Positron emission tomography of patients with head and neck carcinoma before and after high dose irradiation.

abstract：BACKGROUND:RAS/RAF/mitogen-activated protein kinase activation is common in myeloid malignancies. Trametinib, a mitogen-activated protein kinase kinase 1 (MEK1)/MEK2 inhibitor with activity against multiple myeloid cell lines at low nanomolar concentrations, was evaluated for safety and clinical activity in patients wi...

journal_title：Cancer

authors： Borthakur G,Popplewell L,Boyiadzis M,Foran J,Platzbecker U,Vey N,Walter RB,Olin R,Raza A,Giagounidis A,Al-Kali A,Jabbour E,Kadia T,Garcia-Manero G,Bauman JW,Wu Y,Liu Y,Schramek D,Cox DS,Wissel P,Kantarjian H

更新日期：2016-06-15 00:00:00

abstract：BACKGROUND:Molecular genetic studies of ovarian cancer have been limited by the inaccessible location of the ovary, the advanced stage of tumors available for analysis, and the lack of a well-defined precursor lesion. However, genetic alterations important in ovarian tumorigenesis have been identified recently. METHOD...

journal_title：Cancer

authors： Gallion HH,Pieretti M,DePriest PD,van Nagell JR Jr

更新日期：1995-11-15 00:00:00

abstract：BACKGROUND:In this prospective study, the authors evaluated potential treatment toxicity and progression-free survival in patients with low-grade glioma who received treatment with proton radiation therapy. METHODS:Twenty patients with World Health Organization grade 2 glioma who were eligible for radiation therapy we...

journal_title：Cancer

authors： Shih HA,Sherman JC,Nachtigall LB,Colvin MK,Fullerton BC,Daartz J,Winrich BK,Batchelor TT,Thornton LT,Mancuso SM,Saums MK,Oh KS,Curry WT,Loeffler JS,Yeap BY

更新日期：2015-05-15 00:00:00

abstract：:Sixty-four evaluable patients with hepatic metastases from colorectal carcinoma, who did not have evidence of extrahepatic disease, were treated with intrahepatic (IH) mitomycin C (M) after disease progression or intolerance to treatment with IH fluorodeoxyuridine (FUDR). Eleven patients (17%) had a partial response (...

journal_title：Cancer

authors： Schneider A,Kemeny N,Chapman D,Niedzwiecki D,Oderman P

更新日期：1989-12-01 00:00:00

abstract：:Research trends on quality of life outcomes for cancer survivors are discussed. Epidemiologic data indicate that female cancer survivors, coming primarily from patient groups with gynecologic, breast, and colorectal cancers, will outnumber male survivors 3 to 1. Male survivors will come from the ranks of patient group...

journal_title：Cancer

authors： Andersen BL

更新日期：1994-08-15 00:00:00

abstract：:A case is reported of a patient with pancreatic carcinoma who developed pancreatic ascites after intraoperative fine-needle aspiration cytology (FNAC) biopsy. This complication of FNAC has not previously been reported to the authors' knowledge. The literature is reviewed, and FNAC is shown to be the safest method of p...

journal_title：Cancer

authors： Rosenbaum DA,Frost DB

更新日期：1990-06-01 00:00:00

abstract：BACKGROUND:It is important for clinicians, researchers, and others who shape public health policy to understand the demographic correlates and psychologic factors that drive health behaviors, such as screening for early detection of cancer, particularly among individuals at high risk for developing the disease. METHOD...

journal_title：Cancer

authors： Beebe-Dimmer JL,Wood DP Jr,Gruber SB,Chilson DM,Zuhlke KA,Claeys GB,Cooney KA

更新日期：2004-04-01 00:00:00

abstract：:Nickel-related cancers of the respiratory tract have been recognized for nearly 50 years and represent a unique opportunity for prevention among refinery workers. Studies of exposed employees have been conducted in which evaluations were made of the histopathologic changes in the respiratory mucosa and the body burden...

journal_title：Cancer

authors： Barton RT,Hogetveit AC

更新日期：1980-06-15 00:00:00

abstract：BACKGROUND:Crizotinib is a tyrosine kinase inhibitor active against ALK, MET, and ROS1. We previously reported that crizotinib decreases testosterone in male patients. The detailed etiology of the effect, its symptomatic significance, and the effectiveness of subsequent testosterone replacement have not been previously...

journal_title：Cancer

authors： Weickhardt AJ,Doebele RC,Purcell WT,Bunn PA,Oton AB,Rothman MS,Wierman ME,Mok T,Popat S,Bauman J,Nieva J,Novello S,Ou SH,Camidge DR

更新日期：2013-07-01 00:00:00

abstract：BACKGROUND:There are large geographic gradients in mortality rates for a number of cancers in the U.S. (e.g., rates are approximately twice as high in the northeast compared with the southwest). Risk factors such as diet fail to explain this variation. Previous studies have demonstrated that the geographic distribution...

journal_title：Cancer

authors： Grant WB

更新日期：2002-03-15 00:00:00

abstract：:Trabecular carcinoma of the skin (Merkel cell tumor), a neoplasm of putative neural origin, must be differentiated from other small cell tumors primary or metastatic to skin. In order to provide more objective diagnostic criteria, four were examined using monoclonal antibodies against neurofilament proteins (NF) and a...

journal_title：Cancer

authors： Leff EL,Brooks JS,Trojanowski JQ

更新日期：1985-08-01 00:00:00

abstract：:As the toll taken by breast cancer continues unabated, screening programs are widely perceived to play a critical role to improve diagnosis and successful treatment. Breast cancer screening programs are increasingly promoted to women; however, the economic implications of mass screening is a subject of much health pol...

journal_title：Cancer

authors： Mushlin AI,Fintor L

更新日期：1992-04-01 00:00:00

abstract：:Patients with cancer experience a much higher than expected incidence of thromboembolic disorders, commonly referred as Trousseau syndrome. Although this association has been well documented, the etiology of the hypercoagulable state is not known. The expression on tumor cells of tissue factor (TF), a membrane-bound l...

journal_title：Cancer

authors： Callander NS,Varki N,Rao LV

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:The majority of patients with astrocytomas of the cerebellum have an excellent prognosis; however, a small percentage of patients continue to do poorly. To clarify the clinical, pathologic, and treatment characteristics that determine prognosis and therapeutic recommendations, a large group of patients with ...

journal_title：Cancer

authors： Hayostek CJ,Shaw EG,Scheithauer B,O'Fallon JR,Weiland TL,Schomberg PJ,Kelly PJ,Hu TC

更新日期：1993-08-01 00:00:00

abstract：BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular ...

journal_title：Cancer

authors： Shiro T,Seki T,Naitoh Y,Inoue K,Okamura A

更新日期：1993-01-01 00:00:00

abstract：:Spindle cell lipoma is a specific type of lipoma that is easily mistaken for a liposarcoma. An analysis of 114 cases of this tumor from the files of the Armed Forces Institute of Pathology reveals that is occurs chiefly in male patients between 45 and 70 years of age and affects the regions of the shoulder and posteri...

journal_title：Cancer

authors： Enzinger FM,Harvey DA

更新日期：1975-11-01 00:00:00

abstract：:Three patients with carcinoid tumors of the anterior mediastinum are described. Study of these patients and an analysis of previously reported cases indicates that the thymus is the primary site of these tumors, which are probably related to the presence of Kulchitsky cells in normal thymus. These neoplasms differ cli...

journal_title：Cancer

authors： Salyer WR,Salyer DC,Eggleston JC

更新日期：1976-02-01 00:00:00

abstract：METHODS:The prognostic significance of flow cytometric analysis in patients with node-negative invasive breast carcinoma was evaluated in a retrospective series of 158 patients with a minimum follow-up study of 9 years. RESULTS:The ploidy status could be assessed in 147 specimens (93%), and the proliferative phase or ...

journal_title：Cancer

authors： Bosari S,Lee AK,Tahan SR,Figoni MA,Wiley BD,Heatley GJ,Silverman ML

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND:Nilotinib is a potent, second-generation inhibitor of BCR-ABL1 tyrosine kinase and has been approved as frontline and salvage therapy for patients with chronic-phase chronic myeloid leukemia (CP-CML). METHODS:In this single-institution, phase 2 study, 122 patients with newly diagnosed CP-CML received niloti...

journal_title：Cancer

authors： Masarova L,Cortes JE,Patel KP,O'Brien S,Nogueras-Gonzalez GM,Konopleva M,Verstovsek S,Garcia-Manero G,Ferrajoli A,Kadia TM,Ravandi-Kashani F,Borthakur G,DellaSala S,Estrov Z,Jabbour EJ,Kantarjian HM

更新日期：2020-04-01 00:00:00

abstract：:Findings from 1665 women with primary breast cancer, treated at 34 NSABP institutions in Canada and the United States, have failed to demonstrate that patients with medial-central tumors had a greater probability of developing distant metastases or dying than did those with lateral tumors despite the greater incidence...

journal_title：Cancer

authors： Fisher B,Wolmark N,Redmond C,Deutsch M,Fisher ER

更新日期：1981-10-15 00:00:00

abstract：BACKGROUND:Pigmented villonodular synovitis (PVNS) (also known as diffuse-type giant cell tumor) and tenosynovial giant cell tumors (TGCT) are rare, usually benign neoplasms that affect the synovium and tendon sheaths in young adults. These tumors are driven by the overexpression of colony stimulating factor-1 (CSF1). ...

journal_title：Cancer

authors： Cassier PA,Gelderblom H,Stacchiotti S,Thomas D,Maki RG,Kroep JR,van der Graaf WT,Italiano A,Seddon B,Dômont J,Bompas E,Wagner AJ,Blay JY

更新日期：2012-03-15 00:00:00

abstract：:This article reports on the diagnostic features, radiographic findings, staging, operative management, treatments, and treatment results for 95 children (mean age, 10 years) with paratesticular sarcoma; they were treated on the Intergroup Rhabdomyosarcoma Study (IRS) I and II protocols. Embryonal rhabdomyosarcoma (RMS...

journal_title：Cancer

authors： Raney RB Jr,Tefft M,Lawrence W Jr,Ragab AH,Soule EH,Beltangady M,Gehan EA

更新日期：1987-11-01 00:00:00

abstract：:Over the years, there has been a continuous increase in clinically relevant driver mutations in patients with non-small cell lung cancer (NSCLC). Among these, dysregulated activation of the MET tyrosine kinase receptor has gained importance due to the recent development of quite effective treatments. MET dysregulation...

journal_title：Cancer

authors： Friedlaender A,Drilon A,Banna GL,Peters S,Addeo A

更新日期：2020-11-15 00:00:00

abstract：:Exposure of tumor cells to reduced folates before or with the fluoropyrimidines, 5-fluorouracil or 5-fluoro-2'deoxyuridine, results in a substantial increase in the activity of these drugs. Available evidence suggests that the mechanism of this synergism is a kinetic stabilization of complex formed between thymidylate...

journal_title：Cancer

authors： Morgan RG

更新日期：1989-03-15 00:00:00

abstract：BACKGROUND:The development of novel therapies for the myelodysplastic syndromes (MDS) is hampered by inadequate trial recruitment. Factors contributing to low trial accrual are incompletely understood. METHODS:This study analyzed a pooled patient database from institutions of the US MDS Clinical Research Consortium to...

journal_title：Cancer

authors： Brierley CK,Zabor EC,Komrokji RS,DeZern AE,Roboz GJ,Brunner AM,Stone RM,Sekeres MA,Steensma DP

更新日期：2020-11-01 00:00:00

abstract：:If radical surgery is the only rational policy for most cases of rectal cancer, the problem of local treatment in poor surgical risk patients should be discussed in selected cases. Only limited, fairly-well-differentiated tumors, still confined to the rectal wall may have a sufficiently low probability of lymphatic sp...

journal_title：Cancer

authors： Papillon J

更新日期：1975-08-01 00:00:00

abstract：:Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...

journal_title：Cancer

authors： Recloux P,Weiser M,Piccart M,Sculier JP

更新日期：1988-05-01 00:00:00

abstract：:Grilled or fried meat and fish contain various mutagenic heterocyclic amines, and structures of at least 19 compounds have already been determined. Among these, 10 have been examined for long term carcinogenicity, all proving to be positive. 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP), for example, preferen...

journal_title：Cancer

authors： Nagao M,Ushijima T,Wakabayashi K,Ochiai M,Kushida H,Sugimura T,Hasegawa R,Shirai T,Ito N

更新日期：1994-08-01 00:00:00

abstract：:The clinical course of a 33-year-old man with generalized lymphadenopathy bearing all physical, laboratory and histologic characteristics of "angio-immunoblastic lymphadenopathy with dysproteinemia" (AILD) is described. Therapy was without significant benefit and the patient died 22 months after initial diagnosis. At ...

journal_title：Cancer

authors： Yataganas X,Papadimitriou C,Pangalis G,Loukopoulos D,Fessas P,Papacharalampous N

更新日期：1977-05-01 00:00:00

abstract：BACKGROUND:Prostate carcinoma is often associated with perineural (PN) invasion. The common occurrence of this phenomenon has led to speculation regarding the mechanisms of this association, yet to date there have been no studies that clearly define biologic differences between PN and nonperineural (NPN) carcinoma cell...

journal_title：Cancer

authors： Yang G,Wheeler TM,Kattan MW,Scardino PT,Thompson TC

更新日期：1996-09-15 00:00:00