Urinary neopterin excretion in patients with uterine sarcomas.

Abstract:

:Neopterin, a pyrazinopyrimidine compound, is a marker of activation of cell-mediated immunity. Urinary neopterin concentrations were measured in a total of 44 patients with uterine sarcomas. Pretherapeutic neopterin excretions were elevated in 78% (14/18). The mean neopterin concentration of patients with sarcomas was significantly higher (P less than 0.0001) than that obtained in women with benign myomas and healthy controls. Furthermore, a significant correlation of normal or raised neopterin concentrations with the clinical course of disease was found. These data suggest that urinary neopterin measurement might be a useful immunologic marker for women with uterine sarcomas.

journal_name

Cancer

journal_title

Cancer

authors

Fuith LC,Fuchs D,Hausen A,Hetzel H,Reibnegger G,Werner ER,Wachter H

doi

10.1002/1097-0142(19900301)65:5<1228::aid-cncr2820

subject

Has Abstract

pub_date

1990-03-01 00:00:00

pages

1228-31

issue

5

eissn

0008-543X

issn

1097-0142

journal_volume

65

pub_type

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