Pui CH,Hudson MM,Robison LL,Ness KK

更新日期：2020-02-15 00:00:00

abstract：BACKGROUND:The current study was performed to describe frequencies and risk factors of altered oral health and odontogenesis in childhood cancer survivors. METHODS:In total, 9308 survivors who were diagnosed between 1970 and 1986 and 2951 siblings from the Childhood Cancer Survivor Study completed a survey that contai...

journal_title：Cancer

authors： Kaste SC,Goodman P,Leisenring W,Stovall M,Hayashi RJ,Yeazel M,Beiraghi S,Hudson MM,Sklar CA,Robison LL,Baker KS

更新日期：2009-12-15 00:00:00

abstract：:Two cases of primary non-Hodgkin's lymphomas of the breast were studied with light and electron microscopy. By light microscopy, according to Rappaport's classification, one was a poorly differentiated lymphocytic lymphoma, the other a diffuse histiocytic lymphoma. However, the ultrastructural features of the latter w...

journal_title：Cancer

authors： Navas JJ,Battifora H

更新日期：1977-05-01 00:00:00

abstract：:Radiation therapy alone, surgery alone, or the combination of these two modalities, remain the accepted treatments in the management of epidermoid carcinomas of the mucosa of the head and neck. These modalities of therapy produce comparable results; but, radiotherapy alone has the advantage that it can conserve anatom...

journal_title：Cancer

authors： Marcial VA,Pajak TF

更新日期：1985-05-01 00:00:00

abstract：BACKGROUND:Clinical trials of monoclonal antibodies in combination with chemotherapy have reported previously unattained response rates in patients with B-cell chronic lymphocytic leukemia (B-CLL); however, the analysis of ZAP-70 protein and/or CD38 may explain better the discordant outcomes independent of treatment. ...

journal_title：Cancer

authors： Del Poeta G,Del Principe MI,Consalvo MA,Maurillo L,Buccisano F,Venditti A,Mazzone C,Bruno A,Gianní L,Capelli G,Lo Coco F,Cantonetti M,Gattei V,Amadori S

更新日期：2005-12-15 00:00:00

abstract：:Four cases of childhood hepatic angiosarcoma (HAS), representing the malignant form of infantile hemangioendothelioma, are described. The morphologic appearance of childhood HAS differs from the adult form in the following features: the associated presence of benign infantile hemangioendothelioma; the presence of dyso...

journal_title：Cancer

authors： Falk H,Herbert JT,Edmonds L,Heath CW Jr,Thomas LB,Popper H

更新日期：1981-01-15 00:00:00

abstract：BACKGROUND:Cyclins, cyclin dependent kinases (cdks), and their inhibitors act in combination to regulate progression through the cell cycle and often are dysregulated in carcinoma. The authors hypothesized that cyclin E plays an important role in ovarian carcinogenesis and that its overexpression may be an indicator of...

journal_title：Cancer

authors： Rosen DG,Yang G,Deavers MT,Malpica A,Kavanagh JJ,Mills GB,Liu J

更新日期：2006-05-01 00:00:00

abstract：:The case history of a woman with a "female adnexal tumor of probable Wolffian origin" is described in which the neoplasm recurred three times during a 16-year interval and responded with prolonged remission after repeated surgical excision and radiotherapy. Ultrastructural data are given to support the Wolffian nature...

journal_title：Cancer

authors： Brescia RJ,Cardoso de Almeida PC,Fuller AF Jr,Dickersin GR,Robboy SJ

更新日期：1985-09-15 00:00:00

abstract：:Extremely high concentrations of human chorionic gonadotropin in the cerebrospinal fluid were found in a 5-year-old boy presenting sexual precocity and leg pain. An intramedullary spinal cord tumor was revealed by myelogram and metrizamide computerized tomography, and a biopsy specimen taken at laminectomy. Histologic...

journal_title：Cancer

authors： Hisa S,Morinaga S,Kobayashi Y,Ojima M,Chikaoka H,Sasano N

更新日期：1985-06-15 00:00:00

abstract：:Twenty-two patients who previously responded to first-line hormonal therapy were evaluated for factors which would predict for response to second hormonal manipulation. Investigations performed at progression after initial hormone response included immunocytochemical estimation of estrogen and progesterone receptors a...

journal_title：Cancer

authors： Seymour L,Bezwoda WR,Meyer K

更新日期：1990-06-15 00:00:00

abstract：:Pain management often is difficult in patients with bone metastases. Metastatic disease represents >40% of oncologic practice, and >70% of patients with metastatic disease have uncontrolled cancer-related pain. Significant morbidity caused by pathologic fracture and spinal cord compression can result from untreated bo...

journal_title：Cancer

authors： Janjan NA

更新日期：1997-10-15 00:00:00

abstract：BACKGROUND:Pelvic irradiation to patients with prostate cancer is accompanied by urinary and intestinal reactions. In men older than 60 years, treatment-induced problems should be evaluated in relation to problems in an age-matched nonirradiated population. METHODS:In the present study, problems in the urinary tract a...

journal_title：Cancer

authors： Widmark A,Fransson P,Tavelin B

更新日期：1994-11-01 00:00:00

abstract：BACKGROUND:Gemcitabine-associated thrombotic microangiopathy (TMA) is believed to be very rare, with an estimated incidence rate of 0.015%. Indications for gemcitabine are expanding, and comprehensive characterization of this complication is therefore important. METHODS:The authors performed a retrospective chart revi...

journal_title：Cancer

authors： Humphreys BD,Sharman JP,Henderson JM,Clark JW,Marks PW,Rennke HG,Zhu AX,Magee CC

更新日期：2004-06-15 00:00:00