Abstract:
BACKGROUND:Recently, the number and morphologic features of argyrophilic nucleolar organizer regions (AgNOR), silver-stained nucleolar organizer regions, were thought to reflect the cellular proliferative activity and the grade of malignancy. In liver diseases, it has been reported that AgNOR scores for hepatocellular carcinomas (HCC) were significantly higher than those for benign and borderline lesions; the scores increased with histologic tumor grade. METHODS:Using the colloid silver staining technique to reveal AgNOR, 64 liver biopsy specimens with HCC were examined of which 14 had Stage I disease, 20 had Stage II, 14 had Stage III, 10 had Stage IVA, and 6 had Stage IVB (by International Union Against Cancer criteria). RESULTS:AgNOR in nuclei were divided into two types. Type 1 (T1-NOR) contained large and medium-sized brown dots with well-defined margins. Nucleoli were included in this type. Type 2 (T2-NOR) had fine black single dots and clusters without well-defined margins outside T1-NOR, but within the nucleus. The size and irregularity of T1-NOR changed with the progress of cancerous stages. The increase in the number of T2-NOR contributed preponderantly to the overall increase in Ag-NOR scores. CONCLUSIONS:These results suggest that HCC with smaller and/or irregular T1-NOR in combination with high T2-NOR scores have a more aggressive potential. AgNOR may be useful indicators for evaluating the progress of HCC.
journal_name
Cancerjournal_title
Cancerauthors
Shiro T,Seki T,Naitoh Y,Inoue K,Okamura Adoi
10.1002/1097-0142(19930101)71:1<44::aid-cncr282071subject
Has Abstractpub_date
1993-01-01 00:00:00pages
44-9issue
1eissn
0008-543Xissn
1097-0142journal_volume
71pub_type
杂志文章相关文献
CANCER文献大全abstract::A useful approach to establishing the biologic actions, in vivo, of granulocyte-macrophage colony-stimulating factor (GM-CSF) is to assess the consequences of long-term elevation of the factor in transgenic mice. Two lines of transgenic GM-CSF mice were analyzed. The major abnormality exhibited was an elevation in the...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19910515)67:10+<2695::aid-cncr28
更新日期:1991-05-15 00:00:00
abstract::The histopathology of 43 cases of carcinoma in the extrahepatic bile ducts was reported. All four cases of noninfiltrating carcinoma were papillary or polypoid in gross shape. Only one of the eight cases of papillary or polypoid cancers penetrated beyond the fibromuscular layer of the bile ducts, while most cases of n...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840701)54:1<65::aid-cncr282054
更新日期:1984-07-01 00:00:00
abstract:BACKGROUND:The current study was conducted to evaluate severe mucocutaneous toxicity during treatment with hydroxyurea (HU) in a large cohort of patients with Philadelphia chromosome-negative myeloproliferative neoplasms (MPN). METHODS:Among 993 consecutive patients newly diagnosed with MPN at 4 centers in Rome betwee...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.26194
更新日期:2012-01-15 00:00:00
abstract::Thirty-eight metastatic breast cancer patients were treated with aminoglutethimide. All patients had progressive metastatic disease following initial response to Tamoxifen therapy. Thirty-two patients were evaluable for response, of these, two patients (6%) had complete remission, 13 patients (41%) had partial respons...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19821101)50:9<1708::aid-cncr2820
更新日期:1982-11-01 00:00:00
abstract::Radiation-induced small bowel injury is a limiting factor to postoperative tumoricidal pelvic doses exceeding 4500 to 5000 cGy. Data from a review of the literature showed the inadequacy of medical measures and the bad reproducibility of radiation therapeutic attempts to decrease small intestine damage. Recent studies...
journal_title:Cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1002/1097-0142(19911215)68:12<2545::aid-cncr282
更新日期:1991-12-15 00:00:00
abstract:BACKGROUND:Because the addition of nimotuzumab to chemoradiation in patients with locally advanced head and neck cancer improved outcomes in a phase 2 study, the authors conducted a phase 3 study to confirm these findings. METHODS:This open-label, investigator-initiated, phase 3, randomized trial was conducted from 20...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.32179
更新日期:2019-09-15 00:00:00
abstract::An unusual tumor of the cystic duct in a 28-year-old woman is described. The patient presented with a painful distended gallbladder due to a small tumor occluding the cystic duct. Microscopically the tumor cells showed a nesting pattern suggestive of endocrine differentiation, but contained numerous lipid vacuoles and...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19840201)53:3<498::aid-cncr28205
更新日期:1984-02-01 00:00:00
abstract:BACKGROUND:Accelerated radiotherapy (RT) represents a promising method with which to improve the treatment outcome in patients with head and neck carcinoma. However, its applicability to elderly patients has not been well established. This study assessed treatment toxicities, patient compliance, and oncologic results i...
journal_title:Cancer
pub_type: 杂志文章
doi:
更新日期:2000-02-01 00:00:00
abstract::Interleukin (IL)-2 therapy leads to respiratory dysfunction due to increased vascular permeability. This study examines the role of the chemoattractant, immunomodulator, and permeability-promoting agent leukotriene (LT) B4 in this setting. Sheep with chronic lung lymph fistulae were given IL-2, 10(5) U/kg as an IV bol...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19901201)66:11<2357::aid-cncr282
更新日期:1990-12-01 00:00:00
abstract::Acid phosphatase activity biochemically in the primary tumor of 20 patients with prostatic carcinoma, was studied in an attempt to understand the basis for a correlation or lack of correlation between serum and/or bone marrow acid phosphatase levels and the presence and/or clinical behavior of prostatic carcinoma. The...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830701)52:1<155::aid-cncr28205
更新日期:1983-07-01 00:00:00
abstract:BACKGROUND:This paper gives an outline of the Casley-Smith method for the treatment of lymphedema of the arm. It includes a brief summary of the development of manual techniques and the terminology applied to them. METHODS:The four principles of this method are skin care, manual lymphatic drainage, compression in the ...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/(sici)1097-0142(19981215)83:12b+<2843::aid
更新日期:1998-12-15 00:00:00
abstract::External-beam irradiation of prostatic cancer was introduced at Stanford in 1956. The program has sought to determine the following: whether prostatic carcinoma can be cured by external beam radiation therapy, with what frequency this can be accomplished, which patients are best suited for irradiation, and what techni...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19870801)60:3+<521::aid-cncr2820
更新日期:1987-08-01 00:00:00
abstract::A family with histopathologically proven intraocular malignant melanoma involving two generations is reported. A member of third generation was likely involved by history. Intraocular malignant melanoma, its familial occurrence, its occurrence with multiple malignancies, and its relationship to multiple malignancies o...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197806)41:6<2481::aid-cncr282041
更新日期:1978-06-01 00:00:00
abstract:BACKGROUND:Carfilzomib improves survival in patients with recurrent myeloma. Given the strict eligibility criteria in clinical trials, the actual frequency of cardiac adverse events (CAEs) and pulmonary adverse events (PAEs) and the risk factors associated with these AEs in the general population need to be established...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.32601
更新日期:2020-02-15 00:00:00
abstract:BACKGROUND:Recent scientific advances provide the opportunity to identify women in the general population at increased breast cancer risk and to offer effective early detection and disease prevention interventions. METHODS:A pedigree assessment tool (PAT) was designed to identify women in primary care settings who are...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22202
更新日期:2006-10-15 00:00:00
abstract::Since single drug therapy of chronic lymphocytic leukemia (CLL) has not resulted in prolonged remissions of advanced disease, we initiated a program of combination chemotherapy, COP (cycloposphamide, vincristine sulfate, prednisone) for CLL patients with increasing adenopathy, spenomegaly, and/or signs of marrow failu...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(197805)41:5<1664::aid-cncr282041
更新日期:1978-05-01 00:00:00
abstract:BACKGROUND:Patients age > or = 75 years with acute myeloid leukemia (AML) generally are offered palliative treatments instead of induction chemotherapy. The authors conducted a retrospective study comparing the outcomes among these elderly patients with the outcomes among younger patients to assess the impact of intens...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.20353
更新日期:2004-07-15 00:00:00
abstract:BACKGROUND:Preclinical studies have demonstrated that the inhibition of the PI3K/Akt/mTOR pathway restores gefitinib sensitivity in resistant cancer cell lines. A phase 1 study was conducted of the combination of everolimus, an mTOR inhibitor, and gefitinib to determine a daily dose of everolimus with gefitinib in pati...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.22816
更新日期:2007-08-01 00:00:00
abstract::Previous studies have shown that magnetic resonance imaging (MRI) is sensitive to white matter changes in children receiving cranial radiation of 3000 cGy or greater. The current study used MRI to investigate the integrity of white matter in children receiving 1800 to 2400 cGy of cranial radiation. Ten survivors of ac...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880301)61:5<928::aid-cncr28206
更新日期:1988-03-01 00:00:00
abstract:BACKGROUND:Information regarding prognostic factors and survival in elderly women with metastatic breast cancer treated with tamoxifen is limited. METHODS:The data from 4 prospective clinical trials were analyzed, including information on 396 postmenopausal women with advanced breast cancer who received tamoxifen as i...
journal_title:Cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/(sici)1097-0142(19960215)77:4<683::aid-cnc
更新日期:1996-02-15 00:00:00
abstract:BACKGROUND:Gastrointestinal stromal tumors (GISTs) are KIT-positive mesenchymal tumors of the gastrointestinal tract that are driven by activated KIT-signalling or platelet-derived growth factor receptor-alpha (PDFGRA) signaling. These tumors most commonly occur in the stomach and small intestine and encompass a clinic...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.23216
更新日期:2008-02-01 00:00:00
abstract:BACKGROUND:Optic pathway gliomas (OPGs) are commonly noted in pediatric oncology services. Radiotherapy is effective at controlling tumors, but has many undesirable late effects, especially in patients with neurofibromatosis. Chemotherapy is commonly used to preserve vision and delay or eliminate the need for radiother...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.29649
更新日期:2015-12-01 00:00:00
abstract:BACKGROUND:Hormone replacement therapy (HRT) has proven and presumable benefits for women desiring postmenopausal health preservation. Among HRT-associated risks, the fear of breast carcinoma intimidates women and physicians contemplating hormonal treatment and limits long-term compliance. Identifying effective alterna...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/cncr.11049
更新日期:2003-01-01 00:00:00
abstract::To additionally understand the molecular mechanisms and biologic indicators of colonic tumorigenesis through the adenoma-carcinoma sequence, protein kinase C (PKC) activity was examined in the cytosol and particulate fraction of specimen homogenates from 18 human colonic carcinomas and seven coexisting colonic adenoma...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19920101)69:1<24::aid-cncr282069
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:Testicular cancer survivors (TCS) have an increased risk of treatment-related cardiovascular disease (CVD), which may limit their overall survival. We evaluated the effects of high-intensity aerobic interval training (HIIT) on traditional and novel CVD risk factors and surrogate markers of mortality in a pop...
journal_title:Cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/cncr.30859
更新日期:2017-10-15 00:00:00
abstract:BACKGROUND:Vitiligo is a dermatologic disease characterized by local, dispersed, or diffuse white patches on the skin. The disease is defined as an autoimmune disorder because autoantibodies against membranal components of melanocytes are found in the patients' sera. The current study examined whether the autoantibodie...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19931015)72:8<2365::aid-cncr2820
更新日期:1993-10-15 00:00:00
abstract::Breast reconstruction is not a new idea. Techniques have been developing since the late 1800s. The state of the art is such that the knowledge of its availability and success has significant effect on the willingness of women to seek earlier diagnosis and treatment. However, reconstruction is not for everyone. This pa...
journal_title:Cancer
pub_type: 杂志文章,评审
doi:10.1002/1097-0142(19910901)68:5+<1167::aid-cncr282
更新日期:1991-09-01 00:00:00
abstract::Data from 133 patients with cancer and suspected compression of the spinal cord or cauda equina was reviewed. Although there were differences in presenting symptoms and signs between the group of 62 patients with compression and the 71 without, no single symptom or sign discriminated adequately between the two groups....
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19830515)51:10<1953::aid-cncr282
更新日期:1983-05-15 00:00:00
abstract:BACKGROUND:The staging system for non-small cell lung cancer (NSCLC) does not consider tumor burden or number of metastatic sites, although oligometastases are more favorable. METHODS:Using log-rank testing, the authors analyzed overall survival (OS) in 1284 patients newly presenting with metastatic NSCLC by number of...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/cncr.24333
更新日期:2009-07-01 00:00:00
abstract::Six breast cancer patients were treated recently for renal insufficiency secondary to neoplasic involvement of the ureters. This complication usually occurs in long standing hormonal-dependent breast cancer with bone metastases. Diagnosis was performed by abdominal echography. Ureteral catheterization or percutaneous ...
journal_title:Cancer
pub_type: 杂志文章
doi:10.1002/1097-0142(19880501)61:9<1904::aid-cncr2820
更新日期:1988-05-01 00:00:00