Abstract:
:Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell-mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was significantly higher (P less than 0.0001) than that obtained in women with benign myomas and healthy controls. Furthermore, a significant correlation of normal or raised neopterin concentrations with the clinical course of disease was found. These data suggest that urinary neopterin measurement might be a useful immunologic marker for women with uterine sarcomas.
journal_name
Cancerjournal_title
Cancerauthors
Fuith LC,Fuchs D,Hausen A,Hetzel H,Reibnegger G,Werner ER,Wachter Hdoi
10.1002/1097-0142(19900301)65:5<1228::aid-cncr2820subject
Has Abstractpub_date
1990-03-01 00:00:00pages
1228-31issue
5eissn
0008-543Xissn
1097-0142journal_volume
65pub_type
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